3hof - Revision history

OCA at 15:51, 1 November 2023

OCA — Wed, 01 Nov 2023 15:51:55 GMT

←Older revision		Revision as of 15:51, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3hof' size='340' side='right'caption='[[3hof]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3hof' size='340' side='right'caption='[[3hof]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hof]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HOF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hof]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HOF FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=DHC:CAFFEIC+ACID'>DHC</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>MIF ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DHC:CAFFEIC+ACID'>DHC</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Phenylpyruvate_tautomerase Phenylpyruvate tautomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.2.1 5.3.2.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hof OCA], [https://pdbe.org/3hof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hof RCSB], [https://www.ebi.ac.uk/pdbsum/3hof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hof ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hof OCA], [https://pdbe.org/3hof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hof RCSB], [https://www.ebi.ac.uk/pdbsum/3hof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hof ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[https://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.	+	[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[https://omim.org/entry/604302 604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>	+	[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Phenylpyruvate tautomerase]]~~	+	[[Category: Barker J]]
-	[[Category: Barker, J]]	+	[[Category: Cheng RKY]]
-	[[Category: Cheng~~, R K.Y~~]]	+	[[Category: Crawley L]]
-	[[Category: Crawley, L]]	+	[[Category: Felicetti B]]
-	[[Category: Felicetti, B]]	+	[[Category: Wood M]]
-	[[Category: Wood, M]]	+
-	~~[[Category: Cytokine]]~~	+
-	~~[[Category: Homotrimer]]~~	+
-	~~[[Category: Inflammatory response]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Tautomerase~~]]	+

OCA at 12:54, 23 March 2022

OCA — Wed, 23 Mar 2022 12:54:34 GMT

←Older revision		Revision as of 12:54, 23 March 2022
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	==Structure of macrophage migration inhibitory factor (MIF) with caffeic acid at 1.9A resolution==		==Structure of macrophage migration inhibitory factor (MIF) with caffeic acid at 1.9A resolution==
-	<StructureSection load='3hof' size='340' side='right' caption='[[3hof]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='3hof' size='340' side='right'caption='[[3hof]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hof]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HOF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3HOF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hof]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HOF FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DHC:CAFFEIC+ACID'>DHC</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DHC:CAFFEIC+ACID'>DHC</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MIF ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MIF ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phenylpyruvate_tautomerase Phenylpyruvate tautomerase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.2.1 5.3.2.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phenylpyruvate_tautomerase Phenylpyruvate tautomerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.2.1 5.3.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3hof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hof OCA], [~~http~~://pdbe.org/3hof PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3hof RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3hof PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3hof ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hof OCA], [https://pdbe.org/3hof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hof RCSB], [https://www.ebi.ac.uk/pdbsum/3hof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hof ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[~~http~~://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.	+	[[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[https://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>	+	[[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 25:

	==See Also==		==See Also==
-	*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]	+	*[[Macrophage inhibitory factor 3D structures\|Macrophage inhibitory factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Phenylpyruvate tautomerase]]		[[Category: Phenylpyruvate tautomerase]]
	[[Category: Barker, J]]		[[Category: Barker, J]]

OCA at 07:54, 12 December 2018

OCA — Wed, 12 Dec 2018 07:54:09 GMT

←Older revision		Revision as of 07:54, 12 December 2018
Line 1:		Line 1:
		+
	==Structure of macrophage migration inhibitory factor (MIF) with caffeic acid at 1.9A resolution==		==Structure of macrophage migration inhibitory factor (MIF) with caffeic acid at 1.9A resolution==
	<StructureSection load='3hof' size='340' side='right' caption='[[3hof]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3hof' size='340' side='right' caption='[[3hof]], [[Resolution\|resolution]] 1.90Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylpyruvate_tautomerase Phenylpyruvate tautomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.2.1 5.3.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylpyruvate_tautomerase Phenylpyruvate tautomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.2.1 5.3.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hof OCA], [http://pdbe.org/3hof PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hof RCSB], [http://www.ebi.ac.uk/pdbsum/3hof PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hof OCA], [http://pdbe.org/3hof PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hof RCSB], [http://www.ebi.ac.uk/pdbsum/3hof PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hof ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ho/3hof_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ho/3hof_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 13:08, 9 February 2016

OCA — Tue, 09 Feb 2016 13:08:24 GMT

←Older revision		Revision as of 13:08, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3hof' size='340' side='right' caption='[[3hof]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3hof' size='340' side='right' caption='[[3hof]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hof]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HOF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HOF FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hof]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HOF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HOF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DHC:CAFFEIC+ACID'>DHC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DHC:CAFFEIC+ACID'>DHC</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylpyruvate_tautomerase Phenylpyruvate tautomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.2.1 5.3.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylpyruvate_tautomerase Phenylpyruvate tautomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.2.1 5.3.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hof OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hof RCSB], [http://www.ebi.ac.uk/pdbsum/3hof PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hof OCA], [http://pdbe.org/3hof PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hof RCSB], [http://www.ebi.ac.uk/pdbsum/3hof PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hof ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Phenylpyruvate tautomerase]]		[[Category: Phenylpyruvate tautomerase]]
	[[Category: Barker, J]]		[[Category: Barker, J]]

OCA at 15:05, 18 December 2014

OCA — Thu, 18 Dec 2014 15:05:32 GMT

←Older revision		Revision as of 15:05, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3hof\| PDB=3hof \| SCENE= }}~~	+	==Structure of macrophage migration inhibitory factor (MIF) with caffeic acid at 1.9A resolution==
-	===Structure of macrophage migration inhibitory factor (MIF) with caffeic acid at 1.9A resolution===	+	<StructureSection load='3hof' size='340' side='right' caption='[[3hof]], [[Resolution\|resolution]] 1.90Å' scene=''>
-		+	== Structural highlights ==
-	==Disease==	+	<table><tr><td colspan='2'>[[3hof]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HOF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HOF FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DHC:CAFFEIC+ACID'>DHC</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylpyruvate_tautomerase Phenylpyruvate tautomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.2.1 5.3.2.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hof OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hof RCSB], [http://www.ebi.ac.uk/pdbsum/3hof PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.		[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ho/3hof_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

-	==~~Function~~==	+	==See Also==
-	[[~~http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN~~]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref><ref>PMID:17443469</ref>	+	*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]
-		+	== References ==
-	==~~About this Structure==~~	+	<references/>
-	[[3hof]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HOF OCA].	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	<references ~~group="xtra"~~/><~~references~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phenylpyruvate tautomerase]]		[[Category: Phenylpyruvate tautomerase]]
-	[[Category: Barker, J.]]	+	[[Category: Barker, J]]
-	[[Category: Cheng, R K.Y.]]	+	[[Category: Cheng, R K.Y]]
-	[[Category: Crawley, L.]]	+	[[Category: Crawley, L]]
-	[[Category: Felicetti, B.]]	+	[[Category: Felicetti, B]]
-	[[Category: Wood, M.]]	+	[[Category: Wood, M]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
	[[Category: Homotrimer]]		[[Category: Homotrimer]]

OCA at 09:28, 24 March 2013

OCA — Sun, 24 Mar 2013 09:28:20 GMT

←Older revision		Revision as of 09:28, 24 March 2013
Line 1:		Line 1:
-	[[Image:3hof.png\|left\|200px]]
-
	{{STRUCTURE_3hof\| PDB=3hof \| SCENE= }}		{{STRUCTURE_3hof\| PDB=3hof \| SCENE= }}
-
	===Structure of macrophage migration inhibitory factor (MIF) with caffeic acid at 1.9A resolution===		===Structure of macrophage migration inhibitory factor (MIF) with caffeic acid at 1.9A resolution===

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref><ref>PMID:17443469</ref>

	==About this Structure==		==About this Structure==
	[[3hof]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HOF OCA].		[[3hof]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HOF OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phenylpyruvate tautomerase]]		[[Category: Phenylpyruvate tautomerase]]

OCA: Protected "3hof" [edit=sysop:move=sysop]

OCA — Wed, 06 Mar 2013 14:59:54 GMT

Protected "3hof" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:59, 6 March 2013

OCA at 14:59, 6 March 2013

OCA — Wed, 06 Mar 2013 14:59:49 GMT

←Older revision		Revision as of 14:59, 6 March 2013
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3hof.png\|left\|200px]]
-	[[Image:3hof.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3hof", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3hof\| PDB=3hof \| SCENE= }}		{{STRUCTURE_3hof\| PDB=3hof \| SCENE= }}

	===Structure of macrophage migration inhibitory factor (MIF) with caffeic acid at 1.9A resolution===		===Structure of macrophage migration inhibitory factor (MIF) with caffeic acid at 1.9A resolution===

-
-	==Disease==
-	Known disease associated with this structure: Persistent Mullerian duct syndrome, type I OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600957 600957]], Rheumatoid arthritis, systemic juvenile, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153620 153620]]

	==About this Structure==		==About this Structure==
-	~~3HOF~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HOF OCA].	+	[[3hof]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HOF OCA].
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phenylpyruvate tautomerase]]		[[Category: Phenylpyruvate tautomerase]]
Line 31:		Line 21:
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	[[Category: Tautomerase]]		[[Category: Tautomerase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 17 11:36:30 2009''

OCA at 08:36, 17 June 2009

OCA — Wed, 17 Jun 2009 08:36:33 GMT

←Older revision		Revision as of 08:36, 17 June 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3hof.jpg\|left\|200px]]

-	The ~~entry 3hof~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3hof", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3hof\| PDB=3hof \| SCENE= }}

-	~~Authors: Crawley, L., Barker, J., Cheng, R.K.Y., Wood, M., Felicetti, B~~.	+	===Structure of macrophage migration inhibitory factor (MIF) with caffeic acid at 1.9A resolution===

-	Description: Structure of macrophage migration inhibitory factor (MIF) with caffeic acid at 1.9A resolution

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun ~~10 18~~:00:33 2009''	+	==Disease==
		+	Known disease associated with this structure: Persistent Mullerian duct syndrome, type I OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600957 600957]], Rheumatoid arthritis, systemic juvenile, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=153620 153620]]
		+
		+	==About this Structure==
		+	3HOF is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HOF OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Phenylpyruvate tautomerase]]
		+	[[Category: Barker, J.]]
		+	[[Category: Cheng, R K.Y.]]
		+	[[Category: Crawley, L.]]
		+	[[Category: Felicetti, B.]]
		+	[[Category: Wood, M.]]
		+	[[Category: Cytokine]]
		+	[[Category: Homotrimer]]
		+	[[Category: Inflammatory response]]
		+	[[Category: Isomerase]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Tautomerase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 17 11:36:30 2009''

OCA: New page: '''Unreleased structure''' The entry 3hof is ON HOLD Authors: Crawley, L., Barker, J., Cheng, R.K.Y., Wood, M., Felicetti, B. Description: Structure of macrophage migration inhibitory ...

OCA — Wed, 10 Jun 2009 15:00:33 GMT

New page: '''Unreleased structure''' The entry 3hof is ON HOLD Authors: Crawley, L., Barker, J., Cheng, R.K.Y., Wood, M., Felicetti, B. Description: Structure of macrophage migration inhibitory ...

New page

'''Unreleased structure'''

The entry 3hof is ON HOLD

Authors: Crawley, L., Barker, J., Cheng, R.K.Y., Wood, M., Felicetti, B.

Description: Structure of macrophage migration inhibitory factor (MIF) with caffeic acid at 1.9A resolution

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 10 18:00:33 2009''