3hp8 - Revision history

OCA at 07:25, 6 September 2023

OCA — Wed, 06 Sep 2023 07:25:56 GMT

←Older revision		Revision as of 07:25, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3hp8' size='340' side='right'caption='[[3hp8]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3hp8' size='340' side='right'caption='[[3hp8]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hp8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Tubbo Tubbo~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HP8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hp8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa] and [https://en.wikipedia.org/wiki/Tuber_borchii Tuber borchii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HP8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=~~GLC~~:~~ALPHA-D-GLUCOSE~~'>~~GLC~~</scene>, <scene name='pdbligand=~~FRU~~:~~FRUCTOSE~~'>~~FRU~~</scene><~~/td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;~~'>~~[[2kjl\|2kjl]], [[3hnu\|3hnu]], [[3hnx\|3hnx]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=FRU:FRUCTOSE'>FRU</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900003:sucrose'>PRD_900003</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hp8 OCA], [https://pdbe.org/3hp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hp8 RCSB], [https://www.ebi.ac.uk/pdbsum/3hp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hp8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hp8 OCA], [https://pdbe.org/3hp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hp8 RCSB], [https://www.ebi.ac.uk/pdbsum/3hp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hp8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CVNH_TUBBO CVNH_TUBBO]] Mannose-binding lectin.<ref>PMID:18400178</ref>	+	[https://www.uniprot.org/uniprot/CVNH_NEUCR CVNH_NEUCR] Mannose-binding lectin.<ref>PMID:18400178</ref> [https://www.uniprot.org/uniprot/CVNH_TUBBO CVNH_TUBBO] Mannose-binding lectin.<ref>PMID:18400178</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Tubbo~~]]	+	[[Category: Neurospora crassa]]
-	[[Category: ~~Furey, W~~]]	+	[[Category: Tuber borchii]]
-	[[Category: ~~Gronenborn, A M~~]]	+	[[Category: Furey W]]
-	[[Category: ~~Koharudin, L M.I~~]]	+	[[Category: Gronenborn AM]]
-	[[Category: ~~Carbohydrate]]~~	+	[[Category: Koharudin LMI]]
-	~~[[Category: Cvnh]]~~	+
-	~~[[Category: Cyanovirin-n]]~~	+
-	~~[[Category: Lectin]]~~	+
-	~~[[Category: Sucrose]]~~	+
-	~~[[Category: Sugar binding protein~~]]	+

OCA at 11:53, 30 March 2022

OCA — Wed, 30 Mar 2022 11:53:52 GMT

←Older revision		Revision as of 11:53, 30 March 2022
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	<StructureSection load='3hp8' size='340' side='right'caption='[[3hp8]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3hp8' size='340' side='right'caption='[[3hp8]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hp8]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Tubbo Tubbo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HP8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3HP8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hp8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Tubbo Tubbo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HP8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=~~SUC~~:~~SUCROSE~~'>~~SUC~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=FRU:FRUCTOSE'>FRU</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kjl\|2kjl]], [[3hnu\|3hnu]], [[3hnx\|3hnx]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2kjl\|2kjl]], [[3hnu\|3hnu]], [[3hnx\|3hnx]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3hp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hp8 OCA], [~~http~~://pdbe.org/3hp8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3hp8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3hp8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3hp8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hp8 OCA], [https://pdbe.org/3hp8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hp8 RCSB], [https://www.ebi.ac.uk/pdbsum/3hp8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hp8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CVNH_TUBBO CVNH_TUBBO]] Mannose-binding lectin.<ref>PMID:18400178</ref>	+	[[https://www.uniprot.org/uniprot/CVNH_TUBBO CVNH_TUBBO]] Mannose-binding lectin.<ref>PMID:18400178</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 16:51, 28 August 2019

OCA — Wed, 28 Aug 2019 16:51:52 GMT

←Older revision		Revision as of 16:51, 28 August 2019
Line 1:		Line 1:

	==Crystal structure of a designed Cyanovirin-N homolog lectin; LKAMG, bound to sucrose==		==Crystal structure of a designed Cyanovirin-N homolog lectin; LKAMG, bound to sucrose==
-	<StructureSection load='3hp8' size='340' side='right' caption='[[3hp8]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3hp8' size='340' side='right'caption='[[3hp8]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3hp8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Tubbo Tubbo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HP8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HP8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3hp8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Tubbo Tubbo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HP8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HP8 FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hp/3hp8_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hp/3hp8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Tubbo]]		[[Category: Tubbo]]
	[[Category: Furey, W]]		[[Category: Furey, W]]

OCA at 22:01, 5 August 2016

OCA — Fri, 05 Aug 2016 22:01:28 GMT

←Older revision		Revision as of 22:01, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of a designed Cyanovirin-N homolog lectin; LKAMG, bound to sucrose==		==Crystal structure of a designed Cyanovirin-N homolog lectin; LKAMG, bound to sucrose==
	<StructureSection load='3hp8' size='340' side='right' caption='[[3hp8]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3hp8' size='340' side='right' caption='[[3hp8]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hp8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Tuber_borchii Tuber borchii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HP8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HP8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hp8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Tubbo Tubbo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HP8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HP8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=SUC:SUCROSE'>SUC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=SUC:SUCROSE'>SUC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kjl\|2kjl]], [[3hnu\|3hnu]], [[3hnx\|3hnx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kjl\|2kjl]], [[3hnu\|3hnu]], [[3hnx\|3hnx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hp8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hp8 RCSB], [http://www.ebi.ac.uk/pdbsum/3hp8 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hp8 OCA], [http://pdbe.org/3hp8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hp8 RCSB], [http://www.ebi.ac.uk/pdbsum/3hp8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hp8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hp8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3hp8" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Tuber borchii~~]]	+	[[Category: Tubbo]]
	[[Category: Furey, W]]		[[Category: Furey, W]]
	[[Category: Gronenborn, A M]]		[[Category: Gronenborn, A M]]

OCA at 22:16, 25 December 2014

OCA — Thu, 25 Dec 2014 22:16:45 GMT

←Older revision		Revision as of 22:16, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hp8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hp8 RCSB], [http://www.ebi.ac.uk/pdbsum/3hp8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hp8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hp8 RCSB], [http://www.ebi.ac.uk/pdbsum/3hp8 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CVNH_TUBBO CVNH_TUBBO]] Mannose-binding lectin.<ref>PMID:18400178</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:33, 8 December 2014

OCA — Mon, 08 Dec 2014 09:33:10 GMT

←Older revision		Revision as of 09:33, 8 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3hp8.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of a designed Cyanovirin-N homolog lectin; LKAMG, bound to sucrose==
		+	<StructureSection load='3hp8' size='340' side='right' caption='[[3hp8]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3hp8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Tuber_borchii Tuber borchii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HP8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HP8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=SUC:SUCROSE'>SUC</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2kjl\|2kjl]], [[3hnu\|3hnu]], [[3hnx\|3hnx]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hp8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hp8 RCSB], [http://www.ebi.ac.uk/pdbsum/3hp8 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hp/3hp8_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The NMR and X-ray structures of a designed chimeric cyanovirin-N homolog (CVNH) protein were determined. The individual halves of the structure are similar to their counterparts in the parent proteins, with domains A and B resembling the structures of TbCVNH and NcCVNH, respectively. No significant differences between the solution and crystal conformations were observed, although details in loop conformations and distinct crystal packing-induced features are present. Carbohydrate binding studies by NMR revealed affinity and specificity for Glc alpha(1-2)Frc and Man alpha(1-2)Man, and the parental half that is devoid of any sucrose affinity in NcCVNH was transformed into a genuine sucrose binding site in the context of the chimera. The atomic details of sugar recognition are seen in the crystal structure of the protein with two bound Glc alpha(1-2)Frc molecules. Both sugars exhibit different conformations around the glycosidic bond and engage in unique hydrogen bonding networks in the two sites. Although the protein is able to bind two Man alpha(1-2)Man molecules, a property associated with HIV-inactivation, no anti-HIV activity was observed for the hybrid protein. These results provide the structural basis for sugar recognition in the CVNH family and aid in deciphering the relationship between sugar binding and anti-HIV activity.

-	~~{{STRUCTURE_3hp8\| PDB=3hp8 \| SCENE= }}~~	+	A designed chimeric cyanovirin-N homolog lectin: structure and molecular basis of sucrose binding.,Koharudin LM, Furey W, Gronenborn AM Proteins. 2009 Dec;77(4):904-15. PMID:19639634<ref>PMID:19639634</ref>

-	~~===Crystal structure of a designed Cyanovirin-N homolog lectin~~; ~~LKAMG~~, ~~bound to sucrose===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19639634}}~~	+	== References ==
-		+	<references/>
-	~~==About this Structure==~~	+	__TOC__
-	~~[[3hp8]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Tuber_borchii Tuber borchii]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3HP8 OCA].~~	+	</StructureSection>
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019639634<~~/~~ref~~><~~ref group="xtra">PMID:018400178</ref><references group="xtra"~~/>	+
	[[Category: Tuber borchii]]		[[Category: Tuber borchii]]
-	[[Category: Furey, W.]]	+	[[Category: Furey, W]]
-	[[Category: Gronenborn, A M.]]	+	[[Category: Gronenborn, A M]]
-	[[Category: Koharudin, L M.I.]]	+	[[Category: Koharudin, L M.I]]
	[[Category: Carbohydrate]]		[[Category: Carbohydrate]]
	[[Category: Cvnh]]		[[Category: Cvnh]]

OCA at 14:56, 6 March 2013

OCA — Wed, 06 Mar 2013 14:56:39 GMT

←Older revision		Revision as of 14:56, 6 March 2013
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	[[Image:3hp8.png\|left\|200px]]		[[Image:3hp8.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_3hp8\| PDB=3hp8 \| SCENE= }}		{{STRUCTURE_3hp8\| PDB=3hp8 \| SCENE= }}

	===Crystal structure of a designed Cyanovirin-N homolog lectin; LKAMG, bound to sucrose===		===Crystal structure of a designed Cyanovirin-N homolog lectin; LKAMG, bound to sucrose===

-
-	<!--
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	{{ABSTRACT_PUBMED_19639634}}		{{ABSTRACT_PUBMED_19639634}}

	==About this Structure==		==About this Structure==
-	[[3hp8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Tuber_borchii~~,neurospora_crassa,tuber_borchii~~ Tuber ~~borchii,neurospora crassa,tuber~~ borchii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HP8 OCA].	+	[[3hp8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Tuber_borchii Tuber borchii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HP8 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19639634~~</ref><ref group="xtra">PMID:~~18400178~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019639634</ref><ref group="xtra">PMID:018400178</ref><references group="xtra"/>
-	[[Category: Tuber ~~borchii,neurospora crassa,tuber~~ borchii]]	+	[[Category: Tuber borchii]]
	[[Category: Furey, W.]]		[[Category: Furey, W.]]
	[[Category: Gronenborn, A M.]]		[[Category: Gronenborn, A M.]]

OCA: Protected "3hp8" [edit=sysop:move=sysop]

OCA — Mon, 14 Mar 2011 22:46:49 GMT

Protected "3hp8" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:46, 14 March 2011

OCA at 22:46, 14 March 2011

OCA — Mon, 14 Mar 2011 22:46:48 GMT

←Older revision		Revision as of 22:46, 14 March 2011
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-	{{Seed}}
	[[Image:3hp8.png\|left\|200px]]		[[Image:3hp8.png\|left\|200px]]

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	===Crystal structure of a designed Cyanovirin-N homolog lectin; LKAMG, bound to sucrose===		===Crystal structure of a designed Cyanovirin-N homolog lectin; LKAMG, bound to sucrose===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19639634}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19639634 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19639634}}

	==About this Structure==		==About this Structure==
-	~~3HP8~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Tuber_borchii,neurospora_crassa,tuber_borchii Tuber borchii,neurospora crassa,tuber borchii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HP8 OCA].	+	[[3hp8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Tuber_borchii,neurospora_crassa,tuber_borchii Tuber borchii,neurospora crassa,tuber borchii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HP8 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:18400178</ref><references group="xtra"/>	+	<ref group="xtra">PMID:19639634</ref><ref group="xtra">PMID:18400178</ref><references group="xtra"/>
	[[Category: Tuber borchii,neurospora crassa,tuber borchii]]		[[Category: Tuber borchii,neurospora crassa,tuber borchii]]
	[[Category: Furey, W.]]		[[Category: Furey, W.]]
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	[[Category: Sucrose]]		[[Category: Sucrose]]
	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 4 20:17:21 2009''

OCA at 18:08, 4 November 2009

OCA — Wed, 04 Nov 2009 18:08:32 GMT

←Older revision		Revision as of 18:08, 4 November 2009
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	===Crystal structure of a designed Cyanovirin-N homolog lectin; LKAMG, bound to sucrose===		===Crystal structure of a designed Cyanovirin-N homolog lectin; LKAMG, bound to sucrose===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19639634}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19639634 is the PubMed ID number.
-	-->
-	{{ABSTRACT_PUBMED_19639634}}

	==About this Structure==		==About this Structure==
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	==Reference==		==Reference==
-	~~<ref group="xtra">PMID:19639634</ref>~~<ref group="xtra">PMID:18400178</ref><references group="xtra"/>	+	<ref group="xtra">PMID:18400178</ref><references group="xtra"/>
	[[Category: Tuber borchii,neurospora crassa,tuber borchii]]		[[Category: Tuber borchii,neurospora crassa,tuber borchii]]
	[[Category: Furey, W.]]		[[Category: Furey, W.]]
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	[[Category: Sugar binding protein]]		[[Category: Sugar binding protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 4 12:33:02 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 4 20:17:21 2009''