3hpl - Revision history

OCA at 12:02, 13 October 2021

OCA — Wed, 13 Oct 2021 12:02:26 GMT

←Older revision		Revision as of 12:02, 13 October 2021
Line 1:		Line 1:

	==KcsA E71H-F103A mutant in the closed state==		==KcsA E71H-F103A mutant in the closed state==
-	<StructureSection load='3hpl' size='340' side='right' caption='[[3hpl]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='3hpl' size='340' side='right'caption='[[3hpl]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hpl]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"actinomyces_lividans"_krasil'nikov_et_al._1965 "actinomyces lividans" krasil'nikov et al. 1965] and [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HPL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3HPL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hpl]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/"actinomyces_lividans"_krasil'nikov_et_al._1965 "actinomyces lividans" krasil'nikov et al. 1965] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HPL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HPL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kcsA, skc1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1916 "Actinomyces lividans" Krasil'nikov et al. 1965])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kcsA, skc1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1916 "Actinomyces lividans" Krasil'nikov et al. 1965])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3hpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hpl OCA], [~~http~~://pdbe.org/3hpl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3hpl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3hpl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3hpl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hpl OCA], [https://pdbe.org/3hpl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hpl RCSB], [https://www.ebi.ac.uk/pdbsum/3hpl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hpl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>	+	[[https://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]		*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
-	*[[Potassium ~~Channel~~\|Potassium ~~Channel~~]]	+	*[[Potassium channel 3D structures\|Potassium channel 3D structures]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 40:
	</StructureSection>		</StructureSection>
	[[Category: Actinomyces lividans krasil'nikov et al. 1965]]		[[Category: Actinomyces lividans krasil'nikov et al. 1965]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Cortes, D M]]		[[Category: Cortes, D M]]

OCA at 08:23, 12 December 2018

OCA — Wed, 12 Dec 2018 08:23:58 GMT

←Older revision		Revision as of 08:23, 12 December 2018
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hp/3hpl_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hp/3hpl_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 31:

	==See Also==		==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	*[[Potassium Channel\|Potassium Channel]]		*[[Potassium Channel\|Potassium Channel]]
-	*[[3D structures of antibody\|3D structures of antibody]]
-	*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:40, 5 August 2016

OCA — Fri, 05 Aug 2016 11:40:35 GMT

←Older revision		Revision as of 11:40, 5 August 2016
Line 1:		Line 1:
		+
	==KcsA E71H-F103A mutant in the closed state==		==KcsA E71H-F103A mutant in the closed state==
	<StructureSection load='3hpl' size='340' side='right' caption='[[3hpl]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='3hpl' size='340' side='right' caption='[[3hpl]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hpl]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~] and [http://en.wikipedia.org/wiki/~~Streptomyces_lividans Streptomyces lividans~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HPL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HPL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hpl]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_lividans"_krasil'nikov_et_al._1965 "actinomyces lividans" krasil'nikov et al. 1965] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HPL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HPL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kcsA, skc1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1916 ~~Streptomyces~~ lividans])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kcsA, skc1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1916 "Actinomyces lividans" Krasil'nikov et al. 1965])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hpl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hpl RCSB], [http://www.ebi.ac.uk/pdbsum/3hpl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hpl OCA], [http://pdbe.org/3hpl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hpl RCSB], [http://www.ebi.ac.uk/pdbsum/3hpl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hpl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hpl ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3hpl" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Antibody\|Antibody]]
-	*[[Monoclonal Antibody\|Monoclonal Antibody]]
	*[[Potassium Channel\|Potassium Channel]]		*[[Potassium Channel\|Potassium Channel]]
		+	*[[3D structures of antibody\|3D structures of antibody]]
		+	*[[3D structures of monoclonal antibody\|3D structures of monoclonal antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Actinomyces lividans krasil'nikov et al. 1965]]
-	[[Category: ~~Streptomyces lividans~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Cortes, D M]]		[[Category: Cortes, D M]]
	[[Category: Cuello, L G]]		[[Category: Cuello, L G]]

OCA at 02:06, 25 December 2014

OCA — Thu, 25 Dec 2014 02:06:57 GMT

←Older revision		Revision as of 02:06, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hpl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hpl RCSB], [http://www.ebi.ac.uk/pdbsum/3hpl PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hpl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hpl RCSB], [http://www.ebi.ac.uk/pdbsum/3hpl PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:39, 8 December 2014

OCA — Mon, 08 Dec 2014 09:39:50 GMT

←Older revision		Revision as of 09:39, 8 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3hpl.~~png~~\|~~left~~\|200px]]	+	==KcsA E71H-F103A mutant in the closed state==
		+	<StructureSection load='3hpl' size='340' side='right' caption='[[3hpl]], [[Resolution\|resolution]] 3.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3hpl]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HPL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HPL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">kcsA, skc1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1916 Streptomyces lividans])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hpl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hpl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hpl RCSB], [http://www.ebi.ac.uk/pdbsum/3hpl PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hp/3hpl_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The coupled interplay between activation and inactivation gating is a functional hallmark of K(+) channels. This coupling has been experimentally demonstrated through ion interaction effects and cysteine accessibility, and is associated with a well defined boundary of energetically coupled residues. The structure of the K(+) channel KcsA in its fully open conformation, in addition to four other partial channel openings, richly illustrates the structural basis of activation-inactivation gating. Here, we identify the mechanistic principles by which movements on the inner bundle gate trigger conformational changes at the selectivity filter, leading to the non-conductive C-type inactivated state. Analysis of a series of KcsA open structures suggests that, as a consequence of the hinge-bending and rotation of the TM2 helix, the aromatic ring of Phe 103 tilts towards residues Thr 74 and Thr 75 in the pore-helix and towards Ile 100 in the neighbouring subunit. This allows the network of hydrogen bonds among residues Trp 67, Glu 71 and Asp 80 to destabilize the selectivity filter, allowing entry to its non-conductive conformation. Mutations at position 103 have a size-dependent effect on gating kinetics: small side-chain substitutions F103A and F103C severely impair inactivation kinetics, whereas larger side chains such as F103W have more subtle effects. This suggests that the allosteric coupling between the inner helical bundle and the selectivity filter might rely on straightforward mechanical deformation propagated through a network of steric contacts. Average interactions calculated from molecular dynamics simulations show favourable open-state interaction-energies between Phe 103 and the surrounding residues. We probed similar interactions in the Shaker K(+) channel where inactivation was impaired in the mutant I470A. We propose that side-chain rearrangements at position 103 mechanically couple activation and inactivation in KcsA and a variety of other K(+) channels.

-	~~{{STRUCTURE_3hpl\| PDB=3hpl \| SCENE= }}~~	+	Structural basis for the coupling between activation and inactivation gates in K(+) channels.,Cuello LG, Jogini V, Cortes DM, Pan AC, Gagnon DG, Dalmas O, Cordero-Morales JF, Chakrapani S, Roux B, Perozo E Nature. 2010 Jul 8;466(7303):272-5. PMID:20613845<ref>PMID:20613845</ref>

-	~~===KcsA E71H-F103A mutant in~~ the ~~closed state===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20613845}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3hpl]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus] and [http://en~~.~~wikipedia.org~~/~~wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HPL OCA].~~	+

	==See Also==		==See Also==
		+	*[[Antibody\|Antibody]]
	*[[Monoclonal Antibody\|Monoclonal Antibody]]		*[[Monoclonal Antibody\|Monoclonal Antibody]]
	*[[Potassium Channel\|Potassium Channel]]		*[[Potassium Channel\|Potassium Channel]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020613845<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Streptomyces lividans]]		[[Category: Streptomyces lividans]]
-	[[Category: Cortes, D M.]]	+	[[Category: Cortes, D M]]
-	[[Category: Cuello, L G.]]	+	[[Category: Cuello, L G]]
-	[[Category: Jogini, V.]]	+	[[Category: Jogini, V]]
-	[[Category: Perozo, E.]]	+	[[Category: Perozo, E]]
	[[Category: Cell membrane]]		[[Category: Cell membrane]]
	[[Category: Closed]]		[[Category: Closed]]

OCA at 11:27, 20 October 2012

OCA — Sat, 20 Oct 2012 11:27:51 GMT

←Older revision		Revision as of 11:27, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3hpl]] is a 3 chain structure ~~of [[Monoclonal Antibody]] and [[Potassium Channel]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HPL OCA].	+	[[3hpl]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HPL OCA].

	==See Also==		==See Also==

OCA at 05:28, 26 July 2012

OCA — Thu, 26 Jul 2012 05:28:26 GMT

←Older revision		Revision as of 05:28, 26 July 2012
Line 1:		Line 1:
	[[Image:3hpl.png\|left\|200px]]		[[Image:3hpl.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3hpl", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_3hpl\| PDB=3hpl \| SCENE= }}		{{STRUCTURE_3hpl\| PDB=3hpl \| SCENE= }}

	===KcsA E71H-F103A mutant in the closed state===		===KcsA E71H-F103A mutant in the closed state===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20613845}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20613845 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20613845}}		{{ABSTRACT_PUBMED_20613845}}

	==About this Structure==		==About this Structure==
-	[[3hpl]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HPL OCA].	+	[[3hpl]] is a 3 chain structure of [[Monoclonal Antibody]] and [[Potassium Channel]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HPL OCA].
		+
		+	==See Also==
		+	*[[Monoclonal Antibody\|Monoclonal Antibody]]
		+	*[[Potassium Channel\|Potassium Channel]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20613845~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020613845</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Streptomyces lividans]]		[[Category: Streptomyces lividans]]
Line 29:		Line 22:
	[[Category: Jogini, V.]]		[[Category: Jogini, V.]]
	[[Category: Perozo, E.]]		[[Category: Perozo, E.]]
		+	[[Category: Cell membrane]]
		+	[[Category: Closed]]
		+	[[Category: E71h]]
		+	[[Category: F103a]]
		+	[[Category: Immune system-metal transport complex]]
		+	[[Category: Inactivation]]
		+	[[Category: Ion transport]]
		+	[[Category: Ionic channel]]
		+	[[Category: Kcsa]]
		+	[[Category: Membrane]]
		+	[[Category: Transmembrane]]
		+	[[Category: Transport]]
		+	[[Category: Voltage-gated channel]]

OCA: Protected "3hpl" [edit=sysop:move=sysop]

OCA — Wed, 12 Jan 2011 05:23:38 GMT

Protected "3hpl" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:23, 12 January 2011

OCA at 05:23, 12 January 2011

OCA — Wed, 12 Jan 2011 05:23:35 GMT

←Older revision		Revision as of 05:23, 12 January 2011
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-	~~{{Seed}}~~	+	[[Image:3hpl.png\|left\|200px]]
-	[[Image:3hpl.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	===KcsA E71H-F103A mutant in the closed state===		===KcsA E71H-F103A mutant in the closed state===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20613845}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20613845 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20613845}}

	==About this Structure==		==About this Structure==
-	~~3HPL~~ is a 3 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HPL OCA].	+	[[3hpl]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HPL OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20613845</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Streptomyces lividans]]		[[Category: Streptomyces lividans]]
Line 21:		Line 29:
	[[Category: Jogini, V.]]		[[Category: Jogini, V.]]
	[[Category: Perozo, E.]]		[[Category: Perozo, E.]]
-	[[Category: Cell membrane]]
-	[[Category: Closed]]
-	[[Category: E71h]]
-	[[Category: F103a]]
-	[[Category: Immune system-metal transport complex]]
-	[[Category: Inactivation]]
-	[[Category: Ion transport]]
-	[[Category: Ionic channel]]
-	[[Category: Kcsa]]
-	[[Category: Membrane]]
-	[[Category: Transmembrane]]
-	[[Category: Transport]]
-	[[Category: Voltage-gated channel]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 23 08:48:16 2010''

OCA at 04:42, 23 June 2010

OCA — Wed, 23 Jun 2010 04:42:59 GMT

←Older revision		Revision as of 04:42, 23 June 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3hpl.jpg\|left\|200px]]

-	The ~~entry 3hpl~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3hpl", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3hpl\| PDB=3hpl \| SCENE= }}

-	~~Authors: Cuello, L.G., Jogini, V., Cortes, D.M., Perozo, E.~~	+	===KcsA E71H-F103A mutant in the closed state===

-	Description: KcsA E71H-F103A mutant in the closed state

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~May 5 11~~:34:20 2010''	+	==About this Structure==
		+	3HPL is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HPL OCA].
		+	[[Category: Mus musculus]]
		+	[[Category: Streptomyces lividans]]
		+	[[Category: Cortes, D M.]]
		+	[[Category: Cuello, L G.]]
		+	[[Category: Jogini, V.]]
		+	[[Category: Perozo, E.]]
		+	[[Category: Cell membrane]]
		+	[[Category: Closed]]
		+	[[Category: E71h]]
		+	[[Category: F103a]]
		+	[[Category: Immune system-metal transport complex]]
		+	[[Category: Inactivation]]
		+	[[Category: Ion transport]]
		+	[[Category: Ionic channel]]
		+	[[Category: Kcsa]]
		+	[[Category: Membrane]]
		+	[[Category: Transmembrane]]
		+	[[Category: Transport]]
		+	[[Category: Voltage-gated channel]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 23 08:48:16 2010''