3hsh - Revision history

OCA at 10:01, 21 February 2024

OCA — Wed, 21 Feb 2024 10:01:25 GMT

←Older revision		Revision as of 10:01, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3hsh' size='340' side='right'caption='[[3hsh]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3hsh' size='340' side='right'caption='[[3hsh]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hsh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HSH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hsh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HSH FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[3hon\|3hon]]~~</~~div~~><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">COL18A1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hsh OCA], [https://pdbe.org/3hsh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hsh RCSB], [https://www.ebi.ac.uk/pdbsum/3hsh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hsh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hsh OCA], [https://pdbe.org/3hsh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hsh RCSB], [https://www.ebi.ac.uk/pdbsum/3hsh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hsh ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/COIA1_HUMAN COIA1_HUMAN]] Defects in COL18A1 are a cause of Knobloch syndrome type 1 (KNO1) [MIM:[https://omim.org/entry/267750 267750]]. An autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.<ref>PMID:10942434</ref>	+	[https://www.uniprot.org/uniprot/COIA1_HUMAN COIA1_HUMAN] Defects in COL18A1 are a cause of Knobloch syndrome type 1 (KNO1) [MIM:[https://omim.org/entry/267750 267750]. An autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.<ref>PMID:10942434</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/COIA1_HUMAN COIA1_HUMAN]] COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.	+	[https://www.uniprot.org/uniprot/COIA1_HUMAN COIA1_HUMAN] COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hsh ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hsh ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Collagens contain a unique triple-helical structure with a repeating sequence -G-X-Y-, where proline and hydroxyproline are major constituents in X and Y positions, respectively. Folding of the collagen triple helix requires trimerization domains. Once trimerized, collagen chains are correctly aligned and the folding of the triple helix proceeds in a zipper-like fashion. Here we report the isolation, characterization, and crystal structure of the trimerization domain of human type XVIII collagen, a member of the multiplexin family. This domain differs from all other known trimerization domains in other collagens and exhibits a high trimerization potential at picomolar concentrations. Strong chain association and high specificity of binding are needed for multiplexins, which are present at very low levels.
-
-	Crystal structure of human collagen XVIII trimerization domain: A novel collagen trimerization Fold.,Boudko SP, Sasaki T, Engel J, Lerch TF, Nix J, Chapman MS, Bachinger HP J Mol Biol. 2009 Sep 25;392(3):787-802. Epub 2009 Jul 23. PMID:19631658<ref>PMID:19631658</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3hsh" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 39:		Line 29:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bachinger~~, H P~~]]	+	[[Category: Bachinger HP]]
-	[[Category: Boudko~~, S P]]~~	+	[[Category: Boudko SP]]
-	~~[[Category: Alternative promoter usage]]~~	+
-	~~[[Category: Association]]~~	+
-	~~[[Category: Basement membrane]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Chain selection]]~~	+
-	~~[[Category: Collagen]]~~	+
-	~~[[Category: Collagen xviii]]~~	+
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: Endostatin]]~~	+
-	~~[[Category: Extracellular matrix]]~~	+
-	~~[[Category: Folding]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Hydroxylation]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Trimerization domain]]~~	+
-	~~[[Category: Triple helix~~]]	+

OCA at 12:03, 13 October 2021

OCA — Wed, 13 Oct 2021 12:03:19 GMT

←Older revision		Revision as of 12:03, 13 October 2021
Line 1:		Line 1:

	==Crystal structure of human collagen XVIII trimerization domain (Tetragonal crystal form)==		==Crystal structure of human collagen XVIII trimerization domain (Tetragonal crystal form)==
-	<StructureSection load='3hsh' size='340' side='right' caption='[[3hsh]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3hsh' size='340' side='right'caption='[[3hsh]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hsh]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3HSH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hsh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HSH FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hon\|3hon]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3hon\|3hon]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">COL18A1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">COL18A1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3hsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hsh OCA], [~~http~~://pdbe.org/3hsh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3hsh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3hsh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3hsh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hsh OCA], [https://pdbe.org/3hsh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hsh RCSB], [https://www.ebi.ac.uk/pdbsum/3hsh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hsh ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/COIA1_HUMAN COIA1_HUMAN]] Defects in COL18A1 are a cause of Knobloch syndrome type 1 (KNO1) [MIM:[~~http~~://omim.org/entry/267750 267750]]. An autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.<ref>PMID:10942434</ref>	+	[[https://www.uniprot.org/uniprot/COIA1_HUMAN COIA1_HUMAN]] Defects in COL18A1 are a cause of Knobloch syndrome type 1 (KNO1) [MIM:[https://omim.org/entry/267750 267750]]. An autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.<ref>PMID:10942434</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/COIA1_HUMAN COIA1_HUMAN]] COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.	+	[[https://www.uniprot.org/uniprot/COIA1_HUMAN COIA1_HUMAN]] COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hs/3hsh_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hs/3hsh_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	</div>		</div>
	<div class="pdbe-citations 3hsh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3hsh" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Collagen 3D structures\|Collagen 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 40:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Bachinger, H P]]		[[Category: Bachinger, H P]]
	[[Category: Boudko, S P]]		[[Category: Boudko, S P]]

OCA at 07:46, 1 November 2017

OCA — Wed, 01 Nov 2017 07:46:17 GMT

←Older revision		Revision as of 07:46, 1 November 2017
Line 32:		Line 32:
	</div>		</div>
	<div class="pdbe-citations 3hsh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3hsh" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Collagen\|Collagen]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:55, 5 August 2016

OCA — Fri, 05 Aug 2016 01:55:17 GMT

←Older revision		Revision as of 01:55, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of human collagen XVIII trimerization domain (Tetragonal crystal form)==		==Crystal structure of human collagen XVIII trimerization domain (Tetragonal crystal form)==
	<StructureSection load='3hsh' size='340' side='right' caption='[[3hsh]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3hsh' size='340' side='right' caption='[[3hsh]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3hsh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HSH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3hsh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HSH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hon\|3hon]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hon\|3hon]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">COL18A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">COL18A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hsh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hsh RCSB], [http://www.ebi.ac.uk/pdbsum/3hsh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hsh OCA], [http://pdbe.org/3hsh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3hsh RCSB], [http://www.ebi.ac.uk/pdbsum/3hsh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3hsh ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 21:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hsh ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 30:		Line 31:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3hsh" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 39:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Bachinger, H P]]		[[Category: Bachinger, H P]]
	[[Category: Boudko, S P]]		[[Category: Boudko, S P]]

OCA at 17:43, 18 December 2014

OCA — Thu, 18 Dec 2014 17:43:27 GMT

←Older revision		Revision as of 17:43, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3hsh\| PDB=3hsh \| SCENE= }}~~	+	==Crystal structure of human collagen XVIII trimerization domain (Tetragonal crystal form)==
-	===Crystal structure of human collagen XVIII trimerization domain (Tetragonal crystal form)===	+	<StructureSection load='3hsh' size='340' side='right' caption='[[3hsh]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19631658}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3hsh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3HSH FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hon\|3hon]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">COL18A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hsh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hsh RCSB], [http://www.ebi.ac.uk/pdbsum/3hsh PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/COIA1_HUMAN COIA1_HUMAN]] Defects in COL18A1 are a cause of Knobloch syndrome type 1 (KNO1) [MIM:[http://omim.org/entry/267750 267750]]. An autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.<ref>PMID:10942434</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/COIA1_HUMAN COIA1_HUMAN]] COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hs/3hsh_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Collagens contain a unique triple-helical structure with a repeating sequence -G-X-Y-, where proline and hydroxyproline are major constituents in X and Y positions, respectively. Folding of the collagen triple helix requires trimerization domains. Once trimerized, collagen chains are correctly aligned and the folding of the triple helix proceeds in a zipper-like fashion. Here we report the isolation, characterization, and crystal structure of the trimerization domain of human type XVIII collagen, a member of the multiplexin family. This domain differs from all other known trimerization domains in other collagens and exhibits a high trimerization potential at picomolar concentrations. Strong chain association and high specificity of binding are needed for multiplexins, which are present at very low levels.

-	~~==Disease==~~	+	Crystal structure of human collagen XVIII trimerization domain: A novel collagen trimerization Fold.,Boudko SP, Sasaki T, Engel J, Lerch TF, Nix J, Chapman MS, Bachinger HP J Mol Biol. 2009 Sep 25;392(3):787-802. Epub 2009 Jul 23. PMID:19631658<ref>PMID:19631658</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org/uniprot/COIA1_HUMAN COIA1_HUMAN]] Defects in COL18A1 are a cause of Knobloch syndrome type 1~~ (~~KNO1~~) ~~[MIM~~:~~[http://omim~~.org/entry/267750 267750]]. An autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.<ref>PMID:~~10942434~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http://www.uniprot.org/uniprot~~/~~COIA1_HUMAN COIA1_HUMAN]] COLA18A probably plays~~ a ~~major role in determining the retinal structure as well as in the closure~~ of the ~~neural tube~~. ~~Endostatin potently inhibits endothelial cell proliferation and angiogenesis~~. ~~May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling~~.	+	</div>
-		+
-	~~==About this Structure==~~	+
-	~~[[3hsh]] is a 6 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSH OCA].~~	+

	==See Also==		==See Also==
	*[[Collagen\|Collagen]]		*[[Collagen\|Collagen]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:019631658</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Bachinger, H P.]]	+	[[Category: Bachinger, H P]]
-	[[Category: Boudko, S P.]]	+	[[Category: Boudko, S P]]
	[[Category: Alternative promoter usage]]		[[Category: Alternative promoter usage]]
	[[Category: Association]]		[[Category: Association]]

OCA at 06:52, 25 March 2013

OCA — Mon, 25 Mar 2013 06:52:10 GMT

←Older revision		Revision as of 06:52, 25 March 2013
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-	[[Image:3hsh.png\|left\|200px]]
-
	{{STRUCTURE_3hsh\| PDB=3hsh \| SCENE= }}		{{STRUCTURE_3hsh\| PDB=3hsh \| SCENE= }}
-
	===Crystal structure of human collagen XVIII trimerization domain (Tetragonal crystal form)===		===Crystal structure of human collagen XVIII trimerization domain (Tetragonal crystal form)===
		+	{{ABSTRACT_PUBMED_19631658}}

-	~~{{ABSTRACT_PUBMED_19631658}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/COIA1_HUMAN COIA1_HUMAN]] Defects in COL18A1 are a cause of Knobloch syndrome type 1 (KNO1) [MIM:[http://omim.org/entry/267750 267750]]. An autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele.<ref>PMID:10942434</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/COIA1_HUMAN COIA1_HUMAN]] COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:019631658</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019631658</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bachinger, H P.]]		[[Category: Bachinger, H P.]]

OCA at 18:01, 20 October 2012

OCA — Sat, 20 Oct 2012 18:01:42 GMT

←Older revision		Revision as of 18:01, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3hsh]] is a 6 chain structure ~~of [[Collagen]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSH OCA].	+	[[3hsh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSH OCA].

	==See Also==		==See Also==

OCA: Protected "3hsh" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 02:45:34 GMT

Protected "3hsh" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:45, 27 July 2012

OCA at 02:45, 27 July 2012

OCA — Fri, 27 Jul 2012 02:45:32 GMT

←Older revision		Revision as of 02:45, 27 July 2012
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-	{{Seed}}
	[[Image:3hsh.png\|left\|200px]]		[[Image:3hsh.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3hsh", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3hsh\| PDB=3hsh \| SCENE= }}		{{STRUCTURE_3hsh\| PDB=3hsh \| SCENE= }}

	===Crystal structure of human collagen XVIII trimerization domain (Tetragonal crystal form)===		===Crystal structure of human collagen XVIII trimerization domain (Tetragonal crystal form)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19631658}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19631658 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19631658}}		{{ABSTRACT_PUBMED_19631658}}
-
-	==Disease==
-	Known disease associated with this structure: Knobloch syndrome, type 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120328 120328]]

	==About this Structure==		==About this Structure==
-	~~3HSH~~ is a 6 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSH OCA].	+	[[3hsh]] is a 6 chain structure of [[Collagen]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HSH OCA].
		+
		+	==See Also==
		+	*[[Collagen\|Collagen]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19631658~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019631658</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bachinger, H P.]]		[[Category: Bachinger, H P.]]
	[[Category: Boudko, S P.]]		[[Category: Boudko, S P.]]
	[[Category: Alternative promoter usage]]		[[Category: Alternative promoter usage]]
-	[[Category: Alternative splicing]]
	[[Category: Association]]		[[Category: Association]]
	[[Category: Basement membrane]]		[[Category: Basement membrane]]
Line 45:		Line 32:
	[[Category: Hydroxylation]]		[[Category: Hydroxylation]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
-	[[Category: Polymorphism]]
	[[Category: Protein binding]]		[[Category: Protein binding]]
	[[Category: Secreted]]		[[Category: Secreted]]
	[[Category: Trimerization domain]]		[[Category: Trimerization domain]]
	[[Category: Triple helix]]		[[Category: Triple helix]]
-	[[Category: Zinc]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 14 09:50:27 2009''

OCA at 07:50, 14 October 2009

OCA — Wed, 14 Oct 2009 07:50:27 GMT

←Older revision		Revision as of 07:50, 14 October 2009
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	{{Seed}}		{{Seed}}
-	[[Image:3hsh.~~jpg~~\|left\|200px]]	+	[[Image:3hsh.png\|left\|200px]]

	<!--		<!--
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	[[Category: Zinc]]		[[Category: Zinc]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 12 12~~:36:17 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 14 09:50:27 2009''