3i0i - Revision history

OCA at 07:35, 6 September 2023

OCA — Wed, 06 Sep 2023 07:35:56 GMT

←Older revision		Revision as of 07:35, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3i0i' size='340' side='right'caption='[[3i0i]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3i0i' size='340' side='right'caption='[[3i0i]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3i0i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I0I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3i0i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I0I FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=UDP:URIDINE~~-~~5-DIPHOSPHATE'>UDP</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[1lz7\|1lz7]], [[3i0c\|3i0c]], [[3i0d\|3i0d]], [[3i0e\|3i0e]], [[3i0f\|3i0f]], [[3i0g\|3i0g]], [[3i0h\|3i0h]], [[3i0j\|3i0j]], [[3i0k\|3i0k]], [[3i0l\|3i0l]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>GTB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=9606 HUMAN])</td></tr>~~	+
-	~~<tr id='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Fucosylgalactoside_3~~-~~alpha~~-~~galactosyltransferase Fucosylgalactoside 3-alpha-galactosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.37 2.4.1.37]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0i OCA], [https://pdbe.org/3i0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i0i RCSB], [https://www.ebi.ac.uk/pdbsum/3i0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i0i ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0i OCA], [https://pdbe.org/3i0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i0i RCSB], [https://www.ebi.ac.uk/pdbsum/3i0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i0i ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Fucosylgalactoside 3-alpha-galactosyltransferase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Borisova, S]]	+	[[Category: Borisova S]]
-	[[Category: Evans~~, S V~~]]	+	[[Category: Evans SV]]
-	[[Category: Landry~~, R C~~]]	+	[[Category: Landry RC]]
-	[[Category: Palcic~~, M M~~]]	+	[[Category: Palcic MM]]
-	[[Category: Persson, M]]	+	[[Category: Persson M]]
-	[[Category: Polakowski, R]]	+	[[Category: Polakowski R]]
-	[[Category: Schuman, B]]	+	[[Category: Schuman B]]
-	[[Category: Seto~~, N O.L~~]]	+	[[Category: Seto NOL]]
-	[[Category: Weadge~~, J T]]~~	+	[[Category: Weadge JT]]
-	~~[[Category: Abo blood group]]~~	+
-	~~[[Category: Glycosyltransferase]]~~	+
-	~~[[Category: Gtb]]~~	+
-	~~[[Category: Retaining]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 12:06, 13 October 2021

OCA — Wed, 13 Oct 2021 12:06:40 GMT

←Older revision		Revision as of 12:06, 13 October 2021
Line 1:		Line 1:

	==Crystal structure of GTB C80S/C196S/C209S + UDP==		==Crystal structure of GTB C80S/C196S/C209S + UDP==
-	<StructureSection load='3i0i' size='340' side='right' caption='[[3i0i]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='3i0i' size='340' side='right'caption='[[3i0i]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3i0i]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3I0I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3i0i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I0I FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lz7\|1lz7]], [[3i0c\|3i0c]], [[3i0d\|3i0d]], [[3i0e\|3i0e]], [[3i0f\|3i0f]], [[3i0g\|3i0g]], [[3i0h\|3i0h]], [[3i0j\|3i0j]], [[3i0k\|3i0k]], [[3i0l\|3i0l]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lz7\|1lz7]], [[3i0c\|3i0c]], [[3i0d\|3i0d]], [[3i0e\|3i0e]], [[3i0f\|3i0f]], [[3i0g\|3i0g]], [[3i0h\|3i0h]], [[3i0j\|3i0j]], [[3i0k\|3i0k]], [[3i0l\|3i0l]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GTB ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GTB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Fucosylgalactoside_3-alpha-galactosyltransferase Fucosylgalactoside 3-alpha-galactosyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.37 2.4.1.37] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Fucosylgalactoside_3-alpha-galactosyltransferase Fucosylgalactoside 3-alpha-galactosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.37 2.4.1.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3i0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0i OCA], [~~http~~://pdbe.org/3i0i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3i0i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3i0i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3i0i ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0i OCA], [https://pdbe.org/3i0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i0i RCSB], [https://www.ebi.ac.uk/pdbsum/3i0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i0i ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Glycosyltransferase\|Glycosyltransferase]]	+	*[[Glycosyltransferase 3D structures\|Glycosyltransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	[[Category: Fucosylgalactoside 3-alpha-galactosyltransferase]]		[[Category: Fucosylgalactoside 3-alpha-galactosyltransferase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Borisova, S]]		[[Category: Borisova, S]]
	[[Category: Evans, S V]]		[[Category: Evans, S V]]

OCA at 07:33, 12 December 2018

OCA — Wed, 12 Dec 2018 07:33:41 GMT

←Older revision		Revision as of 07:33, 12 December 2018
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i0/3i0i_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i0/3i0i_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:17, 9 December 2016

OCA — Fri, 09 Dec 2016 20:17:34 GMT

←Older revision		Revision as of 20:17, 9 December 2016
Line 1:		Line 1:
		+
	==Crystal structure of GTB C80S/C196S/C209S + UDP==		==Crystal structure of GTB C80S/C196S/C209S + UDP==
	<StructureSection load='3i0i' size='340' side='right' caption='[[3i0i]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='3i0i' size='340' side='right' caption='[[3i0i]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3i0i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I0I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3i0i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I0I FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lz7\|1lz7]], [[3i0c\|3i0c]], [[3i0d\|3i0d]], [[3i0e\|3i0e]], [[3i0f\|3i0f]], [[3i0g\|3i0g]], [[3i0h\|3i0h]], [[3i0j\|3i0j]], [[3i0k\|3i0k]], [[3i0l\|3i0l]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lz7\|1lz7]], [[3i0c\|3i0c]], [[3i0d\|3i0d]], [[3i0e\|3i0e]], [[3i0f\|3i0f]], [[3i0g\|3i0g]], [[3i0h\|3i0h]], [[3i0j\|3i0j]], [[3i0k\|3i0k]], [[3i0l\|3i0l]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GTB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GTB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fucosylgalactoside_3-alpha-galactosyltransferase Fucosylgalactoside 3-alpha-galactosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.37 2.4.1.37] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fucosylgalactoside_3-alpha-galactosyltransferase Fucosylgalactoside 3-alpha-galactosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.37 2.4.1.37] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i0i RCSB], [http://www.ebi.ac.uk/pdbsum/3i0i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0i OCA], [http://pdbe.org/3i0i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i0i RCSB], [http://www.ebi.ac.uk/pdbsum/3i0i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3i0i ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i0i ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3i0i" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Fucosylgalactoside 3-alpha-galactosyltransferase]]		[[Category: Fucosylgalactoside 3-alpha-galactosyltransferase]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Borisova, S]]		[[Category: Borisova, S]]
	[[Category: Evans, S V]]		[[Category: Evans, S V]]

OCA at 08:37, 8 December 2014

OCA — Mon, 08 Dec 2014 08:37:58 GMT

←Older revision		Revision as of 08:37, 8 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3i0i.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of GTB C80S/C196S/C209S + UDP==
		+	<StructureSection load='3i0i' size='340' side='right' caption='[[3i0i]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3i0i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I0I FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lz7\|1lz7]], [[3i0c\|3i0c]], [[3i0d\|3i0d]], [[3i0e\|3i0e]], [[3i0f\|3i0f]], [[3i0g\|3i0g]], [[3i0h\|3i0h]], [[3i0j\|3i0j]], [[3i0k\|3i0k]], [[3i0l\|3i0l]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GTB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fucosylgalactoside_3-alpha-galactosyltransferase Fucosylgalactoside 3-alpha-galactosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.37 2.4.1.37] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i0i RCSB], [http://www.ebi.ac.uk/pdbsum/3i0i PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i0/3i0i_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A common feature in the structures of GT-A-fold-type glycosyltransferases is a mobile polypeptide loop that has been observed to participate in substrate recognition and enclose the active site upon substrate binding. This is the case for the human ABO(H) blood group B glycosyltransferase GTB, where amino acid residues 177-195 display significantly higher levels of disorder in the unliganded state than in the fully liganded state. Structural studies of mutant enzymes GTB/C80S/C196S and GTB/C80S/C196S/C209S at resolutions ranging from 1.93 to 1.40 A display the opposite trend, where the unliganded structures show nearly complete ordering of the mobile loop residues that is lost upon substrate binding. In the liganded states of the mutant structures, while the UDP moiety of the donor molecule is observed to bind in the expected location, the galactose moiety is observed to bind in a conformation significantly different from that observed for the wild-type chimeric structures. Although this would be expected to impede catalytic turnover, the kinetics of the transfer reaction are largely unaffected. These structures demonstrate that the enzymes bind the donor in a conformation more similar to the dominant solution rotamer and facilitate its gyration into the catalytically competent form. Further, by preventing active-site closure, these structures provide a basis for recently observed cooperativity in substrate binding. Finally, the mutation of C80S introduces a fully occupied UDP binding site at the enzyme dimer interface that is observed to be dependent on the binding of H antigen acceptor analog.

-	~~{{STRUCTURE_3i0i\| PDB=3i0i \| SCENE= }}~~	+	Cysteine-to-serine mutants dramatically reorder the active site of human ABO(H) blood group B glycosyltransferase without affecting activity: structural insights into cooperative substrate binding.,Schuman B, Persson M, Landry RC, Polakowski R, Weadge JT, Seto NO, Borisova SN, Palcic MM, Evans SV J Mol Biol. 2010 Sep 17;402(2):399-411. Epub 2010 Jul 23. PMID:20655926<ref>PMID:20655926</ref>

-	~~===Crystal structure of GTB C80S~~/~~C196S/C209S + UDP===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20655926}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3i0i]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3I0I OCA].~~	+

	==See Also==		==See Also==
-	*[[Galactosyltransferase\|Galactosyltransferase]]
	*[[Glycosyltransferase\|Glycosyltransferase]]		*[[Glycosyltransferase\|Glycosyltransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020655926<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Fucosylgalactoside 3-alpha-galactosyltransferase]]		[[Category: Fucosylgalactoside 3-alpha-galactosyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Borisova, S.]]	+	[[Category: Borisova, S]]
-	[[Category: Evans, S V.]]	+	[[Category: Evans, S V]]
-	[[Category: Landry, R C.]]	+	[[Category: Landry, R C]]
-	[[Category: Palcic, M M.]]	+	[[Category: Palcic, M M]]
-	[[Category: Persson, M.]]	+	[[Category: Persson, M]]
-	[[Category: Polakowski, R.]]	+	[[Category: Polakowski, R]]
-	[[Category: Schuman, B.]]	+	[[Category: Schuman, B]]
-	[[Category: Seto, N O.L.]]	+	[[Category: Seto, N O.L]]
-	[[Category: Weadge, J T.]]	+	[[Category: Weadge, J T]]
	[[Category: Abo blood group]]		[[Category: Abo blood group]]
	[[Category: Glycosyltransferase]]		[[Category: Glycosyltransferase]]

OCA at 15:43, 20 October 2012

OCA — Sat, 20 Oct 2012 15:43:26 GMT

←Older revision		Revision as of 15:43, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3i0i]] is a 1 chain structure ~~of [[Galactosyltransferase]] and [[Glycosyltransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0I OCA].	+	[[3i0i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0I OCA].

	==See Also==		==See Also==

OCA: Protected "3i0i" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 19:16:48 GMT

Protected "3i0i" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:16, 26 July 2012

OCA at 19:16, 26 July 2012

OCA — Thu, 26 Jul 2012 19:16:46 GMT

←Older revision		Revision as of 19:16, 26 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3i0i.png\|left\|200px]]		[[Image:3i0i.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3i0i", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3i0i\| PDB=3i0i \| SCENE= }}		{{STRUCTURE_3i0i\| PDB=3i0i \| SCENE= }}

	===Crystal structure of GTB C80S/C196S/C209S + UDP===		===Crystal structure of GTB C80S/C196S/C209S + UDP===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20655926}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20655926 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20655926}}		{{ABSTRACT_PUBMED_20655926}}

	==About this Structure==		==About this Structure==
-	~~3I0I~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0I OCA].	+	[[3i0i]] is a 1 chain structure of [[Galactosyltransferase]] and [[Glycosyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0I OCA].
		+
		+	==See Also==
		+	*[[Galactosyltransferase\|Galactosyltransferase]]
		+	*[[Glycosyltransferase\|Glycosyltransferase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20655926~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020655926</ref><references group="xtra"/>
	[[Category: Fucosylgalactoside 3-alpha-galactosyltransferase]]		[[Category: Fucosylgalactoside 3-alpha-galactosyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 40:		Line 32:
	[[Category: Retaining]]		[[Category: Retaining]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 6 05:33:16 2010''

OCA at 02:23, 6 October 2010

OCA — Wed, 06 Oct 2010 02:23:45 GMT

←Older revision		Revision as of 02:23, 6 October 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3i0i.~~jpg~~\|left\|200px]]	+	[[Image:3i0i.png\|left\|200px]]

	<!--		<!--
Line 12:		Line 12:
	===Crystal structure of GTB C80S/C196S/C209S + UDP===		===Crystal structure of GTB C80S/C196S/C209S + UDP===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20655926}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20655926 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20655926}}

	==About this Structure==		==About this Structure==
	3I0I is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0I OCA].		3I0I is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0I OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20655926</ref><references group="xtra"/>
	[[Category: Fucosylgalactoside 3-alpha-galactosyltransferase]]		[[Category: Fucosylgalactoside 3-alpha-galactosyltransferase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
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	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 11 23~~:52:47 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 6 05:33:16 2010''

OCA at 19:45, 11 August 2010

OCA — Wed, 11 Aug 2010 19:45:30 GMT

←Older revision		Revision as of 19:45, 11 August 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3i0i.jpg\|left\|200px]]

-	The ~~entry 3i0i~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3i0i", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3i0i\| PDB=3i0i \| SCENE= }}

-	~~Authors: Schuman, B., Persson, M., Landry, R.C., Polakowski, R., Weadge, J.T., Seto, N.O.L., Borisova, S., Palcic, M.M., Evans, S.V.~~	+	===Crystal structure of GTB C80S/C196S/C209S + UDP===

-	Description: Crystal structure of GTB C80S/C196S/C209S + UDP

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jul 22 20~~:33:~~56 2009~~''	+	==About this Structure==
		+	3I0I is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0I OCA].
		+	[[Category: Fucosylgalactoside 3-alpha-galactosyltransferase]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Borisova, S.]]
		+	[[Category: Evans, S V.]]
		+	[[Category: Landry, R C.]]
		+	[[Category: Palcic, M M.]]
		+	[[Category: Persson, M.]]
		+	[[Category: Polakowski, R.]]
		+	[[Category: Schuman, B.]]
		+	[[Category: Seto, N O.L.]]
		+	[[Category: Weadge, J T.]]
		+	[[Category: Abo blood group]]
		+	[[Category: Glycosyltransferase]]
		+	[[Category: Gtb]]
		+	[[Category: Retaining]]
		+	[[Category: Transferase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 11 23:52:47 2010''