3i0n - Revision history

OCA at 15:54, 1 November 2023

OCA — Wed, 01 Nov 2023 15:54:53 GMT

←Older revision		Revision as of 15:54, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3i0n' size='340' side='right'caption='[[3i0n]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3i0n' size='340' side='right'caption='[[3i0n]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3i0n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bcrc:21461 Bcrc:21461~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I0N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3i0n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I0N FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~MLY~~:~~N-DIMETHYL-LYSINE~~'>~~MLY~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;~~'>~~[[3i0m\|3i0m]]~~</~~div~~>~~</td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nbs1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 BCRC:21461])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0n OCA], [https://pdbe.org/3i0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i0n RCSB], [https://www.ebi.ac.uk/pdbsum/3i0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i0n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0n OCA], [https://pdbe.org/3i0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i0n RCSB], [https://www.ebi.ac.uk/pdbsum/3i0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i0n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NBS1_SCHPO NBS1_SCHPO]] Required for DNA damage repair and S-phase DNA damage checkpoint. Involved in telomere length maintenance and maintenance of chromatin structure.<ref>PMID:12944481</ref> <ref>PMID:12944482</ref>	+	[https://www.uniprot.org/uniprot/NBS1_SCHPO NBS1_SCHPO] Required for DNA damage repair and S-phase DNA damage checkpoint. Involved in telomere length maintenance and maintenance of chromatin structure.<ref>PMID:12944481</ref> <ref>PMID:12944482</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bcrc:21461]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Chapman, J R~~]]	+	[[Category: Schizosaccharomyces pombe]]
-	[[Category: ~~Clapperton, J A~~]]	+	[[Category: Chapman JR]]
-	[[Category: ~~Jackson, S P~~]]	+	[[Category: Clapperton JA]]
-	[[Category: ~~Lloyd, J~~]]	+	[[Category: Jackson SP]]
-	[[Category: ~~Smerdon, S~~ J]]	+	[[Category: Lloyd J]]
-	[[Category: ~~Brct-repeat]]~~	+	[[Category: Smerdon SJ]]
-	~~[[Category: Cell cycle]]~~	+
-	~~[[Category: Chromosomal protein]]~~	+
-	~~[[Category: Dna damage]]~~	+
-	~~[[Category: Dna repair]]~~	+
-	~~[[Category: Dna-damage]]~~	+
-	~~[[Category: Fha]]~~	+
-	~~[[Category: Gene regulation]]~~	+
-	~~[[Category: Nbs1]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Telomere~~]]	+

OCA at 11:19, 6 April 2022

OCA — Wed, 06 Apr 2022 11:19:28 GMT

←Older revision		Revision as of 11:19, 6 April 2022
Line 1:		Line 1:

	==Structure of the S. pombe Nbs1 FHA/BRCT-repeat domain==		==Structure of the S. pombe Nbs1 FHA/BRCT-repeat domain==
-	<StructureSection load='3i0n' size='340' side='right' caption='[[3i0n]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='3i0n' size='340' side='right'caption='[[3i0n]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3i0n]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bcrc:21461 Bcrc:21461]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3I0N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3i0n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bcrc:21461 Bcrc:21461]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I0N FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i0m\|3i0m]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3i0m\|3i0m]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nbs1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 BCRC:21461])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nbs1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 BCRC:21461])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3i0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0n OCA], [~~http~~://pdbe.org/3i0n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3i0n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3i0n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3i0n ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0n OCA], [https://pdbe.org/3i0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i0n RCSB], [https://www.ebi.ac.uk/pdbsum/3i0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i0n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NBS1_SCHPO NBS1_SCHPO]] Required for DNA damage repair and S-phase DNA damage checkpoint. Involved in telomere length maintenance and maintenance of chromatin structure.<ref>PMID:12944481</ref> <ref>PMID:12944482</ref>	+	[[https://www.uniprot.org/uniprot/NBS1_SCHPO NBS1_SCHPO]] Required for DNA damage repair and S-phase DNA damage checkpoint. Involved in telomere length maintenance and maintenance of chromatin structure.<ref>PMID:12944481</ref> <ref>PMID:12944482</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Bcrc:21461]]		[[Category: Bcrc:21461]]
		+	[[Category: Large Structures]]
	[[Category: Chapman, J R]]		[[Category: Chapman, J R]]
	[[Category: Clapperton, J A]]		[[Category: Clapperton, J A]]

OCA at 08:20, 12 December 2018

OCA — Wed, 12 Dec 2018 08:20:53 GMT

←Older revision		Revision as of 08:20, 12 December 2018
Line 3:		Line 3:
	<StructureSection load='3i0n' size='340' side='right' caption='[[3i0n]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3i0n' size='340' side='right' caption='[[3i0n]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3i0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Cbs_356 Cbs 356~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I0N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3i0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bcrc:21461 Bcrc:21461]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I0N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i0m\|3i0m]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i0m\|3i0m]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nbs1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 ~~CBS 356~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nbs1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 BCRC:21461])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0n OCA], [http://pdbe.org/3i0n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i0n RCSB], [http://www.ebi.ac.uk/pdbsum/3i0n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3i0n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0n OCA], [http://pdbe.org/3i0n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i0n RCSB], [http://www.ebi.ac.uk/pdbsum/3i0n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3i0n ProSAT]</span></td></tr>
	</table>		</table>
Line 16:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i0/3i0n_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i0/3i0n_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cbs 356~~]]	+	[[Category: Bcrc:21461]]
	[[Category: Chapman, J R]]		[[Category: Chapman, J R]]
	[[Category: Clapperton, J A]]		[[Category: Clapperton, J A]]

OCA at 18:04, 5 August 2016

OCA — Fri, 05 Aug 2016 18:04:24 GMT

←Older revision		Revision as of 18:04, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of the S. pombe Nbs1 FHA/BRCT-repeat domain==		==Structure of the S. pombe Nbs1 FHA/BRCT-repeat domain==
	<StructureSection load='3i0n' size='340' side='right' caption='[[3i0n]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3i0n' size='340' side='right' caption='[[3i0n]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3i0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Schizosaccharomyces_pombe Schizosaccharomyces pombe~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I0N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3i0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I0N FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i0m\|3i0m]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i0m\|3i0m]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nbs1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 ~~Schizosaccharomyces pombe~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nbs1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i0n RCSB], [http://www.ebi.ac.uk/pdbsum/3i0n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0n OCA], [http://pdbe.org/3i0n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i0n RCSB], [http://www.ebi.ac.uk/pdbsum/3i0n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3i0n ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i0n ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3i0n" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Schizosaccharomyces pombe~~]]	+	[[Category: Cbs 356]]
	[[Category: Chapman, J R]]		[[Category: Chapman, J R]]
	[[Category: Clapperton, J A]]		[[Category: Clapperton, J A]]

OCA at 20:49, 25 December 2014

OCA — Thu, 25 Dec 2014 20:49:57 GMT

←Older revision		Revision as of 20:49, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3i0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I0N FirstGlance]. <br>		<table><tr><td colspan='2'>[[3i0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I0N FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i0m\|3i0m]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i0m\|3i0m]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nbs1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 Schizosaccharomyces pombe])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nbs1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 Schizosaccharomyces pombe])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i0n RCSB], [http://www.ebi.ac.uk/pdbsum/3i0n PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i0n RCSB], [http://www.ebi.ac.uk/pdbsum/3i0n PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NBS1_SCHPO NBS1_SCHPO]] Required for DNA damage repair and S-phase DNA damage checkpoint. Involved in telomere length maintenance and maintenance of chromatin structure.<ref>PMID:12944481</ref> <ref>PMID:12944482</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 25:		Line 27:
	A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage.,Lloyd J, Chapman JR, Clapperton JA, Haire LF, Hartsuiker E, Li J, Carr AM, Jackson SP, Smerdon SJ Cell. 2009 Oct 2;139(1):100-11. PMID:19804756<ref>PMID:19804756</ref>		A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage.,Lloyd J, Chapman JR, Clapperton JA, Haire LF, Hartsuiker E, Li J, Carr AM, Jackson SP, Smerdon SJ Cell. 2009 Oct 2;139(1):100-11. PMID:19804756<ref>PMID:19804756</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
-	[[Category: Chapman, J R.]]	+	[[Category: Chapman, J R]]
-	[[Category: Clapperton, J A.]]	+	[[Category: Clapperton, J A]]
-	[[Category: Jackson, S P.]]	+	[[Category: Jackson, S P]]
-	[[Category: Lloyd, J.]]	+	[[Category: Lloyd, J]]
-	[[Category: Smerdon, S J.]]	+	[[Category: Smerdon, S J]]
	[[Category: Brct-repeat]]		[[Category: Brct-repeat]]
	[[Category: Cell cycle]]		[[Category: Cell cycle]]

OCA at 09:50, 21 May 2014

OCA — Wed, 21 May 2014 09:50:17 GMT

←Older revision		Revision as of 09:50, 21 May 2014
Line 1:		Line 1:
-	[[~~Image:~~3i0n.~~png~~\|~~left~~\|200px]]	+	==Structure of the S. pombe Nbs1 FHA/BRCT-repeat domain==
		+	<StructureSection load='3i0n' size='340' side='right' caption='[[3i0n]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3i0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I0N FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i0m\|3i0m]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nbs1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 Schizosaccharomyces pombe])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i0n RCSB], [http://www.ebi.ac.uk/pdbsum/3i0n PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i0/3i0n_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Mre11/Rad50/Nbs1 protein complex plays central enzymatic and signaling roles in the DNA-damage response. Nuclease (Mre11) and scaffolding (Rad50) components of MRN have been extensively characterized, but the molecular basis of Nbs1 function has remained elusive. Here, we present a 2.3A crystal structure of the N-terminal region of fission yeast Nbs1, revealing an unusual but conserved architecture in which the FHA- and BRCT-repeat domains structurally coalesce. We demonstrate that diphosphorylated pSer-Asp-pThr-Asp motifs, recently identified as multicopy docking sites within Mdc1, are evolutionarily conserved Nbs1 binding targets. Furthermore, we show that similar phosphomotifs within Ctp1, the fission yeast ortholog of human CtIP, promote interactions with the Nbs1 FHA domain that are necessary for Ctp1-dependent resistance to DNA damage. Finally, we establish that human Nbs1 interactions with Mdc1 occur through both its FHA- and BRCT-repeat domains, suggesting how their structural and functional interdependence underpins Nbs1 adaptor functions in the DNA-damage response.

-	<!--	+	A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage.,Lloyd J, Chapman JR, Clapperton JA, Haire LF, Hartsuiker E, Li J, Carr AM, Jackson SP, Smerdon SJ Cell. 2009 Oct 2;139(1):100-11. PMID:19804756<ref>PMID:19804756</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3i0n"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet~~)	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~	+
-	~~or leave the SCENE parameter empty for the default display.~~	+
-	-->	+
-	~~{{STRUCTURE_3i0n\| PDB=3i0n \| SCENE= }}~~	+

-	~~===Structure of the S. pombe Nbs1 FHA~~/~~BRCT-repeat domain===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph~~, ~~{{ABSTRACT_PUBMED_19804756}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 19804756 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_19804756}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3i0n]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0N OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:019804756<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
	[[Category: Chapman, J R.]]		[[Category: Chapman, J R.]]

OCA: Protected "3i0n" [edit=sysop:move=sysop]

OCA — Wed, 02 May 2012 18:27:53 GMT

Protected "3i0n" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:27, 2 May 2012

OCA at 18:27, 2 May 2012

OCA — Wed, 02 May 2012 18:27:51 GMT

←Older revision		Revision as of 18:27, 2 May 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3i0n.png\|left\|200px]]
-	[[Image:3i0n.~~jpg~~\|left\|200px]]	+

	<!--		<!--
Line 12:		Line 11:
	===Structure of the S. pombe Nbs1 FHA/BRCT-repeat domain===		===Structure of the S. pombe Nbs1 FHA/BRCT-repeat domain===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19804756}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19804756 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19804756}}

	==About this Structure==		==About this Structure==
-	~~3I0N~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0N OCA].	+	[[3i0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0N OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:019804756</ref><references group="xtra"/>
	[[Category: Schizosaccharomyces pombe]]		[[Category: Schizosaccharomyces pombe]]
	[[Category: Chapman, J R.]]		[[Category: Chapman, J R.]]
Line 33:		Line 41:
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]
	[[Category: Telomere]]		[[Category: Telomere]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 14 10:35:35 2009''

OCA at 08:35, 14 October 2009

OCA — Wed, 14 Oct 2009 08:35:36 GMT

←Older revision		Revision as of 08:35, 14 October 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3i0n.jpg\|left\|200px]]

-	The ~~entry 3i0n~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3i0n", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3i0n\| PDB=3i0n \| SCENE= }}

-	~~Authors: Clapperton, J.A., Lloyd, J., Chapman, J.R., Jackson,~~ S.~~P., Smerdon, S.J.~~	+	===Structure of the S. pombe Nbs1 FHA/BRCT-repeat domain===

-	Description: Structure of the S. pombe Nbs1 FHA/BRCT-repeat domain

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jul 15 08~~:29:06 2009''	+	==About this Structure==
		+	3I0N is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0N OCA].
		+	[[Category: Schizosaccharomyces pombe]]
		+	[[Category: Chapman, J R.]]
		+	[[Category: Clapperton, J A.]]
		+	[[Category: Jackson, S P.]]
		+	[[Category: Lloyd, J.]]
		+	[[Category: Smerdon, S J.]]
		+	[[Category: Brct-repeat]]
		+	[[Category: Cell cycle]]
		+	[[Category: Chromosomal protein]]
		+	[[Category: Dna damage]]
		+	[[Category: Dna repair]]
		+	[[Category: Dna-damage]]
		+	[[Category: Fha]]
		+	[[Category: Gene regulation]]
		+	[[Category: Nbs1]]
		+	[[Category: Nucleus]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Telomere]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 14 10:35:35 2009''

OCA at 05:29, 15 July 2009

OCA — Wed, 15 Jul 2009 05:29:06 GMT

←Older revision		Revision as of 05:29, 15 July 2009
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3i0n is ON HOLD	+	The entry 3i0n is ON HOLD until Paper Publication

	Authors: Clapperton, J.A., Lloyd, J., Chapman, J.R., Jackson, S.P., Smerdon, S.J.		Authors: Clapperton, J.A., Lloyd, J., Chapman, J.R., Jackson, S.P., Smerdon, S.J.
Line 7:		Line 7:
	Description: Structure of the S. pombe Nbs1 FHA/BRCT-repeat domain		Description: Structure of the S. pombe Nbs1 FHA/BRCT-repeat domain

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul ~~8 09:~~15:46 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 15 08:29:06 2009''