3i0v - Revision history

OCA at 11:51, 23 September 2020

OCA — Wed, 23 Sep 2020 11:51:28 GMT

←Older revision		Revision as of 11:51, 23 September 2020
Line 1:		Line 1:

	==Bacillus cereus metallo-beta-lactamase: apo form==		==Bacillus cereus metallo-beta-lactamase: apo form==
-	<StructureSection load='3i0v' size='340' side='right' caption='[[3i0v]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='3i0v' size='340' side='right'caption='[[3i0v]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3i0v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_14579 Atcc 14579]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0V OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3I0V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3i0v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_14579 Atcc 14579]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3I0V FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvt\|1bvt]], [[1bc2\|1bc2]], [[3i11\|3i11]], [[3i13\|3i13]], [[3i14\|3i14]], [[3i15\|3i15]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvt\|1bvt]], [[1bc2\|1bc2]], [[3i11\|3i11]], [[3i13\|3i13]], [[3i14\|3i14]], [[3i15\|3i15]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3i0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0v OCA], [http://pdbe.org/3i0v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i0v RCSB], [http://www.ebi.ac.uk/pdbsum/3i0v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3i0v ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3i0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0v OCA], [http://pdbe.org/3i0v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i0v RCSB], [http://www.ebi.ac.uk/pdbsum/3i0v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3i0v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Beta-lactamase\|Beta-lactamase]]	+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 39:
	[[Category: Atcc 14579]]		[[Category: Atcc 14579]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
		+	[[Category: Large Structures]]
	[[Category: Buschiazzo, A]]		[[Category: Buschiazzo, A]]
	[[Category: Gonzalez, J M]]		[[Category: Gonzalez, J M]]

OCA at 09:57, 19 December 2018

OCA — Wed, 19 Dec 2018 09:57:08 GMT

←Older revision		Revision as of 09:57, 19 December 2018
Line 1:		Line 1:
		+
	==Bacillus cereus metallo-beta-lactamase: apo form==		==Bacillus cereus metallo-beta-lactamase: apo form==
	<StructureSection load='3i0v' size='340' side='right' caption='[[3i0v]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3i0v' size='340' side='right' caption='[[3i0v]], [[Resolution\|resolution]] 1.60Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvt\|1bvt]], [[1bc2\|1bc2]], [[3i11\|3i11]], [[3i13\|3i13]], [[3i14\|3i14]], [[3i15\|3i15]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvt\|1bvt]], [[1bc2\|1bc2]], [[3i11\|3i11]], [[3i13\|3i13]], [[3i14\|3i14]], [[3i15\|3i15]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0v OCA], [http://pdbe.org/3i0v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i0v RCSB], [http://www.ebi.ac.uk/pdbsum/3i0v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0v OCA], [http://pdbe.org/3i0v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i0v RCSB], [http://www.ebi.ac.uk/pdbsum/3i0v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3i0v ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i0/3i0v_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i0/3i0v_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 11:30, 7 February 2016

OCA — Sun, 07 Feb 2016 11:30:57 GMT

←Older revision		Revision as of 11:30, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3i0v' size='340' side='right' caption='[[3i0v]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3i0v' size='340' side='right' caption='[[3i0v]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3i0v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_cereus Bacillus cereus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I0V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3i0v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_14579 Atcc 14579]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I0V FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvt\|1bvt]], [[1bc2\|1bc2]], [[3i11\|3i11]], [[3i13\|3i13]], [[3i14\|3i14]], [[3i15\|3i15]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvt\|1bvt]], [[1bc2\|1bc2]], [[3i11\|3i11]], [[3i13\|3i13]], [[3i14\|3i14]], [[3i15\|3i15]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i0v RCSB], [http://www.ebi.ac.uk/pdbsum/3i0v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0v OCA], [http://pdbe.org/3i0v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i0v RCSB], [http://www.ebi.ac.uk/pdbsum/3i0v PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i0v ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3i0v" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus cereus~~]]	+	[[Category: Atcc 14579]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
	[[Category: Buschiazzo, A]]		[[Category: Buschiazzo, A]]

OCA at 14:45, 24 December 2014

OCA — Wed, 24 Dec 2014 14:45:06 GMT

←Older revision		Revision as of 14:45, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3i0v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I0V FirstGlance]. <br>		<table><tr><td colspan='2'>[[3i0v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I0V FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvt\|1bvt]], [[1bc2\|1bc2]], [[3i11\|3i11]], [[3i13\|3i13]], [[3i14\|3i14]], [[3i15\|3i15]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvt\|1bvt]], [[1bc2\|1bc2]], [[3i11\|3i11]], [[3i13\|3i13]], [[3i14\|3i14]], [[3i15\|3i15]]</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i0v RCSB], [http://www.ebi.ac.uk/pdbsum/3i0v PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i0v RCSB], [http://www.ebi.ac.uk/pdbsum/3i0v PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BLA2_BACCE BLA2_BACCE]] Can hydrolyze carbapenem compounds.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Bacillus cereus]]		[[Category: Bacillus cereus]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
-	[[Category: Buschiazzo, A.]]	+	[[Category: Buschiazzo, A]]
-	[[Category: Gonzalez, J M.]]	+	[[Category: Gonzalez, J M]]
-	[[Category: Vila, A J.]]	+	[[Category: Vila, A J]]
	[[Category: Antibiotic resistance]]		[[Category: Antibiotic resistance]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 11:13, 29 September 2014

OCA — Mon, 29 Sep 2014 11:13:27 GMT

←Older revision		Revision as of 11:13, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3i0v.~~png~~\|~~left~~\|200px]]	+	==Bacillus cereus metallo-beta-lactamase: apo form==
		+	<StructureSection load='3i0v' size='340' side='right' caption='[[3i0v]], [[Resolution\|resolution]] 1.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3i0v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I0V FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OCS:CYSTEINESULFONIC+ACID'>OCS</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bvt\|1bvt]], [[1bc2\|1bc2]], [[3i11\|3i11]], [[3i13\|3i13]], [[3i14\|3i14]], [[3i15\|3i15]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i0v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i0v RCSB], [http://www.ebi.ac.uk/pdbsum/3i0v PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i0/3i0v_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Subclass B1 beta-lactamases are Zn(II)-dependent hydrolases that confer bacterial resistance to most clinically useful beta-lactam antibiotics. The enzyme BcII from Bacillus cereus is a prototypical enzyme that belongs to this group, the first Zn(II)-dependent beta-lactamase to be discovered. Crucial aspects of the BcII catalytic mechanism and metal binding mode have been assessed mostly on the Co(II)-substituted surrogate. Here we report a high-resolution structure of Co(II)-BcII, revealing a metal coordination geometry identical to that of the native zinc enzyme. In addition, a high-resolution structure of the apoenzyme, together with structures with different degrees of metal occupancy and oxidation levels of a conserved Cys ligand, discloses a considerable mobility of two loops containing four metal ligands (namely, regions His116-Arg121 and Gly219-Cys221). This flexibility is expected to assist in the structural rearrangement of the metal sites during catalytic turnover, which, along with the coordination geometry adaptability of Zn(II) ions, grants the interaction with a variety of substrates, a characteristic feature of B1 metallo-beta-lactamases.

-	~~{{STRUCTURE_3i0v\| PDB=3i0v \| SCENE= }}~~	+	Evidence of adaptability in metal coordination geometry and active-site loop conformation among B1 metallo-beta-lactamases .,Gonzalez JM, Buschiazzo A, Vila AJ Biochemistry. 2010 Sep 14;49(36):7930-8. PMID:20677753<ref>PMID:20677753</ref>

-	~~===Bacillus cereus metallo-beta-lactamase: apo form===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20677753}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3i0v]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bacillus_cereus Bacillus cereus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3I0V OCA].~~	+

	==See Also==		==See Also==
	*[[Beta-lactamase\|Beta-lactamase]]		*[[Beta-lactamase\|Beta-lactamase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020677753<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus cereus]]		[[Category: Bacillus cereus]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]

OCA at 06:30, 20 October 2012

OCA — Sat, 20 Oct 2012 06:30:24 GMT

←Older revision		Revision as of 06:30, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3i0v]] is a 1 chain structure ~~of [[Beta-lactamase]]~~ with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0V OCA].	+	[[3i0v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0V OCA].

	==See Also==		==See Also==

OCA: Protected "3i0v" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 13:23:20 GMT

Protected "3i0v" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:23, 25 July 2012

OCA at 13:23, 25 July 2012

OCA — Wed, 25 Jul 2012 13:23:19 GMT

←Older revision		Revision as of 13:23, 25 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3i0v.png\|left\|200px]]		[[Image:3i0v.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3i0v", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3i0v\| PDB=3i0v \| SCENE= }}		{{STRUCTURE_3i0v\| PDB=3i0v \| SCENE= }}

	===Bacillus cereus metallo-beta-lactamase: apo form===		===Bacillus cereus metallo-beta-lactamase: apo form===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20677753}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20677753 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20677753}}		{{ABSTRACT_PUBMED_20677753}}

	==About this Structure==		==About this Structure==
-	~~3I0V~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0V OCA].	+	[[3i0v]] is a 1 chain structure of [[Beta-lactamase]] with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0V OCA].
		+
		+	==See Also==
		+	*[[Beta-lactamase\|Beta-lactamase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20677753~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020677753</ref><references group="xtra"/>
	[[Category: Bacillus cereus]]		[[Category: Bacillus cereus]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
Line 34:		Line 25:
	[[Category: Metallo-beta-lactamase superfamily]]		[[Category: Metallo-beta-lactamase superfamily]]
	[[Category: Zn-dependent hydrolase]]		[[Category: Zn-dependent hydrolase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 20 06:10:58 2010''

OCA at 03:00, 20 October 2010

OCA — Wed, 20 Oct 2010 03:00:54 GMT

←Older revision		Revision as of 03:00, 20 October 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3i0v.~~jpg~~\|left\|200px]]	+	[[Image:3i0v.png\|left\|200px]]

	<!--		<!--
Line 12:		Line 12:
	===Bacillus cereus metallo-beta-lactamase: apo form===		===Bacillus cereus metallo-beta-lactamase: apo form===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20677753}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20677753 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20677753}}

	==About this Structure==		==About this Structure==
-	3I0V is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0V OCA].	+	3I0V is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0V OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20677753</ref><references group="xtra"/>
	[[Category: Bacillus cereus]]		[[Category: Bacillus cereus]]
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
Line 24:		Line 33:
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Metallo-beta-lactamase superfamily]]		[[Category: Metallo-beta-lactamase superfamily]]
-	[[Category: Zinc]]
	[[Category: Zn-dependent hydrolase]]		[[Category: Zn-dependent hydrolase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 30 14~~:44:~~18 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 20 06:10:58 2010''

OCA at 12:44, 30 December 2009

OCA — Wed, 30 Dec 2009 12:44:19 GMT

←Older revision		Revision as of 12:44, 30 December 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3i0v.jpg\|left\|200px]]

-	The ~~entry 3i0v~~ is ~~ON HOLD~~ ~~until Dec 25 2010~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3i0v", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3i0v\| PDB=3i0v \| SCENE= }}

-	~~Authors~~: ~~Gonzalez, J.M., Buschiazzo, A., Vila, A.J.~~	+	===Bacillus cereus metallo-beta-lactamase: apo form===

-	Description: Bacillus cereus metallo-beta-lactamase: apo form

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov 18 18~~:44:38 2009''	+	==About this Structure==
		+	3I0V is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus Bacillus cereus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I0V OCA].
		+	[[Category: Bacillus cereus]]
		+	[[Category: Beta-lactamase]]
		+	[[Category: Buschiazzo, A.]]
		+	[[Category: Gonzalez, J M.]]
		+	[[Category: Vila, A J.]]
		+	[[Category: Antibiotic resistance]]
		+	[[Category: Hydrolase]]
		+	[[Category: Metal-binding]]
		+	[[Category: Metallo-beta-lactamase superfamily]]
		+	[[Category: Zinc]]
		+	[[Category: Zn-dependent hydrolase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 30 14:44:18 2009''