3i4w - Revision history

OCA at 15:55, 1 November 2023

OCA — Wed, 01 Nov 2023 15:55:39 GMT

←Older revision		Revision as of 15:55, 1 November 2023
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	<StructureSection load='3i4w' size='340' side='right'caption='[[3i4w]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='3i4w' size='340' side='right'caption='[[3i4w]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3i4w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I4W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I4W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3i4w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I4W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I4W FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.35Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=SNN:L-3-AMINOSUCCINIMIDE'>SNN</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SNN:L-3-AMINOSUCCINIMIDE'>SNN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i4w OCA], [https://pdbe.org/3i4w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i4w RCSB], [https://www.ebi.ac.uk/pdbsum/3i4w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i4w ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i4w OCA], [https://pdbe.org/3i4w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i4w RCSB], [https://www.ebi.ac.uk/pdbsum/3i4w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i4w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).	+	[https://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3i4w" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3i4w" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Postsynaptic density protein 3D structures\|Postsynaptic density protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Camara-Artigas, A]]	+	[[Category: Camara-Artigas A]]
-	[[Category: Gavira~~, J A]]~~	+	[[Category: Gavira JA]]
-	~~[[Category: Alpha and beta protein]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Cell junction]]~~	+
-	~~[[Category: Cell membrane]]~~	+
-	~~[[Category: Lipoprotein]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Palmitate]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Postsynaptic cell membrane]]~~	+
-	~~[[Category: Sh3 domain]]~~	+
-	~~[[Category: Synapse~~]]	+

OCA at 07:46, 10 November 2021

OCA — Wed, 10 Nov 2021 07:46:08 GMT

←Older revision		Revision as of 07:46, 10 November 2021
Line 3:		Line 3:
	<StructureSection load='3i4w' size='340' side='right'caption='[[3i4w]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='3i4w' size='340' side='right'caption='[[3i4w]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3i4w]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I4W OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3I4W FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3i4w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I4W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I4W FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SNN:L-3-AMINOSUCCINIMIDE'>SNN</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SNN:L-3-AMINOSUCCINIMIDE'>SNN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3i4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i4w OCA], [~~http~~://pdbe.org/3i4w PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3i4w RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3i4w PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3i4w ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i4w OCA], [https://pdbe.org/3i4w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i4w RCSB], [https://www.ebi.ac.uk/pdbsum/3i4w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i4w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).	+	[[https://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:59, 7 August 2019

OCA — Wed, 07 Aug 2019 06:59:29 GMT

←Older revision		Revision as of 06:59, 7 August 2019
Line 1:		Line 1:

	==Crystal Structure of the third PDZ domain of PSD-95==		==Crystal Structure of the third PDZ domain of PSD-95==
-	<StructureSection load='3i4w' size='340' side='right' caption='[[3i4w]], [[Resolution\|resolution]] 1.35Å' scene=''>	+	<StructureSection load='3i4w' size='340' side='right'caption='[[3i4w]], [[Resolution\|resolution]] 1.35Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3i4w]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I4W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I4W FirstGlance]. <br>		<table><tr><td colspan='2'>[[3i4w]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I4W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I4W FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i4/3i4w_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i4/3i4w_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Camara-Artigas, A]]		[[Category: Camara-Artigas, A]]
	[[Category: Gavira, J A]]		[[Category: Gavira, J A]]

OCA at 18:52, 5 August 2016

OCA — Fri, 05 Aug 2016 18:52:39 GMT

←Older revision		Revision as of 18:52, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of the third PDZ domain of PSD-95==		==Crystal Structure of the third PDZ domain of PSD-95==
	<StructureSection load='3i4w' size='340' side='right' caption='[[3i4w]], [[Resolution\|resolution]] 1.35Å' scene=''>		<StructureSection load='3i4w' size='340' side='right' caption='[[3i4w]], [[Resolution\|resolution]] 1.35Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SNN:L-3-AMINOSUCCINIMIDE'>SNN</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SNN:L-3-AMINOSUCCINIMIDE'>SNN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i4w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i4w RCSB], [http://www.ebi.ac.uk/pdbsum/3i4w PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i4w OCA], [http://pdbe.org/3i4w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i4w RCSB], [http://www.ebi.ac.uk/pdbsum/3i4w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3i4w ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i4w ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3i4w" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:58, 25 December 2014

OCA — Thu, 25 Dec 2014 04:58:52 GMT

←Older revision		Revision as of 04:58, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i4w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i4w RCSB], [http://www.ebi.ac.uk/pdbsum/3i4w PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i4w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i4w RCSB], [http://www.ebi.ac.uk/pdbsum/3i4w PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 17:01, 21 December 2014

OCA — Sun, 21 Dec 2014 17:01:54 GMT

←Older revision		Revision as of 17:01, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3i4w\| PDB=3i4w \| SCENE= }}~~	+	==Crystal Structure of the third PDZ domain of PSD-95==
-	===Crystal Structure of the third PDZ domain of PSD-95===	+	<StructureSection load='3i4w' size='340' side='right' caption='[[3i4w]], [[Resolution\|resolution]] 1.35Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20227506}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3i4w]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I4W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I4W FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SNN:L-3-AMINOSUCCINIMIDE'>SNN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i4w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i4w RCSB], [http://www.ebi.ac.uk/pdbsum/3i4w PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i4/3i4w_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The crystal structure of the third PDZ domain of the neuronal post-synaptic density-95 protein (PSD95-PDZ3, residues 302-402) has been solved at 1.4 and 1.35A from two different crystal forms. These structures lack the cloning artefact present in the carboxyl terminal sequence of the former crystallographic structures and they belong to the space groups P4(3) and P1. The new PDZ structures are identical between the two crystal forms and among the four chains of the P1 crystal form. When we compare the new structures with the previous ones, some important conformational differences in the C-terminal alpha-helix and in the loop connecting beta2 and beta3 strands have been found. Additionally, the high resolution of the new structures has allowed us to indentify a succinimide residue at the position corresponding to Asp332 in the beta2-beta3 loop, which may contribute to the alternate conformation of this loop, and at the same time, to the interaction between residues from this loop and the C-terminal alpha-helix. Thus, these features would have implications in the recently proposed allosteric role of this third alpha-helix in the binding of the carboxyl terminal fragments to the PSD95-PDZ3.

-	~~==Function==~~	+	Novel conformational aspects of the third PDZ domain of the neuronal post-synaptic density-95 protein revealed from two 1.4A X-ray structures.,Camara-Artigas A, Murciano-Calles J, Gavira JA, Cobos ES, Martinez JC J Struct Biol. 2010 Jun;170(3):565-9. Epub 2010 Mar 19. PMID:20227506<ref>PMID:20227506</ref>
-	~~[[http://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN]] Interacts with~~ the ~~cytoplasmic tail~~ of ~~NMDA receptor subunits and shaker~~-~~type potassium channels. Required for~~ synaptic ~~plasticity associated with NMDA receptor signaling~~. ~~Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons~~. ~~May reduce the amplitude of ASIC3 acid~~-~~evoked currents by retaining the channel intracellularly~~. ~~May regulate the intracellular trafficking of ADR1B~~ (~~By similarity~~).	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3i4w]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human Human]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3I4W OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020227506</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Camara-Artigas, A.]]	+	[[Category: Camara-Artigas, A]]
-	[[Category: Gavira, J A.]]	+	[[Category: Gavira, J A]]
	[[Category: Alpha and beta protein]]		[[Category: Alpha and beta protein]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]

OCA at 03:17, 13 February 2014

OCA — Thu, 13 Feb 2014 03:17:29 GMT

←Older revision		Revision as of 03:17, 13 February 2014
Line 2:		Line 2:
	===Crystal Structure of the third PDZ domain of PSD-95===		===Crystal Structure of the third PDZ domain of PSD-95===
	{{ABSTRACT_PUBMED_20227506}}		{{ABSTRACT_PUBMED_20227506}}
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).

	==About this Structure==		==About this Structure==
-	[[3i4w]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I4W OCA].	+	[[3i4w]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I4W OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020227506</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020227506</ref><references group="xtra"/><references/>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Camara-Artigas, A.]]		[[Category: Camara-Artigas, A.]]
	[[Category: Gavira, J A.]]		[[Category: Gavira, J A.]]

OCA: Protected "3i4w" [edit=sysop:move=sysop]

OCA — Wed, 13 Mar 2013 10:39:38 GMT

Protected "3i4w" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:39, 13 March 2013

OCA at 10:39, 13 March 2013

OCA — Wed, 13 Mar 2013 10:39:32 GMT

←Older revision		Revision as of 10:39, 13 March 2013
Line 1:		Line 1:
-	{{Seed}}
-	[[Image:3i4w.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3i4w", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3i4w\| PDB=3i4w \| SCENE= }}		{{STRUCTURE_3i4w\| PDB=3i4w \| SCENE= }}
-
	===Crystal Structure of the third PDZ domain of PSD-95===		===Crystal Structure of the third PDZ domain of PSD-95===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20227506}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20227506 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20227506}}		{{ABSTRACT_PUBMED_20227506}}

	==About this Structure==		==About this Structure==
-	~~3I4W~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I4W OCA].	+	[[3i4w]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I4W OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20227506~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020227506</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Camara-Artigas, A.]]		[[Category: Camara-Artigas, A.]]
	[[Category: Gavira, J A.]]		[[Category: Gavira, J A.]]
	[[Category: Alpha and beta protein]]		[[Category: Alpha and beta protein]]
-	[[Category: Alternative splicing]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Cell junction]]		[[Category: Cell junction]]
Line 39:		Line 22:
	[[Category: Sh3 domain]]		[[Category: Sh3 domain]]
	[[Category: Synapse]]		[[Category: Synapse]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 7 10:33:06 2010''

OCA at 07:33, 7 April 2010

OCA — Wed, 07 Apr 2010 07:33:07 GMT

←Older revision		Revision as of 07:33, 7 April 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3i4w.jpg\|left\|200px]]

-	The ~~entry 3i4w~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3i4w", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3i4w\| PDB=3i4w \| SCENE= }}

-	~~Authors: Camara~~-~~Artigas, A., Gavira, J.A.~~	+	===Crystal Structure of the third PDZ domain of PSD-95===

-	Description: Crystal Structure of the third PDZ domain of PSD-95

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug~~ ~~5 09~~:47:~~32 2009~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20227506}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20227506 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20227506}}
		+
		+	==About this Structure==
		+	3I4W is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I4W OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20227506</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Camara-Artigas, A.]]
		+	[[Category: Gavira, J A.]]
		+	[[Category: Alpha and beta protein]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Cell junction]]
		+	[[Category: Cell membrane]]
		+	[[Category: Lipoprotein]]
		+	[[Category: Membrane]]
		+	[[Category: Palmitate]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Postsynaptic cell membrane]]
		+	[[Category: Sh3 domain]]
		+	[[Category: Synapse]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 7 10:33:06 2010''