3i5p - Revision history

OCA at 10:03, 21 February 2024

OCA — Wed, 21 Feb 2024 10:03:58 GMT

←Older revision		Revision as of 10:03, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3i5p' size='340' side='right'caption='[[3i5p]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='3i5p' size='340' side='right'caption='[[3i5p]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3i5p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I5P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I5P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3i5p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I5P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I5P FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3i4r\|3i4r]], [[3i5q\|3i5q]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">NLE3, NUP170, YBL0725, YBL079W ([https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=4932 ATCC 18824])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i5p OCA], [https://pdbe.org/3i5p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i5p RCSB], [https://www.ebi.ac.uk/pdbsum/3i5p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i5p ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i5p OCA], [https://pdbe.org/3i5p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i5p RCSB], [https://www.ebi.ac.uk/pdbsum/3i5p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i5p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/NU170_YEAST NU170_YEAST]] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP170 probably plays an important role in NPC assembly and organization. In addition it is required for chromosome transmission fidelity.<ref>PMID:9864357</ref> <ref>PMID:12403813</ref> <ref>PMID:14697200</ref> <ref>PMID:11290711</ref> <ref>PMID:12473689</ref>	+	[https://www.uniprot.org/uniprot/NU170_YEAST NU170_YEAST] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP170 probably plays an important role in NPC assembly and organization. In addition it is required for chromosome transmission fidelity.<ref>PMID:9864357</ref> <ref>PMID:12403813</ref> <ref>PMID:14697200</ref> <ref>PMID:11290711</ref> <ref>PMID:12473689</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i5p ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i5p ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	The nuclear pore complex (NPC) constitutes one of the largest protein assemblies in the eukaryotic cell and forms the exclusive gateway to the nucleus. The stable, approximately 15-20-MDa scaffold ring of the NPC is built from two multiprotein complexes arranged around a central 8-fold axis. Here we present crystal structures of two large architectural units, yNup170(979-1502) and hNup107(658-925) x hNup133(517-1156), each a constituent of one of the two multiprotein complexes. Conservation of domain arrangement and of tertiary structure suggests that Nup157/170 and Nup133 derived from a common ancestor. Together with the previously established ancestral coatomer element (ACE1), these two elements constitute the major alpha-helical building blocks of the NPC scaffold and define its branched, lattice-like architecture, similar to vesicle coats like COPII. We hypothesize that the extant NPC evolved early during eukaryotic evolution from a rudimentary structure composed of several identical copies of a few ancestral elements, later diversified and specified by gene duplication.
-
-	Architectural nucleoporins Nup157/170 and Nup133 are structurally related and descend from a second ancestral element.,Whittle JR, Schwartz TU J Biol Chem. 2009 Oct 9;284(41):28442-52. Epub 2009 Aug 11. PMID:19674973<ref>PMID:19674973</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3i5p" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Schwartz, T U~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Whittle, J R.R~~]]	+	[[Category: Schwartz TU]]
-	[[Category: ~~Helical stack]]~~	+	[[Category: Whittle JRR]]
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Mrna transport]]~~	+
-	~~[[Category: Nuclear pore complex]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Translocation]]~~	+
-	~~[[Category: Transmembrane]]~~	+
-	~~[[Category: Transport~~]]	+

OCA at 10:58, 13 April 2022

OCA — Wed, 13 Apr 2022 10:58:18 GMT

←Older revision		Revision as of 10:58, 13 April 2022
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	==Nup170(aa979-1502), S.cerevisiae==		==Nup170(aa979-1502), S.cerevisiae==
-	<StructureSection load='3i5p' size='340' side='right' caption='[[3i5p]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<StructureSection load='3i5p' size='340' side='right'caption='[[3i5p]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3i5p]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I5P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3I5P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3i5p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I5P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I5P FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i4r\|3i4r]], [[3i5q\|3i5q]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3i4r\|3i4r]], [[3i5q\|3i5q]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NLE3, NUP170, YBL0725, YBL079W ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NLE3, NUP170, YBL0725, YBL079W ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3i5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i5p OCA], [~~http~~://pdbe.org/3i5p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3i5p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3i5p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3i5p ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i5p OCA], [https://pdbe.org/3i5p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i5p RCSB], [https://www.ebi.ac.uk/pdbsum/3i5p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i5p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/NU170_YEAST NU170_YEAST]] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP170 probably plays an important role in NPC assembly and organization. In addition it is required for chromosome transmission fidelity.<ref>PMID:9864357</ref> <ref>PMID:12403813</ref> <ref>PMID:14697200</ref> <ref>PMID:11290711</ref> <ref>PMID:12473689</ref>	+	[[https://www.uniprot.org/uniprot/NU170_YEAST NU170_YEAST]] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP170 probably plays an important role in NPC assembly and organization. In addition it is required for chromosome transmission fidelity.<ref>PMID:9864357</ref> <ref>PMID:12403813</ref> <ref>PMID:14697200</ref> <ref>PMID:11290711</ref> <ref>PMID:12473689</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Nucleoporin\|Nucleoporin]]	+	*[[Nucleoporin 3D structures\|Nucleoporin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Schwartz, T U]]		[[Category: Schwartz, T U]]
	[[Category: Whittle, J R.R]]		[[Category: Whittle, J R.R]]

OCA at 10:07, 19 December 2018

OCA — Wed, 19 Dec 2018 10:07:30 GMT

←Older revision		Revision as of 10:07, 19 December 2018
Line 1:		Line 1:
		+
	==Nup170(aa979-1502), S.cerevisiae==		==Nup170(aa979-1502), S.cerevisiae==
	<StructureSection load='3i5p' size='340' side='right' caption='[[3i5p]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='3i5p' size='340' side='right' caption='[[3i5p]], [[Resolution\|resolution]] 3.20Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i4r\|3i4r]], [[3i5q\|3i5q]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i4r\|3i4r]], [[3i5q\|3i5q]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NLE3, NUP170, YBL0725, YBL079W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NLE3, NUP170, YBL0725, YBL079W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i5p OCA], [http://pdbe.org/3i5p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i5p RCSB], [http://www.ebi.ac.uk/pdbsum/3i5p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i5p OCA], [http://pdbe.org/3i5p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i5p RCSB], [http://www.ebi.ac.uk/pdbsum/3i5p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3i5p ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i5/3i5p_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i5/3i5p_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 08:29, 8 February 2016

OCA — Mon, 08 Feb 2016 08:29:53 GMT

←Older revision		Revision as of 08:29, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3i5p' size='340' side='right' caption='[[3i5p]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='3i5p' size='340' side='right' caption='[[3i5p]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3i5p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I5P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I5P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3i5p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I5P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I5P FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i4r\|3i4r]], [[3i5q\|3i5q]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i4r\|3i4r]], [[3i5q\|3i5q]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NLE3, NUP170, YBL0725, YBL079W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NLE3, NUP170, YBL0725, YBL079W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i5p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i5p RCSB], [http://www.ebi.ac.uk/pdbsum/3i5p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i5p OCA], [http://pdbe.org/3i5p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i5p RCSB], [http://www.ebi.ac.uk/pdbsum/3i5p PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i5p ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3i5p" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Schwartz, T U]]		[[Category: Schwartz, T U]]
	[[Category: Whittle, J R.R]]		[[Category: Whittle, J R.R]]

OCA at 21:58, 24 December 2014

OCA — Wed, 24 Dec 2014 21:58:59 GMT

←Older revision		Revision as of 21:58, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3i5p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I5P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I5P FirstGlance]. <br>		<table><tr><td colspan='2'>[[3i5p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I5P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I5P FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i4r\|3i4r]], [[3i5q\|3i5q]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i4r\|3i4r]], [[3i5q\|3i5q]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NLE3, NUP170, YBL0725, YBL079W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NLE3, NUP170, YBL0725, YBL079W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i5p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i5p RCSB], [http://www.ebi.ac.uk/pdbsum/3i5p PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i5p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i5p RCSB], [http://www.ebi.ac.uk/pdbsum/3i5p PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NU170_YEAST NU170_YEAST]] Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP170 probably plays an important role in NPC assembly and organization. In addition it is required for chromosome transmission fidelity.<ref>PMID:9864357</ref> <ref>PMID:12403813</ref> <ref>PMID:14697200</ref> <ref>PMID:11290711</ref> <ref>PMID:12473689</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Schwartz, T U.]]	+	[[Category: Schwartz, T U]]
-	[[Category: Whittle, J R.R.]]	+	[[Category: Whittle, J R.R]]
	[[Category: Helical stack]]		[[Category: Helical stack]]
	[[Category: Membrane]]		[[Category: Membrane]]

OCA at 13:32, 29 September 2014

OCA — Mon, 29 Sep 2014 13:32:54 GMT

←Older revision		Revision as of 13:32, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3i5p.~~png~~\|~~left~~\|200px]]	+	==Nup170(aa979-1502), S.cerevisiae==
		+	<StructureSection load='3i5p' size='340' side='right' caption='[[3i5p]], [[Resolution\|resolution]] 3.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3i5p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I5P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I5P FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i4r\|3i4r]], [[3i5q\|3i5q]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NLE3, NUP170, YBL0725, YBL079W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i5p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i5p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i5p RCSB], [http://www.ebi.ac.uk/pdbsum/3i5p PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i5/3i5p_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The nuclear pore complex (NPC) constitutes one of the largest protein assemblies in the eukaryotic cell and forms the exclusive gateway to the nucleus. The stable, approximately 15-20-MDa scaffold ring of the NPC is built from two multiprotein complexes arranged around a central 8-fold axis. Here we present crystal structures of two large architectural units, yNup170(979-1502) and hNup107(658-925) x hNup133(517-1156), each a constituent of one of the two multiprotein complexes. Conservation of domain arrangement and of tertiary structure suggests that Nup157/170 and Nup133 derived from a common ancestor. Together with the previously established ancestral coatomer element (ACE1), these two elements constitute the major alpha-helical building blocks of the NPC scaffold and define its branched, lattice-like architecture, similar to vesicle coats like COPII. We hypothesize that the extant NPC evolved early during eukaryotic evolution from a rudimentary structure composed of several identical copies of a few ancestral elements, later diversified and specified by gene duplication.

-	~~{{STRUCTURE_3i5p\| PDB=3i5p \| SCENE= }}~~	+	Architectural nucleoporins Nup157/170 and Nup133 are structurally related and descend from a second ancestral element.,Whittle JR, Schwartz TU J Biol Chem. 2009 Oct 9;284(41):28442-52. Epub 2009 Aug 11. PMID:19674973<ref>PMID:19674973</ref>

-	~~===Nup170(aa979-1502)~~, ~~S.cerevisiae===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19674973}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3i5p]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3I5P OCA].~~	+

	==See Also==		==See Also==
	*[[Nucleoporin\|Nucleoporin]]		*[[Nucleoporin\|Nucleoporin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019674973<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Schwartz, T U.]]		[[Category: Schwartz, T U.]]

OCA at 09:33, 20 October 2012

OCA — Sat, 20 Oct 2012 09:33:12 GMT

←Older revision		Revision as of 09:33, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3i5p]] is a 1 chain structure ~~of [[Nucleoporin]]~~ with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I5P OCA].	+	[[3i5p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I5P OCA].

	==See Also==		==See Also==

OCA: Protected "3i5p" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 23:14:57 GMT

Protected "3i5p" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:14, 25 July 2012

OCA at 23:14, 25 July 2012

OCA — Wed, 25 Jul 2012 23:14:55 GMT

←Older revision		Revision as of 23:14, 25 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3i5p.png\|left\|200px]]		[[Image:3i5p.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3i5p", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3i5p\| PDB=3i5p \| SCENE= }}		{{STRUCTURE_3i5p\| PDB=3i5p \| SCENE= }}

	===Nup170(aa979-1502), S.cerevisiae===		===Nup170(aa979-1502), S.cerevisiae===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19674973}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19674973 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19674973}}		{{ABSTRACT_PUBMED_19674973}}

	==About this Structure==		==About this Structure==
-	~~3I5P~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I5P OCA].	+	[[3i5p]] is a 1 chain structure of [[Nucleoporin]] with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I5P OCA].
		+
		+	==See Also==
		+	*[[Nucleoporin\|Nucleoporin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19674973~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019674973</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Schwartz, T U.]]		[[Category: Schwartz, T U.]]
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	[[Category: Transmembrane]]		[[Category: Transmembrane]]
	[[Category: Transport]]		[[Category: Transport]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 24 08:30:06 2010''

OCA at 06:30, 24 March 2010

OCA — Wed, 24 Mar 2010 06:30:06 GMT

←Older revision		Revision as of 06:30, 24 March 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3i5p.~~jpg~~\|left\|200px]]	+	[[Image:3i5p.png\|left\|200px]]

	<!--		<!--
Line 12:		Line 12:
	===Nup170(aa979-1502), S.cerevisiae===		===Nup170(aa979-1502), S.cerevisiae===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19674973}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19674973 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19674973}}

	==About this Structure==		==About this Structure==
-	3I5P is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I5P OCA].	+	3I5P is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I5P OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19674973</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Schwartz, T U.]]		[[Category: Schwartz, T U.]]
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	[[Category: Transport]]		[[Category: Transport]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug 12 13~~:45:~~35 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 24 08:30:06 2010''