3i9q - Revision history

OCA at 07:41, 6 September 2023

OCA — Wed, 06 Sep 2023 07:41:19 GMT

←Older revision		Revision as of 07:41, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3i9q' size='340' side='right'caption='[[3i9q]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='3i9q' size='340' side='right'caption='[[3i9q]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3i9q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Chick Chick~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I9Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I9Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3i9q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I9Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I9Q FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~SPTAN1, SPTA2 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i9q OCA], [https://pdbe.org/3i9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i9q RCSB], [https://www.ebi.ac.uk/pdbsum/3i9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i9q ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i9q OCA], [https://pdbe.org/3i9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i9q RCSB], [https://www.ebi.ac.uk/pdbsum/3i9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i9q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK]] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.	+	[https://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Spectrin\|Spectrin]]	+	*[[Spectrin 3D structures\|Spectrin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Chick~~]]	+	[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Camara-Artigas, A]]	+	[[Category: Camara-Artigas A]]
-	[[Category: Gavira~~, J A]]~~	+	[[Category: Gavira JA]]
-	~~[[Category: Actin capping]]~~	+
-	~~[[Category: Actin-binding]]~~	+
-	~~[[Category: Calmodulin-binding]]~~	+
-	~~[[Category: Cytoskeleton]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Sh3 domain]]~~	+
-	~~[[Category: Sh3-like barrel]]~~	+
-	~~[[Category: Structural protein~~]]	+

OCA at 12:08, 13 October 2021

OCA — Wed, 13 Oct 2021 12:08:46 GMT

←Older revision		Revision as of 12:08, 13 October 2021
Line 1:		Line 1:

	==Crystal Structure of the triple mutant S19G-P20D-R21S of alpha spectrin SH3 domain==		==Crystal Structure of the triple mutant S19G-P20D-R21S of alpha spectrin SH3 domain==
-	<StructureSection load='3i9q' size='340' side='right' caption='[[3i9q]], [[Resolution\|resolution]] 1.45Å' scene=''>	+	<StructureSection load='3i9q' size='340' side='right'caption='[[3i9q]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3i9q]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I9Q OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3I9Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3i9q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I9Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I9Q FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPTAN1, SPTA2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPTAN1, SPTA2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3i9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i9q OCA], [~~http~~://pdbe.org/3i9q PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3i9q RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3i9q PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3i9q ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i9q OCA], [https://pdbe.org/3i9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i9q RCSB], [https://www.ebi.ac.uk/pdbsum/3i9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i9q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK]] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.	+	[[https://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK]] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i9/3i9q_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i9/3i9q_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3i9q" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3i9q" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Spectrin\|Spectrin]]
	== References ==		== References ==
	<references/>		<references/>
Line 34:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Chick]]		[[Category: Chick]]
		+	[[Category: Large Structures]]
	[[Category: Camara-Artigas, A]]		[[Category: Camara-Artigas, A]]
	[[Category: Gavira, J A]]		[[Category: Gavira, J A]]

OCA at 08:00, 1 November 2017

OCA — Wed, 01 Nov 2017 08:00:48 GMT

←Older revision		Revision as of 08:00, 1 November 2017
Line 1:		Line 1:
		+
	==Crystal Structure of the triple mutant S19G-P20D-R21S of alpha spectrin SH3 domain==		==Crystal Structure of the triple mutant S19G-P20D-R21S of alpha spectrin SH3 domain==
	<StructureSection load='3i9q' size='340' side='right' caption='[[3i9q]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='3i9q' size='340' side='right' caption='[[3i9q]], [[Resolution\|resolution]] 1.45Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPTAN1, SPTA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPTAN1, SPTA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i9q OCA], [http://pdbe.org/3i9q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i9q RCSB], [http://www.ebi.ac.uk/pdbsum/3i9q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i9q OCA], [http://pdbe.org/3i9q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i9q RCSB], [http://www.ebi.ac.uk/pdbsum/3i9q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3i9q ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3i9q" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3i9q" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Spectrin\|Spectrin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:59, 8 February 2016

OCA — Mon, 08 Feb 2016 01:59:37 GMT

←Older revision		Revision as of 01:59, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3i9q' size='340' side='right' caption='[[3i9q]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='3i9q' size='340' side='right' caption='[[3i9q]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3i9q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Gallus_gallus Gallus gallus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I9Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I9Q FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3i9q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I9Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I9Q FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPTAN1, SPTA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 ~~Gallus gallus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPTAN1, SPTA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i9q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i9q RCSB], [http://www.ebi.ac.uk/pdbsum/3i9q PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i9q OCA], [http://pdbe.org/3i9q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i9q RCSB], [http://www.ebi.ac.uk/pdbsum/3i9q PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i9q ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3i9q" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Gallus gallus~~]]	+	[[Category: Chick]]
	[[Category: Camara-Artigas, A]]		[[Category: Camara-Artigas, A]]
	[[Category: Gavira, J A]]		[[Category: Gavira, J A]]

OCA at 19:44, 24 December 2014

OCA — Wed, 24 Dec 2014 19:44:11 GMT

←Older revision		Revision as of 19:44, 24 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i9q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i9q RCSB], [http://www.ebi.ac.uk/pdbsum/3i9q PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i9q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i9q RCSB], [http://www.ebi.ac.uk/pdbsum/3i9q PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK]] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 14:48, 18 December 2014

OCA — Thu, 18 Dec 2014 14:48:27 GMT

←Older revision		Revision as of 14:48, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3i9q\| PDB=3i9q \| SCENE= }}~~	+	==Crystal Structure of the triple mutant S19G-P20D-R21S of alpha spectrin SH3 domain==
-	===Crystal Structure of the triple mutant S19G-P20D-R21S of alpha spectrin SH3 domain===	+	<StructureSection load='3i9q' size='340' side='right' caption='[[3i9q]], [[Resolution\|resolution]] 1.45Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19966410}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3i9q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I9Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I9Q FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SPTAN1, SPTA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 Gallus gallus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i9q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i9q RCSB], [http://www.ebi.ac.uk/pdbsum/3i9q PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i9/3i9q_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	alpha-Spectrin SH3-domain (Spc-SH3) crystallization is characterized by very fast growth of the crystals in the presence of ammonium sulfate as a precipitant agent. The origin of this behaviour can be attributed to the presence of a proline residue that participates in a crystal contact mimicking the binding of proline-rich sequences to SH3 domains. This residue, Pro20, is located in the RT loop and is the main contact in one of the interfaces present in the orthorhombic Spc-SH3 crystal structures. In order to understand the molecular interactions that are responsible for the very fast crystal growth of the wild-type (WT) Spc-SH3 crystals, the crystal structure of a triple mutant in which the residues Ser19-Pro20-Arg21 in the RT loop have been replaced by Gly19-Asp20-Ser21 (GDS Spc-SH3 mutant) has been solved. The removal of the critical proline residue results in slower nucleation of the Spc-SH3 crystals and a different arrangement of the protein molecules in the unit cell, leading to a crystal that belongs to the tetragonal space group P4(1)2(1)2, with unit-cell parameters a = b = 42.231, c = 93.655 A, and that diffracts to 1.45 A resolution. For both WT Spc-SH3 and the GDS mutant, light-scattering experiments showed that a dimer was formed in solution within a few minutes of the addition of 2 M ammonium sulfate at pH 6.5 and allowed the proposal of a mechanism for the nucleation and crystal growth of Spc-SH3 in which the Pro20 residue plays a key role in the rate of crystal growth.

-	~~==Function==~~	+	The effect of a proline residue on the rate of growth and the space group of alpha-spectrin SH3-domain crystals.,Camara-Artigas A, Andujar-Sanchez M, Ortiz-Salmeron E, Cuadri C, Casares S Acta Crystallogr D Biol Crystallogr. 2009 Dec;65(Pt 12):1247-52. Epub 2009, Nov 17. PMID:19966410<ref>PMID:19966410</ref>
-	~~[[http://www~~.~~uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK]] Morphologically~~, ~~spectrin~~-~~like proteins appear to be related to spectrin~~, ~~showing a flexible rod~~-~~like structure~~. ~~They can bind actin but seem to differ in their calmodulin~~-~~binding activity~~. ~~In nonerythroid tissues~~, ~~spectrins, in association with some other proteins, may play an important role in membrane organization~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3i9q]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Gallus_gallus Gallus gallus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3I9Q OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:019966410</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Spectrin\|Spectrin]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
-	[[Category: Camara-Artigas, A.]]	+	[[Category: Camara-Artigas, A]]
-	[[Category: Gavira, J A.]]	+	[[Category: Gavira, J A]]
	[[Category: Actin capping]]		[[Category: Actin capping]]
	[[Category: Actin-binding]]		[[Category: Actin-binding]]

OCA at 13:25, 19 June 2013

OCA — Wed, 19 Jun 2013 13:25:32 GMT

←Older revision		Revision as of 13:25, 19 June 2013
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-	[[Image:3i9q.png\|left\|200px]]
-
	{{STRUCTURE_3i9q\| PDB=3i9q \| SCENE= }}		{{STRUCTURE_3i9q\| PDB=3i9q \| SCENE= }}
-
	===Crystal Structure of the triple mutant S19G-P20D-R21S of alpha spectrin SH3 domain===		===Crystal Structure of the triple mutant S19G-P20D-R21S of alpha spectrin SH3 domain===
		+	{{ABSTRACT_PUBMED_19966410}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK]] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.

	==About this Structure==		==About this Structure==
	[[3i9q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I9Q OCA].		[[3i9q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I9Q OCA].

-	==~~See Also~~==	+	==Reference==
-	*[[Spectrin\|Spectrin]]	+	<ref group="xtra">PMID:019966410</ref><references group="xtra"/><references/>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Camara-Artigas, A.]]		[[Category: Camara-Artigas, A.]]

OCA at 08:31, 20 October 2012

OCA — Sat, 20 Oct 2012 08:31:24 GMT

←Older revision		Revision as of 08:31, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[3i9q]] is a 1 chain structure ~~of [[Spectrin]]~~ with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I9Q OCA].	+	[[3i9q]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I9Q OCA].

	==See Also==		==See Also==

OCA at 19:47, 25 July 2012

OCA — Wed, 25 Jul 2012 19:47:49 GMT

←Older revision		Revision as of 19:47, 25 July 2012
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	[[Image:3i9q.png\|left\|200px]]		[[Image:3i9q.png\|left\|200px]]

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	{{STRUCTURE_3i9q\| PDB=3i9q \| SCENE= }}		{{STRUCTURE_3i9q\| PDB=3i9q \| SCENE= }}

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	==See Also==		==See Also==
-	*[[Spectrin]]	+	*[[Spectrin\|Spectrin]]
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Camara-Artigas, A.]]		[[Category: Camara-Artigas, A.]]
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	[[Category: Actin capping]]		[[Category: Actin capping]]
	[[Category: Actin-binding]]		[[Category: Actin-binding]]
-	[[Category: Calcium]]
	[[Category: Calmodulin-binding]]		[[Category: Calmodulin-binding]]
-	[[Category: Cytoplasm]]
	[[Category: Cytoskeleton]]		[[Category: Cytoskeleton]]
	[[Category: Phosphoprotein]]		[[Category: Phosphoprotein]]

OCA: Protected "3i9q" [edit=sysop:move=sysop]

OCA — Sun, 26 Dec 2010 23:36:17 GMT

Protected "3i9q" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:36, 26 December 2010