3iaj - Revision history

OCA at 15:56, 1 November 2023

OCA — Wed, 01 Nov 2023 15:56:52 GMT

←Older revision		Revision as of 15:56, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3iaj' size='340' side='right'caption='[[3iaj]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3iaj' size='340' side='right'caption='[[3iaj]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3iaj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Clob8 Clob8~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IAJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3iaj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_beijerinckii_NCIMB_8052 Clostridium beijerinckii NCIMB 8052]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IAJ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[3i9h\|3i9h]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">5294019 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=290402 CLOB8])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iaj OCA], [https://pdbe.org/3iaj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iaj RCSB], [https://www.ebi.ac.uk/pdbsum/3iaj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iaj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iaj OCA], [https://pdbe.org/3iaj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iaj RCSB], [https://www.ebi.ac.uk/pdbsum/3iaj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iaj ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A6LX94_CLOB8 A6LX94_CLOB8]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Clob8~~]]	+	[[Category: Clostridium beijerinckii NCIMB 8052]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aravind, P]]	+	[[Category: Aravind P]]
-	[[Category: Sankaranarayanan, R]]	+	[[Category: Sankaranarayanan R]]
-	~~[[Category: Calcium-bound betagamma-crystallin]]~~	+
-	~~[[Category: Metal binding protein~~]]	+

OCA at 11:02, 13 April 2022

OCA — Wed, 13 Apr 2022 11:02:20 GMT

←Older revision		Revision as of 11:02, 13 April 2022
Line 1:		Line 1:

	==Crystal structure of a betagamma-crystallin domain from Clostridium beijerinckii-in alternate space group I422==		==Crystal structure of a betagamma-crystallin domain from Clostridium beijerinckii-in alternate space group I422==
-	<StructureSection load='3iaj' size='340' side='right' caption='[[3iaj]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='3iaj' size='340' side='right'caption='[[3iaj]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3iaj]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Clob8 Clob8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IAJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3iaj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clob8 Clob8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IAJ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i9h\|3i9h]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3i9h\|3i9h]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">5294019 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=290402 CLOB8])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">5294019 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=290402 CLOB8])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3iaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iaj OCA], [~~http~~://pdbe.org/3iaj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3iaj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3iaj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3iaj ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iaj OCA], [https://pdbe.org/3iaj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iaj RCSB], [https://www.ebi.ac.uk/pdbsum/3iaj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iaj ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/3iaj_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/3iaj_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 28:
	</div>		</div>
	<div class="pdbe-citations 3iaj" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3iaj" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Crystallin 3D structures\|Crystallin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Clob8]]		[[Category: Clob8]]
		+	[[Category: Large Structures]]
	[[Category: Aravind, P]]		[[Category: Aravind, P]]
	[[Category: Sankaranarayanan, R]]		[[Category: Sankaranarayanan, R]]
	[[Category: Calcium-bound betagamma-crystallin]]		[[Category: Calcium-bound betagamma-crystallin]]
	[[Category: Metal binding protein]]		[[Category: Metal binding protein]]

OCA at 08:01, 1 November 2017

OCA — Wed, 01 Nov 2017 08:01:32 GMT

←Older revision		Revision as of 08:01, 1 November 2017
Line 1:		Line 1:
		+
	==Crystal structure of a betagamma-crystallin domain from Clostridium beijerinckii-in alternate space group I422==		==Crystal structure of a betagamma-crystallin domain from Clostridium beijerinckii-in alternate space group I422==
	<StructureSection load='3iaj' size='340' side='right' caption='[[3iaj]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3iaj' size='340' side='right' caption='[[3iaj]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i9h\|3i9h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i9h\|3i9h]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">5294019 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=290402 CLOB8])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">5294019 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=290402 CLOB8])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iaj OCA], [http://pdbe.org/3iaj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iaj RCSB], [http://www.ebi.ac.uk/pdbsum/3iaj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iaj OCA], [http://pdbe.org/3iaj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iaj RCSB], [http://www.ebi.ac.uk/pdbsum/3iaj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3iaj ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 21:28, 8 February 2016

OCA — Mon, 08 Feb 2016 21:28:32 GMT

←Older revision		Revision as of 21:28, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3iaj' size='340' side='right' caption='[[3iaj]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3iaj' size='340' side='right' caption='[[3iaj]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3iaj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Clostridium_beijerinckii Clostridium beijerinckii~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IAJ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3iaj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clob8 Clob8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IAJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i9h\|3i9h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i9h\|3i9h]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">5294019 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1520 Clostridium beijerinckii~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">5294019 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=290402 CLOB8])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iaj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iaj RCSB], [http://www.ebi.ac.uk/pdbsum/3iaj PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iaj OCA], [http://pdbe.org/3iaj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iaj RCSB], [http://www.ebi.ac.uk/pdbsum/3iaj PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iaj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3iaj" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Clostridium beijerinckii~~]]	+	[[Category: Clob8]]
	[[Category: Aravind, P]]		[[Category: Aravind, P]]
	[[Category: Sankaranarayanan, R]]		[[Category: Sankaranarayanan, R]]
	[[Category: Calcium-bound betagamma-crystallin]]		[[Category: Calcium-bound betagamma-crystallin]]
	[[Category: Metal binding protein]]		[[Category: Metal binding protein]]

OCA at 06:22, 18 December 2014

OCA — Thu, 18 Dec 2014 06:22:32 GMT

←Older revision		Revision as of 06:22, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3iaj\| PDB=3iaj \| SCENE= }}~~	+	==Crystal structure of a betagamma-crystallin domain from Clostridium beijerinckii-in alternate space group I422==
-	===Crystal structure of a betagamma-crystallin domain from Clostridium beijerinckii-in alternate space group I422===	+	<StructureSection load='3iaj' size='340' side='right' caption='[[3iaj]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19921810}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3iaj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_beijerinckii Clostridium beijerinckii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IAJ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i9h\|3i9h]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">5294019 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1520 Clostridium beijerinckii])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iaj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iaj RCSB], [http://www.ebi.ac.uk/pdbsum/3iaj PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/3iaj_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The betagamma-crystallin superfamily consists of evolutionarily related proteins with domain topology similar to lens beta- and gamma-crystallins, formed from duplicated Greek key motifs. Ca2+-binding was found in a few betagamma-crystallin members earlier, although its prevalence and diversity as an inherent molecular property among members of the superfamily is not well-studied. To increase our understanding of Ca2+-binding in various betagamma-crystallins, we undertook comprehensive structural and Ca2+-binding studies of seven members of the superfamily from bacteria, archaea and vertebrates, including determination of high resolution crystal structures of three proteins. Our structural observations show that the determinants of Ca2+ coordination remain conserved in the form of an N/D-N/D-#-I-S/T-S motif in all domains. However, binding of Ca2+ elicits varied physico-chemical responses, ranging from passive sequestration to active stabilization. The motif in this superfamily is modified in some members like lens crystallins where Ca2+-binding abilities are partly or completely compromised. We show that reduction or loss of Ca2+-binding in members of the superfamily, particularly in vertebrates, is due to the selective presence of unfavorable amino acids (largely Arg) at key Ca2+-ligation positions and that engineering of the canonical Ca2+-binding residues can confer binding activity on an otherwise inactive domain. Through this work, we demonstrate that betagamma-crystallins with the N/D-N/D-#-I-S/T-S motif form an extensive set of Ca2+-binding proteins prevalent in all the three kingdoms of life.

-	~~==About this Structure==~~	+	betagamma-Crystallin superfamily contains a universal motif for binding calcium.,Aravind P, Mishra A, Suman SK, Jobby MK, Sankaranarayanan R, Sharma Y Biochemistry. 2009 Nov 18. PMID:19921810<ref>PMID:19921810</ref>
-	~~[[3iaj]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Clostridium_beijerinckii Clostridium beijerinckii]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3IAJ OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	<~~ref group="xtra">PMID:019921810<~~/~~ref~~><~~references group="xtra"~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Clostridium beijerinckii]]		[[Category: Clostridium beijerinckii]]
-	[[Category: Aravind, P.]]	+	[[Category: Aravind, P]]
-	[[Category: Sankaranarayanan, R.]]	+	[[Category: Sankaranarayanan, R]]
	[[Category: Calcium-bound betagamma-crystallin]]		[[Category: Calcium-bound betagamma-crystallin]]
	[[Category: Metal binding protein]]		[[Category: Metal binding protein]]

OCA: Protected "3iaj" [edit=sysop:move=sysop]

OCA — Wed, 13 Mar 2013 10:56:52 GMT

Protected "3iaj" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:56, 13 March 2013

OCA at 10:56, 13 March 2013

OCA — Wed, 13 Mar 2013 10:56:47 GMT

←Older revision		Revision as of 10:56, 13 March 2013
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-	{{Seed}}
-	[[Image:3iaj.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3iaj", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3iaj\| PDB=3iaj \| SCENE= }}		{{STRUCTURE_3iaj\| PDB=3iaj \| SCENE= }}
-
	===Crystal structure of a betagamma-crystallin domain from Clostridium beijerinckii-in alternate space group I422===		===Crystal structure of a betagamma-crystallin domain from Clostridium beijerinckii-in alternate space group I422===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19921810}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19921810 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19921810}}		{{ABSTRACT_PUBMED_19921810}}

	==About this Structure==		==About this Structure==
-	~~3IAJ~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_beijerinckii Clostridium beijerinckii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAJ OCA].	+	[[3iaj]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_beijerinckii Clostridium beijerinckii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAJ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19921810~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019921810</ref><references group="xtra"/>
	[[Category: Clostridium beijerinckii]]		[[Category: Clostridium beijerinckii]]
	[[Category: Aravind, P.]]		[[Category: Aravind, P.]]
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	[[Category: Calcium-bound betagamma-crystallin]]		[[Category: Calcium-bound betagamma-crystallin]]
	[[Category: Metal binding protein]]		[[Category: Metal binding protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 2 10:11:40 2009''

OCA at 08:11, 2 December 2009

OCA — Wed, 02 Dec 2009 08:11:41 GMT

←Older revision		Revision as of 08:11, 2 December 2009
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3iaj.jpg\|left\|200px]]

-	The ~~entry 3iaj~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3iaj", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3iaj\| PDB=3iaj \| SCENE= }}

-	~~Authors: Aravind, P., Sankaranarayanan, R.~~	+	===Crystal structure of a betagamma-crystallin domain from Clostridium beijerinckii-in alternate space group I422===

-	Description: Crystal structure of a betagamma-crystallin domain from Clostridium beijerinckii-in alternate space group I422

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Aug~~ ~~5 09~~:49:18 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19921810}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19921810 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19921810}}
		+
		+	==About this Structure==
		+	3IAJ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_beijerinckii Clostridium beijerinckii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAJ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19921810</ref><references group="xtra"/>
		+	[[Category: Clostridium beijerinckii]]
		+	[[Category: Aravind, P.]]
		+	[[Category: Sankaranarayanan, R.]]
		+	[[Category: Calcium-bound betagamma-crystallin]]
		+	[[Category: Metal binding protein]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 2 10:11:40 2009''

OCA at 06:49, 5 August 2009

OCA — Wed, 05 Aug 2009 06:49:19 GMT

←Older revision		Revision as of 06:49, 5 August 2009
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3iaj is ON HOLD	+	The entry 3iaj is ON HOLD until Paper Publication

	Authors: Aravind, P., Sankaranarayanan, R.		Authors: Aravind, P., Sankaranarayanan, R.
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	Description: Crystal structure of a betagamma-crystallin domain from Clostridium beijerinckii-in alternate space group I422		Description: Crystal structure of a betagamma-crystallin domain from Clostridium beijerinckii-in alternate space group I422

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jul 22 20~~:36:05 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 5 09:49:18 2009''

OCA: New page: '''Unreleased structure''' The entry 3iaj is ON HOLD Authors: Aravind, P., Sankaranarayanan, R. Description: Crystal structure of a betagamma-crystallin domain from Clostridium beijeri...

OCA — Wed, 22 Jul 2009 17:36:05 GMT

New page: '''Unreleased structure''' The entry 3iaj is ON HOLD Authors: Aravind, P., Sankaranarayanan, R. Description: Crystal structure of a betagamma-crystallin domain from Clostridium beijeri...

New page

'''Unreleased structure'''

The entry 3iaj is ON HOLD

Authors: Aravind, P., Sankaranarayanan, R.

Description: Crystal structure of a betagamma-crystallin domain from Clostridium beijerinckii-in alternate space group I422

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 22 20:36:05 2009''