3ial - Revision history

OCA at 07:41, 6 September 2023

OCA — Wed, 06 Sep 2023 07:41:39 GMT

←Older revision		Revision as of 07:41, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3ial' size='340' side='right'caption='[[3ial]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3ial' size='340' side='right'caption='[[3ial]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ial]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Giaic Giaic~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IAL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ial]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Giardia_lamblia_ATCC_50803 Giardia lamblia ATCC 50803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IAL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~, ~~<scene name='pdbligand=PR8:5-O-~~[~~(R)-HYDROXY{~~[~~(2S)-PYRROLIDIN-2-YLCARBONYL~~]~~OXY}PHOSPHORYL~~]~~ADENOSINE'>PR8</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>GL50803_15983, ProRS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~184922 GIAIC])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PR8:5-O-[(R)-HYDROXY{[(2S)-PYRROLIDIN-2-YLCARBONYL]OXY}PHOSPHORYL]ADENOSINE'>PR8</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Proline~~--~~tRNA_ligase Proline~~-~~-tRNA ligase], with EC number~~ [~~https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=6.1.1.15 6.1.1.15~~] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ial FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ial OCA], [https://pdbe.org/3ial PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ial RCSB], [https://www.ebi.ac.uk/pdbsum/3ial PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ial ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ial FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ial OCA], [https://pdbe.org/3ial PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ial RCSB], [https://www.ebi.ac.uk/pdbsum/3ial PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ial ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A8BR89_GIAIC A8BR89_GIAIC]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Giaic~~]]	+	[[Category: Giardia lamblia ATCC 50803]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Proline--tRNA ligase]]~~	+	[[Category: Larson ET]]
-	[[Category: Larson~~, E T~~]]	+
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
-	[[Category: Merritt~~, E A]]~~	+	[[Category: Merritt EA]]
-	~~[[Category: Aar]]~~	+
-	~~[[Category: Aminoacyl-trna synthetase]]~~	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Cysr]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Msgpp]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Pror]]~~	+
-	~~[[Category: Translation]]~~	+
-	~~[[Category: Trna ligase~~]]	+

OCA at 03:27, 21 April 2022

OCA — Thu, 21 Apr 2022 03:27:48 GMT

←Older revision		Revision as of 03:27, 21 April 2022
Line 1:		Line 1:

	==Giardia lamblia Prolyl-tRNA synthetase in complex with prolyl-adenylate==		==Giardia lamblia Prolyl-tRNA synthetase in complex with prolyl-adenylate==
-	<StructureSection load='3ial' size='340' side='right' caption='[[3ial]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='3ial' size='340' side='right'caption='[[3ial]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ial]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Giaic Giaic]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IAL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ial]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Giaic Giaic]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IAL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PR8:5-O-[(R)-HYDROXY{[(2S)-PYRROLIDIN-2-YLCARBONYL]OXY}PHOSPHORYL]ADENOSINE'>PR8</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PR8:5-O-[(R)-HYDROXY{[(2S)-PYRROLIDIN-2-YLCARBONYL]OXY}PHOSPHORYL]ADENOSINE'>PR8</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GL50803_15983, ProRS ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=184922 GIAIC])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GL50803_15983, ProRS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=184922 GIAIC])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Proline--tRNA_ligase Proline--tRNA ligase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.15 6.1.1.15] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Proline--tRNA_ligase Proline--tRNA ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.15 6.1.1.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ial FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ial OCA], [~~http~~://pdbe.org/3ial PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ial RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ial PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ial ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ial FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ial OCA], [https://pdbe.org/3ial PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ial RCSB], [https://www.ebi.ac.uk/pdbsum/3ial PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ial ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 30:		Line 30:

	==See Also==		==See Also==
-	*[[Aminoacyl tRNA ~~Synthetase~~\|Aminoacyl tRNA ~~Synthetase~~]]	+	*[[Aminoacyl tRNA synthetase 3D structures\|Aminoacyl tRNA synthetase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Giaic]]		[[Category: Giaic]]
		+	[[Category: Large Structures]]
	[[Category: Proline--tRNA ligase]]		[[Category: Proline--tRNA ligase]]
	[[Category: Larson, E T]]		[[Category: Larson, E T]]

OCA at 10:13, 19 December 2018

OCA — Wed, 19 Dec 2018 10:13:06 GMT

←Older revision		Revision as of 10:13, 19 December 2018
Line 1:		Line 1:
		+
	==Giardia lamblia Prolyl-tRNA synthetase in complex with prolyl-adenylate==		==Giardia lamblia Prolyl-tRNA synthetase in complex with prolyl-adenylate==
	<StructureSection load='3ial' size='340' side='right' caption='[[3ial]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3ial' size='340' side='right' caption='[[3ial]], [[Resolution\|resolution]] 2.20Å' scene=''>
Line 6:		Line 7:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GL50803_15983, ProRS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=184922 GIAIC])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GL50803_15983, ProRS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=184922 GIAIC])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline--tRNA_ligase Proline--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.15 6.1.1.15] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline--tRNA_ligase Proline--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.15 6.1.1.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ial FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ial OCA], [http://pdbe.org/3ial PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ial RCSB], [http://www.ebi.ac.uk/pdbsum/3ial PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ial FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ial OCA], [http://pdbe.org/3ial PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ial RCSB], [http://www.ebi.ac.uk/pdbsum/3ial PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ial ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/3ial_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/3ial_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 37:		Line 38:
	[[Category: Proline--tRNA ligase]]		[[Category: Proline--tRNA ligase]]
	[[Category: Larson, E T]]		[[Category: Larson, E T]]
-	[[Category: Merritt, E A]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
		+	[[Category: Merritt, E A]]
	[[Category: Aar]]		[[Category: Aar]]
	[[Category: Aminoacyl-trna synthetase]]		[[Category: Aminoacyl-trna synthetase]]

OCA at 21:50, 7 February 2016

OCA — Sun, 07 Feb 2016 21:50:39 GMT

←Older revision		Revision as of 21:50, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3ial' size='340' side='right' caption='[[3ial]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3ial' size='340' side='right' caption='[[3ial]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ial]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Giardia_lamblia_atcc_50803 Giardia lamblia atcc 50803~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IAL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ial]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Giaic Giaic]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IAL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PR8:5-O-[(R)-HYDROXY{[(2S)-PYRROLIDIN-2-YLCARBONYL]OXY}PHOSPHORYL]ADENOSINE'>PR8</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PR8:5-O-[(R)-HYDROXY{[(2S)-PYRROLIDIN-2-YLCARBONYL]OXY}PHOSPHORYL]ADENOSINE'>PR8</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GL50803_15983, ProRS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=184922 ~~Giardia lamblia ATCC 50803~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GL50803_15983, ProRS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=184922 GIAIC])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline--tRNA_ligase Proline--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.15 6.1.1.15] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline--tRNA_ligase Proline--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.15 6.1.1.15] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ial FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ial OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ial RCSB], [http://www.ebi.ac.uk/pdbsum/3ial PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ial FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ial OCA], [http://pdbe.org/3ial PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ial RCSB], [http://www.ebi.ac.uk/pdbsum/3ial PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ial ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ial" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Giardia lamblia atcc 50803~~]]	+	[[Category: Giaic]]
	[[Category: Proline--tRNA ligase]]		[[Category: Proline--tRNA ligase]]
	[[Category: Larson, E T]]		[[Category: Larson, E T]]

OCA at 09:51, 20 January 2015

OCA — Tue, 20 Jan 2015 09:51:47 GMT

←Older revision		Revision as of 09:51, 20 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ial]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Giardia_lamblia_atcc_50803 Giardia lamblia atcc 50803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IAL FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ial]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Giardia_lamblia_atcc_50803 Giardia lamblia atcc 50803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IAL FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PR8:5-O-[(R)-HYDROXY{[(2S)-PYRROLIDIN-2-YLCARBONYL]OXY}PHOSPHORYL]ADENOSINE'>PR8</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PR8:5-O-[(R)-HYDROXY{[(2S)-PYRROLIDIN-2-YLCARBONYL]OXY}PHOSPHORYL]ADENOSINE'>PR8</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GL50803_15983, ProRS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=184922 Giardia lamblia ATCC 50803])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GL50803_15983, ProRS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=184922 Giardia lamblia ATCC 50803])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline--tRNA_ligase Proline--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.15 6.1.1.15] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline--tRNA_ligase Proline--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.15 6.1.1.15] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ial FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ial OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ial RCSB], [http://www.ebi.ac.uk/pdbsum/3ial PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ial FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ial OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ial RCSB], [http://www.ebi.ac.uk/pdbsum/3ial PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Giardia lamblia atcc 50803]]		[[Category: Giardia lamblia atcc 50803]]
	[[Category: Proline--tRNA ligase]]		[[Category: Proline--tRNA ligase]]
-	[[Category: Larson, E T.]]	+	[[Category: Larson, E T]]
-	[[Category: Merritt, E A.]]	+	[[Category: Merritt, E A]]
-	[[Category: ~~Protozoa, Medical~~ Structural ~~Genomics of Pathogenic.~~]]	+	[[Category: Structural genomic]]
	[[Category: Aar]]		[[Category: Aar]]
	[[Category: Aminoacyl-trna synthetase]]		[[Category: Aminoacyl-trna synthetase]]
Line 43:		Line 43:
	[[Category: Cysr]]		[[Category: Cysr]]
	[[Category: Ligase]]		[[Category: Ligase]]
-	[[Category: Medical structural genomics of pathogenic protazoa]]
-	[[Category: Medical structural genomics of pathogenic protozoa]]
	[[Category: Msgpp]]		[[Category: Msgpp]]
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
	[[Category: Pror]]		[[Category: Pror]]
-	[[Category: Structural genomic]]
	[[Category: Translation]]		[[Category: Translation]]
	[[Category: Trna ligase]]		[[Category: Trna ligase]]

OCA at 13:39, 29 September 2014

OCA — Mon, 29 Sep 2014 13:39:13 GMT

←Older revision		Revision as of 13:39, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3ial.~~png~~\|~~left~~\|200px]]	+	==Giardia lamblia Prolyl-tRNA synthetase in complex with prolyl-adenylate==
		+	<StructureSection load='3ial' size='340' side='right' caption='[[3ial]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ial]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Giardia_lamblia_atcc_50803 Giardia lamblia atcc 50803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IAL FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PR8:5-O-[(R)-HYDROXY{[(2S)-PYRROLIDIN-2-YLCARBONYL]OXY}PHOSPHORYL]ADENOSINE'>PR8</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GL50803_15983, ProRS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=184922 Giardia lamblia ATCC 50803])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proline--tRNA_ligase Proline--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.15 6.1.1.15] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ial FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ial OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ial RCSB], [http://www.ebi.ac.uk/pdbsum/3ial PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/3ial_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The genome of the human intestinal parasite Giardia lamblia contains only a single aminoacyl-tRNA synthetase gene for each amino acid. The Giardia prolyl-tRNA synthetase gene product was originally misidentified as a dual-specificity Pro/Cys enzyme, in part owing to its unexpectedly high off-target activation of cysteine, but is now believed to be a normal representative of the class of archaeal/eukaryotic prolyl-tRNA synthetases. The 2.2 A resolution crystal structure of the G. lamblia enzyme presented here is thus the first structure determination of a prolyl-tRNA synthetase from a eukaryote. The relative occupancies of substrate (proline) and product (prolyl-AMP) in the active site are consistent with half-of-the-sites reactivity, as is the observed biphasic thermal denaturation curve for the protein in the presence of proline and MgATP. However, no corresponding induced asymmetry is evident in the structure of the protein. No thermal stabilization is observed in the presence of cysteine and ATP. The implied low affinity for the off-target activation product cysteinyl-AMP suggests that translational fidelity in Giardia is aided by the rapid release of misactivated cysteine.

-	~~{{STRUCTURE_3ial\| PDB=3ial \| SCENE= }}~~	+	Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia.,Larson ET, Kim JE, Napuli AJ, Verlinde CL, Fan E, Zucker FH, Van Voorhis WC, Buckner FS, Hol WG, Merritt EA Acta Crystallogr D Biol Crystallogr. 2012 Sep;68(Pt 9):1194-200. doi:, 10.1107/S0907444912024699. Epub 2012 Aug 18. PMID:22948920<ref>PMID:22948920</ref>

-	~~===Giardia lamblia Prolyl-tRNA synthetase in complex with prolyl-adenylate===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+
-	~~==About this Structure==~~	+
-	~~[[3ial]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Giardia_lamblia_atcc_50803 Giardia lamblia atcc 50803]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3IAL OCA].~~	+

	==See Also==		==See Also==
	*[[Aminoacyl tRNA Synthetase\|Aminoacyl tRNA Synthetase]]		*[[Aminoacyl tRNA Synthetase\|Aminoacyl tRNA Synthetase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Giardia lamblia atcc 50803]]		[[Category: Giardia lamblia atcc 50803]]
	[[Category: Proline--tRNA ligase]]		[[Category: Proline--tRNA ligase]]

OCA at 07:57, 20 October 2012

OCA — Sat, 20 Oct 2012 07:57:50 GMT

←Older revision		Revision as of 07:57, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3ial]] is a 2 chain structure ~~of [[Aminoacyl tRNA Synthetase]]~~ with sequence from [http://en.wikipedia.org/wiki/Giardia_lamblia_atcc_50803 Giardia lamblia atcc 50803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAL OCA].	+	[[3ial]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Giardia_lamblia_atcc_50803 Giardia lamblia atcc 50803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAL OCA].

	==See Also==		==See Also==

OCA: Protected "3ial" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 18:01:13 GMT

Protected "3ial" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:01, 25 July 2012

OCA at 18:01, 25 July 2012

OCA — Wed, 25 Jul 2012 18:01:11 GMT

←Older revision		Revision as of 18:01, 25 July 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3ial.png\|left\|200px]]
-	[[Image:3ial.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ial", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ial\| PDB=3ial \| SCENE= }}		{{STRUCTURE_3ial\| PDB=3ial \| SCENE= }}

Line 14:		Line 7:

	==About this Structure==		==About this Structure==
-	~~3IAL~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Giardia_lamblia_atcc_50803 Giardia lamblia atcc 50803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAL OCA].	+	[[3ial]] is a 2 chain structure of [[Aminoacyl tRNA Synthetase]] with sequence from [http://en.wikipedia.org/wiki/Giardia_lamblia_atcc_50803 Giardia lamblia atcc 50803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAL OCA].
		+
		+	==See Also==
		+	*[[Aminoacyl tRNA Synthetase\|Aminoacyl tRNA Synthetase]]
	[[Category: Giardia lamblia atcc 50803]]		[[Category: Giardia lamblia atcc 50803]]
	[[Category: Proline--tRNA ligase]]		[[Category: Proline--tRNA ligase]]
Line 33:		Line 29:
	[[Category: Translation]]		[[Category: Translation]]
	[[Category: Trna ligase]]		[[Category: Trna ligase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 12 13:45:59 2009''

OCA at 10:46, 12 August 2009

OCA — Wed, 12 Aug 2009 10:46:00 GMT

←Older revision		Revision as of 10:46, 12 August 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3ial.jpg\|left\|200px]]

-	The ~~entry 3ial~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ial", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ial\| PDB=3ial \| SCENE= }}

-	~~Authors: Larson, E.T., Merritt, E.A., Medical Structural Genomics of Pathogenic Protozoa~~	+	===Giardia lamblia Prolyl-tRNA synthetase in complex with prolyl-adenylate===

-	Description: Giardia lamblia Prolyl-tRNA synthetase in complex with prolyl-adenylate

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jul 22 20~~:36:06 2009''	+	==About this Structure==
		+	3IAL is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Giardia_lamblia_atcc_50803 Giardia lamblia atcc 50803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAL OCA].
		+	[[Category: Giardia lamblia atcc 50803]]
		+	[[Category: Proline--tRNA ligase]]
		+	[[Category: Larson, E T.]]
		+	[[Category: Merritt, E A.]]
		+	[[Category: Protozoa, Medical Structural Genomics of Pathogenic.]]
		+	[[Category: Aar]]
		+	[[Category: Aminoacyl-trna synthetase]]
		+	[[Category: Atp-binding]]
		+	[[Category: Cysr]]
		+	[[Category: Ligase]]
		+	[[Category: Medical structural genomics of pathogenic protazoa]]
		+	[[Category: Medical structural genomics of pathogenic protozoa]]
		+	[[Category: Msgpp]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Pror]]
		+	[[Category: Structural genomic]]
		+	[[Category: Translation]]
		+	[[Category: Trna ligase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 12 13:45:59 2009''