3iaw - Revision history

OCA at 07:45, 29 June 2022

OCA — Wed, 29 Jun 2022 07:45:59 GMT

←Older revision		Revision as of 07:45, 29 June 2022
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	<StructureSection load='3iaw' size='340' side='right'caption='[[3iaw]], [[Resolution\|resolution]] 1.61Å' scene=''>		<StructureSection load='3iaw' size='340' side='right'caption='[[3iaw]], [[Resolution\|resolution]] 1.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3iaw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3IAW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3iaw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IAW FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2NC:N-{(2S)-2-[(N-ACETYL-L-THREONYL-L-ISOLEUCYL)AMINO]HEXYL}-L-NORLEUCYL-L-GLUTAMINYL-N~5~-[AMINO(IMINIO)METHYL]-L-ORNITHINAMIDE'>2NC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2NC:N-{(2S)-2-[(N-ACETYL-L-THREONYL-L-ISOLEUCYL)AMINO]HEXYL}-L-NORLEUCYL-L-GLUTAMINYL-N~5~-[AMINO(IMINIO)METHYL]-L-ORNITHINAMIDE'>2NC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hau\|3hau]], [[3haw\|3haw]], [[3hbo\|3hbo]], [[3hdk\|3hdk]], [[3hlo\|3hlo]], [[3fsm\|3fsm]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3hau\|3hau]], [[3haw\|3haw]], [[3hbo\|3hbo]], [[3hdk\|3hdk]], [[3hlo\|3hlo]], [[3fsm\|3fsm]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3iaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iaw OCA], [~~http~~://pdbe.org/3iaw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3iaw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3iaw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3iaw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iaw OCA], [https://pdbe.org/3iaw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iaw RCSB], [https://www.ebi.ac.uk/pdbsum/3iaw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iaw ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:54, 23 September 2020

OCA — Wed, 23 Sep 2020 11:54:10 GMT

←Older revision		Revision as of 11:54, 23 September 2020
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	==Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51;Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.6 A resolution==		==Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51;Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.6 A resolution==
-	<StructureSection load='3iaw' size='340' side='right' caption='[[3iaw]], [[Resolution\|resolution]] 1.61Å' scene=''>	+	<StructureSection load='3iaw' size='340' side='right'caption='[[3iaw]], [[Resolution\|resolution]] 1.61Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3iaw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IAW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3iaw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3IAW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2NC:N-{(2S)-2-[(N-ACETYL-L-THREONYL-L-ISOLEUCYL)AMINO]HEXYL}-L-NORLEUCYL-L-GLUTAMINYL-N~5~-[AMINO(IMINIO)METHYL]-L-ORNITHINAMIDE'>2NC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2NC:N-{(2S)-2-[(N-ACETYL-L-THREONYL-L-ISOLEUCYL)AMINO]HEXYL}-L-NORLEUCYL-L-GLUTAMINYL-N~5~-[AMINO(IMINIO)METHYL]-L-ORNITHINAMIDE'>2NC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hau\|3hau]], [[3haw\|3haw]], [[3hbo\|3hbo]], [[3hdk\|3hdk]], [[3hlo\|3hlo]], [[3fsm\|3fsm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hau\|3hau]], [[3haw\|3haw]], [[3hbo\|3hbo]], [[3hdk\|3hdk]], [[3hlo\|3hlo]], [[3fsm\|3fsm]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3iaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iaw OCA], [http://pdbe.org/3iaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iaw RCSB], [http://www.ebi.ac.uk/pdbsum/3iaw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3iaw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3iaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iaw OCA], [http://pdbe.org/3iaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iaw RCSB], [http://www.ebi.ac.uk/pdbsum/3iaw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3iaw ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	==See Also==		==See Also==
-	*[[Immunodeficiency virus protease\|Immunodeficiency virus protease]]	+	*[[Immunodeficiency virus protease 3D structures\|Immunodeficiency virus protease 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: HIV-1 retropepsin]]		[[Category: HIV-1 retropepsin]]
		+	[[Category: Large Structures]]
	[[Category: Kent, S B.H]]		[[Category: Kent, S B.H]]
	[[Category: Torbeev, V Y]]		[[Category: Torbeev, V Y]]

OCA at 09:15, 19 December 2018

OCA — Wed, 19 Dec 2018 09:15:10 GMT

←Older revision		Revision as of 09:15, 19 December 2018
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[~~Virus~~ protease\|~~Virus~~ protease]]	+	*[[Immunodeficiency virus protease\|Immunodeficiency virus protease]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 20:17, 9 December 2016

OCA — Fri, 09 Dec 2016 20:17:47 GMT

←Older revision		Revision as of 20:17, 9 December 2016
Line 1:		Line 1:
		+
	==Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51;Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.6 A resolution==		==Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51;Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.6 A resolution==
	<StructureSection load='3iaw' size='340' side='right' caption='[[3iaw]], [[Resolution\|resolution]] 1.61Å' scene=''>		<StructureSection load='3iaw' size='340' side='right' caption='[[3iaw]], [[Resolution\|resolution]] 1.61Å' scene=''>
Line 7:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hau\|3hau]], [[3haw\|3haw]], [[3hbo\|3hbo]], [[3hdk\|3hdk]], [[3hlo\|3hlo]], [[3fsm\|3fsm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hau\|3hau]], [[3haw\|3haw]], [[3hbo\|3hbo]], [[3hdk\|3hdk]], [[3hlo\|3hlo]], [[3fsm\|3fsm]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iaw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iaw RCSB], [http://www.ebi.ac.uk/pdbsum/3iaw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iaw OCA], [http://pdbe.org/3iaw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iaw RCSB], [http://www.ebi.ac.uk/pdbsum/3iaw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3iaw ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3iaw" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 08:37, 8 December 2014

OCA — Mon, 08 Dec 2014 08:37:55 GMT

←Older revision		Revision as of 08:37, 8 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3iaw.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51;Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.6 A resolution==
		+	<StructureSection load='3iaw' size='340' side='right' caption='[[3iaw]], [[Resolution\|resolution]] 1.61Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3iaw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IAW FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2NC:N-{(2S)-2-[(N-ACETYL-L-THREONYL-L-ISOLEUCYL)AMINO]HEXYL}-L-NORLEUCYL-L-GLUTAMINYL-N~5~-[AMINO(IMINIO)METHYL]-L-ORNITHINAMIDE'>2NC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=NLE:NORLEUCINE'>NLE</scene>, <scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3hau\|3hau]], [[3haw\|3haw]], [[3hbo\|3hbo]], [[3hdk\|3hdk]], [[3hlo\|3hlo]], [[3fsm\|3fsm]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iaw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iaw RCSB], [http://www.ebi.ac.uk/pdbsum/3iaw PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We have used chemical protein synthesis and advanced physical methods to probe dynamics-function correlations for the HIV-1 protease, an enzyme that has received considerable attention as a target for the treatment of AIDS. Chemical synthesis was used to prepare a series of unique analogues of the HIV-1 protease in which the flexibility of the "flap" structures (residues 37-61 in each monomer of the homodimeric protein molecule) was systematically varied. These analogue enzymes were further studied by X-ray crystallography, NMR relaxation, and pulse-EPR methods, in conjunction with molecular dynamics simulations. We show that conformational isomerization in the flaps is correlated with structural reorganization of residues in the active site, and that it is preorganization of the active site that is a rate-limiting factor in catalysis.

-	~~{{STRUCTURE_3iaw\| PDB=3iaw \| SCENE= }}~~	+	Protein conformational dynamics in the mechanism of HIV-1 protease catalysis.,Torbeev VY, Raghuraman H, Hamelberg D, Tonelli M, Westler WM, Perozo E, Kent SB Proc Natl Acad Sci U S A. 2011 Dec 27;108(52):20982-7. Epub 2011 Dec 8. PMID:22158985<ref>PMID:22158985</ref>

-	~~===Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51~~;~~Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.6 A resolution===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_22158985}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3iaw]] is~~ a ~~1 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3IAW OCA].~~	+

	==See Also==		==See Also==
	*[[Virus protease\|Virus protease]]		*[[Virus protease\|Virus protease]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:022158985<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: HIV-1 retropepsin]]		[[Category: HIV-1 retropepsin]]
-	[[Category: Kent, S B.H.]]	+	[[Category: Kent, S B.H]]
-	[[Category: Torbeev, V Y.]]	+	[[Category: Torbeev, V Y]]
	[[Category: Asymmetric dimer]]		[[Category: Asymmetric dimer]]
	[[Category: Beta-sheet]]		[[Category: Beta-sheet]]

OCA at 10:56, 20 October 2012

OCA — Sat, 20 Oct 2012 10:56:42 GMT

←Older revision		Revision as of 10:56, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3iaw]] is a 1 chain structure ~~of [[Virus protease]]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAW OCA].	+	[[3iaw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAW OCA].

	==See Also==		==See Also==

OCA at 03:45, 26 July 2012

OCA — Thu, 26 Jul 2012 03:45:50 GMT

←Older revision		Revision as of 03:45, 26 July 2012
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	[[Image:3iaw.png\|left\|200px]]		[[Image:3iaw.png\|left\|200px]]

-	<!--
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	{{STRUCTURE_3iaw\| PDB=3iaw \| SCENE= }}		{{STRUCTURE_3iaw\| PDB=3iaw \| SCENE= }}

	===Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51;Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.6 A resolution===		===Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51;Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.6 A resolution===

-
-	<!--
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	{{ABSTRACT_PUBMED_22158985}}		{{ABSTRACT_PUBMED_22158985}}

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	==See Also==		==See Also==
-	*[[Virus protease]]	+	*[[Virus protease\|Virus protease]]

	==Reference==		==Reference==

OCA at 05:31, 11 January 2012

OCA — Wed, 11 Jan 2012 05:31:26 GMT

←Older revision		Revision as of 05:31, 11 January 2012
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-	[[Image:3iaw.~~jpg~~\|left\|200px]]	+	[[Image:3iaw.png\|left\|200px]]

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	===Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51;Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.6 A resolution===		===Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51;Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.6 A resolution===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22158985}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22158985 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22158985}}

	==About this Structure==		==About this Structure==
-	[[3iaw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAW OCA].	+	[[3iaw]] is a 1 chain structure of [[Virus protease]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAW OCA].
		+
		+	==See Also==
		+	*[[Virus protease]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022158985</ref><references group="xtra"/>
	[[Category: HIV-1 retropepsin]]		[[Category: HIV-1 retropepsin]]
	[[Category: Kent, S B.H.]]		[[Category: Kent, S B.H.]]
	[[Category: Torbeev, V Y.]]		[[Category: Torbeev, V Y.]]
		+	[[Category: Asymmetric dimer]]
		+	[[Category: Beta-sheet]]
		+	[[Category: Covalent dimer]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 07:23, 27 April 2011

OCA — Wed, 27 Apr 2011 07:23:11 GMT

←Older revision		Revision as of 07:23, 27 April 2011
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-	~~'''Unreleased structure'''~~	+	[[Image:3iaw.jpg\|left\|200px]]

-	The ~~entry 3iaw~~ is ~~ON HOLD~~ ~~until Apr 30 2012~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3iaw", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3iaw\| PDB=3iaw \| SCENE= }}

-	~~Authors: Torbeev, V.Y., Kent, S.B.H~~.	+	===Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51;Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.6 A resolution===

-	~~Description: Crystal structure of~~ a ~~chemically synthesized 203 amino acid 'covalent dimer'~~ [~~Gly51;Aib51'~~]HIV-1 ~~protease molecule complexed with MVT-101 reduced isostere inhibitor at 1~~.~~6 A resolution~~	+
		+	==About this Structure==
		+	[[3iaw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IAW OCA].
		+	[[Category: HIV-1 retropepsin]]
		+	[[Category: Kent, S B.H.]]
		+	[[Category: Torbeev, V Y.]]

OCA at 07:39, 30 March 2011

OCA — Wed, 30 Mar 2011 07:39:19 GMT

←Older revision		Revision as of 07:39, 30 March 2011
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3iaw is ON HOLD until ~~Mar 28~~ 2012	+	The entry 3iaw is ON HOLD until Apr 30 2012

	Authors: Torbeev, V.Y., Kent, S.B.H.		Authors: Torbeev, V.Y., Kent, S.B.H.

	Description: Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51;Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.6 A resolution		Description: Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51;Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor at 1.6 A resolution