3idw - Revision history

OCA at 10:05, 21 February 2024

OCA — Wed, 21 Feb 2024 10:05:03 GMT

←Older revision		Revision as of 10:05, 21 February 2024
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	<StructureSection load='3idw' size='340' side='right'caption='[[3idw]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='3idw' size='340' side='right'caption='[[3idw]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3idw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IDW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IDW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3idw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IDW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IDW FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~SLA1~~, ~~YBL007C, YBL0321 (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=4932 ATCC 18824])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3idw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3idw OCA], [https://pdbe.org/3idw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3idw RCSB], [https://www.ebi.ac.uk/pdbsum/3idw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3idw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3idw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3idw OCA], [https://pdbe.org/3idw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3idw RCSB], [https://www.ebi.ac.uk/pdbsum/3idw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3idw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/SLA1_YEAST SLA1_YEAST]] Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.<ref>PMID:8335689</ref> <ref>PMID:8756649</ref> <ref>PMID:9008707</ref> <ref>PMID:9128251</ref> <ref>PMID:10198057</ref> <ref>PMID:10594004</ref> <ref>PMID:11940605</ref> <ref>PMID:11950888</ref> <ref>PMID:12388763</ref> <ref>PMID:12237851</ref> <ref>PMID:12814545</ref> <ref>PMID:12734398</ref> <ref>PMID:14761940</ref> <ref>PMID:15525671</ref> <ref>PMID:17286805</ref>	+	[https://www.uniprot.org/uniprot/SLA1_YEAST SLA1_YEAST] Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.<ref>PMID:8335689</ref> <ref>PMID:8756649</ref> <ref>PMID:9008707</ref> <ref>PMID:9128251</ref> <ref>PMID:10198057</ref> <ref>PMID:10594004</ref> <ref>PMID:11940605</ref> <ref>PMID:11950888</ref> <ref>PMID:12388763</ref> <ref>PMID:12237851</ref> <ref>PMID:12814545</ref> <ref>PMID:12734398</ref> <ref>PMID:14761940</ref> <ref>PMID:15525671</ref> <ref>PMID:17286805</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3idw ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3idw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	During clathrin-mediated endocytosis, adaptor proteins play central roles in coordinating the assembly of clathrin coats and cargo selection. Here we characterize the binding of the yeast endocytic adaptor Sla1p to clathrin through a variant clathrin-binding motif that is negatively regulated by the Sla1p SHD2 domain. The crystal structure of SHD2 identifies the domain as a sterile alpha-motif (SAM) domain and shows a propensity to oligomerize. By co-immunoprecipitation, Sla1p binds to clathrin and self-associates in vivo. Mutations in the clathrin-binding motif that abolish clathrin binding and structure-based mutations in SHD2 that impede self-association result in endocytosis defects and altered dynamics of Sla1p assembly at the sites of endocytosis. These results define a novel mechanism for negative regulation of clathrin binding by an adaptor and suggest a role for SAM domains in clathrin-mediated endocytosis.
-
-	Regulation of clathrin adaptor function in endocytosis: novel role for the SAM domain.,Di Pietro SM, Cascio D, Feliciano D, Bowie JU, Payne GS EMBO J. 2010 Mar 17;29(6):1033-44. Epub 2010 Feb 11. PMID:20150898<ref>PMID:20150898</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3idw" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 18824]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Bowie, J U~~]]	+	[[Category: Saccharomyces cerevisiae]]
-	[[Category: ~~Cascio, D~~]]	+	[[Category: Bowie JU]]
-	[[Category: ~~Payne, G S~~]]	+	[[Category: Cascio D]]
-	[[Category: Pietro~~, S M.Di~~]]	+	[[Category: Di Pietro SM]]
-	[[Category: ~~Actin-binding]]~~	+	[[Category: Payne GS]]
-	~~[[Category: Cell membrane]]~~	+
-	~~[[Category: Clathrin adaptor]]~~	+
-	~~[[Category: Cytoskeleton]]~~	+
-	~~[[Category: Endocytosis]]~~	+
-	~~[[Category: Endosome]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Sam domain]]~~	+
-	~~[[Category: Sh3 domain]]~~	+
-	~~[[Category: Yeast~~]]	+

OCA at 03:30, 21 April 2022

OCA — Thu, 21 Apr 2022 03:30:17 GMT

←Older revision		Revision as of 03:30, 21 April 2022
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	==Crystal structure of Sla1 homology domain 2==		==Crystal structure of Sla1 homology domain 2==
-	<StructureSection load='3idw' size='340' side='right' caption='[[3idw]], [[Resolution\|resolution]] 1.85Å' scene=''>	+	<StructureSection load='3idw' size='340' side='right'caption='[[3idw]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3idw]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IDW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IDW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3idw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IDW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IDW FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SLA1, YBL007C, YBL0321 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SLA1, YBL007C, YBL0321 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3idw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3idw OCA], [~~http~~://pdbe.org/3idw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3idw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3idw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3idw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3idw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3idw OCA], [https://pdbe.org/3idw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3idw RCSB], [https://www.ebi.ac.uk/pdbsum/3idw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3idw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/SLA1_YEAST SLA1_YEAST]] Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.<ref>PMID:8335689</ref> <ref>PMID:8756649</ref> <ref>PMID:9008707</ref> <ref>PMID:9128251</ref> <ref>PMID:10198057</ref> <ref>PMID:10594004</ref> <ref>PMID:11940605</ref> <ref>PMID:11950888</ref> <ref>PMID:12388763</ref> <ref>PMID:12237851</ref> <ref>PMID:12814545</ref> <ref>PMID:12734398</ref> <ref>PMID:14761940</ref> <ref>PMID:15525671</ref> <ref>PMID:17286805</ref>	+	[[https://www.uniprot.org/uniprot/SLA1_YEAST SLA1_YEAST]] Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.<ref>PMID:8335689</ref> <ref>PMID:8756649</ref> <ref>PMID:9008707</ref> <ref>PMID:9128251</ref> <ref>PMID:10198057</ref> <ref>PMID:10594004</ref> <ref>PMID:11940605</ref> <ref>PMID:11950888</ref> <ref>PMID:12388763</ref> <ref>PMID:12237851</ref> <ref>PMID:12814545</ref> <ref>PMID:12734398</ref> <ref>PMID:14761940</ref> <ref>PMID:15525671</ref> <ref>PMID:17286805</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/id/3idw_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/id/3idw_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
		+	[[Category: Large Structures]]
	[[Category: Bowie, J U]]		[[Category: Bowie, J U]]
	[[Category: Cascio, D]]		[[Category: Cascio, D]]

OCA at 08:03, 1 November 2017

OCA — Wed, 01 Nov 2017 08:03:48 GMT

←Older revision		Revision as of 08:03, 1 November 2017
Line 1:		Line 1:
		+
	==Crystal structure of Sla1 homology domain 2==		==Crystal structure of Sla1 homology domain 2==
	<StructureSection load='3idw' size='340' side='right' caption='[[3idw]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='3idw' size='340' side='right' caption='[[3idw]], [[Resolution\|resolution]] 1.85Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3idw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IDW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IDW FirstGlance]. <br>		<table><tr><td colspan='2'>[[3idw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IDW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IDW FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SLA1, YBL007C, YBL0321 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SLA1, YBL007C, YBL0321 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3idw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3idw OCA], [http://pdbe.org/3idw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3idw RCSB], [http://www.ebi.ac.uk/pdbsum/3idw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3idw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3idw OCA], [http://pdbe.org/3idw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3idw RCSB], [http://www.ebi.ac.uk/pdbsum/3idw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3idw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 22:09, 9 February 2016

OCA — Tue, 09 Feb 2016 22:09:44 GMT

←Older revision		Revision as of 22:09, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3idw' size='340' side='right' caption='[[3idw]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='3idw' size='340' side='right' caption='[[3idw]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3idw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IDW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IDW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3idw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IDW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IDW FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SLA1, YBL007C, YBL0321 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SLA1, YBL007C, YBL0321 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3idw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3idw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3idw RCSB], [http://www.ebi.ac.uk/pdbsum/3idw PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3idw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3idw OCA], [http://pdbe.org/3idw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3idw RCSB], [http://www.ebi.ac.uk/pdbsum/3idw PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3idw ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3idw" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Saccharomyces cerevisiae~~]]	+	[[Category: Atcc 18824]]
	[[Category: Bowie, J U]]		[[Category: Bowie, J U]]
	[[Category: Cascio, D]]		[[Category: Cascio, D]]

OCA at 09:52, 25 December 2014

OCA — Thu, 25 Dec 2014 09:52:14 GMT

←Older revision		Revision as of 09:52, 25 December 2014
Line 6:		Line 6:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3idw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3idw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3idw RCSB], [http://www.ebi.ac.uk/pdbsum/3idw PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3idw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3idw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3idw RCSB], [http://www.ebi.ac.uk/pdbsum/3idw PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SLA1_YEAST SLA1_YEAST]] Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.<ref>PMID:8335689</ref> <ref>PMID:8756649</ref> <ref>PMID:9008707</ref> <ref>PMID:9128251</ref> <ref>PMID:10198057</ref> <ref>PMID:10594004</ref> <ref>PMID:11940605</ref> <ref>PMID:11950888</ref> <ref>PMID:12388763</ref> <ref>PMID:12237851</ref> <ref>PMID:12814545</ref> <ref>PMID:12734398</ref> <ref>PMID:14761940</ref> <ref>PMID:15525671</ref> <ref>PMID:17286805</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 06:35, 18 December 2014

OCA — Thu, 18 Dec 2014 06:35:05 GMT

←Older revision		Revision as of 06:35, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3idw~~\| ~~PDB~~=3idw \| ~~SCENE~~= }}	+	==Crystal structure of Sla1 homology domain 2==
-	===~~Crystal~~ structure of ~~Sla1 homology domain 2~~===	+	<StructureSection load='3idw' size='340' side='right' caption='[[3idw]], [[Resolution\|resolution]] 1.85Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20150898}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3idw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IDW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IDW FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SLA1, YBL007C, YBL0321 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3idw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3idw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3idw RCSB], [http://www.ebi.ac.uk/pdbsum/3idw PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/id/3idw_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	During clathrin-mediated endocytosis, adaptor proteins play central roles in coordinating the assembly of clathrin coats and cargo selection. Here we characterize the binding of the yeast endocytic adaptor Sla1p to clathrin through a variant clathrin-binding motif that is negatively regulated by the Sla1p SHD2 domain. The crystal structure of SHD2 identifies the domain as a sterile alpha-motif (SAM) domain and shows a propensity to oligomerize. By co-immunoprecipitation, Sla1p binds to clathrin and self-associates in vivo. Mutations in the clathrin-binding motif that abolish clathrin binding and structure-based mutations in SHD2 that impede self-association result in endocytosis defects and altered dynamics of Sla1p assembly at the sites of endocytosis. These results define a novel mechanism for negative regulation of clathrin binding by an adaptor and suggest a role for SAM domains in clathrin-mediated endocytosis.

-	~~==About this Structure==~~	+	Regulation of clathrin adaptor function in endocytosis: novel role for the SAM domain.,Di Pietro SM, Cascio D, Feliciano D, Bowie JU, Payne GS EMBO J. 2010 Mar 17;29(6):1033-44. Epub 2010 Feb 11. PMID:20150898<ref>PMID:20150898</ref>
-	~~[[3idw]] is a 1 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3IDW OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	<~~ref group="xtra">PMID:020150898<~~/~~ref~~><~~references group="xtra"~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Bowie, J U.]]	+	[[Category: Bowie, J U]]
-	[[Category: Cascio, D.]]	+	[[Category: Cascio, D]]
-	[[Category: Payne, G S.]]	+	[[Category: Payne, G S]]
-	[[Category: Pietro, S M.Di.]]	+	[[Category: Pietro, S M.Di]]
	[[Category: Actin-binding]]		[[Category: Actin-binding]]
	[[Category: Cell membrane]]		[[Category: Cell membrane]]

OCA: Protected "3idw" [edit=sysop:move=sysop]

OCA — Wed, 13 Mar 2013 11:07:21 GMT

Protected "3idw" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:07, 13 March 2013

OCA at 11:07, 13 March 2013

OCA — Wed, 13 Mar 2013 11:07:16 GMT

←Older revision		Revision as of 11:07, 13 March 2013
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-	{{Seed}}
-	[[Image:3idw.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3idw", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3idw\| PDB=3idw \| SCENE= }}		{{STRUCTURE_3idw\| PDB=3idw \| SCENE= }}
-
	===Crystal structure of Sla1 homology domain 2===		===Crystal structure of Sla1 homology domain 2===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20150898}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20150898 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_20150898}}		{{ABSTRACT_PUBMED_20150898}}

	==About this Structure==		==About this Structure==
-	~~3IDW~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IDW OCA].	+	[[3idw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IDW OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20150898~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020150898</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Bowie, J U.]]		[[Category: Bowie, J U.]]
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	[[Category: Cell membrane]]		[[Category: Cell membrane]]
	[[Category: Clathrin adaptor]]		[[Category: Clathrin adaptor]]
-	[[Category: Cytoplasm]]
	[[Category: Cytoskeleton]]		[[Category: Cytoskeleton]]
	[[Category: Endocytosis]]		[[Category: Endocytosis]]
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	[[Category: Sh3 domain]]		[[Category: Sh3 domain]]
	[[Category: Yeast]]		[[Category: Yeast]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 14 08:58:53 2010''

OCA at 05:58, 14 April 2010

OCA — Wed, 14 Apr 2010 05:58:54 GMT

←Older revision		Revision as of 05:58, 14 April 2010
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	{{Seed}}		{{Seed}}
-	[[Image:3idw.~~jpg~~\|left\|200px]]	+	[[Image:3idw.png\|left\|200px]]

	<!--		<!--
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	[[Category: Yeast]]		[[Category: Yeast]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu Feb 25 13~~:39:48 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 14 08:58:53 2010''

OCA at 11:39, 25 February 2010

OCA — Thu, 25 Feb 2010 11:39:49 GMT

←Older revision		Revision as of 11:39, 25 February 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3idw.jpg\|left\|200px]]

-	The ~~entry 3idw~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3idw", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3idw\| PDB=3idw \| SCENE= }}

-	~~Authors: Di Pietro, S.M., Cascio, D., Bowie, J.U., Payne, G.S.~~	+	===Crystal structure of Sla1 homology domain 2===

-	Description: Crystal structure of Sla1 homology domain 2

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Aug 5 09~~:51:~~00 2009~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20150898}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20150898 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20150898}}
		+
		+	==About this Structure==
		+	3IDW is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IDW OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20150898</ref><references group="xtra"/>
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Bowie, J U.]]
		+	[[Category: Cascio, D.]]
		+	[[Category: Payne, G S.]]
		+	[[Category: Pietro, S M.Di.]]
		+	[[Category: Actin-binding]]
		+	[[Category: Cell membrane]]
		+	[[Category: Clathrin adaptor]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Cytoskeleton]]
		+	[[Category: Endocytosis]]
		+	[[Category: Endosome]]
		+	[[Category: Membrane]]
		+	[[Category: Nucleus]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Sam domain]]
		+	[[Category: Sh3 domain]]
		+	[[Category: Yeast]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 25 13:39:48 2010''