3ihy - Revision history

OCA at 10:05, 21 February 2024

OCA — Wed, 21 Feb 2024 10:05:29 GMT

←Older revision		Revision as of 10:05, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3ihy' size='340' side='right'caption='[[3ihy]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3ihy' size='340' side='right'caption='[[3ihy]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ihy]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IHY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ihy]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IHY FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>PIK3C3, PIK3C3A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=9606 HUMAN])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphatidylinositol_3~~-~~kinase Phosphatidylinositol 3-kinase]~~, ~~with EC number~~ [~~https://www.brenda-enzymes.info/php/result_flat.php4?ecno=~~2.~~7.1.137 2.7.1.137] </span>~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ihy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihy OCA], [https://pdbe.org/3ihy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ihy RCSB], [https://www.ebi.ac.uk/pdbsum/3ihy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ihy ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ihy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihy OCA], [https://pdbe.org/3ihy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ihy RCSB], [https://www.ebi.ac.uk/pdbsum/3ihy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ihy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN]] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref>	+	[https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Phosphatidylinositol 3-kinase]]~~	+	[[Category: Arrowsmith CH]]
-	[[Category: Arrowsmith~~, C H]]~~	+	[[Category: Berglund H]]
-	~~[[Category: Berg, S Van Den~~]]	+	[[Category: Bountra C]]
-	[[Category: Berglund, H]]	+	[[Category: Collins R]]
-	[[Category: Bountra, C]]	+	[[Category: Edwards AM]]
-	[[Category: Collins, R]]	+	[[Category: Flodin S]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Flores A]]
-	[[Category: Flodin, S]]	+	[[Category: Graslund S]]
-	[[Category: Flores, A]]	+	[[Category: Hammarstrom M]]
-	[[Category: Graslund, S]]	+	[[Category: Johansson A]]
-	[[Category: Hammarstrom, M]]	+	[[Category: Johansson I]]
-	[[Category: Johansson, A]]	+	[[Category: Karlberg T]]
-	[[Category: Johansson, I]]	+	[[Category: Kotenyova T]]
-	[[Category: Karlberg, T]]	+	[[Category: Kotzsch A]]
-	[[Category: Kotenyova, T]]	+	[[Category: Kragh Nielsen T]]
-	[[Category: Kotzsch, A]]	+	[[Category: Moche M]]
-	[[Category: ~~Moche, M~~]]	+	[[Category: Nordlund P]]
-	[[Category: ~~Nielsen, T Kragh~~]]	+	[[Category: Nyman T]]
-	[[Category: Nordlund, P]]	+	[[Category: Persson C]]
-	[[Category: Nyman, T]]	+	[[Category: Roos AK]]
-	[[Category: Persson, C]]	+	[[Category: Sagemark J]]
-	[[Category: Roos~~, A K]]~~	+	[[Category: Schueler H]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Schutz P]]
-	[[Category: Sagemark, J]]	+	[[Category: Siponen MI]]
-	[[Category: Schueler, H]]	+	[[Category: Thorsell AG]]
-	[[Category: Schutz, P]]	+	[[Category: Tresaugues L]]
-	[[Category: Siponen~~, M I~~]]	+	[[Category: Van Den Berg S]]
-	[[Category: Thorsell~~, A G~~]]	+	[[Category: Weigelt J]]
-	[[Category: Tresaugues, L]]	+	[[Category: Welin M]]
-	[[Category: ~~Weigelt, J~~]]	+	[[Category: Wisniewska M]]
-	[[Category: ~~Welin, M~~]]	+
-	[[Category: ~~Wisniewska,~~ M]]	+
-	[[Category: ~~Alpha/beta protein]]~~	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Kinase]]~~	+
-	~~[[Category: Manganese]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Sgc stockholm]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 03:33, 21 April 2022

OCA — Thu, 21 Apr 2022 03:33:11 GMT

←Older revision		Revision as of 03:33, 21 April 2022
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	==Human PIK3C3 crystal structure==		==Human PIK3C3 crystal structure==
-	<StructureSection load='3ihy' size='340' side='right' caption='[[3ihy]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='3ihy' size='340' side='right'caption='[[3ihy]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ihy]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IHY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ihy]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IHY FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PIK3C3, PIK3C3A ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PIK3C3, PIK3C3A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ihy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihy OCA], [~~http~~://pdbe.org/3ihy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ihy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ihy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ihy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ihy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihy OCA], [https://pdbe.org/3ihy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ihy RCSB], [https://www.ebi.ac.uk/pdbsum/3ihy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ihy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN]] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref>	+	[[https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN]] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ihy ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ihy ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+
		+	==See Also==
		+	*[[Phosphoinositide 3-kinase 3D structures\|Phosphoinositide 3-kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Phosphatidylinositol 3-kinase]]		[[Category: Phosphatidylinositol 3-kinase]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA at 19:21, 24 January 2018

OCA — Wed, 24 Jan 2018 19:21:05 GMT

←Older revision		Revision as of 19:21, 24 January 2018
Line 1:		Line 1:
		+
	==Human PIK3C3 crystal structure==		==Human PIK3C3 crystal structure==
	<StructureSection load='3ihy' size='340' side='right' caption='[[3ihy]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3ihy' size='340' side='right' caption='[[3ihy]], [[Resolution\|resolution]] 2.80Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PIK3C3, PIK3C3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PIK3C3, PIK3C3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ihy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihy OCA], [http://pdbe.org/3ihy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ihy RCSB], [http://www.ebi.ac.uk/pdbsum/3ihy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ihy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihy OCA], [http://pdbe.org/3ihy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ihy RCSB], [http://www.ebi.ac.uk/pdbsum/3ihy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ihy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ih/3ihy_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ih/3ihy_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 19:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ihy ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ihy ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-
-	==See Also==
-	*[[Phosphoinositide 3-Kinases\|Phosphoinositide 3-Kinases]]
	== References ==		== References ==
	<references/>		<references/>
Line 40:		Line 38:
	[[Category: Johansson, A]]		[[Category: Johansson, A]]
	[[Category: Johansson, I]]		[[Category: Johansson, I]]
-	[[Category: Karlberg,T]]	+	[[Category: Karlberg, T]]
	[[Category: Kotenyova, T]]		[[Category: Kotenyova, T]]
	[[Category: Kotzsch, A]]		[[Category: Kotzsch, A]]

OCA at 14:53, 8 February 2016

OCA — Mon, 08 Feb 2016 14:53:48 GMT

←Older revision		Revision as of 14:53, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3ihy' size='340' side='right' caption='[[3ihy]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='3ihy' size='340' side='right' caption='[[3ihy]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ihy]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IHY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ihy]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IHY FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PIK3C3, PIK3C3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PIK3C3, PIK3C3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ihy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ihy RCSB], [http://www.ebi.ac.uk/pdbsum/3ihy PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ihy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihy OCA], [http://pdbe.org/3ihy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ihy RCSB], [http://www.ebi.ac.uk/pdbsum/3ihy PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ihy ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Phosphatidylinositol 3-kinase]]		[[Category: Phosphatidylinositol 3-kinase]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA at 00:09, 25 December 2014

OCA — Thu, 25 Dec 2014 00:09:51 GMT

←Older revision		Revision as of 00:09, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ihy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ihy RCSB], [http://www.ebi.ac.uk/pdbsum/3ihy PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ihy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ihy RCSB], [http://www.ebi.ac.uk/pdbsum/3ihy PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN]] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 20:		Line 22:
	==See Also==		==See Also==
	*[[Phosphoinositide 3-Kinases\|Phosphoinositide 3-Kinases]]		*[[Phosphoinositide 3-Kinases\|Phosphoinositide 3-Kinases]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:40, 18 December 2014

OCA — Thu, 18 Dec 2014 17:40:19 GMT

←Older revision		Revision as of 17:40, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3ihy\| PDB=3ihy \| SCENE= }}~~	+	==Human PIK3C3 crystal structure==
-	===Human PIK3C3 crystal structure===	+	<StructureSection load='3ihy' size='340' side='right' caption='[[3ihy]], [[Resolution\|resolution]] 2.80Å' scene=''>
-		+	== Structural highlights ==
-	==~~About this Structure~~==	+	<table><tr><td colspan='2'>[[3ihy]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IHY FirstGlance]. <br>
-	[[3ihy]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHY OCA].	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PIK3C3, PIK3C3A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ihy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ihy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ihy RCSB], [http://www.ebi.ac.uk/pdbsum/3ihy PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ih/3ihy_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Phosphoinositide 3-Kinases\|Phosphoinositide 3-Kinases]]		*[[Phosphoinositide 3-Kinases\|Phosphoinositide 3-Kinases]]
-	*[[Phsphatidylinositol 3-kinase\|Phsphatidylinositol 3-kinase]]	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phosphatidylinositol 3-kinase]]		[[Category: Phosphatidylinositol 3-kinase]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Berg, S Van Den.]]	+	[[Category: Berg, S Van Den]]
-	[[Category: Berglund, H.]]	+	[[Category: Berglund, H]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Collins, R.]]	+	[[Category: Collins, R]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Flodin, S.]]	+	[[Category: Flodin, S]]
-	[[Category: Flores, A.]]	+	[[Category: Flores, A]]
-	[[Category: Graslund, S.]]	+	[[Category: Graslund, S]]
-	[[Category: Hammarstrom, M.]]	+	[[Category: Hammarstrom, M]]
-	[[Category: Johansson, A.]]	+	[[Category: Johansson, A]]
-	[[Category: Johansson, I.]]	+	[[Category: Johansson, I]]
-	[[Category: Karlberg,T.]]	+	[[Category: Karlberg,T]]
-	[[Category: Kotenyova, T.]]	+	[[Category: Kotenyova, T]]
-	[[Category: Kotzsch, A.]]	+	[[Category: Kotzsch, A]]
-	[[Category: Moche, M.]]	+	[[Category: Moche, M]]
-	[[Category: Nielsen, T Kragh.]]	+	[[Category: Nielsen, T Kragh]]
-	[[Category: Nordlund, P.]]	+	[[Category: Nordlund, P]]
-	[[Category: Nyman, T.]]	+	[[Category: Nyman, T]]
-	[[Category: Persson, C.]]	+	[[Category: Persson, C]]
-	[[Category: Roos, A K.]]	+	[[Category: Roos, A K]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Sagemark, J.]]	+	[[Category: Sagemark, J]]
-	[[Category: Schueler, H.]]	+	[[Category: Schueler, H]]
-	[[Category: Schutz, P.]]	+	[[Category: Schutz, P]]
-	[[Category: Siponen, M I.]]	+	[[Category: Siponen, M I]]
-	[[Category: Thorsell, A G.]]	+	[[Category: Thorsell, A G]]
-	[[Category: Tresaugues, L.]]	+	[[Category: Tresaugues, L]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
-	[[Category: Welin, M.]]	+	[[Category: Welin, M]]
-	[[Category: Wisniewska, M.]]	+	[[Category: Wisniewska, M]]
	[[Category: Alpha/beta protein]]		[[Category: Alpha/beta protein]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
Line 49:		Line 63:
	[[Category: Sgc]]		[[Category: Sgc]]
	[[Category: Sgc stockholm]]		[[Category: Sgc stockholm]]
-	[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 10:59, 11 March 2013

OCA — Mon, 11 Mar 2013 10:59:19 GMT

←Older revision		Revision as of 10:59, 11 March 2013
Line 1:		Line 1:
-	[[Image:3ihy.png\|left\|200px]]
-
	{{STRUCTURE_3ihy\| PDB=3ihy \| SCENE= }}		{{STRUCTURE_3ihy\| PDB=3ihy \| SCENE= }}
-
	===Human PIK3C3 crystal structure===		===Human PIK3C3 crystal structure===
-

	==About this Structure==		==About this Structure==

OCA at 10:31, 20 October 2012

OCA — Sat, 20 Oct 2012 10:31:22 GMT

←Older revision		Revision as of 10:31, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3ihy]] is a 5 chain structure ~~of [[Phosphoinositide 3-Kinases]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHY OCA].	+	[[3ihy]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IHY OCA].

	==See Also==		==See Also==

OCA at 02:23, 26 July 2012

OCA — Thu, 26 Jul 2012 02:23:31 GMT

←Older revision		Revision as of 02:23, 26 July 2012
Line 1:		Line 1:
	[[Image:3ihy.png\|left\|200px]]		[[Image:3ihy.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ihy", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ihy\| PDB=3ihy \| SCENE= }}		{{STRUCTURE_3ihy\| PDB=3ihy \| SCENE= }}

Line 16:		Line 10:

	==See Also==		==See Also==
-	*[[Phosphoinositide 3-Kinases]]	+	*[[Phosphoinositide 3-Kinases\|Phosphoinositide 3-Kinases]]
		+	*[[Phsphatidylinositol 3-kinase\|Phsphatidylinositol 3-kinase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phosphatidylinositol 3-kinase]]		[[Category: Phosphatidylinositol 3-kinase]]

OCA: Protected "3ihy" [edit=sysop:move=sysop]

OCA — Sun, 26 Dec 2010 22:51:10 GMT

Protected "3ihy" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:51, 26 December 2010