3ik1 - Revision history

OCA at 15:58, 1 November 2023

OCA — Wed, 01 Nov 2023 15:58:58 GMT

←Older revision		Revision as of 15:58, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3ik1' size='340' side='right'caption='[[3ik1]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='3ik1' size='340' side='right'caption='[[3ik1]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ik1]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_a"_von_freudenreich_1890 "bacillus a" von freudenreich 1890~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3IK1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ik1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IK1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=20C:2-HYDROXY-4-(4-METHYL-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BENZOIC+ACID'>20C</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.25Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bnz\|3bnz]], [[3byx\|3byx]], [[3c06\|3c06]], [[3c0a\|3c0a]], [[3bz0\|3bz0]], [[3ijz\|3ijz]], [[3ik0\|3ik0]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=20C:2-HYDROXY-4-(4-METHYL-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BENZOIC+ACID'>20C</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ik1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ik1 OCA], [https://pdbe.org/3ik1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ik1 RCSB], [https://www.ebi.ac.uk/pdbsum/3ik1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ik1 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3ik1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ik1 OCA], [~~http~~://pdbe.org/3ik1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ik1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ik1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ik1 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA]] Provides the sole de novo source of dTMP for DNA biosynthesis.	+	[https://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA] Provides the sole de novo source of dTMP for DNA biosynthesis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus a von freudenreich 1890~~]]	+	[[Category: Lacticaseibacillus casei]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Thymidylate synthase]]~~	+	[[Category: Cancian L]]
-	[[Category: Cancian, L]]	+	[[Category: Costi MP]]
-	[[Category: Costi~~, M P~~]]	+	[[Category: Ferrari S]]
-	[[Category: Ferrari, S]]	+	[[Category: Leone R]]
-	[[Category: Leone, R]]	+	[[Category: Luciani R]]
-	[[Category: Luciani, R]]	+	[[Category: Mangani S]]
-	[[Category: Mangani, S]]	+	[[Category: Pozzi C]]
-	[[Category: Pozzi, C]]	+
-	~~[[Category: Methyltransferase]]~~	+
-	~~[[Category: Nucleotide biosynthesis]]~~	+
-	~~[[Category: Nucleotide synthase]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 11:57, 23 September 2020

OCA — Wed, 23 Sep 2020 11:57:02 GMT

←Older revision		Revision as of 11:57, 23 September 2020
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	==Lactobacillus casei Thymidylate Synthase in Ternary Complex with dUMP and the Phtalimidic Derivative 20C==		==Lactobacillus casei Thymidylate Synthase in Ternary Complex with dUMP and the Phtalimidic Derivative 20C==
-	<StructureSection load='3ik1' size='340' side='right' caption='[[3ik1]], [[Resolution\|resolution]] 2.25Å' scene=''>	+	<StructureSection load='3ik1' size='340' side='right'caption='[[3ik1]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ik1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_a"_von_freudenreich_1890 "bacillus a" von freudenreich 1890]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK1 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IK1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ik1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_a"_von_freudenreich_1890 "bacillus a" von freudenreich 1890]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3IK1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=20C:2-HYDROXY-4-(4-METHYL-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BENZOIC+ACID'>20C</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=20C:2-HYDROXY-4-(4-METHYL-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BENZOIC+ACID'>20C</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bnz\|3bnz]], [[3byx\|3byx]], [[3c06\|3c06]], [[3c0a\|3c0a]], [[3bz0\|3bz0]], [[3ijz\|3ijz]], [[3ik0\|3ik0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bnz\|3bnz]], [[3byx\|3byx]], [[3c06\|3c06]], [[3c0a\|3c0a]], [[3bz0\|3bz0]], [[3ijz\|3ijz]], [[3ik0\|3ik0]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ik1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ik1 OCA], [http://pdbe.org/3ik1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ik1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ik1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ik1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3ik1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ik1 OCA], [http://pdbe.org/3ik1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ik1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ik1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ik1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Thymidylate synthase\|Thymidylate synthase]]	+	*[[Thymidylate synthase 3D structures\|Thymidylate synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus a von freudenreich 1890]]		[[Category: Bacillus a von freudenreich 1890]]
		+	[[Category: Large Structures]]
	[[Category: Thymidylate synthase]]		[[Category: Thymidylate synthase]]
	[[Category: Cancian, L]]		[[Category: Cancian, L]]

OCA at 09:17, 19 December 2018

OCA — Wed, 19 Dec 2018 09:17:23 GMT

←Older revision		Revision as of 09:17, 19 December 2018
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ik/3ik1_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ik/3ik1_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:14, 5 August 2016

OCA — Fri, 05 Aug 2016 01:14:39 GMT

←Older revision		Revision as of 01:14, 5 August 2016
Line 1:		Line 1:
		+
	==Lactobacillus casei Thymidylate Synthase in Ternary Complex with dUMP and the Phtalimidic Derivative 20C==		==Lactobacillus casei Thymidylate Synthase in Ternary Complex with dUMP and the Phtalimidic Derivative 20C==
	<StructureSection load='3ik1' size='340' side='right' caption='[[3ik1]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='3ik1' size='340' side='right' caption='[[3ik1]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ik1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Lactobacillus_casei Lactobacillus casei~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IK1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ik1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_a"_von_freudenreich_1890 "bacillus a" von freudenreich 1890]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IK1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=20C:2-HYDROXY-4-(4-METHYL-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BENZOIC+ACID'>20C</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=20C:2-HYDROXY-4-(4-METHYL-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BENZOIC+ACID'>20C</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bnz\|3bnz]], [[3byx\|3byx]], [[3c06\|3c06]], [[3c0a\|3c0a]], [[3bz0\|3bz0]], [[3ijz\|3ijz]], [[3ik0\|3ik0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bnz\|3bnz]], [[3byx\|3byx]], [[3c06\|3c06]], [[3c0a\|3c0a]], [[3bz0\|3bz0]], [[3ijz\|3ijz]], [[3ik0\|3ik0]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ik1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ik1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ik1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ik1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ik1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ik1 OCA], [http://pdbe.org/3ik1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ik1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ik1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ik1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ik1 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ik1" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lactobacillus casei~~]]	+	[[Category: Bacillus a von freudenreich 1890]]
	[[Category: Thymidylate synthase]]		[[Category: Thymidylate synthase]]
	[[Category: Cancian, L]]		[[Category: Cancian, L]]

OCA at 21:31, 24 December 2014

OCA — Wed, 24 Dec 2014 21:31:20 GMT

←Older revision		Revision as of 21:31, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ik1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ik1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ik1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ik1 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ik1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ik1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ik1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ik1 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA]] Provides the sole de novo source of dTMP for DNA biosynthesis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 17:22, 18 December 2014

OCA — Thu, 18 Dec 2014 17:22:24 GMT

←Older revision		Revision as of 17:22, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3ik1\| PDB=3ik1 \| SCENE= }}~~	+	==Lactobacillus casei Thymidylate Synthase in Ternary Complex with dUMP and the Phtalimidic Derivative 20C==
-	===Lactobacillus casei Thymidylate Synthase in Ternary Complex with dUMP and the Phtalimidic Derivative 20C===	+	<StructureSection load='3ik1' size='340' side='right' caption='[[3ik1]], [[Resolution\|resolution]] 2.25Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21696158}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ik1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IK1 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=20C:2-HYDROXY-4-(4-METHYL-1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)BENZOIC+ACID'>20C</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3bnz\|3bnz]], [[3byx\|3byx]], [[3c06\|3c06]], [[3c0a\|3c0a]], [[3bz0\|3bz0]], [[3ijz\|3ijz]], [[3ik0\|3ik0]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ik1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ik1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ik1 RCSB], [http://www.ebi.ac.uk/pdbsum/3ik1 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ik/3ik1_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	To identify specific bacterial thymidylate synthase (TS) inhibitors, we exploited phenolphthalein (PTH), which inhibits both bacterial and human enzymes. The X-ray crystal structure of Lactobacillus casei TS (LcTS) that binds PTH showed multiple binding modes of the inhibitor, which prevented a classical structure-based drug design approach. To overcome this issue, we synthesized two phthalimidic libraries that were tested against TS enzymes and then we performed X-ray crystallographic screening of the active compounds. Compounds 6A, 8A, and 12A showed 40-fold higher affinity for bacterial TS than human TS. The X-ray crystallographic screening characterized the binding mode of six inhibitors in complexes with LcTS. Of these, 20A, 23A, and 24A showed a common unique binding mode, whereas 8A showed a different, unique binding mode. A comparative analysis of the LcTS X-ray complexes that were obtained with the pathogenic TS enabled the selection of compounds 8A and 23A as specific compounds and starting points to be exploited for the specific inhibition of pathogen enzymes.

-	~~==Function==~~	+	Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening.,Mangani S, Cancian L, Leone R, Pozzi C, Lazzari S, Luciani R, Ferrari S, Costi MP J Med Chem. 2011 Aug 11;54(15):5454-67. Epub 2011 Jul 12. PMID:21696158<ref>PMID:21696158</ref>
-	~~[[http~~:~~//www~~.~~uniprot~~.~~org/uniprot~~/~~TYSY_LACCA TYSY_LACCA]] Provides the sole de novo source of dTMP for DNA biosynthesis.~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3ik1]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Lactobacillus_casei Lactobacillus casei]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3IK1 OCA].~~	+	</div>

	==See Also==		==See Also==
	*[[Thymidylate synthase\|Thymidylate synthase]]		*[[Thymidylate synthase\|Thymidylate synthase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:021696158</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Lactobacillus casei]]		[[Category: Lactobacillus casei]]
	[[Category: Thymidylate synthase]]		[[Category: Thymidylate synthase]]
-	[[Category: Cancian, L.]]	+	[[Category: Cancian, L]]
-	[[Category: Costi, M P.]]	+	[[Category: Costi, M P]]
-	[[Category: Ferrari, S.]]	+	[[Category: Ferrari, S]]
-	[[Category: Leone, R.]]	+	[[Category: Leone, R]]
-	[[Category: Luciani, R.]]	+	[[Category: Luciani, R]]
-	[[Category: Mangani, S.]]	+	[[Category: Mangani, S]]
-	[[Category: Pozzi, C.]]	+	[[Category: Pozzi, C]]
	[[Category: Methyltransferase]]		[[Category: Methyltransferase]]
	[[Category: Nucleotide biosynthesis]]		[[Category: Nucleotide biosynthesis]]
	[[Category: Nucleotide synthase]]		[[Category: Nucleotide synthase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 11:02, 24 July 2013

OCA — Wed, 24 Jul 2013 11:02:40 GMT

←Older revision		Revision as of 11:02, 24 July 2013
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-	[[Image:3ik1.png\|left\|200px]]
-
	{{STRUCTURE_3ik1\| PDB=3ik1 \| SCENE= }}		{{STRUCTURE_3ik1\| PDB=3ik1 \| SCENE= }}
-
	===Lactobacillus casei Thymidylate Synthase in Ternary Complex with dUMP and the Phtalimidic Derivative 20C===		===Lactobacillus casei Thymidylate Synthase in Ternary Complex with dUMP and the Phtalimidic Derivative 20C===
		+	{{ABSTRACT_PUBMED_21696158}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA]] Provides the sole de novo source of dTMP for DNA biosynthesis.

	==About this Structure==		==About this Structure==
Line 11:		Line 11:
	==See Also==		==See Also==
	*[[Thymidylate synthase\|Thymidylate synthase]]		*[[Thymidylate synthase\|Thymidylate synthase]]
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021696158</ref><references group="xtra"/><references/>
	[[Category: Lactobacillus casei]]		[[Category: Lactobacillus casei]]
	[[Category: Thymidylate synthase]]		[[Category: Thymidylate synthase]]

OCA at 09:19, 20 October 2012

OCA — Sat, 20 Oct 2012 09:19:54 GMT

←Older revision		Revision as of 09:19, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3ik1]] is a 1 chain structure ~~of [[Thymidylate synthase]]~~ with sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK1 OCA].	+	[[3ik1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK1 OCA].

	==See Also==		==See Also==

OCA: Protected "3ik1" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 22:29:57 GMT

Protected "3ik1" [edit=sysop:move=sysop]

←Older revision

Revision as of 22:29, 25 July 2012

OCA at 22:29, 25 July 2012

OCA — Wed, 25 Jul 2012 22:29:53 GMT

←Older revision		Revision as of 22:29, 25 July 2012
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-	~~{{Seed}}~~	+	[[Image:3ik1.png\|left\|200px]]
-	[[Image:3ik1.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ik1", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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	{{STRUCTURE_3ik1\| PDB=3ik1 \| SCENE= }}		{{STRUCTURE_3ik1\| PDB=3ik1 \| SCENE= }}

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	==About this Structure==		==About this Structure==
-	~~3IK1~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK1 OCA].	+	[[3ik1]] is a 1 chain structure of [[Thymidylate synthase]] with sequence from [http://en.wikipedia.org/wiki/Lactobacillus_casei Lactobacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK1 OCA].
		+
		+	==See Also==
		+	*[[Thymidylate synthase\|Thymidylate synthase]]
	[[Category: Lactobacillus casei]]		[[Category: Lactobacillus casei]]
	[[Category: Thymidylate synthase]]		[[Category: Thymidylate synthase]]
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	[[Category: Nucleotide synthase]]		[[Category: Nucleotide synthase]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 11 23:54:12 2010''