3il3 - Revision history

OCA at 07:52, 6 September 2023

OCA — Wed, 06 Sep 2023 07:52:38 GMT

←Older revision		Revision as of 07:52, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3il3' size='340' side='right'caption='[[3il3]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3il3' size='340' side='right'caption='[[3il3]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3il3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium~~ influenzae~~" lehmann and neumann 1896~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IL3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3il3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IL3 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=SCY:S-ACETYL-CYSTEINE'>SCY</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;'>[[3il4\|3il4]]~~, [[~~3il5~~\|~~3il5~~]]~~, [[3il6\|3il6]], [[3il7\|3il7]], [[3il9\|3il9]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SCY:S-ACETYL-CYSTEINE'>SCY</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>fabH, HI0157 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~727~~ "~~Bacterium influenzae~~" ~~Lehmann and Neumann 1896])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>[https://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_III Beta-ketoacyl-[acyl-carrier-protein] synthase III], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.180 2.3.1.180] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3il3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il3 OCA], [https://pdbe.org/3il3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3il3 RCSB], [https://www.ebi.ac.uk/pdbsum/3il3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3il3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3il3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il3 OCA], [https://pdbe.org/3il3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3il3 RCSB], [https://www.ebi.ac.uk/pdbsum/3il3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3il3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FABH_HAEIN FABH_HAEIN]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids (By similarity).	+	[https://www.uniprot.org/uniprot/FABH_HAEIN FABH_HAEIN] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacterium~~ influenzae ~~lehmann and neumann 1896~~]]	+	[[Category: Haemophilus influenzae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Appelt, K]]	+	[[Category: Appelt K]]
-	[[Category: Cortez, J]]	+	[[Category: Cortez J]]
-	[[Category: Gajiwala~~, K S~~]]	+	[[Category: Gajiwala KS]]
-	[[Category: Lu, J]]	+	[[Category: Lu J]]
-	[[Category: Margosiak, S]]	+	[[Category: Margosiak S]]
-	[[Category: Nie, Z]]	+	[[Category: Nie Z]]
-	[[Category: Su, Y]]	+	[[Category: Su Y]]
-	~~[[Category: Acyltransferase]]~~	+
-	~~[[Category: Antibiotic]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Fabh]]~~	+
-	~~[[Category: Fatty acid biosynthesis]]~~	+
-	~~[[Category: Lipid synthesis]]~~	+
-	~~[[Category: Multifunctional enzyme]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 03:35, 21 April 2022

OCA — Thu, 21 Apr 2022 03:35:17 GMT

←Older revision		Revision as of 03:35, 21 April 2022
Line 1:		Line 1:

	==Structure of Haemophilus influenzae FabH==		==Structure of Haemophilus influenzae FabH==
-	<StructureSection load='3il3' size='340' side='right' caption='[[3il3]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='3il3' size='340' side='right'caption='[[3il3]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3il3]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IL3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3il3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IL3 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCY:S-ACETYL-CYSTEINE'>SCY</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCY:S-ACETYL-CYSTEINE'>SCY</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3il4\|3il4]], [[3il5\|3il5]], [[3il6\|3il6]], [[3il7\|3il7]], [[3il9\|3il9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3il4\|3il4]], [[3il5\|3il5]], [[3il6\|3il6]], [[3il7\|3il7]], [[3il9\|3il9]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fabH, HI0157 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fabH, HI0157 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_III Beta-ketoacyl-[acyl-carrier-protein] synthase III], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.180 2.3.1.180] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_III Beta-ketoacyl-[acyl-carrier-protein] synthase III], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.180 2.3.1.180] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3il3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il3 OCA], [~~http~~://pdbe.org/3il3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3il3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3il3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3il3 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3il3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il3 OCA], [https://pdbe.org/3il3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3il3 RCSB], [https://www.ebi.ac.uk/pdbsum/3il3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3il3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FABH_HAEIN FABH_HAEIN]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids (By similarity).	+	[[https://www.uniprot.org/uniprot/FABH_HAEIN FABH_HAEIN]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 33:

	==See Also==		==See Also==
-	*[[Acyl carrier protein synthase\|Acyl carrier protein synthase]]	+	*[[Acyl carrier protein synthase 3D structures\|Acyl carrier protein synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Bacterium influenzae lehmann and neumann 1896]]		[[Category: Bacterium influenzae lehmann and neumann 1896]]
		+	[[Category: Large Structures]]
	[[Category: Appelt, K]]		[[Category: Appelt, K]]
	[[Category: Cortez, J]]		[[Category: Cortez, J]]

OCA at 09:52, 19 December 2018

OCA — Wed, 19 Dec 2018 09:52:19 GMT

←Older revision		Revision as of 09:52, 19 December 2018
Line 1:		Line 1:
		+
	==Structure of Haemophilus influenzae FabH==		==Structure of Haemophilus influenzae FabH==
	<StructureSection load='3il3' size='340' side='right' caption='[[3il3]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3il3' size='340' side='right' caption='[[3il3]], [[Resolution\|resolution]] 2.70Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fabH, HI0157 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fabH, HI0157 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_III Beta-ketoacyl-[acyl-carrier-protein] synthase III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.180 2.3.1.180] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_III Beta-ketoacyl-[acyl-carrier-protein] synthase III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.180 2.3.1.180] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3il3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il3 OCA], [http://pdbe.org/3il3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3il3 RCSB], [http://www.ebi.ac.uk/pdbsum/3il3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3il3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il3 OCA], [http://pdbe.org/3il3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3il3 RCSB], [http://www.ebi.ac.uk/pdbsum/3il3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3il3 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/il/3il3_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/il/3il3_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 47:		Line 48:
	[[Category: Acyltransferase]]		[[Category: Acyltransferase]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]
		+	[[Category: Cytoplasm]]
	[[Category: Fabh]]		[[Category: Fabh]]
	[[Category: Fatty acid biosynthesis]]		[[Category: Fatty acid biosynthesis]]

OCA at 04:47, 9 February 2016

OCA — Tue, 09 Feb 2016 04:47:05 GMT

←Older revision		Revision as of 04:47, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3il3' size='340' side='right' caption='[[3il3]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3il3' size='340' side='right' caption='[[3il3]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3il3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Haemophilus_influenzae Haemophilus~~ influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IL3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3il3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IL3 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCY:S-ACETYL-CYSTEINE'>SCY</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCY:S-ACETYL-CYSTEINE'>SCY</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3il4\|3il4]], [[3il5\|3il5]], [[3il6\|3il6]], [[3il7\|3il7]], [[3il9\|3il9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3il4\|3il4]], [[3il5\|3il5]], [[3il6\|3il6]], [[3il7\|3il7]], [[3il9\|3il9]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fabH, HI0157 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 ~~Haemophilus~~ influenzae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fabH, HI0157 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-~~protein_synthase_III~~ Beta-ketoacyl-acyl-carrier-protein synthase III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.180 2.3.1.180] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_III Beta-ketoacyl-[acyl-carrier-protein] synthase III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.180 2.3.1.180] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3il3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3il3 RCSB], [http://www.ebi.ac.uk/pdbsum/3il3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3il3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il3 OCA], [http://pdbe.org/3il3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3il3 RCSB], [http://www.ebi.ac.uk/pdbsum/3il3 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3il3 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3il3" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Beta-ketoacyl-acyl-carrier-protein synthase III]]~~	+	[[Category: Bacterium influenzae lehmann and neumann 1896]]
-	~~[[Category: Haemophilus~~ influenzae]]	+
	[[Category: Appelt, K]]		[[Category: Appelt, K]]
	[[Category: Cortez, J]]		[[Category: Cortez, J]]

OCA at 04:31, 25 December 2014

OCA — Thu, 25 Dec 2014 04:31:50 GMT

←Older revision		Revision as of 04:31, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3il3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IL3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3il3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IL3 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCY:S-ACETYL-CYSTEINE'>SCY</scene></td></tr>	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCY:S-ACETYL-CYSTEINE'>SCY</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3il4\|3il4]], [[3il5\|3il5]], [[3il6\|3il6]], [[3il7\|3il7]], [[3il9\|3il9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3il4\|3il4]], [[3il5\|3il5]], [[3il6\|3il6]], [[3il7\|3il7]], [[3il9\|3il9]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fabH, HI0157 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 Haemophilus influenzae])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fabH, HI0157 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 Haemophilus influenzae])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_III Beta-ketoacyl-acyl-carrier-protein synthase III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.180 2.3.1.180] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_III Beta-ketoacyl-acyl-carrier-protein synthase III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.180 2.3.1.180] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3il3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3il3 RCSB], [http://www.ebi.ac.uk/pdbsum/3il3 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3il3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3il3 RCSB], [http://www.ebi.ac.uk/pdbsum/3il3 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FABH_HAEIN FABH_HAEIN]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Beta-ketoacyl-acyl-carrier-protein synthase III]]		[[Category: Beta-ketoacyl-acyl-carrier-protein synthase III]]
	[[Category: Haemophilus influenzae]]		[[Category: Haemophilus influenzae]]
-	[[Category: Appelt, K.]]	+	[[Category: Appelt, K]]
-	[[Category: Cortez, J.]]	+	[[Category: Cortez, J]]
-	[[Category: Gajiwala, K S.]]	+	[[Category: Gajiwala, K S]]
-	[[Category: Lu, J.]]	+	[[Category: Lu, J]]
-	[[Category: Margosiak, S.]]	+	[[Category: Margosiak, S]]
-	[[Category: Nie, Z.]]	+	[[Category: Nie, Z]]
-	[[Category: Su, Y.]]	+	[[Category: Su, Y]]
	[[Category: Acyltransferase]]		[[Category: Acyltransferase]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]

OCA at 13:18, 29 September 2014

OCA — Mon, 29 Sep 2014 13:18:35 GMT

←Older revision		Revision as of 13:18, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3il3.~~png~~\|~~left~~\|200px]]	+	==Structure of Haemophilus influenzae FabH==
		+	<StructureSection load='3il3' size='340' side='right' caption='[[3il3]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3il3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IL3 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCY:S-ACETYL-CYSTEINE'>SCY</scene></td></tr>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3il4\|3il4]], [[3il5\|3il5]], [[3il6\|3il6]], [[3il7\|3il7]], [[3il9\|3il9]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fabH, HI0157 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 Haemophilus influenzae])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_III Beta-ketoacyl-acyl-carrier-protein synthase III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.180 2.3.1.180] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3il3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3il3 RCSB], [http://www.ebi.ac.uk/pdbsum/3il3 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/il/3il3_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	FabH (beta-ketoacyl-acyl carrier protein synthase III) is unique in that it initiates fatty acid biosynthesis, is inhibited by long-chain fatty acids providing means for feedback control of the process, and dictates the fatty acid profile of the organism by virtue of its substrate specificity. We report the crystal structures of bacterial FabH enzymes from four different pathogenic species: Enterococcus faecalis, Haemophilus influenzae, Staphylococcus aureus and Escherichia coli. Structural data on the enzyme from different species show important differences in the architecture of the substrate-binding sites that parallel the inter-species diversity in the substrate specificities of these enzymes.

-	~~{{STRUCTURE_3il3\| PDB=3il3 \| SCENE= }}~~	+	Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme.,Gajiwala KS, Margosiak S, Lu J, Cortez J, Su Y, Nie Z, Appelt K FEBS Lett. 2009 Sep 3;583(17):2939-46. Epub 2009 Aug 6. PMID:19665020<ref>PMID:19665020</ref>

-	~~===Structure~~ of ~~Haemophilus influenzae FabH===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19665020}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3il3]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Haemophilus_influenzae Haemophilus influenzae]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3IL3 OCA].~~	+

	==See Also==		==See Also==
	*[[Acyl carrier protein synthase\|Acyl carrier protein synthase]]		*[[Acyl carrier protein synthase\|Acyl carrier protein synthase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019665020<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Beta-ketoacyl-acyl-carrier-protein synthase III]]		[[Category: Beta-ketoacyl-acyl-carrier-protein synthase III]]
	[[Category: Haemophilus influenzae]]		[[Category: Haemophilus influenzae]]

OCA at 12:41, 20 October 2012

OCA — Sat, 20 Oct 2012 12:41:24 GMT

←Older revision		Revision as of 12:41, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3il3]] is a 1 chain structure ~~of [[Acyl carrier protein synthase]]~~ with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL3 OCA].	+	[[3il3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL3 OCA].

	==See Also==		==See Also==

OCA: Protected "3il3" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 09:33:42 GMT

Protected "3il3" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:33, 26 July 2012

OCA at 09:33, 26 July 2012

OCA — Thu, 26 Jul 2012 09:33:41 GMT

←Older revision		Revision as of 09:33, 26 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3il3.png\|left\|200px]]		[[Image:3il3.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3il3", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3il3\| PDB=3il3 \| SCENE= }}		{{STRUCTURE_3il3\| PDB=3il3 \| SCENE= }}

	===Structure of Haemophilus influenzae FabH===		===Structure of Haemophilus influenzae FabH===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19665020}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19665020 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19665020}}		{{ABSTRACT_PUBMED_19665020}}

	==About this Structure==		==About this Structure==
-	~~3IL3~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL3 OCA].	+	[[3il3]] is a 1 chain structure of [[Acyl carrier protein synthase]] with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL3 OCA].
		+
		+	==See Also==
		+	*[[Acyl carrier protein synthase\|Acyl carrier protein synthase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19665020~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019665020</ref><references group="xtra"/>
	[[Category: Beta-ketoacyl-acyl-carrier-protein synthase III]]		[[Category: Beta-ketoacyl-acyl-carrier-protein synthase III]]
	[[Category: Haemophilus influenzae]]		[[Category: Haemophilus influenzae]]
Line 35:		Line 26:
	[[Category: Acyltransferase]]		[[Category: Acyltransferase]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]
-	[[Category: Cytoplasm]]
	[[Category: Fabh]]		[[Category: Fabh]]
	[[Category: Fatty acid biosynthesis]]		[[Category: Fatty acid biosynthesis]]
Line 41:		Line 31:
	[[Category: Multifunctional enzyme]]		[[Category: Multifunctional enzyme]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 21 19:31:03 2009''

OCA at 16:31, 21 September 2009

OCA — Mon, 21 Sep 2009 16:31:05 GMT

←Older revision		Revision as of 16:31, 21 September 2009
Line 12:		Line 12:
	===Structure of Haemophilus influenzae FabH===		===Structure of Haemophilus influenzae FabH===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19665020}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19665020 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19665020}}

	==About this Structure==		==About this Structure==
Line 36:		Line 42:
	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 21 17:23:25 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 21 19:31:03 2009''