3il5 - Revision history

OCA at 07:52, 6 September 2023

OCA — Wed, 06 Sep 2023 07:52:44 GMT

←Older revision		Revision as of 07:52, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3il5' size='340' side='right'caption='[[3il5]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3il5' size='340' side='right'caption='[[3il5]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3il5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IL5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3il5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IL5 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=B82:2~~-~~({[4-BROMO-3-(DIETHYLSULFAMOYL)PHENYL]CARBONYL}AMINO)BENZOIC+ACID'>B82</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3il3\|3il3]], [[3il4\|3il4]], [[3il6\|3il6]], [[3il7\|3il7]], [[3il9\|3il9]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B82:2-({[4-BROMO-3-(DIETHYLSULFAMOYL)PHENYL]CARBONYL}AMINO)BENZOIC+ACID'>B82</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>EF_2885, fabH ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1351~~ "~~Enterococcus proteiformis~~" ~~Thiercelin and Jouhaud 1903])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-ketoacyl~~-[~~acyl~~-~~carrier~~-~~protein]_synthase_III Beta~~-~~ketoacyl-[acyl-carrier-protein] synthase III], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.180 2.3.1.180~~] </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3il5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il5 OCA], [https://pdbe.org/3il5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3il5 RCSB], [https://www.ebi.ac.uk/pdbsum/3il5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3il5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3il5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il5 OCA], [https://pdbe.org/3il5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3il5 RCSB], [https://www.ebi.ac.uk/pdbsum/3il5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3il5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/FABH_ENTFA FABH_ENTFA]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids (By similarity).	+	[https://www.uniprot.org/uniprot/FABH_ENTFA FABH_ENTFA] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Enterococcus ~~proteiformis thiercelin and jouhaud 1903~~]]	+	[[Category: Enterococcus faecalis]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Appelt, K]]	+	[[Category: Appelt K]]
-	[[Category: Cortez, J]]	+	[[Category: Cortez J]]
-	[[Category: Gajiwala~~, K S~~]]	+	[[Category: Gajiwala KS]]
-	[[Category: Lu, J]]	+	[[Category: Lu J]]
-	[[Category: Margosiak, S]]	+	[[Category: Margosiak S]]
-	[[Category: Nie, Z]]	+	[[Category: Nie Z]]
-	[[Category: Su, Y]]	+	[[Category: Su Y]]
-	~~[[Category: Acyltransferase]]~~	+
-	~~[[Category: Antibiotic]]~~	+
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Fabh]]~~	+
-	~~[[Category: Fatty acid biosynthesis]]~~	+
-	~~[[Category: Lipid synthesis]]~~	+
-	~~[[Category: Multifunctional enzyme]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 03:35, 21 April 2022

OCA — Thu, 21 Apr 2022 03:35:18 GMT

←Older revision		Revision as of 03:35, 21 April 2022
Line 1:		Line 1:

	==Structure of E. faecalis FabH in complex with 2-({4-bromo-3-[(diethylamino)sulfonyl]benzoyl}amino)benzoic acid==		==Structure of E. faecalis FabH in complex with 2-({4-bromo-3-[(diethylamino)sulfonyl]benzoyl}amino)benzoic acid==
-	<StructureSection load='3il5' size='340' side='right' caption='[[3il5]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='3il5' size='340' side='right'caption='[[3il5]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3il5]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IL5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3il5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IL5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B82:2-({[4-BROMO-3-(DIETHYLSULFAMOYL)PHENYL]CARBONYL}AMINO)BENZOIC+ACID'>B82</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B82:2-({[4-BROMO-3-(DIETHYLSULFAMOYL)PHENYL]CARBONYL}AMINO)BENZOIC+ACID'>B82</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3il3\|3il3]], [[3il4\|3il4]], [[3il6\|3il6]], [[3il7\|3il7]], [[3il9\|3il9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3il3\|3il3]], [[3il4\|3il4]], [[3il6\|3il6]], [[3il7\|3il7]], [[3il9\|3il9]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EF_2885, fabH ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 "Enterococcus proteiformis" Thiercelin and Jouhaud 1903])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EF_2885, fabH ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 "Enterococcus proteiformis" Thiercelin and Jouhaud 1903])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_III Beta-ketoacyl-[acyl-carrier-protein] synthase III], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.180 2.3.1.180] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_III Beta-ketoacyl-[acyl-carrier-protein] synthase III], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.180 2.3.1.180] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3il5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il5 OCA], [~~http~~://pdbe.org/3il5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3il5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3il5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3il5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3il5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il5 OCA], [https://pdbe.org/3il5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3il5 RCSB], [https://www.ebi.ac.uk/pdbsum/3il5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3il5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/FABH_ENTFA FABH_ENTFA]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids (By similarity).	+	[[https://www.uniprot.org/uniprot/FABH_ENTFA FABH_ENTFA]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 3il5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3il5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Acyl carrier protein synthase 3D structures\|Acyl carrier protein synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Enterococcus proteiformis thiercelin and jouhaud 1903]]		[[Category: Enterococcus proteiformis thiercelin and jouhaud 1903]]
		+	[[Category: Large Structures]]
	[[Category: Appelt, K]]		[[Category: Appelt, K]]
	[[Category: Cortez, J]]		[[Category: Cortez, J]]

OCA at 19:21, 24 January 2018

OCA — Wed, 24 Jan 2018 19:21:43 GMT

←Older revision		Revision as of 19:21, 24 January 2018
Line 1:		Line 1:
		+
	==Structure of E. faecalis FabH in complex with 2-({4-bromo-3-[(diethylamino)sulfonyl]benzoyl}amino)benzoic acid==		==Structure of E. faecalis FabH in complex with 2-({4-bromo-3-[(diethylamino)sulfonyl]benzoyl}amino)benzoic acid==
	<StructureSection load='3il5' size='340' side='right' caption='[[3il5]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3il5' size='340' side='right' caption='[[3il5]], [[Resolution\|resolution]] 2.60Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EF_2885, fabH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 "Enterococcus proteiformis" Thiercelin and Jouhaud 1903])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EF_2885, fabH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 "Enterococcus proteiformis" Thiercelin and Jouhaud 1903])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_III Beta-ketoacyl-[acyl-carrier-protein] synthase III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.180 2.3.1.180] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_III Beta-ketoacyl-[acyl-carrier-protein] synthase III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.180 2.3.1.180] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3il5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il5 OCA], [http://pdbe.org/3il5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3il5 RCSB], [http://www.ebi.ac.uk/pdbsum/3il5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3il5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il5 OCA], [http://pdbe.org/3il5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3il5 RCSB], [http://www.ebi.ac.uk/pdbsum/3il5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3il5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/il/3il5_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/il/3il5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 3il5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3il5" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Acyl carrier protein synthase\|Acyl carrier protein synthase]]
	== References ==		== References ==
	<references/>		<references/>
Line 47:		Line 45:
	[[Category: Acyltransferase]]		[[Category: Acyltransferase]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]
		+	[[Category: Cytoplasm]]
	[[Category: Fabh]]		[[Category: Fabh]]
	[[Category: Fatty acid biosynthesis]]		[[Category: Fatty acid biosynthesis]]

OCA at 18:25, 8 February 2016

OCA — Mon, 08 Feb 2016 18:25:57 GMT

←Older revision		Revision as of 18:25, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3il5' size='340' side='right' caption='[[3il5]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='3il5' size='340' side='right' caption='[[3il5]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3il5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Enterococcus_faecalis Enterococcus faecalis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IL5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3il5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"enterococcus_proteiformis"_thiercelin_and_jouhaud_1903 "enterococcus proteiformis" thiercelin and jouhaud 1903]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IL5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B82:2-({[4-BROMO-3-(DIETHYLSULFAMOYL)PHENYL]CARBONYL}AMINO)BENZOIC+ACID'>B82</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B82:2-({[4-BROMO-3-(DIETHYLSULFAMOYL)PHENYL]CARBONYL}AMINO)BENZOIC+ACID'>B82</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3il3\|3il3]], [[3il4\|3il4]], [[3il6\|3il6]], [[3il7\|3il7]], [[3il9\|3il9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3il3\|3il3]], [[3il4\|3il4]], [[3il6\|3il6]], [[3il7\|3il7]], [[3il9\|3il9]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EF_2885, fabH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 Enterococcus ~~faecalis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EF_2885, fabH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 "Enterococcus proteiformis" Thiercelin and Jouhaud 1903])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-~~protein_synthase_III~~ Beta-ketoacyl-acyl-carrier-protein synthase III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.180 2.3.1.180] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-[acyl-carrier-protein]_synthase_III Beta-ketoacyl-[acyl-carrier-protein] synthase III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.180 2.3.1.180] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3il5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3il5 RCSB], [http://www.ebi.ac.uk/pdbsum/3il5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3il5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il5 OCA], [http://pdbe.org/3il5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3il5 RCSB], [http://www.ebi.ac.uk/pdbsum/3il5 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3il5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3il5" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	~~[[Category: Beta-ketoacyl-acyl-carrier-protein synthase III]]~~	+	[[Category: Enterococcus proteiformis thiercelin and jouhaud 1903]]
-	[[Category: Enterococcus ~~faecalis~~]]	+
	[[Category: Appelt, K]]		[[Category: Appelt, K]]
	[[Category: Cortez, J]]		[[Category: Cortez, J]]

OCA at 01:17, 25 December 2014

OCA — Thu, 25 Dec 2014 01:17:30 GMT

←Older revision		Revision as of 01:17, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3il5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IL5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3il5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IL5 FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B82:2-({[4-BROMO-3-(DIETHYLSULFAMOYL)PHENYL]CARBONYL}AMINO)BENZOIC+ACID'>B82</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B82:2-({[4-BROMO-3-(DIETHYLSULFAMOYL)PHENYL]CARBONYL}AMINO)BENZOIC+ACID'>B82</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3il3\|3il3]], [[3il4\|3il4]], [[3il6\|3il6]], [[3il7\|3il7]], [[3il9\|3il9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3il3\|3il3]], [[3il4\|3il4]], [[3il6\|3il6]], [[3il7\|3il7]], [[3il9\|3il9]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EF_2885, fabH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 Enterococcus faecalis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EF_2885, fabH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 Enterococcus faecalis])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_III Beta-ketoacyl-acyl-carrier-protein synthase III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.180 2.3.1.180] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_III Beta-ketoacyl-acyl-carrier-protein synthase III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.180 2.3.1.180] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3il5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3il5 RCSB], [http://www.ebi.ac.uk/pdbsum/3il5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3il5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3il5 RCSB], [http://www.ebi.ac.uk/pdbsum/3il5 PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FABH_ENTFA FABH_ENTFA]] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Beta-ketoacyl-acyl-carrier-protein synthase III]]		[[Category: Beta-ketoacyl-acyl-carrier-protein synthase III]]
	[[Category: Enterococcus faecalis]]		[[Category: Enterococcus faecalis]]
-	[[Category: Appelt, K.]]	+	[[Category: Appelt, K]]
-	[[Category: Cortez, J.]]	+	[[Category: Cortez, J]]
-	[[Category: Gajiwala, K S.]]	+	[[Category: Gajiwala, K S]]
-	[[Category: Lu, J.]]	+	[[Category: Lu, J]]
	[[Category: Margosiak, S]]		[[Category: Margosiak, S]]
-	[[Category: Nie, Z.]]	+	[[Category: Nie, Z]]
-	[[Category: Su, Y.]]	+	[[Category: Su, Y]]
	[[Category: Acyltransferase]]		[[Category: Acyltransferase]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]

OCA at 13:07, 29 September 2014

OCA — Mon, 29 Sep 2014 13:07:44 GMT

←Older revision		Revision as of 13:07, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3il5.~~png~~\|~~left~~\|200px]]	+	==Structure of E. faecalis FabH in complex with 2-({4-bromo-3-[(diethylamino)sulfonyl]benzoyl}amino)benzoic acid==
		+	<StructureSection load='3il5' size='340' side='right' caption='[[3il5]], [[Resolution\|resolution]] 2.60Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3il5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IL5 FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B82:2-({[4-BROMO-3-(DIETHYLSULFAMOYL)PHENYL]CARBONYL}AMINO)BENZOIC+ACID'>B82</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3il3\|3il3]], [[3il4\|3il4]], [[3il6\|3il6]], [[3il7\|3il7]], [[3il9\|3il9]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EF_2885, fabH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1351 Enterococcus faecalis])</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_III Beta-ketoacyl-acyl-carrier-protein synthase III], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.180 2.3.1.180] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3il5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3il5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3il5 RCSB], [http://www.ebi.ac.uk/pdbsum/3il5 PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/il/3il5_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	FabH (beta-ketoacyl-acyl carrier protein synthase III) is unique in that it initiates fatty acid biosynthesis, is inhibited by long-chain fatty acids providing means for feedback control of the process, and dictates the fatty acid profile of the organism by virtue of its substrate specificity. We report the crystal structures of bacterial FabH enzymes from four different pathogenic species: Enterococcus faecalis, Haemophilus influenzae, Staphylococcus aureus and Escherichia coli. Structural data on the enzyme from different species show important differences in the architecture of the substrate-binding sites that parallel the inter-species diversity in the substrate specificities of these enzymes.

-	~~{{STRUCTURE_3il5\| PDB=3il5 \| SCENE= }}~~	+	Crystal structures of bacterial FabH suggest a molecular basis for the substrate specificity of the enzyme.,Gajiwala KS, Margosiak S, Lu J, Cortez J, Su Y, Nie Z, Appelt K FEBS Lett. 2009 Sep 3;583(17):2939-46. Epub 2009 Aug 6. PMID:19665020<ref>PMID:19665020</ref>

-	~~===Structure~~ of E. ~~faecalis FabH in complex with 2-({4-bromo-3-[(diethylamino)sulfonyl]benzoyl}amino)benzoic acid===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19665020}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3il5]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL5 OCA].~~	+

	==See Also==		==See Also==
	*[[Acyl carrier protein synthase\|Acyl carrier protein synthase]]		*[[Acyl carrier protein synthase\|Acyl carrier protein synthase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019665020<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Beta-ketoacyl-acyl-carrier-protein synthase III]]		[[Category: Beta-ketoacyl-acyl-carrier-protein synthase III]]
	[[Category: Enterococcus faecalis]]		[[Category: Enterococcus faecalis]]

OCA at 11:03, 20 October 2012

OCA — Sat, 20 Oct 2012 11:03:50 GMT

←Older revision		Revision as of 11:03, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3il5]] is a 4 chain structure ~~of [[Acyl carrier protein synthase]]~~ with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL5 OCA].	+	[[3il5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL5 OCA].

	==See Also==		==See Also==

OCA: Protected "3il5" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 04:07:50 GMT

Protected "3il5" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:07, 26 July 2012

OCA at 04:07, 26 July 2012

OCA — Thu, 26 Jul 2012 04:07:47 GMT

←Older revision		Revision as of 04:07, 26 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3il5.png\|left\|200px]]		[[Image:3il5.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3il5", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3il5\| PDB=3il5 \| SCENE= }}		{{STRUCTURE_3il5\| PDB=3il5 \| SCENE= }}

	===Structure of E. faecalis FabH in complex with 2-({4-bromo-3-[(diethylamino)sulfonyl]benzoyl}amino)benzoic acid===		===Structure of E. faecalis FabH in complex with 2-({4-bromo-3-[(diethylamino)sulfonyl]benzoyl}amino)benzoic acid===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19665020}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19665020 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19665020}}		{{ABSTRACT_PUBMED_19665020}}

	==About this Structure==		==About this Structure==
-	~~3IL5~~ is a 4 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL5 OCA].	+	[[3il5]] is a 4 chain structure of [[Acyl carrier protein synthase]] with sequence from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IL5 OCA].
		+
		+	==See Also==
		+	*[[Acyl carrier protein synthase\|Acyl carrier protein synthase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19665020~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019665020</ref><references group="xtra"/>
	[[Category: Beta-ketoacyl-acyl-carrier-protein synthase III]]		[[Category: Beta-ketoacyl-acyl-carrier-protein synthase III]]
	[[Category: Enterococcus faecalis]]		[[Category: Enterococcus faecalis]]
Line 35:		Line 26:
	[[Category: Acyltransferase]]		[[Category: Acyltransferase]]
	[[Category: Antibiotic]]		[[Category: Antibiotic]]
-	[[Category: Cytoplasm]]
	[[Category: Fabh]]		[[Category: Fabh]]
	[[Category: Fatty acid biosynthesis]]		[[Category: Fatty acid biosynthesis]]
Line 41:		Line 31:
	[[Category: Multifunctional enzyme]]		[[Category: Multifunctional enzyme]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 21 19:31:04 2009''

OCA at 16:31, 21 September 2009

OCA — Mon, 21 Sep 2009 16:31:06 GMT

←Older revision		Revision as of 16:31, 21 September 2009
Line 12:		Line 12:
	===Structure of E. faecalis FabH in complex with 2-({4-bromo-3-[(diethylamino)sulfonyl]benzoyl}amino)benzoic acid===		===Structure of E. faecalis FabH in complex with 2-({4-bromo-3-[(diethylamino)sulfonyl]benzoyl}amino)benzoic acid===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19665020}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19665020 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19665020}}

	==About this Structure==		==About this Structure==
Line 36:		Line 42:
	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 21 17:24:14 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 21 19:31:04 2009''