3inq - Revision history

OCA at 16:01, 1 November 2023

OCA — Wed, 01 Nov 2023 16:01:17 GMT

←Older revision		Revision as of 16:01, 1 November 2023
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	<StructureSection load='3inq' size='340' side='right'caption='[[3inq]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3inq' size='340' side='right'caption='[[3inq]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3inq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3INQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3inq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3INQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=X0J:4-[4-(BIPHENYL-3-YLMETHYL)PIPERAZIN-1-YL]-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLSULFANYL)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE'>X0J</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yxj\|2yxj]], [[3fdl\|3fdl]], [[2p1l\|2p1l]], [[3io8\|3io8]], [[3io9\|3io9]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=X0J:4-[4-(BIPHENYL-3-YLMETHYL)PIPERAZIN-1-YL]-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLSULFANYL)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE'>X0J</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3inq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inq OCA], [https://pdbe.org/3inq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3inq RCSB], [https://www.ebi.ac.uk/pdbsum/3inq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3inq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3inq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inq OCA], [https://pdbe.org/3inq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3inq RCSB], [https://www.ebi.ac.uk/pdbsum/3inq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3inq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>	+	[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Colman~~, P M~~]]	+	[[Category: Colman PM]]
-	[[Category: Czabotar~~, P E~~]]	+	[[Category: Czabotar PE]]
-	[[Category: Fairlie~~, W D~~]]	+	[[Category: Fairlie WD]]
-	[[Category: Lee~~, E F~~]]	+	[[Category: Lee EF]]
-	[[Category: Smith~~, B J]]~~	+	[[Category: Smith BJ]]
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Apoptosis]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Mitochondrion]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 03:37, 21 April 2022

OCA — Thu, 21 Apr 2022 03:37:19 GMT

←Older revision		Revision as of 03:37, 21 April 2022
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	<StructureSection load='3inq' size='340' side='right'caption='[[3inq]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3inq' size='340' side='right'caption='[[3inq]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3inq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3INQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3inq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3INQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=X0J:4-[4-(BIPHENYL-3-YLMETHYL)PIPERAZIN-1-YL]-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLSULFANYL)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE'>X0J</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=X0J:4-[4-(BIPHENYL-3-YLMETHYL)PIPERAZIN-1-YL]-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLSULFANYL)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE'>X0J</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yxj\|2yxj]], [[3fdl\|3fdl]], [[2p1l\|2p1l]], [[3io8\|3io8]], [[3io9\|3io9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2yxj\|2yxj]], [[3fdl\|3fdl]], [[2p1l\|2p1l]], [[3io8\|3io8]], [[3io9\|3io9]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3inq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inq OCA], [~~http~~://pdbe.org/3inq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3inq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3inq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3inq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3inq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inq OCA], [https://pdbe.org/3inq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3inq RCSB], [https://www.ebi.ac.uk/pdbsum/3inq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3inq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>	+	[[https://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 16:33, 28 August 2019

OCA — Wed, 28 Aug 2019 16:33:01 GMT

←Older revision		Revision as of 16:33, 28 August 2019
Line 1:		Line 1:

	==Crystal structure of BCL-XL in complex with W1191542==		==Crystal structure of BCL-XL in complex with W1191542==
-	<StructureSection load='3inq' size='340' side='right' caption='[[3inq]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='3inq' size='340' side='right'caption='[[3inq]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3inq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3INQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3inq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3INQ FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/in/3inq_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/in/3inq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3inq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3inq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[B-cell lymphoma proteins 3D structures\|B-cell lymphoma proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Colman, P M]]		[[Category: Colman, P M]]
	[[Category: Czabotar, P E]]		[[Category: Czabotar, P E]]

OCA at 21:50, 15 November 2017

OCA — Wed, 15 Nov 2017 21:50:33 GMT

←Older revision		Revision as of 21:50, 15 November 2017
Line 29:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3inq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3inq" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Bcl-2\|Bcl-2]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 11:08, 24 August 2017

OCA — Thu, 24 Aug 2017 11:08:52 GMT

←Older revision		Revision as of 11:08, 24 August 2017
Line 1:		Line 1:
		+
	==Crystal structure of BCL-XL in complex with W1191542==		==Crystal structure of BCL-XL in complex with W1191542==
	<StructureSection load='3inq' size='340' side='right' caption='[[3inq]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3inq' size='340' side='right' caption='[[3inq]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3inq]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3INQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3inq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3INQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=X0J:4-[4-(BIPHENYL-3-YLMETHYL)PIPERAZIN-1-YL]-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLSULFANYL)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE'>X0J</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=X0J:4-[4-(BIPHENYL-3-YLMETHYL)PIPERAZIN-1-YL]-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLSULFANYL)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE'>X0J</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yxj\|2yxj]], [[3fdl\|3fdl]], [[2p1l\|2p1l]], [[3io8\|3io8]], [[3io9\|3io9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yxj\|2yxj]], [[3fdl\|3fdl]], [[2p1l\|2p1l]], [[3io8\|3io8]], [[3io9\|3io9]]</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCL-X ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3inq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inq OCA], [http://pdbe.org/3inq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3inq RCSB], [http://www.ebi.ac.uk/pdbsum/3inq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3inq ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3inq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inq OCA], [http://pdbe.org/3inq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3inq RCSB], [http://www.ebi.ac.uk/pdbsum/3inq PDBsum]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3inq ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3inq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Antagonists of anti-apoptotic Bcl-2 family members hold promise as cancer therapeutics. Apoptosis is triggered when a peptide containing a BH3 motif or a small molecule BH3 peptidomimetic, such as ABT 737, binds to the relevant Bcl-2 family members. ABT-737 is an antagonist of Bcl-2, Bcl-x(L), and Bcl-w but not of Mcl-1. Here we describe new structures of mutant BH3 peptides bound to Bcl-x(L) and Mcl-1. These structures suggested a rationale for the failure of ABT-737 to bind Mcl-1, but a designed variant of ABT-737 failed to acquire binding affinity for Mcl-1. Rather, it was selective for Bcl-x(L), a result attributable in part to significant backbone refolding and movements of helical segments in its ligand binding site. To date there are few reported crystal structures of organic ligands in complex with their pro-survival protein targets. Our structure of this new organic ligand provided insights into the structural transitions that occur within the BH3 binding groove, highlighting significant differences in the structural properties of members of the Bcl-2 pro-survival protein family. Such differences are likely to influence and be important in the quest for compounds capable of selectively antagonizing the different family members.
		+
		+	Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands.,Lee EF, Czabotar PE, Yang H, Sleebs BE, Lessene G, Colman PM, Smith BJ, Fairlie WD J Biol Chem. 2009 Oct 30;284(44):30508-17. Epub 2009 Sep 2. PMID:19726685<ref>PMID:19726685</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 3inq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 27:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Human]]
	[[Category: Colman, P M]]		[[Category: Colman, P M]]
	[[Category: Czabotar, P E]]		[[Category: Czabotar, P E]]
Line 33:		Line 41:
	[[Category: Lee, E F]]		[[Category: Lee, E F]]
	[[Category: Smith, B J]]		[[Category: Smith, B J]]
		+	[[Category: Alternative splicing]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Membrane]]		[[Category: Membrane]]

OCA at 08:55, 7 February 2016

OCA — Sun, 07 Feb 2016 08:55:27 GMT

←Older revision		Revision as of 08:55, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3inq' size='340' side='right' caption='[[3inq]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='3inq' size='340' side='right' caption='[[3inq]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3inq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3INQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3inq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3INQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=X0J:4-[4-(BIPHENYL-3-YLMETHYL)PIPERAZIN-1-YL]-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLSULFANYL)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE'>X0J</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=X0J:4-[4-(BIPHENYL-3-YLMETHYL)PIPERAZIN-1-YL]-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLSULFANYL)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE'>X0J</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yxj\|2yxj]], [[3fdl\|3fdl]], [[2p1l\|2p1l]], [[3io8\|3io8]], [[3io9\|3io9]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yxj\|2yxj]], [[3fdl\|3fdl]], [[2p1l\|2p1l]], [[3io8\|3io8]], [[3io9\|3io9]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCL-X ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCL-X ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3inq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3inq RCSB], [http://www.ebi.ac.uk/pdbsum/3inq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3inq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inq OCA], [http://pdbe.org/3inq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3inq RCSB], [http://www.ebi.ac.uk/pdbsum/3inq PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3inq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Colman, P M]]		[[Category: Colman, P M]]
	[[Category: Czabotar, P E]]		[[Category: Czabotar, P E]]

OCA at 13:49, 24 December 2014

OCA — Wed, 24 Dec 2014 13:49:59 GMT

←Older revision		Revision as of 13:49, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3inq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3INQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3inq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3INQ FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=X0J:4-[4-(BIPHENYL-3-YLMETHYL)PIPERAZIN-1-YL]-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLSULFANYL)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE'>X0J</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=X0J:4-[4-(BIPHENYL-3-YLMETHYL)PIPERAZIN-1-YL]-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLSULFANYL)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE'>X0J</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yxj\|2yxj]], [[3fdl\|3fdl]], [[2p1l\|2p1l]], [[3io8\|3io8]], [[3io9\|3io9]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yxj\|2yxj]], [[3fdl\|3fdl]], [[2p1l\|2p1l]], [[3io8\|3io8]], [[3io9\|3io9]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCL-X ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCL-X ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3inq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3inq RCSB], [http://www.ebi.ac.uk/pdbsum/3inq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3inq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3inq RCSB], [http://www.ebi.ac.uk/pdbsum/3inq PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 21:		Line 23:
	==See Also==		==See Also==
	*[[Bcl-2\|Bcl-2]]		*[[Bcl-2\|Bcl-2]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Colman, P M.]]	+	[[Category: Colman, P M]]
-	[[Category: Czabotar, P E.]]	+	[[Category: Czabotar, P E]]
-	[[Category: Fairlie, W D.]]	+	[[Category: Fairlie, W D]]
-	[[Category: Lee, E F.]]	+	[[Category: Lee, E F]]
-	[[Category: Smith, B J.]]	+	[[Category: Smith, B J]]
	[[Category: Apoptosis]]		[[Category: Apoptosis]]
	[[Category: Membrane]]		[[Category: Membrane]]

OCA at 13:06, 29 September 2014

OCA — Mon, 29 Sep 2014 13:06:47 GMT

←Older revision		Revision as of 13:06, 29 September 2014
Line 1:		Line 1:
-	~~[[Image:3inq.png\|left\|200px]]~~	+	==Crystal structure of BCL-XL in complex with W1191542==
-		+	<StructureSection load='3inq' size='340' side='right' caption='[[3inq]], [[Resolution\|resolution]] 2.00Å' scene=''>
-	~~{{STRUCTURE_3inq\| PDB=3inq \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3inq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3INQ FirstGlance]. <br>
-	===Crystal structure of BCL-XL in complex with W1191542===	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=X0J:4-[4-(BIPHENYL-3-YLMETHYL)PIPERAZIN-1-YL]-N-{[4-({(1R)-3-(DIMETHYLAMINO)-1-[(PHENYLSULFANYL)METHYL]PROPYL}AMINO)-3-NITROPHENYL]SULFONYL}BENZAMIDE'>X0J</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2yxj\|2yxj]], [[3fdl\|3fdl]], [[2p1l\|2p1l]], [[3io8\|3io8]], [[3io9\|3io9]]</td></tr>
-	~~{{ABSTRACT_PUBMED_019726685}}~~	+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BCL-X ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3inq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3inq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3inq RCSB], [http://www.ebi.ac.uk/pdbsum/3inq PDBsum]</span></td></tr>
-	==~~About this Structure~~==	+	<table>
-	[[3inq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INQ OCA].	+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/in/3inq_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Bcl-2\|Bcl-2]]		*[[Bcl-2\|Bcl-2]]
-		+	__TOC__
-	~~==Reference==~~	+	</StructureSection>
-	~~<ref group="xtra">PMID:019726685</ref>~~<~~references group="xtra"~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Colman, P M.]]		[[Category: Colman, P M.]]

OCA at 06:10, 20 October 2012

OCA — Sat, 20 Oct 2012 06:10:34 GMT

←Older revision		Revision as of 06:10, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3inq]] is a 2 chain structure ~~of [[Bcl-2]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INQ OCA].	+	[[3inq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3INQ OCA].

	==See Also==		==See Also==

OCA: Protected "3inq" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 12:21:30 GMT

Protected "3inq" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:21, 25 July 2012