3iom - Revision history

OCA at 07:54, 6 September 2023

OCA — Wed, 06 Sep 2023 07:54:49 GMT

←Older revision		Revision as of 07:54, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3iom' size='340' side='right'caption='[[3iom]], [[Resolution\|resolution]] 2.14Å' scene=''>		<StructureSection load='3iom' size='340' side='right'caption='[[3iom]], [[Resolution\|resolution]] 2.14Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3iom]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus~~ tuberculosis~~" (zopf 1883) klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IOM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3iom]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IOM FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GNG:2~~-~~DEOXY-GUANOSINE'>GNG</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.14Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[1g2o\|1g2o]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNG:2-DEOXY-GUANOSINE'>GNG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>deoD, MT3406, MTV016.06, punA, punA (deoD) (Rv3307) (MT3406) (MTV016.06), Rv3307 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1773~~ "~~Bacillus tuberculosis~~" ~~(Zopf 1883) Klein 1884])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iom OCA], [https://pdbe.org/3iom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iom RCSB], [https://www.ebi.ac.uk/pdbsum/3iom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iom ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iom OCA], [https://pdbe.org/3iom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iom RCSB], [https://www.ebi.ac.uk/pdbsum/3iom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iom ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PUNA_MYCTU PUNA_MYCTU]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine (By similarity).	+	[https://www.uniprot.org/uniprot/PUNA_MYCTU PUNA_MYCTU] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Purine-nucleoside phosphorylase]]
-	[[Category: Azevedo, W F.de]]
-	[[Category: Basso, L A]]
-	[[Category: Santos, D S]]
-	[[Category: -deoxyguanosine]]
-	[[Category: Glycosyltransferase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
-	[[Category: ~~Purine nucleoside phosphorylase~~]]	+	[[Category: Basso LA]]
-	[[Category: ~~Transferase~~]]	+	[[Category: Santos DS]]
		+	[[Category: De Azevedo Jr WF]]

OCA at 03:37, 21 April 2022

OCA — Thu, 21 Apr 2022 03:37:47 GMT

←Older revision		Revision as of 03:37, 21 April 2022
Line 1:		Line 1:

	==Crystal structure of Purine Nucleoside Phosphorylase from Mycobacterium tuberculosis in complex with 2'-Deoxyguanosine==		==Crystal structure of Purine Nucleoside Phosphorylase from Mycobacterium tuberculosis in complex with 2'-Deoxyguanosine==
-	<StructureSection load='3iom' size='340' side='right' caption='[[3iom]], [[Resolution\|resolution]] 2.14Å' scene=''>	+	<StructureSection load='3iom' size='340' side='right'caption='[[3iom]], [[Resolution\|resolution]] 2.14Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3iom]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IOM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IOM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3iom]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IOM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNG:2-DEOXY-GUANOSINE'>GNG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNG:2-DEOXY-GUANOSINE'>GNG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g2o\|1g2o]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1g2o\|1g2o]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">deoD, MT3406, MTV016.06, punA, punA (deoD) (Rv3307) (MT3406) (MTV016.06), Rv3307 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">deoD, MT3406, MTV016.06, punA, punA (deoD) (Rv3307) (MT3406) (MTV016.06), Rv3307 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3iom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iom OCA], [~~http~~://pdbe.org/3iom PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3iom RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3iom PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3iom ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iom OCA], [https://pdbe.org/3iom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iom RCSB], [https://www.ebi.ac.uk/pdbsum/3iom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iom ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PUNA_MYCTU PUNA_MYCTU]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine (By similarity).	+	[[https://www.uniprot.org/uniprot/PUNA_MYCTU PUNA_MYCTU]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:

	==See Also==		==See Also==
-	*[[Purine nucleoside phosphorylase\|Purine nucleoside phosphorylase]]	+	*[[Purine nucleoside phosphorylase 3D structures\|Purine nucleoside phosphorylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Purine-nucleoside phosphorylase]]		[[Category: Purine-nucleoside phosphorylase]]
	[[Category: Azevedo, W F.de]]		[[Category: Azevedo, W F.de]]

OCA at 17:28, 4 August 2016

OCA — Thu, 04 Aug 2016 17:28:15 GMT

←Older revision		Revision as of 17:28, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of Purine Nucleoside Phosphorylase from Mycobacterium tuberculosis in complex with 2'-Deoxyguanosine==		==Crystal structure of Purine Nucleoside Phosphorylase from Mycobacterium tuberculosis in complex with 2'-Deoxyguanosine==
	<StructureSection load='3iom' size='340' side='right' caption='[[3iom]], [[Resolution\|resolution]] 2.14Å' scene=''>		<StructureSection load='3iom' size='340' side='right' caption='[[3iom]], [[Resolution\|resolution]] 2.14Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3iom]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium~~ tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IOM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IOM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3iom]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IOM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IOM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNG:2-DEOXY-GUANOSINE'>GNG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNG:2-DEOXY-GUANOSINE'>GNG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g2o\|1g2o]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g2o\|1g2o]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">deoD, MT3406, MTV016.06, punA, punA (deoD) (Rv3307) (MT3406) (MTV016.06), Rv3307 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 ~~Mycobacterium~~ tuberculosis])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">deoD, MT3406, MTV016.06, punA, punA (deoD) (Rv3307) (MT3406) (MTV016.06), Rv3307 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iom OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iom RCSB], [http://www.ebi.ac.uk/pdbsum/3iom PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iom OCA], [http://pdbe.org/3iom PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iom RCSB], [http://www.ebi.ac.uk/pdbsum/3iom PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3iom ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3iom" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 26:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Mycobacterium tuberculosis]]
	[[Category: Purine-nucleoside phosphorylase]]		[[Category: Purine-nucleoside phosphorylase]]
	[[Category: Azevedo, W F.de]]		[[Category: Azevedo, W F.de]]
Line 33:		Line 34:
	[[Category: -deoxyguanosine]]		[[Category: -deoxyguanosine]]
	[[Category: Glycosyltransferase]]		[[Category: Glycosyltransferase]]
		+	[[Category: Mycobacterium tuberculosis]]
	[[Category: Purine nucleoside phosphorylase]]		[[Category: Purine nucleoside phosphorylase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 11:24, 25 December 2014

OCA — Thu, 25 Dec 2014 11:24:26 GMT

←Older revision		Revision as of 11:24, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iom OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iom RCSB], [http://www.ebi.ac.uk/pdbsum/3iom PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iom OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iom RCSB], [http://www.ebi.ac.uk/pdbsum/3iom PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PUNA_MYCTU PUNA_MYCTU]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 15:14, 18 December 2014

OCA — Thu, 18 Dec 2014 15:14:28 GMT

←Older revision		Revision as of 15:14, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3iom\| PDB=3iom \| SCENE= }}~~	+	==Crystal structure of Purine Nucleoside Phosphorylase from Mycobacterium tuberculosis in complex with 2'-Deoxyguanosine==
-	===Crystal structure of Purine Nucleoside Phosphorylase from Mycobacterium tuberculosis in complex with 2'-Deoxyguanosine===	+	<StructureSection load='3iom' size='340' side='right' caption='[[3iom]], [[Resolution\|resolution]] 2.14Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20570524}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3iom]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IOM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IOM FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNG:2-DEOXY-GUANOSINE'>GNG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g2o\|1g2o]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">deoD, MT3406, MTV016.06, punA, punA (deoD) (Rv3307) (MT3406) (MTV016.06), Rv3307 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Purine-nucleoside_phosphorylase Purine-nucleoside phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.1 2.4.2.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iom OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iom RCSB], [http://www.ebi.ac.uk/pdbsum/3iom PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	This work describes for the first time the structure of purine nucleoside phosphorylase from Mycobacterium tuberculosis (MtPNP) in complex with sulfate and its natural substrate, 2'-deoxyguanosine, and its application to virtual screening. We report docking studies of a set of molecules against this structure. Application of polynomial empirical scoring function was able to rank docking solutions with good predicting power which opens the possibility to apply this new criterion to analyze docking solutions and screen small-molecule databases for new chemical entities to inhibit MtPNP.

-	~~==Function==~~	+	Crystallographic and docking studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis.,Ducati RG, Basso LA, Santos DS, de Azevedo WF Jr Bioorg Med Chem. 2010 May 10. PMID:20570524<ref>PMID:20570524</ref>
-	~~[[http://www.uniprot.org/uniprot/PUNA_MYCTU PUNA_MYCTU]] The~~ purine nucleoside ~~phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules~~, ~~with the formation of the corresponding free purine bases and pentose-1-phosphate~~. ~~Cleaves guanosine and inosine (By similarity)~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3iom]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3IOM OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:020570524</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Purine nucleoside phosphorylase\|Purine nucleoside phosphorylase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Purine-nucleoside phosphorylase]]		[[Category: Purine-nucleoside phosphorylase]]
-	[[Category: Azevedo, W F.de.]]	+	[[Category: Azevedo, W F.de]]
-	[[Category: Basso, L A.]]	+	[[Category: Basso, L A]]
-	[[Category: Santos, D S.]]	+	[[Category: Santos, D S]]
-	[[Category: 2 -deoxyguanosine]]	+	[[Category: -deoxyguanosine]]
	[[Category: Glycosyltransferase]]		[[Category: Glycosyltransferase]]
-	[[Category: Mycobacterium tuberculosis]]
	[[Category: Purine nucleoside phosphorylase]]		[[Category: Purine nucleoside phosphorylase]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 11:42, 24 April 2013

OCA — Wed, 24 Apr 2013 11:42:06 GMT

←Older revision		Revision as of 11:42, 24 April 2013
Line 1:		Line 1:
-	[[Image:3iom.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3iom", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3iom\| PDB=3iom \| SCENE= }}		{{STRUCTURE_3iom\| PDB=3iom \| SCENE= }}
-
	===Crystal structure of Purine Nucleoside Phosphorylase from Mycobacterium tuberculosis in complex with 2'-Deoxyguanosine===		===Crystal structure of Purine Nucleoside Phosphorylase from Mycobacterium tuberculosis in complex with 2'-Deoxyguanosine===
		+	{{ABSTRACT_PUBMED_20570524}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/PUNA_MYCTU PUNA_MYCTU]] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine (By similarity).
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20570524}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~), ~~where 20570524 is~~ the ~~PubMed ID number.~~	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20570524}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020570524</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020570524</ref><references group="xtra"/><references/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Purine-nucleoside phosphorylase]]		[[Category: Purine-nucleoside phosphorylase]]

OCA at 15:52, 22 June 2011

OCA — Wed, 22 Jun 2011 15:52:09 GMT

←Older revision		Revision as of 15:52, 22 June 2011
Line 1:		Line 1:
-	[[Image:3iom.~~jpg~~\|left\|200px]]	+	[[Image:3iom.png\|left\|200px]]

	<!--		<!--
Line 22:		Line 22:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20570524~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020570524</ref><references group="xtra"/>
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Purine-nucleoside phosphorylase]]		[[Category: Purine-nucleoside phosphorylase]]
Line 28:		Line 28:
	[[Category: Basso, L A.]]		[[Category: Basso, L A.]]
	[[Category: Santos, D S.]]		[[Category: Santos, D S.]]
		+	[[Category: 2 -deoxyguanosine]]
		+	[[Category: Glycosyltransferase]]
		+	[[Category: Mycobacterium tuberculosis]]
		+	[[Category: Purine nucleoside phosphorylase]]
		+	[[Category: Transferase]]

OCA: Protected "3iom" [edit=sysop:move=sysop]

OCA — Wed, 12 Jan 2011 05:12:08 GMT

Protected "3iom" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:12, 12 January 2011

OCA at 05:12, 12 January 2011

OCA — Wed, 12 Jan 2011 05:12:05 GMT

←Older revision		Revision as of 05:12, 12 January 2011
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	[[Image:3iom.jpg\|left\|200px]]

-	The ~~entry 3iom~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3iom", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3iom\| PDB=3iom \| SCENE= }}

-	~~Authors: de Azevedo Jr., W.F., Basso, L.A., Santos, D.S.~~	+	===Crystal structure of Purine Nucleoside Phosphorylase from Mycobacterium tuberculosis in complex with 2'-Deoxyguanosine===

-	Description: Crystal structure of Purine Nucleoside Phosphorylase from Mycobacterium tuberculosis in complex with 2'-Deoxyguanosine

-	~~''Page seeded by~~ [http://oca.weizmann.ac.il/oca OCA ] ~~on Thu Sep 3 15~~:22:~~13 2009''~~	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20570524}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20570524 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20570524}}
		+
		+	==About this Structure==
		+	[[3iom]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IOM OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20570524</ref><references group="xtra"/>
		+	[[Category: Mycobacterium tuberculosis]]
		+	[[Category: Purine-nucleoside phosphorylase]]
		+	[[Category: Azevedo, W F.de.]]
		+	[[Category: Basso, L A.]]
		+	[[Category: Santos, D S.]]

OCA: New page: '''Unreleased structure''' The entry 3iom is ON HOLD Authors: de Azevedo Jr., W.F., Basso, L.A., Santos, D.S. Description: Crystal structure of Purine Nucleoside Phosphorylase from Myc...

OCA — Thu, 03 Sep 2009 12:22:14 GMT

New page: '''Unreleased structure''' The entry 3iom is ON HOLD Authors: de Azevedo Jr., W.F., Basso, L.A., Santos, D.S. Description: Crystal structure of Purine Nucleoside Phosphorylase from Myc...

New page

'''Unreleased structure'''

The entry 3iom is ON HOLD

Authors: de Azevedo Jr., W.F., Basso, L.A., Santos, D.S.

Description: Crystal structure of Purine Nucleoside Phosphorylase from Mycobacterium tuberculosis in complex with 2'-Deoxyguanosine

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Sep 3 15:22:13 2009''