3irm - Revision history

OCA at 07:56, 6 September 2023

OCA — Wed, 06 Sep 2023 07:56:53 GMT

←Older revision		Revision as of 07:56, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3irm' size='340' side='right'caption='[[3irm]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3irm' size='340' side='right'caption='[[3irm]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3irm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Trycr Trycr~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IRM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IRM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3irm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IRM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IRM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CY:1-(4-CHLOROPHENYL)-6,6-DIMETHYL-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>1CY</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3cl9\|3cl9]], [[3hbb\|3hbb]], [[2h2q\|2h2q]], [[3clb\|3clb]], [[3inv\|3inv]], [[3irn\|3irn]], [[3iro\|3iro]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CY:1-(4-CHLOROPHENYL)-6,6-DIMETHYL-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>1CY</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3irm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3irm OCA], [https://pdbe.org/3irm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3irm RCSB], [https://www.ebi.ac.uk/pdbsum/3irm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3irm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3irm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3irm OCA], [https://pdbe.org/3irm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3irm RCSB], [https://www.ebi.ac.uk/pdbsum/3irm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3irm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/DRTS_TRYCR DRTS_TRYCR]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.[HAMAP-Rule:MF_00008]	+	[https://www.uniprot.org/uniprot/DRTS_TRYCR DRTS_TRYCR] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.[HAMAP-Rule:MF_00008]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Trycr]]
-	[[Category: Chitnumsub, P]]
-	[[Category: Yuthavong, Y]]
-	[[Category: Yuvaniyama, J]]
-	[[Category: Dhfr-ts antifolate complex]]
-	[[Category: Methyltransferase]]
-	[[Category: Multifunctional enzyme]]
-	[[Category: Nadp]]
-	[[Category: Nucleotide biosynthesis]]
-	[[Category: One-carbon metabolism]]
-	[[Category: Oxidoreductase]]
-	[[Category: Transferase]]
	[[Category: Trypanosoma cruzi]]		[[Category: Trypanosoma cruzi]]
		+	[[Category: Chitnumsub P]]
		+	[[Category: Yuthavong Y]]
		+	[[Category: Yuvaniyama J]]

OCA at 03:39, 21 April 2022

OCA — Thu, 21 Apr 2022 03:39:45 GMT

←Older revision		Revision as of 03:39, 21 April 2022
Line 3:		Line 3:
	<StructureSection load='3irm' size='340' side='right'caption='[[3irm]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3irm' size='340' side='right'caption='[[3irm]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3irm]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IRM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IRM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3irm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IRM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IRM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1CY:1-(4-CHLOROPHENYL)-6,6-DIMETHYL-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>1CY</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CY:1-(4-CHLOROPHENYL)-6,6-DIMETHYL-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>1CY</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cl9\|3cl9]], [[3hbb\|3hbb]], [[2h2q\|2h2q]], [[3clb\|3clb]], [[3inv\|3inv]], [[3irn\|3irn]], [[3iro\|3iro]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3cl9\|3cl9]], [[3hbb\|3hbb]], [[2h2q\|2h2q]], [[3clb\|3clb]], [[3inv\|3inv]], [[3irn\|3irn]], [[3iro\|3iro]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3irm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3irm OCA], [~~http~~://pdbe.org/3irm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3irm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3irm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3irm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3irm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3irm OCA], [https://pdbe.org/3irm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3irm RCSB], [https://www.ebi.ac.uk/pdbsum/3irm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3irm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/DRTS_TRYCR DRTS_TRYCR]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.[HAMAP-Rule:MF_00008]	+	[[https://www.uniprot.org/uniprot/DRTS_TRYCR DRTS_TRYCR]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.[HAMAP-Rule:MF_00008]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:03, 7 August 2019

OCA — Wed, 07 Aug 2019 07:03:18 GMT

←Older revision		Revision as of 07:03, 7 August 2019
Line 1:		Line 1:

	==Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH Cycloguanil==		==Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH Cycloguanil==
-	<StructureSection load='3irm' size='340' side='right' caption='[[3irm]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='3irm' size='340' side='right'caption='[[3irm]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3irm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IRM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IRM FirstGlance]. <br>		<table><tr><td colspan='2'>[[3irm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IRM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IRM FirstGlance]. <br>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ir/3irm_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ir/3irm_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3irm ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3irm ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+
		+	==See Also==
		+	*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Trycr]]		[[Category: Trycr]]
	[[Category: Chitnumsub, P]]		[[Category: Chitnumsub, P]]

OCA at 08:12, 1 November 2017

OCA — Wed, 01 Nov 2017 08:12:25 GMT

←Older revision		Revision as of 08:12, 1 November 2017
Line 20:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3irm ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3irm ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-
-	==See Also==
-	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 13:45, 5 August 2016

OCA — Fri, 05 Aug 2016 13:45:39 GMT

←Older revision		Revision as of 13:45, 5 August 2016
Line 1:		Line 1:
		+
	==Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH Cycloguanil==		==Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH Cycloguanil==
	<StructureSection load='3irm' size='340' side='right' caption='[[3irm]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='3irm' size='340' side='right' caption='[[3irm]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3irm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Trypanosoma_cruzi Trypanosoma cruzi~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IRM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IRM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3irm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IRM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IRM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1CY:1-(4-CHLOROPHENYL)-6,6-DIMETHYL-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>1CY</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1CY:1-(4-CHLOROPHENYL)-6,6-DIMETHYL-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>1CY</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cl9\|3cl9]], [[3hbb\|3hbb]], [[2h2q\|2h2q]], [[3clb\|3clb]], [[3inv\|3inv]], [[3irn\|3irn]], [[3iro\|3iro]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cl9\|3cl9]], [[3hbb\|3hbb]], [[2h2q\|2h2q]], [[3clb\|3clb]], [[3inv\|3inv]], [[3irn\|3irn]], [[3iro\|3iro]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3irm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3irm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3irm RCSB], [http://www.ebi.ac.uk/pdbsum/3irm PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3irm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3irm OCA], [http://pdbe.org/3irm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3irm RCSB], [http://www.ebi.ac.uk/pdbsum/3irm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3irm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3irm ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Trypanosoma cruzi~~]]	+	[[Category: Trycr]]
	[[Category: Chitnumsub, P]]		[[Category: Chitnumsub, P]]
	[[Category: Yuthavong, Y]]		[[Category: Yuthavong, Y]]
Line 36:		Line 37:
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Transferase]]		[[Category: Transferase]]
		+	[[Category: Trypanosoma cruzi]]

OCA at 02:59, 25 December 2014

OCA — Thu, 25 Dec 2014 02:59:23 GMT

←Older revision		Revision as of 02:59, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3irm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3irm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3irm RCSB], [http://www.ebi.ac.uk/pdbsum/3irm PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3irm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3irm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3irm RCSB], [http://www.ebi.ac.uk/pdbsum/3irm PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DRTS_TRYCR DRTS_TRYCR]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.[HAMAP-Rule:MF_00008]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:21, 8 December 2014

OCA — Mon, 08 Dec 2014 09:21:29 GMT

←Older revision		Revision as of 09:21, 8 December 2014
Line 1:		Line 1:
-	~~[[Image:3irm.png\|left\|200px]]~~	+	==Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH Cycloguanil==
-		+	<StructureSection load='3irm' size='340' side='right' caption='[[3irm]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~{{STRUCTURE_3irm\| PDB=3irm \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3irm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IRM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IRM FirstGlance]. <br>
-	===Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate Synthase COMPLEXED WITH Cycloguanil===	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1CY:1-(4-CHLOROPHENYL)-6,6-DIMETHYL-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE'>1CY</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3cl9\|3cl9]], [[3hbb\|3hbb]], [[2h2q\|2h2q]], [[3clb\|3clb]], [[3inv\|3inv]], [[3irn\|3irn]], [[3iro\|3iro]]</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3irm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3irm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3irm RCSB], [http://www.ebi.ac.uk/pdbsum/3irm PDBsum]</span></td></tr>
-	==~~About this Structure~~==	+	</table>
-	[[3irm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IRM OCA].	+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ir/3irm_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]		*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
-	*[[Thymidylate synthase\|Thymidylate synthase]]	+	__TOC__
		+	</StructureSection>
	[[Category: Trypanosoma cruzi]]		[[Category: Trypanosoma cruzi]]
-	[[Category: Chitnumsub, P.]]	+	[[Category: Chitnumsub, P]]
-	[[Category: Yuthavong, Y.]]	+	[[Category: Yuthavong, Y]]
-	[[Category: Yuvaniyama, J.]]	+	[[Category: Yuvaniyama, J]]
	[[Category: Dhfr-ts antifolate complex]]		[[Category: Dhfr-ts antifolate complex]]
	[[Category: Methyltransferase]]		[[Category: Methyltransferase]]
Line 24:		Line 34:
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Transferase]]		[[Category: Transferase]]
-	[[Category: Trypanosoma cruzi]]

OCA at 11:53, 20 October 2012

OCA — Sat, 20 Oct 2012 11:53:28 GMT

←Older revision		Revision as of 11:53, 20 October 2012
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3irm]] is a 4 chain structure ~~of [[Dihydrofolate reductase]] and [[Thymidylate synthase]]~~ with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IRM OCA].	+	[[3irm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IRM OCA].

	==See Also==		==See Also==

OCA: Protected "3irm" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 06:56:19 GMT

Protected "3irm" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:56, 26 July 2012

OCA at 06:56, 26 July 2012

OCA — Thu, 26 Jul 2012 06:56:17 GMT

←Older revision		Revision as of 06:56, 26 July 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3irm.png\|left\|200px]]
-	[[Image:3irm.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3irm", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3irm\| PDB=3irm \| SCENE= }}		{{STRUCTURE_3irm\| PDB=3irm \| SCENE= }}

Line 14:		Line 7:

	==About this Structure==		==About this Structure==
-	~~3IRM~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IRM OCA].	+	[[3irm]] is a 4 chain structure of [[Dihydrofolate reductase]] and [[Thymidylate synthase]] with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IRM OCA].
		+
		+	==See Also==
		+	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
		+	*[[Thymidylate synthase\|Thymidylate synthase]]
	[[Category: Trypanosoma cruzi]]		[[Category: Trypanosoma cruzi]]
	[[Category: Chitnumsub, P.]]		[[Category: Chitnumsub, P.]]
Line 28:		Line 25:
	[[Category: Transferase]]		[[Category: Transferase]]
	[[Category: Trypanosoma cruzi]]		[[Category: Trypanosoma cruzi]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 28 12:36:18 2010''