3iu5 - Revision history

OCA at 07:58, 6 September 2023

OCA — Wed, 06 Sep 2023 07:58:05 GMT

←Older revision		Revision as of 07:58, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3iu5' size='340' side='right'caption='[[3iu5]], [[Resolution\|resolution]] 1.63Å' scene=''>		<StructureSection load='3iu5' size='340' side='right'caption='[[3iu5]], [[Resolution\|resolution]] 1.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3iu5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IU5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IU5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3iu5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IU5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IU5 FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PB1~~, ~~PBRM1 (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.63Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iu5 OCA], [https://pdbe.org/3iu5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iu5 RCSB], [https://www.ebi.ac.uk/pdbsum/3iu5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iu5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iu5 OCA], [https://pdbe.org/3iu5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iu5 RCSB], [https://www.ebi.ac.uk/pdbsum/3iu5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iu5 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>	+	[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>	+	[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Edwards AM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Filippakopoulos P]]
-	[[Category: Filippakopoulos, P]]	+	[[Category: Keates T]]
-	[[Category: Keates, T]]	+	[[Category: Knapp S]]
-	[[Category: Knapp, S]]	+	[[Category: Picaud S]]
-	[[Category: Picaud, S]]	+	[[Category: Ugochukwu E]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Weigelt J]]
-	[[Category: Ugochukwu, E]]	+	[[Category: Von Delft F]]
-	[[Category: Weigelt, J]]	+
-	[[Category: ~~Baf180]]~~	+
-	~~[[Category: Brg1-associated factor 180]]~~	+
-	~~[[Category: Bromodomain]]~~	+
-	~~[[Category: Chromatin regulator]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Pb1]]~~	+
-	~~[[Category: Pbrm1]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Polybromo 1 isoform 1]]~~	+
-	~~[[Category: Polybromo0id]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation~~]]	+

OCA at 03:42, 21 April 2022

OCA — Thu, 21 Apr 2022 03:42:08 GMT

←Older revision		Revision as of 03:42, 21 April 2022
Line 1:		Line 1:

	==Crystal structure of the first bromodomain of human poly-bromodomain containing protein 1 (PB1)==		==Crystal structure of the first bromodomain of human poly-bromodomain containing protein 1 (PB1)==
-	<StructureSection load='3iu5' size='340' side='right' caption='[[3iu5]], [[Resolution\|resolution]] 1.63Å' scene=''>	+	<StructureSection load='3iu5' size='340' side='right'caption='[[3iu5]], [[Resolution\|resolution]] 1.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3iu5]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IU5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IU5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3iu5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IU5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IU5 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PB1, PBRM1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PB1, PBRM1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3iu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iu5 OCA], [~~http~~://pdbe.org/3iu5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3iu5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3iu5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3iu5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iu5 OCA], [https://pdbe.org/3iu5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iu5 RCSB], [https://www.ebi.ac.uk/pdbsum/3iu5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iu5 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[[~~http~~://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[~~http~~://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>	+	[[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>	+	[[https://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 10:10, 19 December 2018

OCA — Wed, 19 Dec 2018 10:10:37 GMT

←Older revision		Revision as of 10:10, 19 December 2018
Line 1:		Line 1:
		+
	==Crystal structure of the first bromodomain of human poly-bromodomain containing protein 1 (PB1)==		==Crystal structure of the first bromodomain of human poly-bromodomain containing protein 1 (PB1)==
	<StructureSection load='3iu5' size='340' side='right' caption='[[3iu5]], [[Resolution\|resolution]] 1.63Å' scene=''>		<StructureSection load='3iu5' size='340' side='right' caption='[[3iu5]], [[Resolution\|resolution]] 1.63Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3iu5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IU5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IU5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3iu5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IU5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IU5 FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PB1, PBRM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PB1, PBRM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iu5 OCA], [http://pdbe.org/3iu5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iu5 RCSB], [http://www.ebi.ac.uk/pdbsum/3iu5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iu5 OCA], [http://pdbe.org/3iu5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iu5 RCSB], [http://www.ebi.ac.uk/pdbsum/3iu5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3iu5 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iu/3iu5_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iu/3iu5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 17:58, 9 February 2016

OCA — Tue, 09 Feb 2016 17:58:48 GMT

←Older revision		Revision as of 17:58, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3iu5' size='340' side='right' caption='[[3iu5]], [[Resolution\|resolution]] 1.63Å' scene=''>		<StructureSection load='3iu5' size='340' side='right' caption='[[3iu5]], [[Resolution\|resolution]] 1.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3iu5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IU5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IU5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3iu5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IU5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IU5 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PB1, PBRM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PB1, PBRM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iu5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iu5 RCSB], [http://www.ebi.ac.uk/pdbsum/3iu5 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iu5 OCA], [http://pdbe.org/3iu5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iu5 RCSB], [http://www.ebi.ac.uk/pdbsum/3iu5 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iu5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3iu5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 17:16, 18 December 2014

OCA — Thu, 18 Dec 2014 17:16:52 GMT

←Older revision		Revision as of 17:16, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3iu5\| PDB=3iu5 \| SCENE= }}~~	+	==Crystal structure of the first bromodomain of human poly-bromodomain containing protein 1 (PB1)==
-	===Crystal structure of the first bromodomain of human poly-bromodomain containing protein 1 (PB1)===	+	<StructureSection load='3iu5' size='340' side='right' caption='[[3iu5]], [[Resolution\|resolution]] 1.63Å' scene=''>
-	~~{{ABSTRACT_PUBMED_22464331}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3iu5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IU5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IU5 FirstGlance]. <br>
		+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PB1, PBRM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iu5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iu5 RCSB], [http://www.ebi.ac.uk/pdbsum/3iu5 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[http://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iu/3iu5_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bromodomains (BRDs) are protein interaction modules that specifically recognize epsilon-N-lysine acetylation motifs, a key event in the reading process of epigenetic marks. The 61 BRDs in the human genome cluster into eight families based on structure/sequence similarity. Here, we present 29 high-resolution crystal structures, covering all BRD families. Comprehensive crossfamily structural analysis identifies conserved and family-specific structural features that are necessary for specific acetylation-dependent substrate recognition. Screening of more than 30 representative BRDs against systematic histone-peptide arrays identifies new BRD substrates and reveals a strong influence of flanking posttranslational modifications, such as acetylation and phosphorylation, suggesting that BRDs recognize combinations of marks rather than singly acetylated sequences. We further uncovered a structural mechanism for the simultaneous binding and recognition of diverse diacetyl-containing peptides by BRD4. These data provide a foundation for structure-based drug design of specific inhibitors for this emerging target family.

-	~~==Disease==~~	+	Histone recognition and large-scale structural analysis of the human bromodomain family.,Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Muller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S Cell. 2012 Mar 30;149(1):214-31. PMID:22464331<ref>PMID:22464331</ref>
-	[[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[http://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the ~~proximal renal tubular epithelium~~. ~~It is subclassified into clear cell renal carcinoma (non~~-~~papillary carcinoma)~~, ~~papillary renal cell carcinoma~~, ~~chromophobe renal cell carcinoma~~, ~~collecting duct carcinoma with medullary carcinoma of the kidney~~, ~~and unclassified renal cell carcinoma~~.<ref>PMID:~~21248752~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www~~.~~uniprot~~.~~org/uniprot/PB1_HUMAN PB1_HUMAN]] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration~~ of ~~DNA-nucleosome topology). Acts as a negative regulator of cell proliferation~~.<~~ref~~>~~PMID:21248752~~</~~ref~~>	+	</div>
-		+	== References ==
-	==~~About this Structure==~~	+	<references/>
-	[[3iu5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IU5 OCA].	+	__TOC__
-		+	</StructureSection>
-	~~==Reference~~==	+
-	~~<ref group="xtra">PMID:022464331</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Delft, F von.]]	+	[[Category: Delft, F von]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Filippakopoulos, P.]]	+	[[Category: Filippakopoulos, P]]
-	[[Category: Keates, T.]]	+	[[Category: Keates, T]]
-	[[Category: Knapp, S.]]	+	[[Category: Knapp, S]]
-	[[Category: Picaud, S.]]	+	[[Category: Picaud, S]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Ugochukwu, E.]]	+	[[Category: Ugochukwu, E]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
	[[Category: Baf180]]		[[Category: Baf180]]
	[[Category: Brg1-associated factor 180]]		[[Category: Brg1-associated factor 180]]
Line 38:		Line 56:
	[[Category: Polybromo0id]]		[[Category: Polybromo0id]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium]]
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]

OCA at 16:51, 24 March 2013

OCA — Sun, 24 Mar 2013 16:51:22 GMT

←Older revision		Revision as of 16:51, 24 March 2013
Line 1:		Line 1:
-	[[Image:3iu5.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3iu5", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3iu5\| PDB=3iu5 \| SCENE= }}		{{STRUCTURE_3iu5\| PDB=3iu5 \| SCENE= }}
-
	===Crystal structure of the first bromodomain of human poly-bromodomain containing protein 1 (PB1)===		===Crystal structure of the first bromodomain of human poly-bromodomain containing protein 1 (PB1)===
		+	{{ABSTRACT_PUBMED_22464331}}

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[http://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>

-	~~<!--~~	+	==Function==
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_22464331}}, adds the Publication Abstract to the page~~	+	[[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~)~~, where 22464331 is the PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_22464331}}~~	+

	==About this Structure==		==About this Structure==
Line 22:		Line 13:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:022464331</ref><references group="xtra"/>	+	<ref group="xtra">PMID:022464331</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]

OCA: Protected "3iu5" [edit=sysop:move=sysop]

OCA — Wed, 11 Apr 2012 06:13:13 GMT

Protected "3iu5" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:13, 11 April 2012

OCA at 06:13, 11 April 2012

OCA — Wed, 11 Apr 2012 06:13:11 GMT

←Older revision		Revision as of 06:13, 11 April 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3iu5.png\|left\|200px]]
-	[[Image:3iu5.~~jpg~~\|left\|200px]]	+

	<!--		<!--
Line 12:		Line 11:
	===Crystal structure of the first bromodomain of human poly-bromodomain containing protein 1 (PB1)===		===Crystal structure of the first bromodomain of human poly-bromodomain containing protein 1 (PB1)===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_22464331}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 22464331 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_22464331}}

	==About this Structure==		==About this Structure==
-	~~3IU5~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IU5 OCA].	+	[[3iu5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IU5 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:022464331</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
Line 27:		Line 35:
	[[Category: Ugochukwu, E.]]		[[Category: Ugochukwu, E.]]
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J.]]
-	[[Category: Alternative splicing]]
	[[Category: Baf180]]		[[Category: Baf180]]
	[[Category: Brg1-associated factor 180]]		[[Category: Brg1-associated factor 180]]
Line 44:		Line 51:
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 23 09:01:04 2009''

OCA at 06:01, 23 September 2009

OCA — Wed, 23 Sep 2009 06:01:05 GMT

←Older revision		Revision as of 06:01, 23 September 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3iu5.jpg\|left\|200px]]

-	The ~~entry 3iu5~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3iu5", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3iu5\| PDB=3iu5 \| SCENE= }}

-	~~Authors: Filippakopoulos, P., Picaud, S., Keates, T., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium~~ (~~SGC~~)	+	===Crystal structure of the first bromodomain of human poly-bromodomain containing protein 1 (PB1)===

-	Description: Crystal structure of the first bromodomain of human poly-bromodomain containing protein 1 (PB1)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 9 09:07:52 2009''	+	==About this Structure==
		+	3IU5 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IU5 OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Delft, F von.]]
		+	[[Category: Edwards, A M.]]
		+	[[Category: Filippakopoulos, P.]]
		+	[[Category: Keates, T.]]
		+	[[Category: Knapp, S.]]
		+	[[Category: Picaud, S.]]
		+	[[Category: SGC, Structural Genomics Consortium.]]
		+	[[Category: Ugochukwu, E.]]
		+	[[Category: Weigelt, J.]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Baf180]]
		+	[[Category: Brg1-associated factor 180]]
		+	[[Category: Bromodomain]]
		+	[[Category: Chromatin regulator]]
		+	[[Category: Dna-binding]]
		+	[[Category: Nucleus]]
		+	[[Category: Pb1]]
		+	[[Category: Pbrm1]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Polybromo 1 isoform 1]]
		+	[[Category: Polybromo0id]]
		+	[[Category: Sgc]]
		+	[[Category: Structural genomic]]
		+	[[Category: Structural genomics consortium]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription regulation]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 23 09:01:04 2009''

OCA: New page: '''Unreleased structure''' The entry 3iu5 is ON HOLD Authors: Filippakopoulos, P., Picaud, S., Keates, T., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bo...

OCA — Wed, 09 Sep 2009 06:07:53 GMT

New page: '''Unreleased structure''' The entry 3iu5 is ON HOLD Authors: Filippakopoulos, P., Picaud, S., Keates, T., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bo...

New page

'''Unreleased structure'''

The entry 3iu5 is ON HOLD

Authors: Filippakopoulos, P., Picaud, S., Keates, T., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

Description: Crystal structure of the first bromodomain of human poly-bromodomain containing protein 1 (PB1)

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 9 09:07:52 2009''