3ivz - Revision history

OCA at 07:59, 6 September 2023

OCA — Wed, 06 Sep 2023 07:59:03 GMT

←Older revision		Revision as of 07:59, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3ivz' size='340' side='right'caption='[[3ivz]], [[Resolution\|resolution]] 1.57Å' scene=''>		<StructureSection load='3ivz' size='340' side='right'caption='[[3ivz]], [[Resolution\|resolution]] 1.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ivz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Pyrab Pyrab~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IVZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ivz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_abyssi_GE5 Pyrococcus abyssi GE5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IVZ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.57Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>~~</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3iw3\|3iw3]]</div></td></tr>~~	+
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nit-30~~, ~~PAB1449, PYRAB13990 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272844 PYRAB])~~<~~/td></tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Beta-ureidopropionase Beta-ureidopropionase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.6 3.5.1.6]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ivz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ivz OCA], [https://pdbe.org/3ivz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ivz RCSB], [https://www.ebi.ac.uk/pdbsum/3ivz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ivz ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ivz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ivz OCA], [https://pdbe.org/3ivz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ivz RCSB], [https://www.ebi.ac.uk/pdbsum/3ivz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ivz ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/NITR_PYRAB NITR_PYRAB] Nitrilase that hydrolyzes preferentially aliphatic nitriles like malononitrile and fumaronitrile in vitro. These dinitriles are converted to the corresponding monoacid mononitriles, showing the enzyme is regioselective. Cannot hydrolyze compounds with a nitrile group bound to an aromatic ring or amino acid. Its biological role is unknown.<ref>PMID:16495079</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Beta-ureidopropionase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Pyrab~~]]	+	[[Category: Pyrococcus abyssi GE5]]
-	[[Category: Antranikian, G]]	+	[[Category: Antranikian G]]
-	[[Category: Raczynska, J]]	+	[[Category: Raczynska J]]
-	[[Category: Rypniewski, W]]	+	[[Category: Rypniewski W]]
-	[[Category: Vorgias, C]]	+	[[Category: Vorgias C]]
-	~~[[Category: Alpha-beta sandwich]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 03:43, 21 April 2022

OCA — Thu, 21 Apr 2022 03:43:31 GMT

←Older revision		Revision as of 03:43, 21 April 2022
Line 1:		Line 1:

	==Crystal structure of hyperthermophilic nitrilase==		==Crystal structure of hyperthermophilic nitrilase==
-	<StructureSection load='3ivz' size='340' side='right' caption='[[3ivz]], [[Resolution\|resolution]] 1.57Å' scene=''>	+	<StructureSection load='3ivz' size='340' side='right'caption='[[3ivz]], [[Resolution\|resolution]] 1.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ivz]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Pyrab Pyrab]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IVZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IVZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ivz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrab Pyrab]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IVZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3iw3\|3iw3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3iw3\|3iw3]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nit-30, PAB1449, PYRAB13990 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272844 PYRAB])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nit-30, PAB1449, PYRAB13990 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272844 PYRAB])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Beta-ureidopropionase Beta-ureidopropionase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.6 3.5.1.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-ureidopropionase Beta-ureidopropionase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.6 3.5.1.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ivz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ivz OCA], [~~http~~://pdbe.org/3ivz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ivz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ivz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ivz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ivz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ivz OCA], [https://pdbe.org/3ivz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ivz RCSB], [https://www.ebi.ac.uk/pdbsum/3ivz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ivz ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Beta-ureidopropionase]]		[[Category: Beta-ureidopropionase]]
		+	[[Category: Large Structures]]
	[[Category: Pyrab]]		[[Category: Pyrab]]
	[[Category: Antranikian, G]]		[[Category: Antranikian, G]]

OCA at 09:23, 19 December 2018

OCA — Wed, 19 Dec 2018 09:23:28 GMT

←Older revision		Revision as of 09:23, 19 December 2018
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iv/3ivz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iv/3ivz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 19:42, 5 August 2016

OCA — Fri, 05 Aug 2016 19:42:03 GMT

←Older revision		Revision as of 19:42, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of hyperthermophilic nitrilase==		==Crystal structure of hyperthermophilic nitrilase==
	<StructureSection load='3ivz' size='340' side='right' caption='[[3ivz]], [[Resolution\|resolution]] 1.57Å' scene=''>		<StructureSection load='3ivz' size='340' side='right' caption='[[3ivz]], [[Resolution\|resolution]] 1.57Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ivz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pyrococcus_abyssi Pyrococcus abyssi~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IVZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ivz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrab Pyrab]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IVZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3iw3\|3iw3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3iw3\|3iw3]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nit-30, PAB1449, PYRAB13990 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~29292 Pyrococcus abyssi~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nit-30, PAB1449, PYRAB13990 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272844 PYRAB])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ureidopropionase Beta-ureidopropionase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.6 3.5.1.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ureidopropionase Beta-ureidopropionase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.6 3.5.1.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ivz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ivz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ivz RCSB], [http://www.ebi.ac.uk/pdbsum/3ivz PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ivz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ivz OCA], [http://pdbe.org/3ivz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ivz RCSB], [http://www.ebi.ac.uk/pdbsum/3ivz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ivz ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ivz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ivz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Beta-ureidopropionase]]		[[Category: Beta-ureidopropionase]]
-	[[Category: ~~Pyrococcus abyssi~~]]	+	[[Category: Pyrab]]
	[[Category: Antranikian, G]]		[[Category: Antranikian, G]]
	[[Category: Raczynska, J]]		[[Category: Raczynska, J]]

OCA at 15:51, 18 December 2014

OCA — Thu, 18 Dec 2014 15:51:41 GMT

←Older revision		Revision as of 15:51, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3ivz~~\| ~~PDB~~=3ivz \| ~~SCENE~~= }}	+	==Crystal structure of hyperthermophilic nitrilase==
-	===~~Crystal~~ structure of ~~hyperthermophilic nitrilase~~===	+	<StructureSection load='3ivz' size='340' side='right' caption='[[3ivz]], [[Resolution\|resolution]] 1.57Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21095228}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ivz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_abyssi Pyrococcus abyssi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IVZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3iw3\|3iw3]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">nit-30, PAB1449, PYRAB13990 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29292 Pyrococcus abyssi])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-ureidopropionase Beta-ureidopropionase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.6 3.5.1.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ivz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ivz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ivz RCSB], [http://www.ebi.ac.uk/pdbsum/3ivz PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iv/3ivz_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The nitrilase superfamily is a large and diverse superfamily of enzymes that catalyse the cleavage of various types of carbon-nitrogen bonds using a Cys-Glu-Lys catalytic triad. Thermoactive nitrilase from Pyrococcus abyssi (PaNit) hydrolyses small aliphatic nitriles like fumaro- and malononitryl. Yet, the biological role of this enzyme is unknown. We have analysed several crystal structures of PaNit: without ligands, with an acetate ion bound in the active site and with a bromide ion in the active site. In addition, docking calculations have been performed for fumaro- and malononitriles. The structures provide a proof for specific binding of the carboxylate ion and a general affinity for negatively changed ligands. The role of residues in the active site is considered and an enzymatic reaction mechanism is proposed in which Cys146 acts as the nucleophile, Glu42 as the general base, Lys113/Glu42 as the general acid, WatA as the hydrolytic water and Nzeta_Lys113 and N_Phe147 form the oxyanion hole.

-	~~==About this Structure==~~	+	Crystallographic analysis of a thermoactive nitrilase.,Raczynska JE, Vorgias CE, Antranikian G, Rypniewski W J Struct Biol. 2011 Feb;173(2):294-302. Epub 2010 Nov 21. PMID:21095228<ref>PMID:21095228</ref>
-	~~[[3ivz]] is~~ a 2 ~~chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Pyrococcus_abyssi Pyrococcus abyssi]. Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3IVZ OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:021095228</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Beta-ureidopropionase]]		[[Category: Beta-ureidopropionase]]
	[[Category: Pyrococcus abyssi]]		[[Category: Pyrococcus abyssi]]
-	[[Category: Antranikian, G.]]	+	[[Category: Antranikian, G]]
-	[[Category: Raczynska, J.]]	+	[[Category: Raczynska, J]]
-	[[Category: Rypniewski, W.]]	+	[[Category: Rypniewski, W]]
-	[[Category: Vorgias, C.]]	+	[[Category: Vorgias, C]]
	[[Category: Alpha-beta sandwich]]		[[Category: Alpha-beta sandwich]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 09:19, 27 March 2013

OCA — Wed, 27 Mar 2013 09:19:42 GMT

←Older revision		Revision as of 09:19, 27 March 2013
Line 1:		Line 1:
-	[[Image:3ivz.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ivz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ivz\| PDB=3ivz \| SCENE= }}		{{STRUCTURE_3ivz\| PDB=3ivz \| SCENE= }}
-
	===Crystal structure of hyperthermophilic nitrilase===		===Crystal structure of hyperthermophilic nitrilase===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_21095228}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 21095228 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_21095228}}		{{ABSTRACT_PUBMED_21095228}}

	==About this Structure==		==About this Structure==
-	[[3ivz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pyrococcus_abyssi_ge5~~ Pyrococcus abyssi ~~ge5~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IVZ OCA].	+	[[3ivz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_abyssi Pyrococcus abyssi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IVZ OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~21095228~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021095228</ref><references group="xtra"/><references/>
	[[Category: Beta-ureidopropionase]]		[[Category: Beta-ureidopropionase]]
-	[[Category: Pyrococcus abyssi ~~ge5~~]]	+	[[Category: Pyrococcus abyssi]]
	[[Category: Antranikian, G.]]		[[Category: Antranikian, G.]]
	[[Category: Raczynska, J.]]		[[Category: Raczynska, J.]]
	[[Category: Rypniewski, W.]]		[[Category: Rypniewski, W.]]
	[[Category: Vorgias, C.]]		[[Category: Vorgias, C.]]
		+	[[Category: Alpha-beta sandwich]]
		+	[[Category: Hydrolase]]

OCA: Protected "3ivz" [edit=sysop:move=sysop]

OCA — Wed, 02 Feb 2011 05:50:24 GMT

Protected "3ivz" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:50, 2 February 2011

OCA at 05:50, 2 February 2011

OCA — Wed, 02 Feb 2011 05:50:23 GMT

←Older revision		Revision as of 05:50, 2 February 2011
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3ivz.png\|left\|200px]]
-	[[Image:3ivz.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	===Crystal structure of hyperthermophilic nitrilase===		===Crystal structure of hyperthermophilic nitrilase===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21095228}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21095228 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21095228}}

	==About this Structure==		==About this Structure==
-	~~3IVZ~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Pyrococcus_abyssi_ge5 Pyrococcus abyssi ge5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IVZ OCA].	+	[[3ivz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_abyssi_ge5 Pyrococcus abyssi ge5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IVZ OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:21095228</ref><references group="xtra"/>
	[[Category: Beta-ureidopropionase]]		[[Category: Beta-ureidopropionase]]
	[[Category: Pyrococcus abyssi ge5]]		[[Category: Pyrococcus abyssi ge5]]
Line 21:		Line 29:
	[[Category: Rypniewski, W.]]		[[Category: Rypniewski, W.]]
	[[Category: Vorgias, C.]]		[[Category: Vorgias, C.]]
-	[[Category: Alpha-beta sandwich]]
-	[[Category: Hydrolase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:43:45 2010''

OCA at 11:34, 22 September 2010

OCA — Wed, 22 Sep 2010 11:34:47 GMT

←Older revision		Revision as of 11:34, 22 September 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3ivz.jpg\|left\|200px]]

-	The ~~entry 3ivz~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ivz", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ivz\| PDB=3ivz \| SCENE= }}

-	~~Authors: Raczynska, J., Vorgias, C., Antranikian, G., Rypniewski, W.~~	+	===Crystal structure of hyperthermophilic nitrilase===

-	Description: Crystal structure of hyperthermophilic nitrilase

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep ~~30 08~~:59:~~25 2009~~''	+	==About this Structure==
		+	3IVZ is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Pyrococcus_abyssi_ge5 Pyrococcus abyssi ge5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IVZ OCA].
		+	[[Category: Beta-ureidopropionase]]
		+	[[Category: Pyrococcus abyssi ge5]]
		+	[[Category: Antranikian, G.]]
		+	[[Category: Raczynska, J.]]
		+	[[Category: Rypniewski, W.]]
		+	[[Category: Vorgias, C.]]
		+	[[Category: Alpha-beta sandwich]]
		+	[[Category: Hydrolase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:43:45 2010''

OCA at 06:59, 30 September 2009

OCA — Wed, 30 Sep 2009 06:59:25 GMT

←Older revision		Revision as of 06:59, 30 September 2009
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3ivz is ON HOLD	+	The entry 3ivz is ON HOLD until Paper Publication

	Authors: Raczynska, J., Vorgias, C., Antranikian, G., Rypniewski, W.		Authors: Raczynska, J., Vorgias, C., Antranikian, G., Rypniewski, W.
Line 7:		Line 7:
	Description: Crystal structure of hyperthermophilic nitrilase		Description: Crystal structure of hyperthermophilic nitrilase

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep ~~9 09:~~08:29 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 30 08:59:25 2009''