3iwk - Revision history

OCA at 16:03, 1 November 2023

OCA — Wed, 01 Nov 2023 16:03:25 GMT

←Older revision		Revision as of 16:03, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3iwk' size='340' side='right'caption='[[3iwk]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3iwk' size='340' side='right'caption='[[3iwk]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3iwk]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Garden_pea Garden pea~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IWK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3iwk]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Pisum_sativum Pisum sativum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IWK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3iwj\|3iwj]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">amadh1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3888 Garden pea])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aminobutyraldehyde_dehydrogenase Aminobutyraldehyde dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.19 1.2.1.19] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwk OCA], [https://pdbe.org/3iwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iwk RCSB], [https://www.ebi.ac.uk/pdbsum/3iwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iwk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwk OCA], [https://pdbe.org/3iwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iwk RCSB], [https://www.ebi.ac.uk/pdbsum/3iwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iwk ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/AADH1_PEA AADH1_PEA] Dehydrogenase that catalyzes the oxidation of several aminoaldehydes (PubMed:20026072). Metabolizes and detoxifies aldehyde products of polyamine degradation to non-toxic amino acids (Probable). Catalyzes the oxidation of 3-aminopropanal to beta-alanine (Ref.1, PubMed:20026072). Catalyzes the oxidation of 4-aminobutanal to 4-aminobutanoate (PubMed:20026072). Catalyzes the oxidation of 4-guanidinobutanal to 4-guanidinobutanoate (PubMed:20026072).<ref>PMID:20026072</ref> [UniProtKB:P20000]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Aminobutyraldehyde dehydrogenase]]
-	[[Category: Garden pea]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Briozzo, P~~]]	+	[[Category: Pisum sativum]]
-	[[Category: ~~Kopecny, D~~]]	+	[[Category: Briozzo P]]
-	[[Category: ~~Morera, S~~]]	+	[[Category: Kopecny D]]
-	[[Category: ~~Aminoaldehyde dehydrogenase]]~~	+	[[Category: Morera S]]
-	~~[[Category: Betaine aldehyde dehydrogenase]]~~	+
-	~~[[Category: Dimer]]~~	+
-	~~[[Category: Nad]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Rossmann fold~~]]	+

OCA at 03:43, 21 April 2022

OCA — Thu, 21 Apr 2022 03:43:56 GMT

←Older revision		Revision as of 03:43, 21 April 2022
Line 1:		Line 1:

	==Crystal structure of aminoaldehyde dehydrogenase 1 from Pisum sativum (PsAMADH1)==		==Crystal structure of aminoaldehyde dehydrogenase 1 from Pisum sativum (PsAMADH1)==
-	<StructureSection load='3iwk' size='340' side='right' caption='[[3iwk]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='3iwk' size='340' side='right'caption='[[3iwk]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3iwk]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Garden_pea Garden pea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IWK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3iwk]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Garden_pea Garden pea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IWK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3iwj\|3iwj]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3iwj\|3iwj]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">amadh1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3888 Garden pea])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">amadh1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3888 Garden pea])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Aminobutyraldehyde_dehydrogenase Aminobutyraldehyde dehydrogenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.19 1.2.1.19] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aminobutyraldehyde_dehydrogenase Aminobutyraldehyde dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.19 1.2.1.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3iwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwk OCA], [~~http~~://pdbe.org/3iwk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3iwk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3iwk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3iwk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwk OCA], [https://pdbe.org/3iwk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iwk RCSB], [https://www.ebi.ac.uk/pdbsum/3iwk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iwk ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 31:		Line 31:

	==See Also==		==See Also==
-	*[[Aldehyde dehydrogenase\|Aldehyde dehydrogenase]]	+	*[[Aldehyde dehydrogenase 3D structures\|Aldehyde dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 38:		Line 38:
	[[Category: Aminobutyraldehyde dehydrogenase]]		[[Category: Aminobutyraldehyde dehydrogenase]]
	[[Category: Garden pea]]		[[Category: Garden pea]]
		+	[[Category: Large Structures]]
	[[Category: Briozzo, P]]		[[Category: Briozzo, P]]
	[[Category: Kopecny, D]]		[[Category: Kopecny, D]]

OCA at 09:19, 19 December 2018

OCA — Wed, 19 Dec 2018 09:19:31 GMT

←Older revision		Revision as of 09:19, 19 December 2018
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/3iwk_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/3iwk_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 11:32, 11 August 2016

OCA — Thu, 11 Aug 2016 11:32:16 GMT

←Older revision		Revision as of 11:32, 11 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of aminoaldehyde dehydrogenase 1 from Pisum sativum (PsAMADH1)==		==Crystal structure of aminoaldehyde dehydrogenase 1 from Pisum sativum (PsAMADH1)==
	<StructureSection load='3iwk' size='340' side='right' caption='[[3iwk]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3iwk' size='340' side='right' caption='[[3iwk]], [[Resolution\|resolution]] 2.40Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">amadh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3888 Garden pea])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">amadh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3888 Garden pea])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminobutyraldehyde_dehydrogenase Aminobutyraldehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.19 1.2.1.19] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminobutyraldehyde_dehydrogenase Aminobutyraldehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.19 1.2.1.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iwk RCSB], [http://www.ebi.ac.uk/pdbsum/3iwk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwk OCA], [http://pdbe.org/3iwk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iwk RCSB], [http://www.ebi.ac.uk/pdbsum/3iwk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3iwk ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 17:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iwk ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3iwk" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 08:52, 20 January 2015

OCA — Tue, 20 Jan 2015 08:52:40 GMT

←Older revision		Revision as of 08:52, 20 January 2015
Line 1:		Line 1:
-	~~{{STRUCTURE_3iwk\| PDB=3iwk \| SCENE= }}~~	+	==Crystal structure of aminoaldehyde dehydrogenase 1 from Pisum sativum (PsAMADH1)==
-	===Crystal structure of aminoaldehyde dehydrogenase 1 from Pisum sativum (PsAMADH1)===	+	<StructureSection load='3iwk' size='340' side='right' caption='[[3iwk]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20026072}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3iwk]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Garden_pea Garden pea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IWK FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MRD:(4R)-2-METHYLPENTANE-2,4-DIOL'>MRD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3iwj\|3iwj]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">amadh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3888 Garden pea])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminobutyraldehyde_dehydrogenase Aminobutyraldehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.19 1.2.1.19] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iwk RCSB], [http://www.ebi.ac.uk/pdbsum/3iwk PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/3iwk_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aminoaldehyde dehydrogenases (AMADHs, EC 1.2.1.19) belong to the large aldehyde dehydrogenase (ALDH) superfamily, namely, the ALDH9 family. They oxidize polyamine-derived omega-aminoaldehydes to the corresponding omega-amino acids. Here, we report the first X-ray structures of plant AMADHs: two isoenzymes, PsAMADH1 and PsAMADH2, from Pisum sativum in complex with beta-nicotinamide adenine dinucleotide (NAD(+)) at 2.4 and 2.15 A resolution, respectively. Both recombinant proteins are dimeric and, similarly to other ALDHs, each monomer is composed of an oligomerization domain, a coenzyme binding domain and a catalytic domain. Each subunit binds NAD(+) as a coenzyme, contains a solvent-accessible C-terminal peroxisomal targeting signal (type 1) and a cation bound in the cavity close to the NAD(+) binding site. While the NAD(+) binding mode is classical for PsAMADH2, that for PsAMADH1 is unusual among ALDHs. A glycerol molecule occupies the substrate binding site and mimics a bound substrate. Structural analysis and substrate specificity study of both isoenzymes in combination with data published previously on other ALDH9 family members show that the established categorization of such enzymes into distinct groups based on substrate specificity is no more appropriate, because many of them seem capable of oxidizing a large spectrum of aminoaldehyde substrates. PsAMADH1 and PsAMADH2 can oxidize N,N,N-trimethyl-4-aminobutyraldehyde into gamma-butyrobetaine, which is the carnitine precursor in animal cells. This activity highly suggests that in addition to their contribution to the formation of compatible osmolytes such as glycine betaine, beta-alanine betaine and gamma-aminobutyric acid, AMADHs might participate in carnitine biosynthesis in plants.

-	~~==About this Structure==~~	+	Structural and functional characterization of plant aminoaldehyde dehydrogenase from Pisum sativum with a broad specificity for natural and synthetic aminoaldehydes.,Tylichova M, Kopecny D, Morera S, Briozzo P, Lenobel R, Snegaroff J, Sebela M J Mol Biol. 2010 Mar 5;396(4):870-82. Epub 2009 Dec 21. PMID:20026072<ref>PMID:20026072</ref>
-	~~[[3iwk]] is~~ a ~~12 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Garden_pea Garden pea]. Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=3IWK OCA].~~	+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>

	==See Also==		==See Also==
	*[[Aldehyde dehydrogenase\|Aldehyde dehydrogenase]]		*[[Aldehyde dehydrogenase\|Aldehyde dehydrogenase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020026072</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Aminobutyraldehyde dehydrogenase]]		[[Category: Aminobutyraldehyde dehydrogenase]]
	[[Category: Garden pea]]		[[Category: Garden pea]]
-	[[Category: Briozzo, P.]]	+	[[Category: Briozzo, P]]
-	[[Category: Kopecny, D.]]	+	[[Category: Kopecny, D]]
-	[[Category: Morera, S.]]	+	[[Category: Morera, S]]
	[[Category: Aminoaldehyde dehydrogenase]]		[[Category: Aminoaldehyde dehydrogenase]]
	[[Category: Betaine aldehyde dehydrogenase]]		[[Category: Betaine aldehyde dehydrogenase]]

OCA at 05:55, 4 December 2013

OCA — Wed, 04 Dec 2013 05:55:46 GMT

←Older revision		Revision as of 05:55, 4 December 2013
Line 1:		Line 1:
-	[[Image:3iwk.png\|left\|200px]]
-
	{{STRUCTURE_3iwk\| PDB=3iwk \| SCENE= }}		{{STRUCTURE_3iwk\| PDB=3iwk \| SCENE= }}
-
	===Crystal structure of aminoaldehyde dehydrogenase 1 from Pisum sativum (PsAMADH1)===		===Crystal structure of aminoaldehyde dehydrogenase 1 from Pisum sativum (PsAMADH1)===
-
	{{ABSTRACT_PUBMED_20026072}}		{{ABSTRACT_PUBMED_20026072}}

	==About this Structure==		==About this Structure==
-	[[3iwk]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pisum_sativum Pisum sativum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWK OCA].	+	[[3iwk]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Garden_pea Garden pea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWK OCA].

	==See Also==		==See Also==
Line 14:		Line 10:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020026072</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020026072</ref><references group="xtra"/><references/>
	[[Category: Aminobutyraldehyde dehydrogenase]]		[[Category: Aminobutyraldehyde dehydrogenase]]
-	[[Category: ~~Pisum sativum~~]]	+	[[Category: Garden pea]]
	[[Category: Briozzo, P.]]		[[Category: Briozzo, P.]]
	[[Category: Kopecny, D.]]		[[Category: Kopecny, D.]]

OCA at 19:31, 20 October 2012

OCA — Sat, 20 Oct 2012 19:31:26 GMT

←Older revision		Revision as of 19:31, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3iwk]] is a 12 chain structure ~~of [[Aldehyde dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/Pisum_sativum Pisum sativum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWK OCA].	+	[[3iwk]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Pisum_sativum Pisum sativum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWK OCA].

	==See Also==		==See Also==

OCA: Protected "3iwk" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 07:37:33 GMT

Protected "3iwk" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:37, 27 July 2012

OCA at 07:37, 27 July 2012

OCA — Fri, 27 Jul 2012 07:37:31 GMT

←Older revision		Revision as of 07:37, 27 July 2012
Line 1:		Line 1:
-	~~{{Seed}}~~	+	[[Image:3iwk.png\|left\|200px]]
-	[[Image:3iwk.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3iwk", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3iwk\| PDB=3iwk \| SCENE= }}		{{STRUCTURE_3iwk\| PDB=3iwk \| SCENE= }}

	===Crystal structure of aminoaldehyde dehydrogenase 1 from Pisum sativum (PsAMADH1)===		===Crystal structure of aminoaldehyde dehydrogenase 1 from Pisum sativum (PsAMADH1)===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20026072}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20026072 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20026072}}		{{ABSTRACT_PUBMED_20026072}}

	==About this Structure==		==About this Structure==
-	~~3IWK~~ is a 12 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Pisum_sativum Pisum sativum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWK OCA].	+	[[3iwk]] is a 12 chain structure of [[Aldehyde dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Pisum_sativum Pisum sativum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWK OCA].
		+
		+	==See Also==
		+	*[[Aldehyde dehydrogenase\|Aldehyde dehydrogenase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20026072~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020026072</ref><references group="xtra"/>
	[[Category: Aminobutyraldehyde dehydrogenase]]		[[Category: Aminobutyraldehyde dehydrogenase]]
	[[Category: Pisum sativum]]		[[Category: Pisum sativum]]
Line 35:		Line 26:
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 20 15:51:52 2010''

OCA at 13:51, 20 January 2010

OCA — Wed, 20 Jan 2010 13:51:53 GMT

←Older revision		Revision as of 13:51, 20 January 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3iwk.jpg\|left\|200px]]

-	The ~~entry 3iwk~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3iwk", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3iwk\| PDB=3iwk \| SCENE= }}

-	~~Authors: Kopecny, D., Morera, S., Briozzo, P.~~	+	===Crystal structure of aminoaldehyde dehydrogenase 1 from Pisum sativum (PsAMADH1)===

-	Description: Crystal structure of aminoaldehyde dehydrogenase 1 from Pisum sativum (PsAMADH1)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 16 08~~:44:~~43 2009~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20026072}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20026072 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20026072}}
		+
		+	==About this Structure==
		+	3IWK is a 12 chains structure with sequences from [http://en.wikipedia.org/wiki/Pisum_sativum Pisum sativum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWK OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20026072</ref><references group="xtra"/>
		+	[[Category: Aminobutyraldehyde dehydrogenase]]
		+	[[Category: Pisum sativum]]
		+	[[Category: Briozzo, P.]]
		+	[[Category: Kopecny, D.]]
		+	[[Category: Morera, S.]]
		+	[[Category: Aminoaldehyde dehydrogenase]]
		+	[[Category: Betaine aldehyde dehydrogenase]]
		+	[[Category: Dimer]]
		+	[[Category: Nad]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Rossmann fold]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 20 15:51:52 2010''