3iwl - Revision history

OCA at 10:07, 21 February 2024

OCA — Wed, 21 Feb 2024 10:07:14 GMT

←Older revision		Revision as of 10:07, 21 February 2024
Line 3:		Line 3:
	<StructureSection load='3iwl' size='340' side='right'caption='[[3iwl]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3iwl' size='340' side='right'caption='[[3iwl]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3iwl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IWL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3iwl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IWL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TCE:3,3,3-PHOSPHANETRIYLTRIPROPANOIC+ACID'>TCE</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3iwx\|3iwx]]</div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TCE:3,3,3-PHOSPHANETRIYLTRIPROPANOIC+ACID'>TCE</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATOX1, HAH1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwl OCA], [https://pdbe.org/3iwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iwl RCSB], [https://www.ebi.ac.uk/pdbsum/3iwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iwl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwl OCA], [https://pdbe.org/3iwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iwl RCSB], [https://www.ebi.ac.uk/pdbsum/3iwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iwl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ATOX1_HUMAN ATOX1_HUMAN]] Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.	+	[https://www.uniprot.org/uniprot/ATOX1_HUMAN ATOX1_HUMAN] Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 21:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iwl ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iwl ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Copper trafficking proteins, including the chaperone Atox1 and the P(1B)-type ATPase ATP7B, have been implicated in cellular resistance to the anticancer drug cisplatin. We have determined two crystal structures of cisplatin-Atox1 adducts that reveal platinum coordination by the conserved CXXC copper-binding motif. Direct interaction of cisplatin with this functionally relevant site has significant implications for understanding the molecular basis for resistance mediated by copper transport pathways.
-
-	Crystal structures of cisplatin bound to a human copper chaperone.,Boal AK, Rosenzweig AC J Am Chem Soc. 2009 Oct 14;131(40):14196-7. PMID:19807176<ref>PMID:19807176</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3iwl" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Boal~~, A K~~]]	+	[[Category: Boal AK]]
-	[[Category: Rosenzweig~~, A C]]~~	+	[[Category: Rosenzweig AC]]
-	~~[[Category: Beta-alpha-beta-beta-alpha-beta]]~~	+
-	~~[[Category: Chaperone]]~~	+
-	~~[[Category: Cisplatin]]~~	+
-	~~[[Category: Copper]]~~	+
-	~~[[Category: Copper transport]]~~	+
-	~~[[Category: Ion transport]]~~	+
-	~~[[Category: Metal transport]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Platinum]]~~	+
-	~~[[Category: Transport]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 03:43, 21 April 2022

OCA — Thu, 21 Apr 2022 03:43:57 GMT

←Older revision		Revision as of 03:43, 21 April 2022
Line 1:		Line 1:

	==Crystal structure of cisplatin bound to a human copper chaperone (monomer)==		==Crystal structure of cisplatin bound to a human copper chaperone (monomer)==
-	<StructureSection load='3iwl' size='340' side='right' caption='[[3iwl]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='3iwl' size='340' side='right'caption='[[3iwl]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3iwl]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IWL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3iwl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IWL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TCE:3,3,3-PHOSPHANETRIYLTRIPROPANOIC+ACID'>TCE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TCE:3,3,3-PHOSPHANETRIYLTRIPROPANOIC+ACID'>TCE</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3iwx\|3iwx]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3iwx\|3iwx]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATOX1, HAH1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATOX1, HAH1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3iwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwl OCA], [~~http~~://pdbe.org/3iwl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3iwl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3iwl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3iwl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwl OCA], [https://pdbe.org/3iwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iwl RCSB], [https://www.ebi.ac.uk/pdbsum/3iwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iwl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ATOX1_HUMAN ATOX1_HUMAN]] Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.	+	[[https://www.uniprot.org/uniprot/ATOX1_HUMAN ATOX1_HUMAN]] Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/3iwl_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/3iwl_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Boal, A K]]		[[Category: Boal, A K]]
	[[Category: Rosenzweig, A C]]		[[Category: Rosenzweig, A C]]

OCA at 08:15, 1 November 2017

OCA — Wed, 01 Nov 2017 08:15:41 GMT

←Older revision		Revision as of 08:15, 1 November 2017
Line 1:		Line 1:
		+
	==Crystal structure of cisplatin bound to a human copper chaperone (monomer)==		==Crystal structure of cisplatin bound to a human copper chaperone (monomer)==
	<StructureSection load='3iwl' size='340' side='right' caption='[[3iwl]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3iwl' size='340' side='right' caption='[[3iwl]], [[Resolution\|resolution]] 1.60Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3iwx\|3iwx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3iwx\|3iwx]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATOX1, HAH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATOX1, HAH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwl OCA], [http://pdbe.org/3iwl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iwl RCSB], [http://www.ebi.ac.uk/pdbsum/3iwl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwl OCA], [http://pdbe.org/3iwl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iwl RCSB], [http://www.ebi.ac.uk/pdbsum/3iwl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3iwl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 39:		Line 40:
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Cisplatin]]		[[Category: Cisplatin]]
		+	[[Category: Copper]]
	[[Category: Copper transport]]		[[Category: Copper transport]]
	[[Category: Ion transport]]		[[Category: Ion transport]]

OCA at 12:17, 7 February 2016

OCA — Sun, 07 Feb 2016 12:17:04 GMT

←Older revision		Revision as of 12:17, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3iwl' size='340' side='right' caption='[[3iwl]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='3iwl' size='340' side='right' caption='[[3iwl]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3iwl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IWL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3iwl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IWL FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TCE:3,3,3-PHOSPHANETRIYLTRIPROPANOIC+ACID'>TCE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TCE:3,3,3-PHOSPHANETRIYLTRIPROPANOIC+ACID'>TCE</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3iwx\|3iwx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3iwx\|3iwx]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATOX1, HAH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATOX1, HAH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iwl RCSB], [http://www.ebi.ac.uk/pdbsum/3iwl PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwl OCA], [http://pdbe.org/3iwl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iwl RCSB], [http://www.ebi.ac.uk/pdbsum/3iwl PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iwl ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3iwl" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Boal, A K]]		[[Category: Boal, A K]]
	[[Category: Rosenzweig, A C]]		[[Category: Rosenzweig, A C]]

OCA at 15:01, 24 December 2014

OCA — Wed, 24 Dec 2014 15:01:39 GMT

←Older revision		Revision as of 15:01, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iwl RCSB], [http://www.ebi.ac.uk/pdbsum/3iwl PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iwl RCSB], [http://www.ebi.ac.uk/pdbsum/3iwl PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ATOX1_HUMAN ATOX1_HUMAN]] Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 15:49, 18 December 2014

OCA — Thu, 18 Dec 2014 15:49:48 GMT

←Older revision		Revision as of 15:49, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3iwl\| PDB=3iwl \| SCENE= }}~~	+	==Crystal structure of cisplatin bound to a human copper chaperone (monomer)==
-	===Crystal structure of cisplatin bound to a human copper chaperone (monomer)===	+	<StructureSection load='3iwl' size='340' side='right' caption='[[3iwl]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19807176}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3iwl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IWL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TCE:3,3,3-PHOSPHANETRIYLTRIPROPANOIC+ACID'>TCE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3iwx\|3iwx]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ATOX1, HAH1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iwl RCSB], [http://www.ebi.ac.uk/pdbsum/3iwl PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/3iwl_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Copper trafficking proteins, including the chaperone Atox1 and the P(1B)-type ATPase ATP7B, have been implicated in cellular resistance to the anticancer drug cisplatin. We have determined two crystal structures of cisplatin-Atox1 adducts that reveal platinum coordination by the conserved CXXC copper-binding motif. Direct interaction of cisplatin with this functionally relevant site has significant implications for understanding the molecular basis for resistance mediated by copper transport pathways.

-	~~==Function==~~	+	Crystal structures of cisplatin bound to a human copper chaperone.,Boal AK, Rosenzweig AC J Am Chem Soc. 2009 Oct 14;131(40):14196-7. PMID:19807176<ref>PMID:19807176</ref>
-	~~[[http://www.uniprot.org/uniprot/ATOX1_HUMAN ATOX1_HUMAN]] Binds and deliver cytosolic copper~~ to ~~the~~ copper ~~ATPase proteins~~. ~~May be important in cellular antioxidant defense~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3iwl]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3IWL OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:019807176</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Boal, A K.]]	+	[[Category: Boal, A K]]
-	[[Category: Rosenzweig, A C.]]	+	[[Category: Rosenzweig, A C]]
	[[Category: Beta-alpha-beta-beta-alpha-beta]]		[[Category: Beta-alpha-beta-beta-alpha-beta]]
	[[Category: Chaperone]]		[[Category: Chaperone]]

OCA: Protected "3iwl" [edit=sysop:move=sysop]

OCA — Wed, 27 Mar 2013 09:17:07 GMT

Protected "3iwl" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:17, 27 March 2013

OCA at 09:17, 27 March 2013

OCA — Wed, 27 Mar 2013 09:17:04 GMT

←Older revision		Revision as of 09:17, 27 March 2013
Line 1:		Line 1:
-	{{Seed}}
-	[[Image:3iwl.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3iwl", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3iwl\| PDB=3iwl \| SCENE= }}		{{STRUCTURE_3iwl\| PDB=3iwl \| SCENE= }}
-
	===Crystal structure of cisplatin bound to a human copper chaperone (monomer)===		===Crystal structure of cisplatin bound to a human copper chaperone (monomer)===
		+	{{ABSTRACT_PUBMED_19807176}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/ATOX1_HUMAN ATOX1_HUMAN]] Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_19807176}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 19807176 is~~ the ~~PubMed ID number~~.	+
-	~~-->~~	+
-	~~{{ABSTRACT_PUBMED_19807176}}~~	+

	==About this Structure==		==About this Structure==
-	~~3IWL~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWL OCA].	+	[[3iwl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWL OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19807176~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019807176</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Boal, A K.]]		[[Category: Boal, A K.]]
Line 30:		Line 17:
	[[Category: Chaperone]]		[[Category: Chaperone]]
	[[Category: Cisplatin]]		[[Category: Cisplatin]]
-	[[Category: Copper]]
	[[Category: Copper transport]]		[[Category: Copper transport]]
	[[Category: Ion transport]]		[[Category: Ion transport]]
Line 38:		Line 24:
	[[Category: Transport]]		[[Category: Transport]]
	[[Category: Transport protein]]		[[Category: Transport protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 30 14:10:15 2009''

OCA at 12:10, 30 December 2009

OCA — Wed, 30 Dec 2009 12:10:16 GMT

←Older revision		Revision as of 12:10, 30 December 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3iwl.~~jpg~~\|left\|200px]]	+	[[Image:3iwl.png\|left\|200px]]

	<!--		<!--
Line 12:		Line 12:
	===Crystal structure of cisplatin bound to a human copper chaperone (monomer)===		===Crystal structure of cisplatin bound to a human copper chaperone (monomer)===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19807176}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19807176 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19807176}}

	==About this Structure==		==About this Structure==
	3IWL is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWL OCA].		3IWL is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWL OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19807176</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Boal, A K.]]		[[Category: Boal, A K.]]
Line 30:		Line 39:
	[[Category: Transport protein]]		[[Category: Transport protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 23 09~~:02:34 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 30 14:10:15 2009''

OCA at 06:02, 23 September 2009

OCA — Wed, 23 Sep 2009 06:02:36 GMT

←Older revision		Revision as of 06:02, 23 September 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3iwl.jpg\|left\|200px]]

-	The ~~entry 3iwl~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3iwl", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3iwl\| PDB=3iwl \| SCENE= }}

-	~~Authors: Boal, A.K., Rosenzweig, A.C.~~	+	===Crystal structure of cisplatin bound to a human copper chaperone (monomer)===

-	Description: Crystal structure of cisplatin bound to a human copper chaperone (monomer)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 9 09:08:42 2009''	+	==About this Structure==
		+	3IWL is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWL OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Boal, A K.]]
		+	[[Category: Rosenzweig, A C.]]
		+	[[Category: Beta-alpha-beta-beta-alpha-beta]]
		+	[[Category: Chaperone]]
		+	[[Category: Cisplatin]]
		+	[[Category: Copper]]
		+	[[Category: Copper transport]]
		+	[[Category: Ion transport]]
		+	[[Category: Metal transport]]
		+	[[Category: Metal-binding]]
		+	[[Category: Platinum]]
		+	[[Category: Transport]]
		+	[[Category: Transport protein]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 23 09:02:34 2009''