3iwz - Revision history

OCA at 08:28, 20 March 2024

OCA — Wed, 20 Mar 2024 08:28:10 GMT

←Older revision		Revision as of 08:28, 20 March 2024
Line 3:		Line 3:
	<StructureSection load='3iwz' size='340' side='right'caption='[[3iwz]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3iwz' size='340' side='right'caption='[[3iwz]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3iwz]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Xance Xance~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3IWZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3iwz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._campestris Xanthomonas campestris pv. campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IWZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3iwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwz OCA], [~~http~~://pdbe.org/3iwz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3iwz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3iwz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3iwz ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwz OCA], [https://pdbe.org/3iwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iwz RCSB], [https://www.ebi.ac.uk/pdbsum/3iwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iwz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CLP_XANCP CLP_XANCP]] Global transcriptional regulator that regulates virulence factors production by activating or repressing the expression of a large set of genes in diffusible signal factor (DSF) pathway. It includes, among others, genes involved in extracellular polysaccharide (EPS) synthesis, flagellum synthesis, protein and fatty acid metabolism, multidrug resistance, iron uptake or genes encoding extracellular enzymes, membrane components and a few transcription factors. Regulation can be direct or indirect, via regulation of other transcriptional regulators. Not involved in DSF-mediated biofilm dispersal.<ref>PMID:17378922</ref>	+	[https://www.uniprot.org/uniprot/CLP_XANCP CLP_XANCP] Global transcriptional regulator that regulates virulence factors production by activating or repressing the expression of a large set of genes in diffusible signal factor (DSF) pathway. It includes, among others, genes involved in extracellular polysaccharide (EPS) synthesis, flagellum synthesis, protein and fatty acid metabolism, multidrug resistance, iron uptake or genes encoding extracellular enzymes, membrane components and a few transcription factors. Regulation can be direct or indirect, via regulation of other transcriptional regulators. Not involved in DSF-mediated biofilm dispersal.<ref>PMID:17378922</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iwz ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iwz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Cyclic-di-GMP [bis-(3'-5')-cyclic diguanosine monophosphate] controls a wide range of functions in eubacteria, yet little is known about the underlying regulatory mechanisms. In the plant pathogen Xanthomonas campestris, expression of a subset of virulence genes is regulated by c-di-GMP and also by the CAP (catabolite activation protein)-like protein XcCLP, a global regulator in the CRP/FNR superfamily. Here, we report structural and functional insights into the interplay between XcCLP and c-di-GMP in regulation of gene expression. XcCLP bound target promoter DNA with submicromolar affinity in the absence of any ligand. This DNA-binding capability was abrogated by c-di-GMP, which bound to XcCLP with micromolar affinity. The crystal structure of XcCLP showed that the protein adopted an intrinsically active conformation for DNA binding. Alteration of residues of XcCLP implicated in c-di-GMP binding through modeling studies caused a substantial reduction in binding affinity for the nucleotide and rendered DNA binding by these variant proteins insensitive to inhibition by c-di-GMP. Together, these findings reveal the structural mechanism behind a novel class of c-di-GMP effector proteins in the CRP/FNR superfamily and indicate that XcCLP regulates bacterial virulence gene expression in a manner negatively controlled by the c-di-GMP concentrations.
-
-	The cAMP receptor-like protein CLP is a novel c-di-GMP receptor linking cell-cell signaling to virulence gene expression in Xanthomonas campestris.,Chin KH, Lee YC, Tu ZL, Chen CH, Tseng YH, Yang JM, Ryan RP, McCarthy Y, Dow JM, Wang AH, Chou SH J Mol Biol. 2010 Feb 26;396(3):646-62. Epub 2009 Dec 18. PMID:20004667<ref>PMID:20004667</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3iwz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Xance~~]]	+	[[Category: Xanthomonas campestris pv. campestris]]
-	[[Category: Chin~~, K H~~]]	+	[[Category: Chin KH]]
-	[[Category: Chou~~, S H~~]]	+	[[Category: Chou SH]]
-	[[Category: Dow~~, J M~~]]	+	[[Category: Dow JM]]
-	[[Category: Tseng~~, Y H~~]]	+	[[Category: Tseng YH]]
-	[[Category: Tu~~, Z L~~]]	+	[[Category: Tu ZL]]
-	[[Category: Wang~~, A H.J]]~~	+	[[Category: Wang AHJ]]
-	~~[[Category: C-di-gmp receptor]]~~	+
-	~~[[Category: Clp]]~~	+
-	~~[[Category: Crp]]~~	+
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Pathogenicity]]~~	+
-	~~[[Category: Quorum sensing]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Xcc~~]]	+

OCA at 11:59, 23 September 2020

OCA — Wed, 23 Sep 2020 11:59:01 GMT

←Older revision		Revision as of 11:59, 23 September 2020
Line 1:		Line 1:

	==The c-di-GMP Responsive Global Regulator CLP Links Cell-Cell Signaling to Virulence Gene Expression in Xanthomonas campestris==		==The c-di-GMP Responsive Global Regulator CLP Links Cell-Cell Signaling to Virulence Gene Expression in Xanthomonas campestris==
-	<StructureSection load='3iwz' size='340' side='right' caption='[[3iwz]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='3iwz' size='340' side='right'caption='[[3iwz]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3iwz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Xance Xance]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWZ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IWZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3iwz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Xance Xance]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3IWZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3iwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwz OCA], [http://pdbe.org/3iwz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iwz RCSB], [http://www.ebi.ac.uk/pdbsum/3iwz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3iwz ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3iwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwz OCA], [http://pdbe.org/3iwz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iwz RCSB], [http://www.ebi.ac.uk/pdbsum/3iwz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3iwz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Xance]]		[[Category: Xance]]
	[[Category: Chin, K H]]		[[Category: Chin, K H]]

OCA at 09:17, 19 December 2018

OCA — Wed, 19 Dec 2018 09:17:20 GMT

←Older revision		Revision as of 09:17, 19 December 2018
Line 1:		Line 1:
		+
	==The c-di-GMP Responsive Global Regulator CLP Links Cell-Cell Signaling to Virulence Gene Expression in Xanthomonas campestris==		==The c-di-GMP Responsive Global Regulator CLP Links Cell-Cell Signaling to Virulence Gene Expression in Xanthomonas campestris==
	<StructureSection load='3iwz' size='340' side='right' caption='[[3iwz]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3iwz' size='340' side='right' caption='[[3iwz]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3iwz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Xance Xance]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IWZ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3iwz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Xance Xance]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IWZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwz OCA], [http://pdbe.org/3iwz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iwz RCSB], [http://www.ebi.ac.uk/pdbsum/3iwz PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwz OCA], [http://pdbe.org/3iwz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iwz RCSB], [http://www.ebi.ac.uk/pdbsum/3iwz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3iwz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/3iwz_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/3iwz_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 20:01, 7 February 2016

OCA — Sun, 07 Feb 2016 20:01:58 GMT

←Older revision		Revision as of 20:01, 7 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iwz ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:13, 9 December 2015

OCA — Wed, 09 Dec 2015 07:13:14 GMT

←Older revision		Revision as of 07:13, 9 December 2015
Line 2:		Line 2:
	<StructureSection load='3iwz' size='340' side='right' caption='[[3iwz]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3iwz' size='340' side='right' caption='[[3iwz]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3iwz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Xanthomonas_campestris_pv._campestris Xanthomonas campestris pv. campestris~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IWZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3iwz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Xance Xance]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IWZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iwz RCSB], [http://www.ebi.ac.uk/pdbsum/3iwz PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwz OCA], [http://pdbe.org/3iwz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3iwz RCSB], [http://www.ebi.ac.uk/pdbsum/3iwz PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cyclic-di-GMP [bis-(3'-5')-cyclic diguanosine monophosphate] controls a wide range of functions in eubacteria, yet little is known about the underlying regulatory mechanisms. In the plant pathogen Xanthomonas campestris, expression of a subset of virulence genes is regulated by c-di-GMP and also by the CAP (catabolite activation protein)-like protein XcCLP, a global regulator in the CRP/FNR superfamily. Here, we report structural and functional insights into the interplay between XcCLP and c-di-GMP in regulation of gene expression. XcCLP bound target promoter DNA with submicromolar affinity in the absence of any ligand. This DNA-binding capability was abrogated by c-di-GMP, which bound to XcCLP with micromolar affinity. The crystal structure of XcCLP showed that the protein adopted an intrinsically active conformation for DNA binding. Alteration of residues of XcCLP implicated in c-di-GMP binding through modeling studies caused a substantial reduction in binding affinity for the nucleotide and rendered DNA binding by these variant proteins insensitive to inhibition by c-di-GMP. Together, these findings reveal the structural mechanism behind a novel class of c-di-GMP effector proteins in the CRP/FNR superfamily and indicate that XcCLP regulates bacterial virulence gene expression in a manner negatively controlled by the c-di-GMP concentrations.
		+
		+	The cAMP receptor-like protein CLP is a novel c-di-GMP receptor linking cell-cell signaling to virulence gene expression in Xanthomonas campestris.,Chin KH, Lee YC, Tu ZL, Chen CH, Tseng YH, Yang JM, Ryan RP, McCarthy Y, Dow JM, Wang AH, Chou SH J Mol Biol. 2010 Feb 26;396(3):646-62. Epub 2009 Dec 18. PMID:20004667<ref>PMID:20004667</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 3iwz" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Xanthomonas campestris pv. campestris~~]]	+	[[Category: Xance]]
	[[Category: Chin, K H]]		[[Category: Chin, K H]]
	[[Category: Chou, S H]]		[[Category: Chou, S H]]

OCA at 17:55, 24 December 2014

OCA — Wed, 24 Dec 2014 17:55:01 GMT

←Older revision		Revision as of 17:55, 24 December 2014
Line 5:		Line 5:
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iwz RCSB], [http://www.ebi.ac.uk/pdbsum/3iwz PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iwz RCSB], [http://www.ebi.ac.uk/pdbsum/3iwz PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CLP_XANCP CLP_XANCP]] Global transcriptional regulator that regulates virulence factors production by activating or repressing the expression of a large set of genes in diffusible signal factor (DSF) pathway. It includes, among others, genes involved in extracellular polysaccharide (EPS) synthesis, flagellum synthesis, protein and fatty acid metabolism, multidrug resistance, iron uptake or genes encoding extracellular enzymes, membrane components and a few transcription factors. Regulation can be direct or indirect, via regulation of other transcriptional regulators. Not involved in DSF-mediated biofilm dispersal.<ref>PMID:17378922</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 15:		Line 17:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 15:46, 18 December 2014

OCA — Thu, 18 Dec 2014 15:46:48 GMT

←Older revision		Revision as of 15:46, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3iwz\| PDB=3iwz \| SCENE= }}~~	+	==The c-di-GMP Responsive Global Regulator CLP Links Cell-Cell Signaling to Virulence Gene Expression in Xanthomonas campestris==
-	===The c-di-GMP Responsive Global Regulator CLP Links Cell-Cell Signaling to Virulence Gene Expression in Xanthomonas campestris===	+	<StructureSection load='3iwz' size='340' side='right' caption='[[3iwz]], [[Resolution\|resolution]] 2.30Å' scene=''>
-	~~{{ABSTRACT_PUBMED_020004667}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3iwz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._campestris Xanthomonas campestris pv. campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IWZ FirstGlance]. <br>
-	==~~Function~~==	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iwz RCSB], [http://www.ebi.ac.uk/pdbsum/3iwz PDBsum]</span></td></tr>
-	[[~~http://www.uniprot.org/uniprot/CLP_XANCP CLP_XANCP~~]] ~~Global transcriptional regulator that regulates virulence factors production by activating or repressing the expression of a large set of genes in diffusible signal factor (DSF) pathway. It includes~~, among others, genes involved in extracellular polysaccharide (EPS) synthesis, flagellum synthesis, protein and fatty acid metabolism, multidrug resistance, iron uptake or genes encoding extracellular enzymes, membrane components and a few transcription factors. ~~Regulation can be direct or indirect, via regulation of other transcriptional regulators. Not involved in DSF-mediated biofilm dispersal.<ref>PMID:17378922</ref~~>	+	</table>
-		+	== Evolutionary Conservation ==
-	==~~About this Structure~~==	+	[[Image:Consurf_key_small.gif\|200px\|right]]
-	[[3iwz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._campestris Xanthomonas campestris pv. campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWZ OCA].	+	Check<jmol>
-		+	<jmolCheckbox>
-	==~~Reference~~==	+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/3iwz_consurf.spt"</scriptWhenChecked>
-	<~~references group~~="~~xtra~~"/><~~references~~/>	+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	__TOC__
		+	</StructureSection>
	[[Category: Xanthomonas campestris pv. campestris]]		[[Category: Xanthomonas campestris pv. campestris]]
-	[[Category: Chin, K H.]]	+	[[Category: Chin, K H]]
-	[[Category: Chou, S H.]]	+	[[Category: Chou, S H]]
-	[[Category: Dow, J M.]]	+	[[Category: Dow, J M]]
-	[[Category: Tseng, Y H.]]	+	[[Category: Tseng, Y H]]
-	[[Category: Tu, Z L.]]	+	[[Category: Tu, Z L]]
-	[[Category: Wang, A H.J.]]	+	[[Category: Wang, A H.J]]
	[[Category: C-di-gmp receptor]]		[[Category: C-di-gmp receptor]]
	[[Category: Clp]]		[[Category: Clp]]

OCA: Protected "3iwz" [edit=sysop:move=sysop]

OCA — Wed, 27 Mar 2013 09:11:19 GMT

Protected "3iwz" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:11, 27 March 2013

OCA at 09:11, 27 March 2013

OCA — Wed, 27 Mar 2013 09:11:15 GMT

←Older revision		Revision as of 09:11, 27 March 2013
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-	{{Seed}}
-	[[Image:3iwz.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3iwz", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3iwz\| PDB=3iwz \| SCENE= }}		{{STRUCTURE_3iwz\| PDB=3iwz \| SCENE= }}
-
	===The c-di-GMP Responsive Global Regulator CLP Links Cell-Cell Signaling to Virulence Gene Expression in Xanthomonas campestris===		===The c-di-GMP Responsive Global Regulator CLP Links Cell-Cell Signaling to Virulence Gene Expression in Xanthomonas campestris===
		+	{{ABSTRACT_PUBMED_020004667}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/CLP_XANCP CLP_XANCP]] Global transcriptional regulator that regulates virulence factors production by activating or repressing the expression of a large set of genes in diffusible signal factor (DSF) pathway. It includes, among others, genes involved in extracellular polysaccharide (EPS) synthesis, flagellum synthesis, protein and fatty acid metabolism, multidrug resistance, iron uptake or genes encoding extracellular enzymes, membrane components and a few transcription factors. Regulation can be direct or indirect, via regulation of other transcriptional regulators. Not involved in DSF-mediated biofilm dispersal.<ref>PMID:17378922</ref>

	==About this Structure==		==About this Structure==
-	~~3IWZ~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._campestris Xanthomonas campestris pv. campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWZ OCA].	+	[[3iwz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._campestris Xanthomonas campestris pv. campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWZ OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Xanthomonas campestris pv. campestris]]		[[Category: Xanthomonas campestris pv. campestris]]
	[[Category: Chin, K H.]]		[[Category: Chin, K H.]]
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	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Xcc]]		[[Category: Xcc]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 6 05:34:15 2010''

OCA at 02:24, 6 October 2010

OCA — Wed, 06 Oct 2010 02:24:44 GMT

←Older revision		Revision as of 02:24, 6 October 2010
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	{{Seed}}		{{Seed}}
-	[[Image:3iwz.~~jpg~~\|left\|200px]]	+	[[Image:3iwz.png\|left\|200px]]

	<!--		<!--
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	==About this Structure==		==About this Structure==
-	3IWZ is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._campestris Xanthomonas campestris pv. campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWZ OCA].	+	3IWZ is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._campestris Xanthomonas campestris pv. campestris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWZ OCA].
	[[Category: Xanthomonas campestris pv. campestris]]		[[Category: Xanthomonas campestris pv. campestris]]
	[[Category: Chin, K H.]]		[[Category: Chin, K H.]]
Line 32:		Line 32:
	[[Category: Xcc]]		[[Category: Xcc]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 16 13~~:53:~~09 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 6 05:34:15 2010''