3ix4 - Revision history

OCA at 07:59, 6 September 2023

OCA — Wed, 06 Sep 2023 07:59:48 GMT

←Older revision		Revision as of 07:59, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3ix4' size='340' side='right'caption='[[3ix4]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3ix4' size='340' side='right'caption='[[3ix4]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ix4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IX4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ix4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IX4 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=TX1:2~~,~~4-DIBROMO-6-({~~[~~(2-NITROPHENYL)CARBONYL~~]~~AMINO}METHYL)PHENYL+2-CHLOROBENZOATE'>TX1</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[3ix3\|3ix3]], [[3ix8\|3ix8]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TX1:2,4-DIBROMO-6-({[(2-NITROPHENYL)CARBONYL]AMINO}METHYL)PHENYL+2-CHLOROBENZOATE'>TX1</scene></td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b></td><td class="sblockDat">lasR~~, ~~PA1430~~ ([~~https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus"~~ (~~Schroeter 1872~~) ~~Trevisan 1885~~])</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ix4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ix4 OCA], [https://pdbe.org/3ix4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ix4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ix4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ix4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ix4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ix4 OCA], [https://pdbe.org/3ix4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ix4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ix4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ix4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/LASR_PSEAE LASR_PSEAE]] Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer.	+	[https://www.uniprot.org/uniprot/LASR_PSEAE LASR_PSEAE] Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Nair, S K~~]]	+	[[Category: Pseudomonas aeruginosa]]
-	[[Category: ~~Zou, Y~~]]	+	[[Category: Nair SK]]
-	[[Category: ~~Activator]]~~	+	[[Category: Zou Y]]
-	~~[[Category: Dna-binding]]~~	+
-	~~[[Category: Quorum sensing]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Triphenyl mimic~~]]	+

OCA at 03:44, 21 April 2022

OCA — Thu, 21 Apr 2022 03:44:19 GMT

←Older revision		Revision as of 03:44, 21 April 2022
Line 1:		Line 1:

	==LasR-TP1 complex==		==LasR-TP1 complex==
-	<StructureSection load='3ix4' size='340' side='right' caption='[[3ix4]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3ix4' size='340' side='right'caption='[[3ix4]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ix4]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IX4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IX4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ix4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IX4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IX4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TX1:2,4-DIBROMO-6-({[(2-NITROPHENYL)CARBONYL]AMINO}METHYL)PHENYL+2-CHLOROBENZOATE'>TX1</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TX1:2,4-DIBROMO-6-({[(2-NITROPHENYL)CARBONYL]AMINO}METHYL)PHENYL+2-CHLOROBENZOATE'>TX1</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ix3\|3ix3]], [[3ix8\|3ix8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ix3\|3ix3]], [[3ix8\|3ix8]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lasR, PA1430 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lasR, PA1430 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ix4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ix4 OCA], [~~http~~://pdbe.org/3ix4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ix4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ix4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ix4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ix4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ix4 OCA], [https://pdbe.org/3ix4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ix4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ix4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ix4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/LASR_PSEAE LASR_PSEAE]] Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer.	+	[[https://www.uniprot.org/uniprot/LASR_PSEAE LASR_PSEAE]] Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:

	==See Also==		==See Also==
-	*[[Transcriptional activator\|Transcriptional activator]]	+	*[[Transcriptional activator 3D structures\|Transcriptional activator 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Nair, S K]]		[[Category: Nair, S K]]
	[[Category: Zou, Y]]		[[Category: Zou, Y]]

OCA at 09:49, 19 December 2018

OCA — Wed, 19 Dec 2018 09:49:32 GMT

←Older revision		Revision as of 09:49, 19 December 2018
Line 1:		Line 1:
		+
	==LasR-TP1 complex==		==LasR-TP1 complex==
	<StructureSection load='3ix4' size='340' side='right' caption='[[3ix4]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3ix4' size='340' side='right' caption='[[3ix4]], [[Resolution\|resolution]] 1.80Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ix3\|3ix3]], [[3ix8\|3ix8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ix3\|3ix3]], [[3ix8\|3ix8]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lasR, PA1430 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lasR, PA1430 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ix4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ix4 OCA], [http://pdbe.org/3ix4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ix4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ix4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ix4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ix4 OCA], [http://pdbe.org/3ix4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ix4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ix4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ix4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/3ix4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/3ix4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:26, 9 February 2016

OCA — Tue, 09 Feb 2016 22:26:09 GMT

←Older revision		Revision as of 22:26, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3ix4' size='340' side='right' caption='[[3ix4]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3ix4' size='340' side='right' caption='[[3ix4]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ix4]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_aeruginosa Pseudomonas aeruginosa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IX4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IX4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ix4]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IX4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IX4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TX1:2,4-DIBROMO-6-({[(2-NITROPHENYL)CARBONYL]AMINO}METHYL)PHENYL+2-CHLOROBENZOATE'>TX1</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TX1:2,4-DIBROMO-6-({[(2-NITROPHENYL)CARBONYL]AMINO}METHYL)PHENYL+2-CHLOROBENZOATE'>TX1</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ix3\|3ix3]], [[3ix8\|3ix8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ix3\|3ix3]], [[3ix8\|3ix8]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lasR, PA1430 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 ~~Pseudomonas aeruginosa~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lasR, PA1430 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ix4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ix4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ix4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ix4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ix4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ix4 OCA], [http://pdbe.org/3ix4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ix4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ix4 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ix4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ix4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Pseudomonas aeruginosa]]
	[[Category: Nair, S K]]		[[Category: Nair, S K]]
	[[Category: Zou, Y]]		[[Category: Zou, Y]]

OCA at 09:56, 25 December 2014

OCA — Thu, 25 Dec 2014 09:56:53 GMT

←Older revision		Revision as of 09:56, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ix4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ix4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ix4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ix4 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ix4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ix4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ix4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ix4 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/LASR_PSEAE LASR_PSEAE]] Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 16:13, 18 December 2014

OCA — Thu, 18 Dec 2014 16:13:23 GMT

←Older revision		Revision as of 16:13, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3ix4~~\| ~~PDB~~=3ix4 \| ~~SCENE~~= }}	+	==LasR-TP1 complex==
-	===~~LasR~~-~~TP1 complex~~===	+	<StructureSection load='3ix4' size='340' side='right' caption='[[3ix4]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19778724}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ix4]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IX4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IX4 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TX1:2,4-DIBROMO-6-({[(2-NITROPHENYL)CARBONYL]AMINO}METHYL)PHENYL+2-CHLOROBENZOATE'>TX1</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ix3\|3ix3]], [[3ix8\|3ix8]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lasR, PA1430 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ix4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ix4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ix4 RCSB], [http://www.ebi.ac.uk/pdbsum/3ix4 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/3ix4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The human pathogen Pseudomonas aeruginosa coordinates the expression of virulence factors using quorum sensing, a signaling cascade triggered by the activation of signal receptors by small-molecule autoinducers. These homoserine lactone autoinducers stabilize their cognate receptors and activate their functions as transcription factors. Because quorum sensing regulates the progression of infection and host immune resistance, significant efforts have been devoted toward the identification of small molecules that disrupt this process. Screening efforts have identified a class of triphenyl compounds that are structurally distinct from the homoserine lactone autoinducer, yet interact specifically and potently with LasR receptor to modulate quorum sensing (Muh et al., 2006a). Here we present the high-resolution crystal structures of the ligand binding domain of LasR in complex with the autoinducer N-3-oxo-dodecanoyl homoserine lactone (1.4 A resolution), and with the triphenyl mimics TP-1, TP-3, and TP-4 (to between 1.8 A and 2.3 A resolution). These crystal structures provide a molecular rationale for understanding how chemically distinct compounds can be accommodated by a highly selective receptor, and provide the framework for the development of novel quorum-sensing regulators, utilizing the triphenyl scaffold.

-	~~==Function==~~	+	Molecular basis for the recognition of structurally distinct autoinducer mimics by the Pseudomonas aeruginosa LasR quorum-sensing signaling receptor.,Zou Y, Nair SK Chem Biol. 2009 Sep 25;16(9):961-70. PMID:19778724<ref>PMID:19778724</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/LASR_PSEAE LASR_PSEAE]] Transcriptional activator of elastase structural gene~~ (~~LasB~~). ~~Binds to the PAI autoinducer.~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3ix4]] is~~ a ~~8 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3IX4 OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:019778724</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Transcriptional activator\|Transcriptional activator]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
-	[[Category: Nair, S K.]]	+	[[Category: Nair, S K]]
-	[[Category: Zou, Y.]]	+	[[Category: Zou, Y]]
	[[Category: Activator]]		[[Category: Activator]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]

OCA: Protected "3ix4" [edit=sysop:move=sysop]

OCA — Wed, 27 Mar 2013 09:14:25 GMT

Protected "3ix4" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:14, 27 March 2013

OCA at 09:14, 27 March 2013

OCA — Wed, 27 Mar 2013 09:14:23 GMT

←Older revision		Revision as of 09:14, 27 March 2013
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-	{{Seed}}
-	[[Image:3ix4.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ix4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ix4\| PDB=3ix4 \| SCENE= }}		{{STRUCTURE_3ix4\| PDB=3ix4 \| SCENE= }}
-
	===LasR-TP1 complex===		===LasR-TP1 complex===
		+	{{ABSTRACT_PUBMED_19778724}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/LASR_PSEAE LASR_PSEAE]] Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer.
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_19778724}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~)~~, where 19778724 is~~ the ~~PubMed ID number~~.	+
-	~~-->~~	+
-	~~{{ABSTRACT_PUBMED_19778724}}~~	+

	==About this Structure==		==About this Structure==
-	~~3IX4~~ is a 8 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IX4 OCA].	+	[[3ix4]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IX4 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19778724~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019778724</ref><references group="xtra"/><references/>
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
	[[Category: Nair, S K.]]		[[Category: Nair, S K.]]
Line 33:		Line 20:
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Triphenyl mimic]]		[[Category: Triphenyl mimic]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 14 09:53:46 2009''

OCA at 07:53, 14 October 2009

OCA — Wed, 14 Oct 2009 07:53:47 GMT

←Older revision		Revision as of 07:53, 14 October 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3ix4.~~jpg~~\|left\|200px]]	+	[[Image:3ix4.png\|left\|200px]]

	<!--		<!--
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	===LasR-TP1 complex===		===LasR-TP1 complex===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19778724}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19778724 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19778724}}

	==About this Structure==		==About this Structure==
	3IX4 is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IX4 OCA].		3IX4 is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IX4 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19778724</ref><references group="xtra"/>
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
	[[Category: Nair, S K.]]		[[Category: Nair, S K.]]
Line 25:		Line 34:
	[[Category: Triphenyl mimic]]		[[Category: Triphenyl mimic]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 16~~ 09:15:56 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 14 09:53:46 2009''

OCA at 06:15, 16 September 2009

OCA — Wed, 16 Sep 2009 06:15:57 GMT

←Older revision		Revision as of 06:15, 16 September 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3ix4.jpg\|left\|200px]]

-	The ~~entry 3ix4~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ix4", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ix4\| PDB=3ix4 \| SCENE= }}

-	~~Authors: Zou, Y., Nair, S.K.~~	+	===LasR-TP1 complex===

-	Description: LasR-TP1 complex

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 9 09:08:53 2009''	+	==About this Structure==
		+	3IX4 is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IX4 OCA].
		+	[[Category: Pseudomonas aeruginosa]]
		+	[[Category: Nair, S K.]]
		+	[[Category: Zou, Y.]]
		+	[[Category: Activator]]
		+	[[Category: Dna-binding]]
		+	[[Category: Quorum sensing]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription regulation]]
		+	[[Category: Triphenyl mimic]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 09:15:56 2009''