3ixy - Revision history

OCA at 10:07, 21 February 2024

OCA — Wed, 21 Feb 2024 10:07:31 GMT

←Older revision		Revision as of 10:07, 21 February 2024
Line 3:		Line 3:
	<SX load='3ixy' size='340' side='right' viewer='molstar' caption='[[3ixy]], [[Resolution\|resolution]] 23.00Å' scene=''>		<SX load='3ixy' size='340' side='right' viewer='molstar' caption='[[3ixy]], [[Resolution\|resolution]] 23.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ixy]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IXY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ixy]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IXY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ixy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixy OCA], [https://pdbe.org/3ixy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ixy RCSB], [https://www.ebi.ac.uk/pdbsum/3ixy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ixy ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 23Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ixy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixy OCA], [https://pdbe.org/3ixy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ixy RCSB], [https://www.ebi.ac.uk/pdbsum/3ixy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ixy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~O11875_9FLAV O11875_9FLAV~~]~~] Envelope protein E~~ binding to ~~host~~ cell surface ~~receptor is followed~~ by ~~virus internalization~~ through ~~clathrin-mediated endocytosis~~. ~~Envelope protein E is subsequently involved in membrane fusion between virion and~~ host ~~late endosomes~~. ~~Synthesized as a homodimer with prM which acts as a chaperone for~~ envelope protein E. After ~~cleavage of prM~~, ~~envelope protein E dissociate~~ from ~~small envelope protein M and homodimerizes (By similarity)~~.[~~SAAS~~:~~SAAS026470_004_099774~~] ~~[[https://www.uniprot.org/uniprot/POLG_DEN2U POLG_DEN2U]] prM acts~~ as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the ~~last step of virion assembly, presumably~~ to avoid catastrophic activation of the viral fusion ~~peptide induced by the~~ acidic ~~pH of the trans-~~Golgi ~~network~~. ~~After~~ cleavage ~~by host furin~~, ~~the pr peptide is released in the extracellular medium~~ and ~~small envelope protein M and envelope protein E homodimers~~ are ~~dissociated (By similarity)~~. ~~Envelope protein E binding~~ to host cell surface receptor ~~is followed by virus internalization through clathrin-mediated endocytosis~~. Envelope protein E is ~~subsequently involved~~ in ~~membrane fusion between virion and host late endosomes~~. ~~Synthesized as~~ a ~~homodimer~~ with prM ~~which acts as a chaperone for~~ envelope protein E. ~~After cleavage~~ of prM~~, envelope protein~~ E ~~dissociate~~ from ~~small envelope protein M~~ and ~~homodimerizes~~ (By similarity). ~~Non~~-~~structural protein 1 is involved~~ in ~~virus replication~~ and ~~regulation~~ of the innate immune response. ~~Soluble~~ and ~~membrane~~-~~associated NS1 may activate human complement~~ and ~~induce~~ host ~~vascular leakage~~. ~~This effect might explain~~ the ~~clinical manifestations~~ of ~~dengue hemorrhagic fever~~ and ~~dengue shock syndrome~~ (By similarity).	+	[https://www.uniprot.org/uniprot/POLG_DEN2Q POLG_DEN2Q] Plays a role in virus budding by binding to the cell membrane and gathering the viral RNA into a nucleocapsid that forms the core of a mature virus particle. During virus entry, may induce genome penetration into the host cytoplasm after hemifusion induced by the surface proteins. Can migrate to the cell nucleus where it modulates host functions. Overcomes the anti-viral effects of host EXOC1 by sequestering and degrading the latter through the proteasome degradation pathway.[UniProtKB:P17763] Inhibits RNA silencing by interfering with host Dicer.[UniProtKB:P03314] Prevents premature fusion activity of envelope proteins in trans-Golgi by binding to envelope protein E at pH6.0. After virion release in extracellular space, gets dissociated from E dimers.[UniProtKB:P17763] Acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is the only viral peptide matured by host furin in the trans-Golgi network probably to avoid catastrophic activation of the viral fusion activity in acidic Golgi compartment prior to virion release. prM-E cleavage is inefficient, and many virions are only partially matured. These uncleaved prM would play a role in immune evasion.[UniProtKB:P17763] May play a role in virus budding. Exerts cytotoxic effects by activating a mitochondrial apoptotic pathway through M ectodomain. May display a viroporin activity.[UniProtKB:P17763] Binds to host cell surface receptor and mediates fusion between viral and cellular membranes. Envelope protein is synthesized in the endoplasmic reticulum in the form of heterodimer with protein prM. They play a role in virion budding in the ER, and the newly formed immature particle is covered with 60 spikes composed of heterodimer between precursor prM and envelope protein E. The virion is transported to the Golgi apparatus where the low pH causes dissociation of PrM-E heterodimers and formation of E homodimers. prM-E cleavage is inefficient, and many virions are only partially matured. These uncleaved prM would play a role in immune evasion.[UniProtKB:P17763] Involved in immune evasion, pathogenesis and viral replication. Once cleaved off the polyprotein, is targeted to three destinations: the viral replication cycle, the plasma membrane and the extracellular compartment. Essential for viral replication. Required for formation of the replication complex and recruitment of other non-structural proteins to the ER-derived membrane structures. Excreted as a hexameric lipoparticle that plays a role against host immune response. Antagonizing the complement function. Binds to the host macrophages and dendritic cells. Inhibits signal transduction originating from Toll-like receptor 3 (TLR3).[UniProtKB:Q9Q6P4] Disrupts the host endothelial glycocalyx layer of host pulmonary microvascular endothelial cells, inducing degradation of sialic acid and shedding of heparan sulfate proteoglycans. NS1 induces expression of sialidases, heparanase, and activates cathepsin L, which activates heparanase via enzymatic cleavage. These effects are probably linked to the endothelial hyperpermeability observed in severe dengue disease.[UniProtKB:P17763] Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.[UniProtKB:P17763] Required cofactor for the serine protease function of NS3. May have membrane-destabilizing activity and form viroporins (By similarity).[UniProtKB:P17763][PROSITE-ProRule:PRU00859] Displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS2B, performs its autocleavage and cleaves the polyprotein at dibasic sites in the cytoplasm: C-prM, NS2A-NS2B, NS2B-NS3, NS3-NS4A, NS4A-2K and NS4B-NS5. NS3 RNA helicase binds RNA and unwinds dsRNA in the 3' to 5' direction.[PROSITE-ProRule:PRU00860] Regulates the ATPase activity of the NS3 helicase activity. NS4A allows NS3 helicase to conserve energy during unwinding. Plays a role in the inhibition of the host innate immune response. Interacts with host MAVS and thereby prevents the interaction between RIGI and MAVS. In turn, IFN-beta production is impaired. Interacts with host AUP1 which mediates induction of lipophagy in host cells and facilitates production of virus progeny particles (By similarity).[UniProtKB:P17763][UniProtKB:P29991][UniProtKB:Q9Q6P4] Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.[UniProtKB:P17763] Induces the formation of ER-derived membrane vesicles where the viral replication takes place. Inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway.[UniProtKB:Q9Q6P4] Replicates the viral (+) and (-) RNA genome, and performs the capping of genomes in the cytoplasm. NS5 methylates viral RNA cap at guanine N-7 and ribose 2'-O positions. Besides its role in RNA genome replication, also prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) signaling pathway. Inhibits host TYK2 and STAT2 phosphorylation, thereby preventing activation of JAK-STAT signaling pathway (By similarity). May reduce immune responses by preventing the recruitment of the host PAF1 complex to interferon-responsive genes (By similarity).[UniProtKB:P17763][UniProtKB:P29990]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ixy ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ixy ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Flaviviruses are a group of human pathogens causing severe encephalitic or hemorrhagic diseases that include West Nile, dengue and yellow fever viruses. Here, using X-ray crystallography we have defined the structure of the flavivirus cross-reactive antibody E53 that engages the highly conserved fusion loop of the West Nile virus envelope glycoprotein. Using cryo-electron microscopy, we also determined that E53 Fab binds preferentially to spikes in noninfectious, immature flavivirions but is unable to bind significantly to mature virions, consistent with the limited solvent exposure of the epitope. We conclude that the neutralizing impact of E53 and likely similar fusion-loop-specific antibodies depends on its binding to the frequently observed immature component of flavivirus particles. Our results elucidate how fusion-loop antibodies, which comprise a significant fraction of the humoral response against flaviviruses, can function to control infection without appreciably recognizing mature virions. As these highly cross-reactive antibodies are often weakly neutralizing they also may contribute to antibody-dependent enhancement and flavi virus pathogenesis thereby complicating development of safe and effective vaccines.
-
-	Structural basis for the preferential recognition of immature flaviviruses by a fusion-loop antibody.,Cherrier MV, Kaufmann B, Nybakken GE, Lok SM, Warren JT, Chen BR, Nelson CA, Kostyuchenko VA, Holdaway HA, Chipman PR, Kuhn RJ, Diamond MS, Rossmann MG, Fremont DH EMBO J. 2009 Oct 21;28(20):3269-76. Epub 2009 Aug 27. PMID:19713934<ref>PMID:19713934</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3ixy" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]		*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</SX>		</SX>
	[[Category: Dengue virus 2]]		[[Category: Dengue virus 2]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Cherrier~~, M V~~]]	+	[[Category: Cherrier MV]]
-	[[Category: Chipman~~, P R~~]]	+	[[Category: Chipman PR]]
-	[[Category: Diamond~~, M S~~]]	+	[[Category: Diamond MS]]
-	[[Category: Fremont~~, D H~~]]	+	[[Category: Fremont DH]]
-	[[Category: Holdaway~~, H A~~]]	+	[[Category: Holdaway HA]]
-	[[Category: Kaufmann, B]]	+	[[Category: Kaufmann B]]
-	[[Category: Kostyuchenko~~, V A~~]]	+	[[Category: Kostyuchenko VA]]
-	[[Category: Kuhn~~, R J~~]]	+	[[Category: Kuhn RJ]]
-	[[Category: Lok~~, S M~~]]	+	[[Category: Lok SM]]
-	[[Category: Nelson~~, C A~~]]	+	[[Category: Nelson CA]]
-	[[Category: Nybakken~~, G E~~]]	+	[[Category: Nybakken GE]]
-	[[Category: Rossmann~~, M G~~]]	+	[[Category: Rossmann MG]]
-	[[Category: Warren~~, J T]]~~	+	[[Category: Warren JT]]
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Capsid protein]]~~	+
-	~~[[Category: Cleavage on pair of basic residue]]~~	+
-	~~[[Category: Core protein]]~~	+
-	~~[[Category: Dengue virus]]~~	+
-	~~[[Category: Denv]]~~	+
-	~~[[Category: E53]]~~	+
-	~~[[Category: Endoplasmic reticulum]]~~	+
-	~~[[Category: Envelope protein]]~~	+
-	~~[[Category: Fab]]~~	+
-	~~[[Category: Fusion loop]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Helicase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Immature]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Nucleotide-binding]]~~	+
-	~~[[Category: Rna replication]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Transmembrane]]~~	+
-	~~[[Category: Virion]]~~	+
-	~~[[Category: Virus~~]]	+

OCA at 03:44, 21 April 2022

OCA — Thu, 21 Apr 2022 03:44:46 GMT

←Older revision		Revision as of 03:44, 21 April 2022
Line 3:		Line 3:
	<SX load='3ixy' size='340' side='right' viewer='molstar' caption='[[3ixy]], [[Resolution\|resolution]] 23.00Å' scene=''>		<SX load='3ixy' size='340' side='right' viewer='molstar' caption='[[3ixy]], [[Resolution\|resolution]] 23.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ixy]] is a 10 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3IXY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ixy]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IXY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3ixy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixy OCA], [~~http~~://pdbe.org/3ixy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ixy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ixy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ixy ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ixy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixy OCA], [https://pdbe.org/3ixy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ixy RCSB], [https://www.ebi.ac.uk/pdbsum/3ixy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ixy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/O11875_9FLAV O11875_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774] [[~~http~~://www.uniprot.org/uniprot/POLG_DEN2U POLG_DEN2U]] prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated (By similarity). Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity). Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome (By similarity).	+	[[https://www.uniprot.org/uniprot/O11875_9FLAV O11875_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774] [[https://www.uniprot.org/uniprot/POLG_DEN2U POLG_DEN2U]] prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated (By similarity). Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity). Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[3D structures of non-human antibody\|3D structures of non-human antibody]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 17:24, 10 April 2020

OCA — Fri, 10 Apr 2020 17:24:01 GMT

←Older revision		Revision as of 17:24, 10 April 2020
Line 3:		Line 3:
	<SX load='3ixy' size='340' side='right' viewer='molstar' caption='[[3ixy]], [[Resolution\|resolution]] 23.00Å' scene=''>		<SX load='3ixy' size='340' side='right' viewer='molstar' caption='[[3ixy]], [[Resolution\|resolution]] 23.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ixy]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXY OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3IXY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ixy]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3IXY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ixy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixy OCA], [http://pdbe.org/3ixy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ixy RCSB], [http://www.ebi.ac.uk/pdbsum/3ixy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ixy ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3ixy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixy OCA], [http://pdbe.org/3ixy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ixy RCSB], [http://www.ebi.ac.uk/pdbsum/3ixy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ixy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 04:25, 5 March 2020

OCA — Thu, 05 Mar 2020 04:25:15 GMT

←Older revision		Revision as of 04:25, 5 March 2020
Line 1:		Line 1:

	==The pseudo-atomic structure of dengue immature virus in complex with Fab fragments of the anti-fusion loop antibody E53==		==The pseudo-atomic structure of dengue immature virus in complex with Fab fragments of the anti-fusion loop antibody E53==
-	<~~StructureSection~~ load='3ixy' size='340' side='right' caption='[[3ixy]], [[Resolution\|resolution]] 23.00Å' scene=''>	+	<SX load='3ixy' size='340' side='right' viewer='molstar' caption='[[3ixy]], [[Resolution\|resolution]] 23.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ixy]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IXY FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ixy]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IXY FirstGlance]. <br>
Line 33:		Line 33:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Dengue virus 2]]		[[Category: Dengue virus 2]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Cherrier, M V]]		[[Category: Cherrier, M V]]

OCA at 07:59, 18 July 2018

OCA — Wed, 18 Jul 2018 07:59:21 GMT

←Older revision		Revision as of 07:59, 18 July 2018
Line 1:		Line 1:
		+
	==The pseudo-atomic structure of dengue immature virus in complex with Fab fragments of the anti-fusion loop antibody E53==		==The pseudo-atomic structure of dengue immature virus in complex with Fab fragments of the anti-fusion loop antibody E53==
	<StructureSection load='3ixy' size='340' side='right' caption='[[3ixy]], [[Resolution\|resolution]] 23.00Å' scene=''>		<StructureSection load='3ixy' size='340' side='right' caption='[[3ixy]], [[Resolution\|resolution]] 23.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ixy]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IXY FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ixy]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IXY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ixy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixy OCA], [http://pdbe.org/3ixy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ixy RCSB], [http://www.ebi.ac.uk/pdbsum/3ixy PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ixy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixy OCA], [http://pdbe.org/3ixy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ixy RCSB], [http://www.ebi.ac.uk/pdbsum/3ixy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ixy ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/3ixy_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/3ixy_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:

	==See Also==		==See Also==
-	*[[Antibody\|Antibody]]	+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:22, 9 February 2016

OCA — Tue, 09 Feb 2016 22:22:29 GMT

←Older revision		Revision as of 22:22, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3ixy' size='340' side='right' caption='[[3ixy]], [[Resolution\|resolution]] 23.00Å' scene=''>		<StructureSection load='3ixy' size='340' side='right' caption='[[3ixy]], [[Resolution\|resolution]] 23.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ixy]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IXY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ixy]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IXY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ixy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ixy RCSB], [http://www.ebi.ac.uk/pdbsum/3ixy PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ixy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixy OCA], [http://pdbe.org/3ixy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ixy RCSB], [http://www.ebi.ac.uk/pdbsum/3ixy PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/POLG_DEN2U POLG_DEN2U]] prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated (By similarity). Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity). Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome (By similarity).	+	[[http://www.uniprot.org/uniprot/O11875_9FLAV O11875_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774] [[http://www.uniprot.org/uniprot/POLG_DEN2U POLG_DEN2U]] prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated (By similarity). Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity). Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ixy ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3ixy" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Dengue virus 2]]		[[Category: Dengue virus 2]]
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Cherrier, M V]]		[[Category: Cherrier, M V]]
	[[Category: Chipman, P R]]		[[Category: Chipman, P R]]

OCA at 09:55, 25 December 2014

OCA — Thu, 25 Dec 2014 09:55:41 GMT

←Older revision		Revision as of 09:55, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3ixy]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IXY FirstGlance]. <br>		<table><tr><td colspan='2'>[[3ixy]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IXY FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ixy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ixy RCSB], [http://www.ebi.ac.uk/pdbsum/3ixy PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ixy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ixy RCSB], [http://www.ebi.ac.uk/pdbsum/3ixy PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/POLG_DEN2U POLG_DEN2U]] prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated (By similarity). Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity). Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	[[Category: Dengue virus 2]]		[[Category: Dengue virus 2]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Cherrier, M V.]]	+	[[Category: Cherrier, M V]]
-	[[Category: Chipman, P R.]]	+	[[Category: Chipman, P R]]
-	[[Category: Diamond, M S.]]	+	[[Category: Diamond, M S]]
-	[[Category: Fremont, D H.]]	+	[[Category: Fremont, D H]]
-	[[Category: Holdaway, H A.]]	+	[[Category: Holdaway, H A]]
-	[[Category: Kaufmann, B.]]	+	[[Category: Kaufmann, B]]
-	[[Category: Kostyuchenko, V A.]]	+	[[Category: Kostyuchenko, V A]]
-	[[Category: Kuhn, R J.]]	+	[[Category: Kuhn, R J]]
-	[[Category: Lok, S M.]]	+	[[Category: Lok, S M]]
-	[[Category: Nelson, C A.]]	+	[[Category: Nelson, C A]]
-	[[Category: Nybakken, G E.]]	+	[[Category: Nybakken, G E]]
-	[[Category: Rossmann, M G.]]	+	[[Category: Rossmann, M G]]
-	[[Category: Warren, J T.]]	+	[[Category: Warren, J T]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Capsid protein]]		[[Category: Capsid protein]]

OCA at 13:12, 29 September 2014

OCA — Mon, 29 Sep 2014 13:12:47 GMT

←Older revision		Revision as of 13:12, 29 September 2014
Line 1:		Line 1:
-	[[~~Image~~:3ixy.~~png\|left~~\|200px]]	+	==The pseudo-atomic structure of dengue immature virus in complex with Fab fragments of the anti-fusion loop antibody E53==
		+	<StructureSection load='3ixy' size='340' side='right' caption='[[3ixy]], [[Resolution\|resolution]] 23.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ixy]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3IXY FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ixy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ixy RCSB], [http://www.ebi.ac.uk/pdbsum/3ixy PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/3ixy_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Flaviviruses are a group of human pathogens causing severe encephalitic or hemorrhagic diseases that include West Nile, dengue and yellow fever viruses. Here, using X-ray crystallography we have defined the structure of the flavivirus cross-reactive antibody E53 that engages the highly conserved fusion loop of the West Nile virus envelope glycoprotein. Using cryo-electron microscopy, we also determined that E53 Fab binds preferentially to spikes in noninfectious, immature flavivirions but is unable to bind significantly to mature virions, consistent with the limited solvent exposure of the epitope. We conclude that the neutralizing impact of E53 and likely similar fusion-loop-specific antibodies depends on its binding to the frequently observed immature component of flavivirus particles. Our results elucidate how fusion-loop antibodies, which comprise a significant fraction of the humoral response against flaviviruses, can function to control infection without appreciably recognizing mature virions. As these highly cross-reactive antibodies are often weakly neutralizing they also may contribute to antibody-dependent enhancement and flavi virus pathogenesis thereby complicating development of safe and effective vaccines.

-	~~{{STRUCTURE_3ixy\| PDB=3ixy \| SCENE= }}~~	+	Structural basis for the preferential recognition of immature flaviviruses by a fusion-loop antibody.,Cherrier MV, Kaufmann B, Nybakken GE, Lok SM, Warren JT, Chen BR, Nelson CA, Kostyuchenko VA, Holdaway HA, Chipman PR, Kuhn RJ, Diamond MS, Rossmann MG, Fremont DH EMBO J. 2009 Oct 21;28(20):3269-76. Epub 2009 Aug 27. PMID:19713934<ref>PMID:19713934</ref>

-	~~===The pseudo-atomic structure of dengue immature virus in complex with Fab fragments~~ of the ~~anti-fusion loop antibody E53===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19713934}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3ixy]] is a 10 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en~~.~~wikipedia.org~~/~~wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXY OCA].~~	+

	==See Also==		==See Also==
	*[[Antibody\|Antibody]]		*[[Antibody\|Antibody]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019713934<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Dengue virus 2]]		[[Category: Dengue virus 2]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]

OCA at 15:20, 20 October 2012

OCA — Sat, 20 Oct 2012 15:20:34 GMT

←Older revision		Revision as of 15:20, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3ixy]] is a 10 chain structure ~~of [[Antibody]]~~ with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXY OCA].	+	[[3ixy]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IXY OCA].

	==See Also==		==See Also==

OCA: Protected "3ixy" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 18:04:50 GMT

Protected "3ixy" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:04, 26 July 2012