3j42 - Revision history

OCA at 14:15, 24 January 2024

OCA — Wed, 24 Jan 2024 14:15:18 GMT

←Older revision		Revision as of 14:15, 24 January 2024
Line 3:		Line 3:
	<SX load='3j42' size='340' side='right' viewer='molstar' caption='[[3j42]], [[Resolution\|resolution]] 21.00Å' scene=''>		<SX load='3j42' size='340' side='right' viewer='molstar' caption='[[3j42]], [[Resolution\|resolution]] 21.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3j42]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J42 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3j42]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J42 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[3c6d\|3c6d]], [[4kvc\|4kvc]]</div></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 21Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">Igh-1a, Igh ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10090 LK3 transgenic mice]), Gm16939 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j42 OCA], [https://pdbe.org/3j42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j42 RCSB], [https://www.ebi.ac.uk/pdbsum/3j42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j42 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j42 OCA], [https://pdbe.org/3j42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j42 RCSB], [https://www.ebi.ac.uk/pdbsum/3j42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j42 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/O11875_9FLAV O11875_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774] [[https://www.uniprot.org/uniprot/Q3BCY5_9FLAV Q3BCY5_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]	+	[https://www.uniprot.org/uniprot/O11875_9FLAV O11875_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 24:
	[[Category: Dengue virus 2]]		[[Category: Dengue virus 2]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Jiang, W]]	+	[[Category: Jiang W]]
-	[[Category: Pennington~~, J G~~]]	+	[[Category: Pennington JG]]
-	[[Category: Rossmann~~, M G~~]]	+	[[Category: Rossmann MG]]
-	[[Category: Wang, Z]]	+	[[Category: Wang Z]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Dengue]]~~	+
-	~~[[Category: Immature]]~~	+
-	~~[[Category: Maturation]]~~	+
-	~~[[Category: Virus-immune system complex~~]]	+

OCA at 03:49, 21 April 2022

OCA — Thu, 21 Apr 2022 03:49:37 GMT

←Older revision		Revision as of 03:49, 21 April 2022
Line 3:		Line 3:
	<SX load='3j42' size='340' side='right' viewer='molstar' caption='[[3j42]], [[Resolution\|resolution]] 21.00Å' scene=''>		<SX load='3j42' size='340' side='right' viewer='molstar' caption='[[3j42]], [[Resolution\|resolution]] 21.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3j42]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J42 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3J42 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3j42]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J42 FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c6d\|3c6d]], [[4kvc\|4kvc]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3c6d\|3c6d]], [[4kvc\|4kvc]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Igh-1a, Igh ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Gm16939 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Igh-1a, Igh ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Gm16939 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3j42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j42 OCA], [~~http~~://pdbe.org/3j42 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3j42 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3j42 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3j42 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j42 OCA], [https://pdbe.org/3j42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j42 RCSB], [https://www.ebi.ac.uk/pdbsum/3j42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j42 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/O11875_9FLAV O11875_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774] [[~~http~~://www.uniprot.org/uniprot/Q3BCY5_9FLAV Q3BCY5_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]	+	[[https://www.uniprot.org/uniprot/O11875_9FLAV O11875_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774] [[https://www.uniprot.org/uniprot/Q3BCY5_9FLAV Q3BCY5_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 17:54, 10 April 2020

OCA — Fri, 10 Apr 2020 17:54:09 GMT

←Older revision		Revision as of 17:54, 10 April 2020
Line 3:		Line 3:
	<SX load='3j42' size='340' side='right' viewer='molstar' caption='[[3j42]], [[Resolution\|resolution]] 21.00Å' scene=''>		<SX load='3j42' size='340' side='right' viewer='molstar' caption='[[3j42]], [[Resolution\|resolution]] 21.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3j42]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J42 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3J42 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3j42]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J42 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3J42 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c6d\|3c6d]], [[4kvc\|4kvc]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c6d\|3c6d]], [[4kvc\|4kvc]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Igh-1a, Igh ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Gm16939 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Igh-1a, Igh ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Gm16939 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3j42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j42 OCA], [http://pdbe.org/3j42 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3j42 RCSB], [http://www.ebi.ac.uk/pdbsum/3j42 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3j42 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3j42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j42 OCA], [http://pdbe.org/3j42 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3j42 RCSB], [http://www.ebi.ac.uk/pdbsum/3j42 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3j42 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 04:27, 5 March 2020

OCA — Thu, 05 Mar 2020 04:27:35 GMT

←Older revision		Revision as of 04:27, 5 March 2020
Line 1:		Line 1:

	==Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody==		==Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody==
-	<~~StructureSection~~ load='3j42' size='340' side='right' caption='[[3j42]], [[Resolution\|resolution]] 21.00Å' scene=''>	+	<SX load='3j42' size='340' side='right' viewer='molstar' caption='[[3j42]], [[Resolution\|resolution]] 21.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3j42]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J42 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3j42]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J42 FirstGlance]. <br>
Line 22:		Line 22:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Dengue virus 2]]		[[Category: Dengue virus 2]]
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Jiang, W]]		[[Category: Jiang, W]]

OCA at 08:10, 18 July 2018

OCA — Wed, 18 Jul 2018 08:10:59 GMT

←Older revision		Revision as of 08:10, 18 July 2018
Line 3:		Line 3:
	<StructureSection load='3j42' size='340' side='right' caption='[[3j42]], [[Resolution\|resolution]] 21.00Å' scene=''>		<StructureSection load='3j42' size='340' side='right' caption='[[3j42]], [[Resolution\|resolution]] 21.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3j42]] is a 12 chain structure with sequence from ~~[http://en.wikipedia.org/wiki/Den26 Den26],~~ [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J42 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3j42]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J42 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c6d\|3c6d]], [[4kvc\|4kvc]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c6d\|3c6d]], [[4kvc\|4kvc]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Igh-1a, Igh ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Gm16939 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Igh-1a, Igh ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Gm16939 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
Line 23:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Den26]]
	[[Category: Dengue virus 2]]		[[Category: Dengue virus 2]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]

OCA at 15:41, 4 August 2016

OCA — Thu, 04 Aug 2016 15:41:35 GMT

←Older revision		Revision as of 15:41, 4 August 2016
Line 1:		Line 1:
		+
	==Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody==		==Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody==
	<StructureSection load='3j42' size='340' side='right' caption='[[3j42]], [[Resolution\|resolution]] 21.00Å' scene=''>		<StructureSection load='3j42' size='340' side='right' caption='[[3j42]], [[Resolution\|resolution]] 21.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3j42]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Den26 Den26], [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2~~], [http://en.wikipedia.org/wiki/Gekko_coi Gekko coi~~] and [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J42 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3j42]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Den26 Den26], [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J42 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c6d\|3c6d]], [[4kvc\|4kvc]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c6d\|3c6d]], [[4kvc\|4kvc]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Igh-1a, Igh ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~1118509 Gekko coi~~]), Gm16939 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Igh-1a, Igh ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Gm16939 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j42 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j42 RCSB], [http://www.ebi.ac.uk/pdbsum/3j42 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j42 OCA], [http://pdbe.org/3j42 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3j42 RCSB], [http://www.ebi.ac.uk/pdbsum/3j42 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3j42 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/Q3BCY5_9FLAV Q3BCY5_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]	+	[[http://www.uniprot.org/uniprot/O11875_9FLAV O11875_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774] [[http://www.uniprot.org/uniprot/Q3BCY5_9FLAV Q3BCY5_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3j42" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 25:
	[[Category: Den26]]		[[Category: Den26]]
	[[Category: Dengue virus 2]]		[[Category: Dengue virus 2]]
-	[[Category: ~~Gekko coi]]~~	+	[[Category: Lk3 transgenic mice]]
-	~~[[Category: Mus musculus~~]]	+
	[[Category: Jiang, W]]		[[Category: Jiang, W]]
	[[Category: Pennington, J G]]		[[Category: Pennington, J G]]

OCA at 16:32, 24 December 2014

OCA — Wed, 24 Dec 2014 16:32:27 GMT

←Older revision		Revision as of 16:32, 24 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3j42\| PDB=3j42 \| SCENE= }}~~	+	==Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody==
-	===Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody===	+	<StructureSection load='3j42' size='340' side='right' caption='[[3j42]], [[Resolution\|resolution]] 21.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_23740974}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3j42]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Den26 Den26], [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2], [http://en.wikipedia.org/wiki/Gekko_coi Gekko coi] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J42 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J42 FirstGlance]. <br>
-	==Function==	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3c6d\|3c6d]], [[4kvc\|4kvc]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Igh-1a, Igh ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1118509 Gekko coi]), Gm16939 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j42 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j42 RCSB], [http://www.ebi.ac.uk/pdbsum/3j42 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
	[[http://www.uniprot.org/uniprot/Q3BCY5_9FLAV Q3BCY5_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]		[[http://www.uniprot.org/uniprot/Q3BCY5_9FLAV Q3BCY5_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The 2H2 monoclonal antibody recognizes the precursor peptide on the immature dengue virus and might, therefore, be a useful tool for investigating the conformational change that occurs when the immature virus enters an acidic environment. During dengue virus maturation, the spiky, immature, non-infectious virions change their structure to smooth-surfaced particles in the slightly acid environment of the trans-Golgi network, thereby allowing cellular furin to cleave the precursor-membrane proteins. The dengue virions become fully infectious when they release the cleaved precursor peptide on reaching the neutral pH environment of the extracellular space. Here we report on the cryo-electron microscopy structures of the immature virus complexed with the 2H2 antigen binding fragments (Fab) at different concentrations and varied pH conditions. At neutral pH and high concentration of the Fab molecules, three Fab molecules bind to three precursor-membrane proteins on each spike of the immature virus. However, at a low concentration of the Fab molecules and at pH 7.0, only two Fab molecules bind to each spike. Changing to slightly acidic pH caused no detectable change of structure for the high Fab concentration sample, but caused severe structural damage to the low concentration sample. Therefore, the 2H2 Fab inhibits the maturation process of immature dengue virus when the Fab molecules are at high concentration, because the three Fab molecules on each spike hold the precursor-membrane molecules together, thereby inhibiting the normal conformational change that occurs during maturation.

-	~~==About this Structure==~~	+	Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody.,Wang Z, Li L, Pennington JG, Sheng J, Yap ML, Plevka P, Meng G, Sun L, Jiang W, Rossmann MG J Virol. 2013 Jun 5. PMID:23740974<ref>PMID:23740974</ref>
-	~~[[3j42]] is a 12 chain structure with sequence from [http://en~~.~~wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]~~, ~~[http://en~~.~~wikipedia~~.~~org/wiki/Gekko_coi Gekko coi] and [http~~:~~//en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3J42 OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:023740974</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Den26]]
	[[Category: Dengue virus 2]]		[[Category: Dengue virus 2]]
	[[Category: Gekko coi]]		[[Category: Gekko coi]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Jiang, W.]]	+	[[Category: Jiang, W]]
-	[[Category: Pennington, J G.]]	+	[[Category: Pennington, J G]]
-	[[Category: Rossmann, M G.]]	+	[[Category: Rossmann, M G]]
-	[[Category: Wang, Z.]]	+	[[Category: Wang, Z]]
	[[Category: Antibody]]		[[Category: Antibody]]
	[[Category: Dengue]]		[[Category: Dengue]]

OCA at 04:54, 18 July 2013

OCA — Thu, 18 Jul 2013 04:54:30 GMT

←Older revision		Revision as of 04:54, 18 July 2013
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_3j42\| PDB=3j42 \| SCENE= }}
		+	===Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody===
		+	{{ABSTRACT_PUBMED_23740974}}

-	~~The entry 3j42~~ is ~~ON HOLD~~	+	==Function==
		+	[[http://www.uniprot.org/uniprot/Q3BCY5_9FLAV Q3BCY5_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774]

-	~~Authors~~: ~~Wang, Z~~., ~~Pennington, J~~.G.~~, Jiang, W~~.~~, Rossmann, M~~.G.	+	==About this Structure==
		+	[[3j42]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2], [http://en.wikipedia.org/wiki/Gekko_coi Gekko coi] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J42 OCA].

-	~~Description~~: ~~Obstruction of~~ Dengue ~~Virus Maturation by Fab Fragments of the 2H2~~ Antibody	+	==Reference==
		+	<ref group="xtra">PMID:023740974</ref><references group="xtra"/><references/>
		+	[[Category: Dengue virus 2]]
		+	[[Category: Gekko coi]]
		+	[[Category: Mus musculus]]
		+	[[Category: Jiang, W.]]
		+	[[Category: Pennington, J G.]]
		+	[[Category: Rossmann, M G.]]
		+	[[Category: Wang, Z.]]
		+	[[Category: Antibody]]
		+	[[Category: Dengue]]
		+	[[Category: Immature]]
		+	[[Category: Maturation]]
		+	[[Category: Virus-immune system complex]]

OCA at 12:45, 3 July 2013

OCA — Wed, 03 Jul 2013 12:45:09 GMT

←Older revision		Revision as of 12:45, 3 July 2013
Line 3:		Line 3:
	The entry 3j42 is ON HOLD		The entry 3j42 is ON HOLD

-	Authors: Wang Z, Pennington JG, Jiang W, Rossmann MG	+	Authors: Wang, Z., Pennington, J.G., Jiang, W., Rossmann, M.G.

	Description: Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody		Description: Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody

OCA: Protected "3j42" [edit=sysop:move=sysop]

OCA — Wed, 19 Jun 2013 10:33:10 GMT

Protected "3j42" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:33, 19 June 2013