3j6o - Revision history

OCA at 14:16, 24 January 2024

OCA — Wed, 24 Jan 2024 14:16:34 GMT

←Older revision		Revision as of 14:16, 24 January 2024
Line 3:		Line 3:
	<SX load='3j6o' size='340' side='right' viewer='molstar' caption='[[3j6o]], [[Resolution\|resolution]] 9.00Å' scene=''>		<SX load='3j6o' size='340' side='right' viewer='molstar' caption='[[3j6o]], [[Resolution\|resolution]] 9.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3j6o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J6O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3j6o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J6O FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[3j6l\|3j6l]]~~, [[~~3j6m~~\|~~3j6m~~]]~~, [[3j6n\|3j6n]]</div>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 9Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6o OCA], [https://pdbe.org/3j6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j6o RCSB], [https://www.ebi.ac.uk/pdbsum/3j6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j6o ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6o OCA], [https://pdbe.org/3j6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j6o RCSB], [https://www.ebi.ac.uk/pdbsum/3j6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j6o ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CXAR_HUMAN CXAR_HUMAN] Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN.<ref>PMID:9096397</ref> <ref>PMID:11734628</ref> <ref>PMID:12297051</ref> <ref>PMID:15800062</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Carson~~, S D~~]]	+	[[Category: Carson SD]]
-	[[Category: Conway~~, J F~~]]	+	[[Category: Conway JF]]
-	[[Category: Hafenstein, S]]	+	[[Category: Hafenstein S]]
-	[[Category: Makhov~~, A M~~]]	+	[[Category: Makhov AM]]
-	[[Category: Organtini~~, L J]]~~	+	[[Category: Organtini LJ]]
-	~~[[Category: Car]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Coxsackievirus b3]]~~	+
-	~~[[Category: Cvb3~~]]	+

OCA at 03:50, 21 April 2022

OCA — Thu, 21 Apr 2022 03:50:50 GMT

←Older revision		Revision as of 03:50, 21 April 2022
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	<SX load='3j6o' size='340' side='right' viewer='molstar' caption='[[3j6o]], [[Resolution\|resolution]] 9.00Å' scene=''>		<SX load='3j6o' size='340' side='right' viewer='molstar' caption='[[3j6o]], [[Resolution\|resolution]] 9.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3j6o]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6O OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3J6O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3j6o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J6O FirstGlance]. <br>
-	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3j6l\|3j6l]], [[3j6m\|3j6m]], [[3j6n\|3j6n]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3j6l\|3j6l]], [[3j6m\|3j6m]], [[3j6n\|3j6n]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3j6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6o OCA], [~~http~~://pdbe.org/3j6o PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3j6o RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3j6o PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3j6o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6o OCA], [https://pdbe.org/3j6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j6o RCSB], [https://www.ebi.ac.uk/pdbsum/3j6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j6o ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 18:01, 10 April 2020

OCA — Fri, 10 Apr 2020 18:01:34 GMT

←Older revision		Revision as of 18:01, 10 April 2020
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	<SX load='3j6o' size='340' side='right' viewer='molstar' caption='[[3j6o]], [[Resolution\|resolution]] 9.00Å' scene=''>		<SX load='3j6o' size='340' side='right' viewer='molstar' caption='[[3j6o]], [[Resolution\|resolution]] 9.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3j6o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6O OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3J6O FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3j6o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6O OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3J6O FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3j6l\|3j6l]], [[3j6m\|3j6m]], [[3j6n\|3j6n]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3j6l\|3j6l]], [[3j6m\|3j6m]], [[3j6n\|3j6n]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3j6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6o OCA], [http://pdbe.org/3j6o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3j6o RCSB], [http://www.ebi.ac.uk/pdbsum/3j6o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3j6o ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3j6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6o OCA], [http://pdbe.org/3j6o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3j6o RCSB], [http://www.ebi.ac.uk/pdbsum/3j6o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3j6o ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:26, 6 March 2020

OCA — Fri, 06 Mar 2020 17:26:27 GMT

←Older revision		Revision as of 17:26, 6 March 2020
Line 1:		Line 1:

	==Kinetic and Structural Analysis of Coxsackievirus B3 Receptor Interactions and Formation of the A-particle==		==Kinetic and Structural Analysis of Coxsackievirus B3 Receptor Interactions and Formation of the A-particle==
-	<~~StructureSection~~ load='3j6o' size='340' side='right' caption='[[3j6o]], [[Resolution\|resolution]] 9.00Å' scene=''>	+	<SX load='3j6o' size='340' side='right' viewer='molstar' caption='[[3j6o]], [[Resolution\|resolution]] 9.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3j6o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J6O FirstGlance]. <br>		<table><tr><td colspan='2'>[[3j6o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J6O FirstGlance]. <br>
Line 19:		Line 19:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Carson, S D]]		[[Category: Carson, S D]]
	[[Category: Conway, J F]]		[[Category: Conway, J F]]

OCA at 06:34, 5 August 2016

OCA — Fri, 05 Aug 2016 06:34:52 GMT

←Older revision		Revision as of 06:34, 5 August 2016
Line 1:		Line 1:
		+
	==Kinetic and Structural Analysis of Coxsackievirus B3 Receptor Interactions and Formation of the A-particle==		==Kinetic and Structural Analysis of Coxsackievirus B3 Receptor Interactions and Formation of the A-particle==
	<StructureSection load='3j6o' size='340' side='right' caption='[[3j6o]], [[Resolution\|resolution]] 9.00Å' scene=''>		<StructureSection load='3j6o' size='340' side='right' caption='[[3j6o]], [[Resolution\|resolution]] 9.00Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[3j6o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J6O FirstGlance]. <br>		<table><tr><td colspan='2'>[[3j6o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J6O FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3j6l\|3j6l]], [[3j6m\|3j6m]], [[3j6n\|3j6n]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3j6l\|3j6l]], [[3j6m\|3j6m]], [[3j6n\|3j6n]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j6o RCSB], [http://www.ebi.ac.uk/pdbsum/3j6o PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6o OCA], [http://pdbe.org/3j6o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3j6o RCSB], [http://www.ebi.ac.uk/pdbsum/3j6o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3j6o ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 14:		Line 15:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3j6o" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 22:27, 3 January 2015

OCA — Sat, 03 Jan 2015 22:27:05 GMT

←Older revision		Revision as of 22:27, 3 January 2015
Line 2:		Line 2:
	<StructureSection load='3j6o' size='340' side='right' caption='[[3j6o]], [[Resolution\|resolution]] 9.00Å' scene=''>		<StructureSection load='3j6o' size='340' side='right' caption='[[3j6o]], [[Resolution\|resolution]] 9.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3j6o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6O OCA]. <br>	+	<table><tr><td colspan='2'>[[3j6o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J6O FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3j6l\|3j6l]], [[3j6m\|3j6m]], [[3j6n\|3j6n]]</td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3j6l\|3j6l]], [[3j6m\|3j6m]], [[3j6n\|3j6n]]</td></tr>
-	<tr~~><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class~~='~~plainlinks~~'~~>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j6o RCSB], [http://www.ebi.ac.uk/pdbsum/3j6o PDBsum]</span></td></tr>
-	~~<tr~~><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j6o RCSB], [http://www.ebi.ac.uk/pdbsum/3j6o PDBsum]</span></td></tr>	+	</table>
-	<table>	+
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 13:		Line 12:
	Kinetic and structural analysis of coxsackievirus B3 receptor interactions and formation of the A-particle.,Organtini LJ, Makhov AM, Conway JF, Hafenstein S, Carson SD J Virol. 2014 Mar 12. PMID:24623425<ref>PMID:24623425</ref>		Kinetic and structural analysis of coxsackievirus B3 receptor interactions and formation of the A-particle.,Organtini LJ, Makhov AM, Conway JF, Hafenstein S, Carson SD J Virol. 2014 Mar 12. PMID:24623425<ref>PMID:24623425</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 20:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
-	[[Category: Carson, S D.]]	+	[[Category: Carson, S D]]
-	[[Category: Conway, J F.]]	+	[[Category: Conway, J F]]
-	[[Category: Hafenstein, S.]]	+	[[Category: Hafenstein, S]]
-	[[Category: Makhov, A M.]]	+	[[Category: Makhov, A M]]
-	[[Category: Organtini, L J.]]	+	[[Category: Organtini, L J]]
	[[Category: Car]]		[[Category: Car]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Coxsackievirus b3]]		[[Category: Coxsackievirus b3]]
	[[Category: Cvb3]]		[[Category: Cvb3]]

OCA at 06:40, 7 May 2014

OCA — Wed, 07 May 2014 06:40:39 GMT

←Older revision		Revision as of 06:40, 7 May 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3j6o\| PDB=3j6o \| SCENE= }}~~	+	==Kinetic and Structural Analysis of Coxsackievirus B3 Receptor Interactions and Formation of the A-particle==
-	===Kinetic and Structural Analysis of Coxsackievirus B3 Receptor Interactions and Formation of the A-particle===	+	<StructureSection load='3j6o' size='340' side='right' caption='[[3j6o]], [[Resolution\|resolution]] 9.00Å' scene=''>
-	~~{{ABSTRACT_PUBMED_24623425}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3j6o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6O OCA]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3j6l\|3j6l]], [[3j6m\|3j6m]], [[3j6n\|3j6n]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j6o RCSB], [http://www.ebi.ac.uk/pdbsum/3j6o PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The coxsackievirus and adenovirus receptor (CAR) has been identified as the cellular receptor for group B coxsackieviruses, including serotype 3 (CVB3). CAR mediates infection by binding to CVB3 and catalyzing conformational changes in the virus that result in formation of the altered, non-infectious "A-particle". Kinetic analyses show that the apparent first-order rate constant for the inactivation of CVB3 by soluble CAR (sCAR) at physiological temperatures varies non-linearly with sCAR concentration. The cryo-electron microscopy (cryo-EM) reconstruction of the CVB3-CAR complex resulted in a 9.0 A resolution map that was interpreted with the four available crystal structures of CAR, providing a consensus footprint for the receptor-binding site. The analysis of the cryo-EM structure identifies important virus-receptor interactions that are conserved across picornavirus species. These conserved interactions map to variable antigenic sites or structurally conserved regions, suggesting a combination of evolutionary mechanisms for receptor site preservation. The CAR-catalyzed A-particle structure was solved to 6.6 A resolution and shows significant rearrangement of internal features and symmetric interactions with the RNA genome. STATEMENT OF IMPORTANCE: Our manuscript presents new information about receptor use by picornaviruses and highlights the importance of attaining at least approximately 9 A resolution for the interpretation of cryoEM complex maps. The analysis of receptor binding elucidates two complementary mechanisms for preservation of the low affinity (initial) interaction of receptor and defines the kinetics of receptor catalyzed conformational change to the A-particle.

-	~~==About this Structure==~~	+	Kinetic and structural analysis of coxsackievirus B3 receptor interactions and formation of the A-particle.,Organtini LJ, Makhov AM, Conway JF, Hafenstein S, Carson SD J Virol. 2014 Mar 12. PMID:24623425<ref>PMID:24623425</ref>
-	~~[[3j6o]] is a 1 chain structure~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=3J6O OCA].~~	+

-	==~~Reference~~==	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:024623425</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
	[[Category: Carson, S D.]]		[[Category: Carson, S D.]]
	[[Category: Conway, J F.]]		[[Category: Conway, J F.]]

OCA at 06:23, 9 April 2014

OCA — Wed, 09 Apr 2014 06:23:37 GMT

←Older revision		Revision as of 06:23, 9 April 2014
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{STRUCTURE_3j6o\| PDB=3j6o \| SCENE= }}
		+	===Kinetic and Structural Analysis of Coxsackievirus B3 Receptor Interactions and Formation of the A-particle===
		+	{{ABSTRACT_PUBMED_24623425}}

-	~~The entry~~ 3j6o is ~~ON HOLD until sometime in the future~~	+	==About this Structure==
		+	[[3j6o]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6O OCA].

-	~~Authors~~: ~~Organtini~~, L.~~J., Makhov, A.M.,~~ Conway, J.F., Hafenstein, S., ~~Carson~~, ~~S.D~~.	+	==Reference==
-		+	<ref group="xtra">PMID:024623425</ref><references group="xtra"/><references/>
-	~~Description~~: ~~Kinetic and Structural Analysis of~~ Coxsackievirus ~~B3 Receptor Interactions and Formation of the A-particle~~	+	[[Category: Carson, S D.]]
		+	[[Category: Conway, J F.]]
		+	[[Category: Hafenstein, S.]]
		+	[[Category: Makhov, A M.]]
		+	[[Category: Organtini, L J.]]
		+	[[Category: Car]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Coxsackievirus b3]]
		+	[[Category: Cvb3]]

OCA at 08:06, 2 April 2014

OCA — Wed, 02 Apr 2014 08:06:26 GMT

←Older revision		Revision as of 08:06, 2 April 2014
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3j6o is ON HOLD	+	The entry 3j6o is ON HOLD until sometime in the future

	Authors: Organtini, L.J., Makhov, A.M., Conway, J.F., Hafenstein, S., Carson, S.D.		Authors: Organtini, L.J., Makhov, A.M., Conway, J.F., Hafenstein, S., Carson, S.D.

	Description: Kinetic and Structural Analysis of Coxsackievirus B3 Receptor Interactions and Formation of the A-particle		Description: Kinetic and Structural Analysis of Coxsackievirus B3 Receptor Interactions and Formation of the A-particle

OCA: Protected "3j6o" [edit=sysop:move=sysop]

OCA — Wed, 26 Mar 2014 08:17:21 GMT

Protected "3j6o" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:17, 26 March 2014