3j7a - Revision history

OCA at 14:17, 24 January 2024

OCA — Wed, 24 Jan 2024 14:17:07 GMT

←Older revision		Revision as of 14:17, 24 January 2024
Line 3:		Line 3:
	<SX load='3j7a' size='340' side='right' viewer='molstar' caption='[[3j7a]], [[Resolution\|resolution]] 3.20Å' scene=''>		<SX load='3j7a' size='340' side='right' viewer='molstar' caption='[[3j7a]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3j7a]] is a 33 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Plasmodium_falciparum~~ Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J7A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3j7a]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J7A FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=34G:EMETINE'>34G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.2Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3j79\|3j79]]</div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=34G:EMETINE'>34G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7a OCA], [https://pdbe.org/3j7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j7a RCSB], [https://www.ebi.ac.uk/pdbsum/3j7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j7a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7a OCA], [https://pdbe.org/3j7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j7a RCSB], [https://www.ebi.ac.uk/pdbsum/3j7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j7a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~RSSA_PLAF7 RSSA_PLAF7~~]] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits (By similarity).	+	[https://www.uniprot.org/uniprot/RS3A_PLAF7 RS3A_PLAF7]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
		+	*[[Ribosome 3D structures\|Ribosome 3D structures]]
	*[[Transfer RNA (tRNA)\|Transfer RNA (tRNA)]]		*[[Transfer RNA (tRNA)\|Transfer RNA (tRNA)]]
	== References ==		== References ==
Line 27:		Line 28:
	</SX>		</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Plasmodium falciparum]]	+	[[Category: Plasmodium falciparum 3D7]]
-	[[Category: Bai~~, X C~~]]	+	[[Category: Bai XC]]
-	[[Category: Baum, J]]	+	[[Category: Baum J]]
-	[[Category: Brown, A]]	+	[[Category: Brown A]]
-	[[Category: Condron, M]]	+	[[Category: Condron M]]
-	[[Category: Fernandez~~, I S~~]]	+	[[Category: Fernandez IS]]
-	[[Category: Hanssen, E]]	+	[[Category: Hanssen E]]
-	[[Category: Scheres~~, S H.W~~]]	+	[[Category: Scheres SHW]]
-	[[Category: Tan~~, Y H~~]]	+	[[Category: Tan YH]]
-	[[Category: Wong, W]]	+	[[Category: Wong W]]
-	~~[[Category: Emetine]]~~	+
-	~~[[Category: Ribosome-inhibitor complex~~]]	+

OCA at 03:51, 21 April 2022

OCA — Thu, 21 Apr 2022 03:51:13 GMT

←Older revision		Revision as of 03:51, 21 April 2022
Line 3:		Line 3:
	<SX load='3j7a' size='340' side='right' viewer='molstar' caption='[[3j7a]], [[Resolution\|resolution]] 3.20Å' scene=''>		<SX load='3j7a' size='340' side='right' viewer='molstar' caption='[[3j7a]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3j7a]] is a 33 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7A OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3J7A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3j7a]] is a 33 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3J7A FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=34G:EMETINE'>34G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=34G:EMETINE'>34G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3j79\|3j79]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3j79\|3j79]]</div></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3j7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7a OCA], [~~http~~://pdbe.org/3j7a PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3j7a RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3j7a PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3j7a ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3j7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7a OCA], [https://pdbe.org/3j7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3j7a RCSB], [https://www.ebi.ac.uk/pdbsum/3j7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3j7a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/RSSA_PLAF7 RSSA_PLAF7]] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits (By similarity).	+	[[https://www.uniprot.org/uniprot/RSSA_PLAF7 RSSA_PLAF7]] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 18:04, 10 April 2020

OCA — Fri, 10 Apr 2020 18:04:11 GMT

←Older revision		Revision as of 18:04, 10 April 2020
Line 3:		Line 3:
	<SX load='3j7a' size='340' side='right' viewer='molstar' caption='[[3j7a]], [[Resolution\|resolution]] 3.20Å' scene=''>		<SX load='3j7a' size='340' side='right' viewer='molstar' caption='[[3j7a]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3j7a]] is a 33 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7A OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3J7A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3j7a]] is a 33 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7A OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3J7A FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=34G:EMETINE'>34G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=34G:EMETINE'>34G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3j79\|3j79]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3j79\|3j79]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3j7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7a OCA], [http://pdbe.org/3j7a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3j7a RCSB], [http://www.ebi.ac.uk/pdbsum/3j7a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3j7a ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3j7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7a OCA], [http://pdbe.org/3j7a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3j7a RCSB], [http://www.ebi.ac.uk/pdbsum/3j7a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3j7a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 17:27, 6 March 2020

OCA — Fri, 06 Mar 2020 17:27:44 GMT

←Older revision		Revision as of 17:27, 6 March 2020
Line 1:		Line 1:

	==Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, small subunit==		==Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, small subunit==
-	<~~StructureSection~~ load='3j7a' size='340' side='right' caption='[[3j7a]], [[Resolution\|resolution]] 3.20Å' scene=''>	+	<SX load='3j7a' size='340' side='right' viewer='molstar' caption='[[3j7a]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3j7a]] is a 33 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J7A FirstGlance]. <br>		<table><tr><td colspan='2'>[[3j7a]] is a 33 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J7A FirstGlance]. <br>
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[~~TRNA~~\|~~TRNA~~]]	+	*[[Transfer RNA (tRNA)\|Transfer RNA (tRNA)]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
		+	[[Category: Large Structures]]
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: Bai, X C]]		[[Category: Bai, X C]]

OCA at 17:22, 9 March 2017

OCA — Thu, 09 Mar 2017 17:22:57 GMT

←Older revision		Revision as of 17:22, 9 March 2017
Line 1:		Line 1:
		+
	==Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, small subunit==		==Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, small subunit==
	<StructureSection load='3j7a' size='340' side='right' caption='[[3j7a]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='3j7a' size='340' side='right' caption='[[3j7a]], [[Resolution\|resolution]] 3.20Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=34G:EMETINE'>34G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=34G:EMETINE'>34G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3j79\|3j79]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3j79\|3j79]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j7a RCSB], [http://www.ebi.ac.uk/pdbsum/3j7a PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7a OCA], [http://pdbe.org/3j7a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3j7a RCSB], [http://www.ebi.ac.uk/pdbsum/3j7a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3j7a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3j7a" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[TRNA\|TRNA]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:02, 24 December 2014

OCA — Wed, 24 Dec 2014 15:02:47 GMT

←Older revision		Revision as of 15:02, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3j7a]] is a 33 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J7A FirstGlance]. <br>		<table><tr><td colspan='2'>[[3j7a]] is a 33 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J7A FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=34G:EMETINE'>34G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=34G:EMETINE'>34G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3j79\|3j79]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3j79\|3j79]]</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j7a RCSB], [http://www.ebi.ac.uk/pdbsum/3j7a PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j7a RCSB], [http://www.ebi.ac.uk/pdbsum/3j7a PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/RSSA_PLAF7 RSSA_PLAF7]] Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Bai, X C.]]	+	[[Category: Bai, X C]]
-	[[Category: Baum, J.]]	+	[[Category: Baum, J]]
-	[[Category: Brown, A.]]	+	[[Category: Brown, A]]
-	[[Category: Condron, M.]]	+	[[Category: Condron, M]]
-	[[Category: Fernandez, I S.]]	+	[[Category: Fernandez, I S]]
-	[[Category: Hanssen, E.]]	+	[[Category: Hanssen, E]]
-	[[Category: Scheres, S H.W.]]	+	[[Category: Scheres, S H.W]]
-	[[Category: Tan, Y H.]]	+	[[Category: Tan, Y H]]
-	[[Category: Wong, W.]]	+	[[Category: Wong, W]]
	[[Category: Emetine]]		[[Category: Emetine]]
	[[Category: Ribosome-inhibitor complex]]		[[Category: Ribosome-inhibitor complex]]

OCA at 10:18, 16 July 2014

OCA — Wed, 16 Jul 2014 10:18:17 GMT

←Older revision		Revision as of 10:18, 16 July 2014
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, small subunit==
		+	<StructureSection load='3j7a' size='340' side='right' caption='[[3j7a]], [[Resolution\|resolution]] 3.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3j7a]] is a 33 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J7A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J7A FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=34G:EMETINE'>34G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3j79\|3j79]]</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j7a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j7a RCSB], [http://www.ebi.ac.uk/pdbsum/3j7a PDBsum]</span></td></tr>
		+	<table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Malaria inflicts an enormous burden on global human health. The emergence of parasite resistance to front-line drugs has prompted a renewed focus on the repositioning of clinically approved drugs as potential anti-malarial therapies. Antibiotics that inhibit protein translation are promising candidates for repositioning. We have solved the cryo-EM structure of the cytoplasmic ribosome from the human malaria parasite, Plasmodium falciparum, in complex with emetine at 3.2 A resolution. Emetine is an anti-protozoan drug used in the treatment of ameobiasis that also displays potent anti-malarial activity. Emetine interacts with the E-site of the ribosomal small subunit and shares a similar binding site with the antibiotic pactamycin, thereby delivering its therapeutic effect by blocking mRNA/tRNA translocation. As the first cryo-EM structure that visualizes an antibiotic bound to any ribosome at atomic resolution, this establishes cryo-EM as a powerful tool for screening and guiding the design of drugs that target parasite translation machinery.

-	~~The entry 3j7a is ON HOLD~~	+	Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine.,Wong W, Bai XC, Brown A, Fernandez IS, Hanssen E, Condron M, Tan YH, Baum J, Scheres SH Elife. 2014 Jun 9:e03080. doi: 10.7554/eLife.03080. PMID:24913268<ref>PMID:24913268</ref>

-	~~Authors: Wong~~, W., Bai, X.C., Brown, A., Fernandez, I.S., Hanssen, E., ~~Condron, M~~., Tan, Y.H., ~~Baum, J., Scheres, S.H.~~W.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Cryo~~-~~EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, small subunit~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Plasmodium falciparum]]
		+	[[Category: Bai, X C.]]
		+	[[Category: Baum, J.]]
		+	[[Category: Brown, A.]]
		+	[[Category: Condron, M.]]
		+	[[Category: Fernandez, I S.]]
		+	[[Category: Hanssen, E.]]
		+	[[Category: Scheres, S H.W.]]
		+	[[Category: Tan, Y H.]]
		+	[[Category: Wong, W.]]
		+	[[Category: Emetine]]
		+	[[Category: Ribosome-inhibitor complex]]

OCA at 05:30, 25 June 2014

OCA — Wed, 25 Jun 2014 05:30:48 GMT

←Older revision		Revision as of 05:30, 25 June 2014
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	The entry 3j7a is ON HOLD		The entry 3j7a is ON HOLD

-	Authors: Wong, W., Bai, X.C., Brown, A, Fernandez, I.S., Hanssen, E., Condron, M., Tan, Y.H., Baum, J., Scheres, S.H.W.	+	Authors: Wong, W., Bai, X.C., Brown, A., Fernandez, I.S., Hanssen, E., Condron, M., Tan, Y.H., Baum, J., Scheres, S.H.W.

-	Description: Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine; small subunit	+	Description: Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, small subunit

OCA: Protected "3j7a" [edit=sysop:move=sysop]

OCA — Wed, 11 Jun 2014 07:25:36 GMT

Protected "3j7a" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:25, 11 June 2014

OCA: New page: '''Unreleased structure''' The entry 3j7a is ON HOLD Authors: Wong, W., Bai, X.C., Brown, A, Fernandez, I.S., Hanssen, E., Condron, M., Tan, Y.H., Baum, J., Scheres, S.H.W. Description...

OCA — Wed, 11 Jun 2014 07:25:35 GMT

New page: '''Unreleased structure''' The entry 3j7a is ON HOLD Authors: Wong, W., Bai, X.C., Brown, A, Fernandez, I.S., Hanssen, E., Condron, M., Tan, Y.H., Baum, J., Scheres, S.H.W. Description...

New page

'''Unreleased structure'''

The entry 3j7a is ON HOLD

Authors: Wong, W., Bai, X.C., Brown, A, Fernandez, I.S., Hanssen, E., Condron, M., Tan, Y.H., Baum, J., Scheres, S.H.W.

Description: Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine; small subunit