3jsg - Revision history

OCA at 08:02, 6 September 2023

OCA — Wed, 06 Sep 2023 08:02:59 GMT

←Older revision		Revision as of 08:02, 6 September 2023
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	==Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 707 at 1.58a resolution==		==Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 707 at 1.58a resolution==
-	<StructureSection load='3jsg' size='340' side='right' caption='[[3jsg]], [[Resolution\|resolution]] 1.58Å' scene=''>	+	<StructureSection load='3jsg' size='340' side='right'caption='[[3jsg]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3jsg]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3JSG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3jsg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JSG FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=0IN:7~~-~~(PYRIDIN-3-YLMETHYL)QUINOLIN-8-OL'>0IN</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.58Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[3jsf\|3jsf]], [[3jtu\|3jtu]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0IN:7-(PYRIDIN-3-YLMETHYL)QUINOLIN-8-OL'>0IN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">GLIF, MIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsg OCA], [https://pdbe.org/3jsg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jsg RCSB], [https://www.ebi.ac.uk/pdbsum/3jsg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jsg ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3jsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsg OCA], [~~http~~://pdbe.org/3jsg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3jsg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3jsg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3jsg ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[~~http~~://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.	+	[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[https://omim.org/entry/604302 604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>	+	[https://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/3jsg_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/3jsg_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 3jsg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3jsg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Macrophage inhibitory factor 3D structures\|Macrophage inhibitory factor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Mclean, L~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Zhang, Y~~]]	+	[[Category: Mclean L]]
-	[[Category: ~~Cytokine]]~~	+	[[Category: Zhang Y]]
-	~~[[Category: Cytoplasm]]~~	+
-	~~[[Category: Immune response]]~~	+
-	~~[[Category: Inflammatory response]]~~	+
-	~~[[Category: Innate immunity]]~~	+
-	~~[[Category: Isomerase]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Protein-ligand complex]]~~	+
-	~~[[Category: Secreted~~]]	+

OCA at 08:18, 1 November 2017

OCA — Wed, 01 Nov 2017 08:18:08 GMT

←Older revision		Revision as of 08:18, 1 November 2017
Line 1:		Line 1:
		+
	==Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 707 at 1.58a resolution==		==Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 707 at 1.58a resolution==
	<StructureSection load='3jsg' size='340' side='right' caption='[[3jsg]], [[Resolution\|resolution]] 1.58Å' scene=''>		<StructureSection load='3jsg' size='340' side='right' caption='[[3jsg]], [[Resolution\|resolution]] 1.58Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jsf\|3jsf]], [[3jtu\|3jtu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jsf\|3jsf]], [[3jtu\|3jtu]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLIF, MIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLIF, MIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsg OCA], [http://pdbe.org/3jsg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jsg RCSB], [http://www.ebi.ac.uk/pdbsum/3jsg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsg OCA], [http://pdbe.org/3jsg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jsg RCSB], [http://www.ebi.ac.uk/pdbsum/3jsg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jsg ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 31:		Line 32:
	</div>		</div>
	<div class="pdbe-citations 3jsg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3jsg" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]
	== References ==		== References ==
	<references/>		<references/>
Line 42:		Line 40:
	[[Category: Zhang, Y]]		[[Category: Zhang, Y]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
		+	[[Category: Cytoplasm]]
	[[Category: Immune response]]		[[Category: Immune response]]
	[[Category: Inflammatory response]]		[[Category: Inflammatory response]]

OCA at 23:42, 7 February 2016

OCA — Sun, 07 Feb 2016 23:42:59 GMT

←Older revision		Revision as of 23:42, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3jsg' size='340' side='right' caption='[[3jsg]], [[Resolution\|resolution]] 1.58Å' scene=''>		<StructureSection load='3jsg' size='340' side='right' caption='[[3jsg]], [[Resolution\|resolution]] 1.58Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3jsg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JSG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3jsg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JSG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0IN:7-(PYRIDIN-3-YLMETHYL)QUINOLIN-8-OL'>0IN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0IN:7-(PYRIDIN-3-YLMETHYL)QUINOLIN-8-OL'>0IN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jsf\|3jsf]], [[3jtu\|3jtu]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jsf\|3jsf]], [[3jtu\|3jtu]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLIF, MIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLIF, MIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jsg RCSB], [http://www.ebi.ac.uk/pdbsum/3jsg PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsg OCA], [http://pdbe.org/3jsg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jsg RCSB], [http://www.ebi.ac.uk/pdbsum/3jsg PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 20:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jsg ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3jsg" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Mclean, L]]		[[Category: Mclean, L]]
	[[Category: Zhang, Y]]		[[Category: Zhang, Y]]

OCA at 17:15, 18 December 2014

OCA — Thu, 18 Dec 2014 17:15:18 GMT

←Older revision		Revision as of 17:15, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3jsg\| PDB=3jsg \| SCENE= }}~~	+	==Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 707 at 1.58a resolution==
-	===Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 707 at 1.58a resolution===	+	<StructureSection load='3jsg' size='340' side='right' caption='[[3jsg]], [[Resolution\|resolution]] 1.58Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19836948}}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3jsg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JSG FirstGlance]. <br>
-	==Disease==	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0IN:7-(PYRIDIN-3-YLMETHYL)QUINOLIN-8-OL'>0IN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jsf\|3jsf]], [[3jtu\|3jtu]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GLIF, MIF, MMIF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jsg RCSB], [http://www.ebi.ac.uk/pdbsum/3jsg PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.		[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref> <ref>PMID:17443469</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/3jsg_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Biochemical and X-ray crystallographic studies confirmed that hydroxyquinoline derivatives identified by virtual screening were actually covalent inhibitors of the MIF tautomerase. Adducts were formed by N-alkylation of the Pro-1 at the catalytic site with a loss of an amino group of the inhibitor.

-	~~==Function==~~	+	Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening.,McLean LR, Zhang Y, Li H, Li Z, Lukasczyk U, Choi YM, Han Z, Prisco J, Fordham J, Tsay JT, Reiling S, Vaz RJ, Li Y Bioorg Med Chem Lett. 2009 Dec 1;19(23):6717-20. Epub 2009 Oct 1. PMID:19836948<ref>PMID:19836948</ref>
-	~~[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression~~ of MIF ~~at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense~~. ~~Counteracts the anti-inflammatory activity of glucocorticoids~~. ~~Has phenylpyruvate tautomerase and dopachrome tautomerase activity~~ (~~in vitro~~)~~, but the physiological substrate is not known~~. ~~It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity~~.~~<ref>~~PMID:~~15908412</ref>~~<ref>PMID:~~17443469~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3jsg]] is~~ a ~~3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3JSG OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:019836948</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Macrophage inhibitory factor\|Macrophage inhibitory factor]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Mclean, L.]]	+	[[Category: Mclean, L]]
-	[[Category: Zhang, Y.]]	+	[[Category: Zhang, Y]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
	[[Category: Immune response]]		[[Category: Immune response]]

OCA: Protected "3jsg" [edit=sysop:move=sysop]

OCA — Mon, 25 Mar 2013 01:51:02 GMT

Protected "3jsg" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:51, 25 March 2013

OCA at 01:50, 25 March 2013

OCA — Mon, 25 Mar 2013 01:50:59 GMT

←Older revision		Revision as of 01:50, 25 March 2013
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-	{{Seed}}
-	[[Image:3jsg.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3jsg", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3jsg\| PDB=3jsg \| SCENE= }}		{{STRUCTURE_3jsg\| PDB=3jsg \| SCENE= }}
-
	===Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 707 at 1.58a resolution===		===Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 707 at 1.58a resolution===
		+	{{ABSTRACT_PUBMED_19836948}}

		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Genetic variations in MIF are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[http://omim.org/entry/604302 604302]]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.

-	~~<!--~~	+	==Function==
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_19836948}}, adds the Publication Abstract to the page~~	+	[[http://www.uniprot.org/uniprot/MIF_HUMAN MIF_HUMAN]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.<ref>PMID:15908412</ref><ref>PMID:17443469</ref>
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~), ~~where 19836948~~ is the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_19836948}}~~	+

	==About this Structure==		==About this Structure==
-	~~3JSG~~ is a 3 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSG OCA].	+	[[3jsg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSG OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19836948~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019836948</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Mclean, L.]]		[[Category: Mclean, L.]]
	[[Category: Zhang, Y.]]		[[Category: Zhang, Y.]]
	[[Category: Cytokine]]		[[Category: Cytokine]]
-	[[Category: Cytoplasm]]
	[[Category: Immune response]]		[[Category: Immune response]]
	[[Category: Inflammatory response]]		[[Category: Inflammatory response]]
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	[[Category: Protein-ligand complex]]		[[Category: Protein-ligand complex]]
	[[Category: Secreted]]		[[Category: Secreted]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 28 11:20:50 2010''

OCA at 08:20, 28 April 2010

OCA — Wed, 28 Apr 2010 08:20:51 GMT

←Older revision		Revision as of 08:20, 28 April 2010
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	{{Seed}}		{{Seed}}
-	[[Image:3jsg.~~jpg~~\|left\|200px]]	+	[[Image:3jsg.png\|left\|200px]]

	<!--		<!--
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	==About this Structure==		==About this Structure==
-	3JSG is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSG OCA].	+	3JSG is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSG OCA].

	==Reference==		==Reference==
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	[[Category: Secreted]]		[[Category: Secreted]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov~~ 11 22:33:~~53 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 28 11:20:50 2010''

OCA at 20:33, 11 November 2009

OCA — Wed, 11 Nov 2009 20:33:54 GMT

←Older revision		Revision as of 20:33, 11 November 2009
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3jsg.jpg\|left\|200px]]

-	The ~~entry 3jsg~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3jsg", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3jsg\| PDB=3jsg \| SCENE= }}

-	~~Authors: Mclean, L., Zhang, Y~~.	+	===Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 707 at 1.58a resolution===

-	Description: Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 707 at 1.58a resolution

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 23 08~~:30:26 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19836948}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19836948 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19836948}}
		+
		+	==About this Structure==
		+	3JSG is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSG OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19836948</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Mclean, L.]]
		+	[[Category: Zhang, Y.]]
		+	[[Category: Cytokine]]
		+	[[Category: Cytoplasm]]
		+	[[Category: Immune response]]
		+	[[Category: Inflammatory response]]
		+	[[Category: Innate immunity]]
		+	[[Category: Isomerase]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Protein-ligand complex]]
		+	[[Category: Secreted]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 11 22:33:53 2009''

OCA at 05:30, 23 September 2009

OCA — Wed, 23 Sep 2009 05:30:27 GMT

←Older revision		Revision as of 05:30, 23 September 2009
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3jsg is ON HOLD	+	The entry 3jsg is ON HOLD until Paper Publication

-	Authors: L.~~MCLEAN~~, ~~Y.ZHANG, H.LI, Z.LI, U.LUKASCZYK, Y.M.CHOI, Z.HAN, J.PRISCO, J.FORDHAM, J.T.TSAY, S.REILING, R.J.VAZ~~, Y.LI	+	Authors: Mclean, L., Zhang, Y.

-	Description: ~~CRYSTAL STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR~~ (~~MIF~~) ~~WITH HYDROXYQUINOLINE INHIBITOR~~ 707 AT 1.~~58A RESOLUTION~~	+	Description: Crystal structure of macrophage migration inhibitory factor (mif) with hydroxyquinoline inhibitor 707 at 1.58a resolution

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:46:06 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 23 08:30:26 2009''

OCA: New page: '''Unreleased structure''' The entry 3jsg is ON HOLD Authors: L.MCLEAN, Y.ZHANG, H.LI, Z.LI, U.LUKASCZYK, Y.M.CHOI, Z.HAN, J.PRISCO, J.FORDHAM, J.T.TSAY, S.REILING, R.J.VAZ, Y.LI Descr...

OCA — Wed, 16 Sep 2009 05:46:07 GMT

New page: '''Unreleased structure''' The entry 3jsg is ON HOLD Authors: L.MCLEAN, Y.ZHANG, H.LI, Z.LI, U.LUKASCZYK, Y.M.CHOI, Z.HAN, J.PRISCO, J.FORDHAM, J.T.TSAY, S.REILING, R.J.VAZ, Y.LI Descr...

New page

'''Unreleased structure'''

The entry 3jsg is ON HOLD

Authors: L.MCLEAN, Y.ZHANG, H.LI, Z.LI, U.LUKASCZYK, Y.M.CHOI, Z.HAN, J.PRISCO, J.FORDHAM, J.T.TSAY, S.REILING, R.J.VAZ, Y.LI

Description: CRYSTAL STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH HYDROXYQUINOLINE INHIBITOR 707 AT 1.58A RESOLUTION

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:46:06 2009''