3jsk - Revision history

OCA at 08:03, 6 September 2023

OCA — Wed, 06 Sep 2023 08:03:08 GMT

←Older revision		Revision as of 08:03, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3jsk' size='340' side='right'caption='[[3jsk]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3jsk' size='340' side='right'caption='[[3jsk]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3jsk]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Chrysonilia_crassa Chrysonilia~~ crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JSK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3jsk]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JSK FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=AHZ:ADENOSINE+DIPHOSPHATE+5-(BETA-ETHYL)-4-METHYL-THIAZOLE~~-2~~-CARBOXYLIC+ACID'>AHZ</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~DHA~~:2-~~AMINO~~-~~ACRYLIC~~+ACID'>~~DHA~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AHZ:ADENOSINE+DIPHOSPHATE+5-(BETA-ETHYL)-4-METHYL-THIAZOLE-2-CARBOXYLIC+ACID'>AHZ</scene>, <scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat"><div style='overflow: auto; max~~-~~height: 3em;~~'>~~[[2gjc\|2gjc]], [[1rp0\|1rp0]]~~</~~div~~><~~/td></tr>~~	+
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">NCU06110, NCU06110.1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5141 Chrysonilia crassa])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsk OCA], [https://pdbe.org/3jsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jsk RCSB], [https://www.ebi.ac.uk/pdbsum/3jsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jsk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsk OCA], [https://pdbe.org/3jsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jsk RCSB], [https://www.ebi.ac.uk/pdbsum/3jsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jsk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/THI4_NEUCR THI4_NEUCR]] Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.[HAMAP-Rule:MF_03158]	+	[https://www.uniprot.org/uniprot/THI4_NEUCR THI4_NEUCR] Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.[HAMAP-Rule:MF_03158]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Chrysonilia crassa]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Bale, S~~]]	+	[[Category: Neurospora crassa]]
-	[[Category: ~~Ealick,~~ S E]]	+	[[Category: Bale S]]
-	[[Category: ~~Kang, Y N~~]]	+	[[Category: Ealick SE]]
-	[[Category: ~~Biosynthetic protein]]~~	+	[[Category: Kang YN]]
-	~~[[Category: Octameric thiazole synthase~~]]	+

OCA at 12:17, 13 October 2021

OCA — Wed, 13 Oct 2021 12:17:15 GMT

←Older revision		Revision as of 12:17, 13 October 2021
Line 1:		Line 1:

	==Thiazole synthase from Neurospora crassa==		==Thiazole synthase from Neurospora crassa==
-	<StructureSection load='3jsk' size='340' side='right' caption='[[3jsk]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='3jsk' size='340' side='right'caption='[[3jsk]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3jsk]] is a 16 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Chrysonilia_crassa Chrysonilia crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3JSK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3jsk]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Chrysonilia_crassa Chrysonilia crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JSK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AHZ:ADENOSINE+DIPHOSPHATE+5-(BETA-ETHYL)-4-METHYL-THIAZOLE-2-CARBOXYLIC+ACID'>AHZ</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AHZ:ADENOSINE+DIPHOSPHATE+5-(BETA-ETHYL)-4-METHYL-THIAZOLE-2-CARBOXYLIC+ACID'>AHZ</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gjc\|2gjc]], [[1rp0\|1rp0]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2gjc\|2gjc]], [[1rp0\|1rp0]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCU06110, NCU06110.1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5141 Chrysonilia crassa])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCU06110, NCU06110.1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5141 Chrysonilia crassa])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3jsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsk OCA], [~~http~~://pdbe.org/3jsk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3jsk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3jsk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3jsk ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsk OCA], [https://pdbe.org/3jsk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jsk RCSB], [https://www.ebi.ac.uk/pdbsum/3jsk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jsk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/THI4_NEUCR THI4_NEUCR]] Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.[HAMAP-Rule:MF_03158]	+	[[https://www.uniprot.org/uniprot/THI4_NEUCR THI4_NEUCR]] Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.[HAMAP-Rule:MF_03158]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/3jsk_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/3jsk_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Chrysonilia crassa]]		[[Category: Chrysonilia crassa]]
		+	[[Category: Large Structures]]
	[[Category: Bale, S]]		[[Category: Bale, S]]
	[[Category: Ealick, S E]]		[[Category: Ealick, S E]]

OCA at 13:42, 4 August 2016

OCA — Thu, 04 Aug 2016 13:42:02 GMT

←Older revision		Revision as of 13:42, 4 August 2016
Line 1:		Line 1:
		+
	==Thiazole synthase from Neurospora crassa==		==Thiazole synthase from Neurospora crassa==
	<StructureSection load='3jsk' size='340' side='right' caption='[[3jsk]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3jsk' size='340' side='right' caption='[[3jsk]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3jsk]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Neurospora_crassa Neurospora~~ crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JSK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3jsk]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Chrysonilia_crassa Chrysonilia crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JSK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AHZ:ADENOSINE+DIPHOSPHATE+5-(BETA-ETHYL)-4-METHYL-THIAZOLE-2-CARBOXYLIC+ACID'>AHZ</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AHZ:ADENOSINE+DIPHOSPHATE+5-(BETA-ETHYL)-4-METHYL-THIAZOLE-2-CARBOXYLIC+ACID'>AHZ</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gjc\|2gjc]], [[1rp0\|1rp0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gjc\|2gjc]], [[1rp0\|1rp0]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCU06110, NCU06110.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5141 ~~Neurospora~~ crassa])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCU06110, NCU06110.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5141 Chrysonilia crassa])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jsk RCSB], [http://www.ebi.ac.uk/pdbsum/3jsk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsk OCA], [http://pdbe.org/3jsk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jsk RCSB], [http://www.ebi.ac.uk/pdbsum/3jsk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jsk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~Q9HGR2_NEUCR Q9HGR2_NEUCR~~]] Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance ~~(By similarity)~~.~~<ref>PMID~~:~~15544818</ref>~~	+	[[http://www.uniprot.org/uniprot/THI4_NEUCR THI4_NEUCR]] Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.[HAMAP-Rule:MF_03158]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jsk ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Neurospora~~ crassa]]	+	[[Category: Chrysonilia crassa]]
	[[Category: Bale, S]]		[[Category: Bale, S]]
	[[Category: Ealick, S E]]		[[Category: Ealick, S E]]

OCA at 15:10, 24 December 2014

OCA — Wed, 24 Dec 2014 15:10:40 GMT

←Older revision		Revision as of 15:10, 24 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jsk RCSB], [http://www.ebi.ac.uk/pdbsum/3jsk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jsk RCSB], [http://www.ebi.ac.uk/pdbsum/3jsk PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q9HGR2_NEUCR Q9HGR2_NEUCR]] Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance (By similarity).<ref>PMID:15544818</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 19:		Line 21:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 15:59, 18 December 2014

OCA — Thu, 18 Dec 2014 15:59:52 GMT

←Older revision		Revision as of 15:59, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3jsk\| PDB=3jsk \| SCENE= }}~~	+	==Thiazole synthase from Neurospora crassa==
-	===Thiazole synthase from Neurospora crassa===	+	<StructureSection load='3jsk' size='340' side='right' caption='[[3jsk]], [[Resolution\|resolution]] 2.70Å' scene=''>
-		+	== Structural highlights ==
-	==~~Function~~==	+	<table><tr><td colspan='2'>[[3jsk]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JSK FirstGlance]. <br>
-	[[http://~~www~~.~~uniprot~~.org/~~uniprot~~/~~Q9HGR2_NEUCR Q9HGR2_NEUCR~~]] ~~Involved in biosynthesis of the thiamine precursor thiazole~~. ~~Catalyzes~~ the ~~conversion of NAD and glycine to adenosine diphosphate~~ 5-(2-~~hydroxyethyl~~)-4-~~methylthiazole~~-2-~~carboxylic acid (ADT)~~, an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance (~~By similarity~~).<~~ref~~>~~PMID:15544818~~</~~ref~~>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AHZ:ADENOSINE+DIPHOSPHATE+5-(BETA-ETHYL)-4-METHYL-THIAZOLE-2-CARBOXYLIC+ACID'>AHZ</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr>
-		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DHA:2-AMINO-ACRYLIC+ACID'>DHA</scene></td></tr>
-	==~~About this Structure~~==	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2gjc\|2gjc]], [[1rp0\|1rp0]]</td></tr>
-	[[~~3jsk~~]] ~~is a 16 chain structure with sequence from~~ [http://en.~~wikipedia~~.~~org~~/~~wiki~~/~~Neurospora_crassa~~ Neurospora crassa]. ~~Full crystallographic information is available from~~ [http://oca.weizmann.ac.il/oca-bin/~~ocashort~~?id=~~3JSK~~ OCA].	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">NCU06110, NCU06110.1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5141 Neurospora crassa])</td></tr>
-		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jsk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jsk RCSB], [http://www.ebi.ac.uk/pdbsum/3jsk PDBsum]</span></td></tr>
-	==~~Reference~~==	+	</table>
-	<~~references group~~="~~xtra~~"/><~~references~~/>	+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/3jsk_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	__TOC__
		+	</StructureSection>
	[[Category: Neurospora crassa]]		[[Category: Neurospora crassa]]
-	[[Category: Bale, S.]]	+	[[Category: Bale, S]]
-	[[Category: Ealick, S E.]]	+	[[Category: Ealick, S E]]
-	[[Category: Kang, Y N.]]	+	[[Category: Kang, Y N]]
	[[Category: Biosynthetic protein]]		[[Category: Biosynthetic protein]]
	[[Category: Octameric thiazole synthase]]		[[Category: Octameric thiazole synthase]]

OCA: Protected "3jsk" [edit=sysop:move=sysop]

OCA — Wed, 27 Mar 2013 09:31:42 GMT

Protected "3jsk" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:31, 27 March 2013

OCA at 09:31, 27 March 2013

OCA — Wed, 27 Mar 2013 09:31:36 GMT

←Older revision		Revision as of 09:31, 27 March 2013
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-	{{Seed}}
-	[[Image:3jsk.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3jsk", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3jsk\| PDB=3jsk \| SCENE= }}		{{STRUCTURE_3jsk\| PDB=3jsk \| SCENE= }}
-
	===Thiazole synthase from Neurospora crassa===		===Thiazole synthase from Neurospora crassa===

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/Q9HGR2_NEUCR Q9HGR2_NEUCR]] Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance (By similarity).<ref>PMID:15544818</ref>

	==About this Structure==		==About this Structure==
-	~~3JSK~~ is a 16 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSK OCA].	+	[[3jsk]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSK OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Neurospora crassa]]		[[Category: Neurospora crassa]]
	[[Category: Bale, S.]]		[[Category: Bale, S.]]
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	[[Category: Biosynthetic protein]]		[[Category: Biosynthetic protein]]
	[[Category: Octameric thiazole synthase]]		[[Category: Octameric thiazole synthase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 29 08:12:54 2010''

OCA at 05:03, 29 September 2010

OCA — Wed, 29 Sep 2010 05:03:40 GMT

←Older revision		Revision as of 05:03, 29 September 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3jsk.jpg\|left\|200px]]

-	The ~~entry 3jsk~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3jsk", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3jsk\| PDB=3jsk \| SCENE= }}

-	~~Authors: Kang, Y.N., Bale, S., Ealick, S.E.~~	+	===Thiazole synthase from Neurospora crassa===

-	Description: Thiazole synthase from Neurospora crassa

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 30 08:59:~~53 2009~~''	+	==About this Structure==
		+	3JSK is a 16 chains structure with sequences from [http://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSK OCA].
		+	[[Category: Neurospora crassa]]
		+	[[Category: Bale, S.]]
		+	[[Category: Ealick, S E.]]
		+	[[Category: Kang, Y N.]]
		+	[[Category: Biosynthetic protein]]
		+	[[Category: Octameric thiazole synthase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 29 08:12:54 2010''

OCA at 06:59, 30 September 2009

OCA — Wed, 30 Sep 2009 06:59:54 GMT

←Older revision		Revision as of 06:59, 30 September 2009
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3jsk is ON HOLD	+	The entry 3jsk is ON HOLD until Paper Publication

-	Authors: Kang, Y.N., Bale. S., Ealick, S.E.	+	Authors: Kang, Y.N., Bale, S., Ealick, S.E.

	Description: Thiazole synthase from Neurospora crassa		Description: Thiazole synthase from Neurospora crassa

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 23 08:30:28 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 30 08:59:53 2009''

OCA at 05:30, 23 September 2009

OCA — Wed, 23 Sep 2009 05:30:28 GMT

←Older revision		Revision as of 05:30, 23 September 2009
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	The entry 3jsk is ON HOLD		The entry 3jsk is ON HOLD

-	Authors: Kang, Y.N., Bale, S~~., Begley, T.P~~., Ealick, S.E.	+	Authors: Kang, Y.N., Bale. S., Ealick, S.E.

	Description: Thiazole synthase from Neurospora crassa		Description: Thiazole synthase from Neurospora crassa

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:46:09 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 23 08:30:28 2009''