3jsu - Revision history

OCA at 16:05, 1 November 2023

OCA — Wed, 01 Nov 2023 16:05:09 GMT

←Older revision		Revision as of 16:05, 1 November 2023
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	==Quadruple mutant(N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase(PFDHFR-TS) complexed with QN254, NADPH, and dUMP==		==Quadruple mutant(N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase(PFDHFR-TS) complexed with QN254, NADPH, and dUMP==
-	<StructureSection load='3jsu' size='340' side='right' caption='[[3jsu]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='3jsu' size='340' side='right'caption='[[3jsu]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3jsu]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Plafa Plafa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3JSU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3jsu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JSU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KA5:5-CHLORO-N~6~-(2,5-DIMETHOXYBENZYL)QUINAZOLINE-2,4,6-TRIAMINE'>KA5</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.7Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j3k\|1j3k]], [[1j3j\|1j3j]], [[1j3i\|1j3i]], [[3dg8\|3dg8]], [[3dga\|3dga]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KA5:5-CHLORO-N~6~-(2,5-DIMETHOXYBENZYL)QUINAZOLINE-2,4,6-TRIAMINE'>KA5</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR-TS, V1/S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsu OCA], [https://pdbe.org/3jsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jsu RCSB], [https://www.ebi.ac.uk/pdbsum/3jsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jsu ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3jsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsu OCA], [~~http~~://pdbe.org/3jsu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3jsu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3jsu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3jsu ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~A7UD79_PLAFA A7UD79_PLAFA]~~] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism.[PIRNR:PIRNR000389]	+	[https://www.uniprot.org/uniprot/D9N170_PLAFA D9N170_PLAFA] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism (By similarity).[PIRNR:PIRNR000389]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/3jsu_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/3jsu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 30:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3jsu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3jsu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Plafa~~]]	+	[[Category: Large Structures]]
-	[[Category: Chitnumsub, P]]	+	[[Category: Plasmodium falciparum]]
-	[[Category: Diagana~~, T T~~]]	+	[[Category: Chitnumsub P]]
-	[[Category: Kamchonwongpaisan, S]]	+	[[Category: Diagana TT]]
-	[[Category: Maneeruttanarungroj, C]]	+	[[Category: Kamchonwongpaisan S]]
-	[[Category: Yuthavong, Y]]	+	[[Category: Maneeruttanarungroj C]]
-	~~[[Category: Oxidoreductase]]~~	+	[[Category: Yuthavong Y]]
-	~~[[Category: Rossmann fold]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:18, 1 November 2017

OCA — Wed, 01 Nov 2017 08:18:30 GMT

←Older revision		Revision as of 08:18, 1 November 2017
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	</div>		</div>
	<div class="pdbe-citations 3jsu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3jsu" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:51, 4 August 2016

OCA — Thu, 04 Aug 2016 19:51:50 GMT

←Older revision		Revision as of 19:51, 4 August 2016
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		+
	==Quadruple mutant(N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase(PFDHFR-TS) complexed with QN254, NADPH, and dUMP==		==Quadruple mutant(N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase(PFDHFR-TS) complexed with QN254, NADPH, and dUMP==
	<StructureSection load='3jsu' size='340' side='right' caption='[[3jsu]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='3jsu' size='340' side='right' caption='[[3jsu]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3jsu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum Plasmodium falciparum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JSU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3jsu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plafa Plafa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JSU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KA5:5-CHLORO-N~6~-(2,5-DIMETHOXYBENZYL)QUINAZOLINE-2,4,6-TRIAMINE'>KA5</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KA5:5-CHLORO-N~6~-(2,5-DIMETHOXYBENZYL)QUINAZOLINE-2,4,6-TRIAMINE'>KA5</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j3k\|1j3k]], [[1j3j\|1j3j]], [[1j3i\|1j3i]], [[3dg8\|3dg8]], [[3dga\|3dga]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j3k\|1j3k]], [[1j3j\|1j3j]], [[1j3i\|1j3i]], [[3dg8\|3dg8]], [[3dga\|3dga]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR-TS, V1/S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 ~~Plasmodium falciparum~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR-TS, V1/S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 PLAFA])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jsu RCSB], [http://www.ebi.ac.uk/pdbsum/3jsu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsu OCA], [http://pdbe.org/3jsu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jsu RCSB], [http://www.ebi.ac.uk/pdbsum/3jsu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jsu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jsu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3jsu" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 37:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Plasmodium falciparum~~]]	+	[[Category: Plafa]]
	[[Category: Chitnumsub, P]]		[[Category: Chitnumsub, P]]
	[[Category: Diagana, T T]]		[[Category: Diagana, T T]]

OCA at 19:00, 24 December 2014

OCA — Wed, 24 Dec 2014 19:00:13 GMT

←Older revision		Revision as of 19:00, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jsu RCSB], [http://www.ebi.ac.uk/pdbsum/3jsu PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jsu RCSB], [http://www.ebi.ac.uk/pdbsum/3jsu PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/A7UD79_PLAFA A7UD79_PLAFA]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism.[PIRNR:PIRNR000389]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:31, 8 December 2014

OCA — Mon, 08 Dec 2014 09:31:28 GMT

←Older revision		Revision as of 09:31, 8 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3jsu.~~png~~\|~~left~~\|200px]]	+	==Quadruple mutant(N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase(PFDHFR-TS) complexed with QN254, NADPH, and dUMP==
		+	<StructureSection load='3jsu' size='340' side='right' caption='[[3jsu]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3jsu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JSU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KA5:5-CHLORO-N~6~-(2,5-DIMETHOXYBENZYL)QUINAZOLINE-2,4,6-TRIAMINE'>KA5</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1j3k\|1j3k]], [[1j3j\|1j3j]], [[1j3i\|1j3i]], [[3dg8\|3dg8]], [[3dga\|3dga]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR-TS, V1/S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jsu RCSB], [http://www.ebi.ac.uk/pdbsum/3jsu PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/3jsu_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Drug resistance against dihydrofolate reductase (DHFR) inhibitors-such as pyrimethamine (PM)-has now spread to almost all regions where malaria is endemic, rendering antifolate-based malaria treatments highly ineffective. We have previously shown that the di-amino quinazoline QN254 [5-chloro-N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine] is active against the highly PM-resistant Plasmodium falciparum V1S strain, suggesting that QN254 could be used to treat malaria in regions with a high prevalence of antifolate resistance. Here, we further demonstrate that QN254 is highly active against Plasmodium falciparum clinical isolates, displaying various levels of antifolate drug resistance, and we provide biochemical and structural evidence that QN254 binds and inhibits the function of both the wild-type and the quadruple-mutant (V1S) forms of the DHFR enzyme. In addition, we have assessed QN254 oral bioavailability, efficacy, and safety in vivo. The compound displays favorable pharmacokinetic properties after oral administration in rodents. The drug was remarkably efficacious against Plasmodium berghei and could fully cure infected mice with three daily oral doses of 30 mg/kg. In the course of these efficacy studies, we have uncovered some dose limiting toxicity at higher doses that was confirmed in rats. Thus, despite its relative in vitro selectivity toward the Plasmodium DHFR enzyme, QN254 does not show the adequate therapeutic index to justify its further development as a single agent.

-	~~{{STRUCTURE_3jsu\| PDB=3jsu \| SCENE= }}~~	+	Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate.,Nzila A, Rottmann M, Chitnumsub P, Kiara SM, Kamchonwongpaisan S, Maneeruttanarungroj C, Taweechai S, Yeung BK, Goh A, Lakshminarayana SB, Zou B, Wong J, Ma NL, Weaver M, Keller TH, Dartois V, Wittlin S, Brun R, Yuthavong Y, Diagana TT Antimicrob Agents Chemother. 2010 Jun;54(6):2603-10. Epub 2010 Mar 29. PMID:20350951<ref>PMID:20350951</ref>

-	~~===Quadruple mutant(N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase(PFDHFR-TS) complexed with QN254~~, ~~NADPH, and dUMP===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20350951}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3jsu]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plasmodium_falciparum Plasmodium falciparum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3JSU OCA].~~	+

	==See Also==		==See Also==
	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]		*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
-	*[[Thymidylate synthase\|Thymidylate synthase]]	+	== References ==
-		+	<references/>
-	==~~Reference~~==	+	__TOC__
-	<~~ref group="xtra">PMID:020350951<~~/~~ref~~><~~references group="xtra"~~/>	+	</StructureSection>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
-	[[Category: Chitnumsub, P.]]	+	[[Category: Chitnumsub, P]]
-	[[Category: Diagana, T T.]]	+	[[Category: Diagana, T T]]
-	[[Category: Kamchonwongpaisan, S.]]	+	[[Category: Kamchonwongpaisan, S]]
-	[[Category: Maneeruttanarungroj, C.]]	+	[[Category: Maneeruttanarungroj, C]]
-	[[Category: Yuthavong, Y.]]	+	[[Category: Yuthavong, Y]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 08:10, 20 October 2012

OCA — Sat, 20 Oct 2012 08:10:50 GMT

←Older revision		Revision as of 08:10, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3jsu]] is a 2 chain structure ~~of [[Dihydrofolate reductase]] and [[Thymidylate synthase]]~~ with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSU OCA].	+	[[3jsu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSU OCA].

	==See Also==		==See Also==

OCA: Protected "3jsu" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 18:42:39 GMT

Protected "3jsu" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:42, 25 July 2012

OCA at 18:42, 25 July 2012

OCA — Wed, 25 Jul 2012 18:42:36 GMT

←Older revision		Revision as of 18:42, 25 July 2012
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-	~~{{Seed}}~~	+	[[Image:3jsu.png\|left\|200px]]
-	[[Image:3jsu.~~jpg~~\|left\|200px]]	+

-	<!--
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	{{STRUCTURE_3jsu\| PDB=3jsu \| SCENE= }}		{{STRUCTURE_3jsu\| PDB=3jsu \| SCENE= }}

	===Quadruple mutant(N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase(PFDHFR-TS) complexed with QN254, NADPH, and dUMP===		===Quadruple mutant(N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase(PFDHFR-TS) complexed with QN254, NADPH, and dUMP===

-
-	<!--
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-	(as it appears on PubMed at http://www.pubmed.gov), where 20350951 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_20350951}}		{{ABSTRACT_PUBMED_20350951}}

	==About this Structure==		==About this Structure==
-	~~3JSU~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSU OCA].	+	[[3jsu]] is a 2 chain structure of [[Dihydrofolate reductase]] and [[Thymidylate synthase]] with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSU OCA].
		+
		+	==See Also==
		+	*[[Dihydrofolate reductase\|Dihydrofolate reductase]]
		+	*[[Thymidylate synthase\|Thymidylate synthase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20350951~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020350951</ref><references group="xtra"/>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum]]
	[[Category: Chitnumsub, P.]]		[[Category: Chitnumsub, P.]]
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	[[Category: Rossmann fold]]		[[Category: Rossmann fold]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 28 12:36:36 2010''

OCA at 08:29, 28 July 2010

OCA — Wed, 28 Jul 2010 08:29:54 GMT

←Older revision		Revision as of 08:29, 28 July 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3jsu.jpg\|left\|200px]]

-	The ~~entry 3jsu~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3jsu", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3jsu\| PDB=3jsu \| SCENE= }}

-	~~Authors: Chitnumsub~~, P., ~~Maneeruttanarungroj, C., Kamchonwongpaisan, S., Yuthavong, Y., Diagana, T.T.~~	+	===Quadruple mutant(N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase(PFDHFR-TS) complexed with QN254, NADPH, and dUMP===

-	Description: Quadruple mutant(N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase(PFDHFR-TS) complexed with QN254, NADPH, and dUMP

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct~~ 28 12:55:~~32 2009~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20350951}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20350951 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20350951}}
		+
		+	==About this Structure==
		+	3JSU is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSU OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20350951</ref><references group="xtra"/>
		+	[[Category: Plasmodium falciparum]]
		+	[[Category: Chitnumsub, P.]]
		+	[[Category: Diagana, T T.]]
		+	[[Category: Kamchonwongpaisan, S.]]
		+	[[Category: Maneeruttanarungroj, C.]]
		+	[[Category: Yuthavong, Y.]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Rossmann fold]]
		+	[[Category: Transferase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 28 12:36:36 2010''

OCA at 10:55, 28 October 2009

OCA — Wed, 28 Oct 2009 10:55:33 GMT

←Older revision		Revision as of 10:55, 28 October 2009
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3jsu is ON HOLD	+	The entry 3jsu is ON HOLD until Paper Publication

	Authors: Chitnumsub, P., Maneeruttanarungroj, C., Kamchonwongpaisan, S., Yuthavong, Y., Diagana, T.T.		Authors: Chitnumsub, P., Maneeruttanarungroj, C., Kamchonwongpaisan, S., Yuthavong, Y., Diagana, T.T.
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	Description: Quadruple mutant(N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase(PFDHFR-TS) complexed with QN254, NADPH, and dUMP		Description: Quadruple mutant(N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase(PFDHFR-TS) complexed with QN254, NADPH, and dUMP

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 23 08~~:30:31 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 28 12:55:32 2009''