3jus - Revision history

OCA at 08:03, 6 September 2023

OCA — Wed, 06 Sep 2023 08:03:58 GMT

←Older revision		Revision as of 08:03, 6 September 2023
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	<StructureSection load='3jus' size='340' side='right'caption='[[3jus]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3jus' size='340' side='right'caption='[[3jus]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3jus]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3JUS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3jus]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JUS FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"><~~scene name~~='~~pdbligand~~=~~BCD~~:~~BETA-CYCLODEXTRIN'~~>~~BCD~~</~~scene~~>, <scene name='pdbligand=ECL:1-[(2R)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE'>ECL</scene>, <scene name='pdbligand=ECN:1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE'>ECN</scene>, <scene name='pdbligand=~~HEM~~:~~PROTOPORPHYRIN+IX+CONTAINING+FE~~'>~~HEM~~</scene><~~/td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat">[[3i3k\|3i3k]], [[3juv\|3juv]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ECL:1-[(2R)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE'>ECL</scene>, <scene name='pdbligand=ECN:1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE'>ECN</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PRD_900012:beta-cyclodextrin'>PRD_900012</scene></td></tr>
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b>~~</td><td class="sblockDat">CYP51~~, ~~CYP51A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~<~~/td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jus OCA], [https://pdbe.org/3jus PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jus RCSB], [https://www.ebi.ac.uk/pdbsum/3jus PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jus ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3jus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jus OCA], [~~http~~://pdbe.org/3jus PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3jus RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3jus PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3jus ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CP51A_HUMAN CP51A_HUMAN]] Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.	+	[https://www.uniprot.org/uniprot/CP51A_HUMAN CP51A_HUMAN] Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</div>		</div>
	<div class="pdbe-citations 3jus" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3jus" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cytochrome P450 3D structures\|Cytochrome P450 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Sterol 14-demethylase]]~~	+	[[Category: Arrowsmith CH]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Bountra C]]
-	[[Category: Bountra, C]]	+	[[Category: Edwards AM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: MacKenzie F]]
-	[[Category: MacKenzie, F]]	+	[[Category: Park H]]
-	[[Category: Park, H]]	+	[[Category: Strushkevich N]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Usanov SA]]
-	[[Category: Strushkevich, N]]	+	[[Category: Weigelt J]]
-	[[Category: Usanov~~, S A~~]]	+
-	[[Category: Weigelt, J]]	+
-	~~[[Category: Cholesterol biosynthesis]]~~	+
-	~~[[Category: Cytochrome p450]]~~	+
-	~~[[Category: Econazole]]~~	+
-	~~[[Category: Endoplasmic reticulum]]~~	+
-	~~[[Category: Heme]]~~	+
-	~~[[Category: Iron]]~~	+
-	~~[[Category: Lipid synthesis]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Microsome]]~~	+
-	~~[[Category: Monooxygenase]]~~	+
-	~~[[Category: Nadp]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Steroid biosynthesis]]~~	+
-	~~[[Category: Sterol 14alpha-demethylase]]~~	+
-	~~[[Category: Sterol biosynthesis]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 07:36, 10 April 2019

OCA — Wed, 10 Apr 2019 07:36:28 GMT

←Older revision		Revision as of 07:36, 10 April 2019
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	==Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with econazole==		==Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with econazole==
-	<StructureSection load='3jus' size='340' side='right' caption='[[3jus]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='3jus' size='340' side='right'caption='[[3jus]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3jus]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JUS FirstGlance]. <br>		<table><tr><td colspan='2'>[[3jus]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JUS FirstGlance]. <br>
Line 22:		Line 22:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jus ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jus ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The obligatory step in sterol biosynthesis in eukaryotes is demethylation of sterol precursors at the C14-position, which is catalyzed by CYP51 (sterol 14-alpha demethylase) in three sequential reactions. In mammals, the final product of the pathway is cholesterol, while important intermediates, meiosis-activating sterols, are produced by CYP51. Three crystal structures of human CYP51, ligand-free and complexed with antifungal drugs ketoconazole and econazole, were determined, allowing analysis of the molecular basis for functional conservation within the CYP51 family. Azole binding occurs mostly through hydrophobic interactions with conservative residues of the active site. The substantial conformational changes in the B' helix and F-G loop regions are induced upon ligand binding, consistent with the membrane nature of the protein and its substrate. The access channel is typical for mammalian sterol-metabolizing P450 enzymes, but is different from that observed in Mycobacterium tuberculosis CYP51. Comparison of the azole-bound structures provides insight into the relative binding affinities of human and bacterial P450 enzymes to ketoconazole and fluconazole, which can be useful for the rational design of antifungal compounds and specific modulators of human CYP51.
		+
		+	Structural basis of human CYP51 inhibition by antifungal azoles.,Strushkevich N, Usanov SA, Park HW J Mol Biol. 2010 Apr 9;397(4):1067-78. Epub 2010 Feb 10. PMID:20149798<ref>PMID:20149798</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 3jus" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Sterol 14-demethylase]]		[[Category: Sterol 14-demethylase]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA at 09:37, 26 December 2018

OCA — Wed, 26 Dec 2018 09:37:43 GMT

←Older revision		Revision as of 09:37, 26 December 2018
Line 1:		Line 1:
		+
	==Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with econazole==		==Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with econazole==
	<StructureSection load='3jus' size='340' side='right' caption='[[3jus]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3jus' size='340' side='right' caption='[[3jus]], [[Resolution\|resolution]] 2.90Å' scene=''>
Line 7:		Line 8:
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYP51, CYP51A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYP51, CYP51A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jus OCA], [http://pdbe.org/3jus PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jus RCSB], [http://www.ebi.ac.uk/pdbsum/3jus PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jus OCA], [http://pdbe.org/3jus PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jus RCSB], [http://www.ebi.ac.uk/pdbsum/3jus PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jus ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/3jus_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/3jus_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 15:36, 7 February 2016

OCA — Sun, 07 Feb 2016 15:36:54 GMT

←Older revision		Revision as of 15:36, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3jus' size='340' side='right' caption='[[3jus]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='3jus' size='340' side='right' caption='[[3jus]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3jus]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JUS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3jus]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JUS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCD:BETA-CYCLODEXTRIN'>BCD</scene>, <scene name='pdbligand=ECL:1-[(2R)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE'>ECL</scene>, <scene name='pdbligand=ECN:1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE'>ECN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCD:BETA-CYCLODEXTRIN'>BCD</scene>, <scene name='pdbligand=ECL:1-[(2R)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE'>ECL</scene>, <scene name='pdbligand=ECN:1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE'>ECN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i3k\|3i3k]], [[3juv\|3juv]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i3k\|3i3k]], [[3juv\|3juv]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYP51, CYP51A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYP51, CYP51A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jus OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jus RCSB], [http://www.ebi.ac.uk/pdbsum/3jus PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jus OCA], [http://pdbe.org/3jus PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jus RCSB], [http://www.ebi.ac.uk/pdbsum/3jus PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jus ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Sterol 14-demethylase]]		[[Category: Sterol 14-demethylase]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]

OCA at 16:21, 24 December 2014

OCA — Wed, 24 Dec 2014 16:21:39 GMT

←Older revision		Revision as of 16:21, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3jus]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JUS FirstGlance]. <br>		<table><tr><td colspan='2'>[[3jus]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JUS FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCD:BETA-CYCLODEXTRIN'>BCD</scene>, <scene name='pdbligand=ECL:1-[(2R)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE'>ECL</scene>, <scene name='pdbligand=ECN:1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE'>ECN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCD:BETA-CYCLODEXTRIN'>BCD</scene>, <scene name='pdbligand=ECL:1-[(2R)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE'>ECL</scene>, <scene name='pdbligand=ECN:1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE'>ECN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i3k\|3i3k]], [[3juv\|3juv]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i3k\|3i3k]], [[3juv\|3juv]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYP51, CYP51A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYP51, CYP51A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jus OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jus RCSB], [http://www.ebi.ac.uk/pdbsum/3jus PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jus OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jus RCSB], [http://www.ebi.ac.uk/pdbsum/3jus PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CP51A_HUMAN CP51A_HUMAN]] Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 23:		Line 25:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Sterol 14-demethylase]]		[[Category: Sterol 14-demethylase]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: MacKenzie, F.]]	+	[[Category: MacKenzie, F]]
-	[[Category: Park, H.]]	+	[[Category: Park, H]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Strushkevich, N.]]	+	[[Category: Strushkevich, N]]
-	[[Category: Usanov, S A.]]	+	[[Category: Usanov, S A]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
	[[Category: Cholesterol biosynthesis]]		[[Category: Cholesterol biosynthesis]]
	[[Category: Cytochrome p450]]		[[Category: Cytochrome p450]]
Line 49:		Line 51:
	[[Category: Sterol 14alpha-demethylase]]		[[Category: Sterol 14alpha-demethylase]]
	[[Category: Sterol biosynthesis]]		[[Category: Sterol biosynthesis]]
-	[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]

OCA at 05:29, 4 June 2014

OCA — Wed, 04 Jun 2014 05:29:33 GMT

←Older revision		Revision as of 05:29, 4 June 2014
Line 1:		Line 1:
-	~~[[Image:3jus.png\|left\|200px]]~~	+	==Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with econazole==
-		+	<StructureSection load='3jus' size='340' side='right' caption='[[3jus]], [[Resolution\|resolution]] 2.90Å' scene=''>
-	~~{{STRUCTURE_3jus\| PDB=3jus \| SCENE= }}~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[3jus]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JUS FirstGlance]. <br>
-	===Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with econazole===	+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCD:BETA-CYCLODEXTRIN'>BCD</scene>, <scene name='pdbligand=ECL:1-[(2R)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE'>ECL</scene>, <scene name='pdbligand=ECN:1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE'>ECN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene><br>
-		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3i3k\|3i3k]], [[3juv\|3juv]]</td></tr>
-	~~{{ABSTRACT_PUBMED_020149798}}~~	+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYP51, CYP51A1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-		+	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr>
-	==~~About this Structure~~==	+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jus OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jus RCSB], [http://www.ebi.ac.uk/pdbsum/3jus PDBsum]</span></td></tr>
-	[[3jus]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUS OCA].	+	<table>
-		+	== Evolutionary Conservation ==
-	==~~Reference~~==	+	[[Image:Consurf_key_small.gif\|200px\|right]]
-	<~~ref group~~="~~xtra~~">~~PMID~~:~~020149798~~</~~ref~~><~~references group~~="~~xtra~~"/>	+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ju/3jus_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Sterol 14-demethylase]]		[[Category: Sterol 14-demethylase]]

OCA: Protected "3jus" [edit=sysop:move=sysop]

OCA — Wed, 01 Aug 2012 04:55:59 GMT

Protected "3jus" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:55, 1 August 2012

OCA at 04:55, 1 August 2012

OCA — Wed, 01 Aug 2012 04:55:58 GMT

←Older revision		Revision as of 04:55, 1 August 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3jus.png\|left\|200px]]		[[Image:3jus.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3jus", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3jus\| PDB=3jus \| SCENE= }}		{{STRUCTURE_3jus\| PDB=3jus \| SCENE= }}

	===Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with econazole===		===Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with econazole===

		+	{{ABSTRACT_PUBMED_020149798}}

	==About this Structure==		==About this Structure==
-	~~3JUS~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUS OCA].	+	[[3jus]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUS OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:020149798</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Sterol 14-demethylase]]		[[Category: Sterol 14-demethylase]]
Line 26:		Line 23:
	[[Category: Usanov, S A.]]		[[Category: Usanov, S A.]]
	[[Category: Weigelt, J.]]		[[Category: Weigelt, J.]]
-	[[Category: Alternative splicing]]
	[[Category: Cholesterol biosynthesis]]		[[Category: Cholesterol biosynthesis]]
	[[Category: Cytochrome p450]]		[[Category: Cytochrome p450]]
Line 40:		Line 36:
	[[Category: Nadp]]		[[Category: Nadp]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
-	[[Category: Polymorphism]]
	[[Category: Sgc]]		[[Category: Sgc]]
	[[Category: Steroid biosynthesis]]		[[Category: Steroid biosynthesis]]
Line 48:		Line 43:
	[[Category: Structural genomics consortium]]		[[Category: Structural genomics consortium]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 5 11:12:47 2010''

OCA at 08:12, 5 May 2010

OCA — Wed, 05 May 2010 08:12:47 GMT

←Older revision		Revision as of 08:12, 5 May 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3jus.~~jpg~~\|left\|200px]]	+	[[Image:3jus.png\|left\|200px]]

	<!--		<!--
Line 25:		Line 25:
	[[Category: Strushkevich, N.]]		[[Category: Strushkevich, N.]]
	[[Category: Usanov, S A.]]		[[Category: Usanov, S A.]]
-	[[Category: Weigelt, J U.]]	+	[[Category: Weigelt, J.]]
	[[Category: Alternative splicing]]		[[Category: Alternative splicing]]
	[[Category: Cholesterol biosynthesis]]		[[Category: Cholesterol biosynthesis]]
Line 49:		Line 49:
	[[Category: Transmembrane]]		[[Category: Transmembrane]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar~~ ~~3 17~~:09:07 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 5 11:12:47 2010''

OCA at 15:09, 3 March 2010

OCA — Wed, 03 Mar 2010 15:09:09 GMT

←Older revision		Revision as of 15:09, 3 March 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3jus.jpg\|left\|200px]]

-	The ~~entry 3jus~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3jus", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3jus\| PDB=3jus \| SCENE= }}

-	~~Authors: Strushkevich, N., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J.U., Usanov, S.A., Park, H., Structural Genomics Consortium~~ (~~SGC~~)	+	===Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with econazole===

-	Description: Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with econazole

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jan 27 19~~:13:26 2010''	+	==About this Structure==
		+	3JUS is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JUS OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Sterol 14-demethylase]]
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Edwards, A M.]]
		+	[[Category: MacKenzie, F.]]
		+	[[Category: Park, H.]]
		+	[[Category: SGC, Structural Genomics Consortium.]]
		+	[[Category: Strushkevich, N.]]
		+	[[Category: Usanov, S A.]]
		+	[[Category: Weigelt, J U.]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Cholesterol biosynthesis]]
		+	[[Category: Cytochrome p450]]
		+	[[Category: Econazole]]
		+	[[Category: Endoplasmic reticulum]]
		+	[[Category: Heme]]
		+	[[Category: Iron]]
		+	[[Category: Lipid synthesis]]
		+	[[Category: Membrane]]
		+	[[Category: Metal-binding]]
		+	[[Category: Microsome]]
		+	[[Category: Monooxygenase]]
		+	[[Category: Nadp]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Polymorphism]]
		+	[[Category: Sgc]]
		+	[[Category: Steroid biosynthesis]]
		+	[[Category: Sterol 14alpha-demethylase]]
		+	[[Category: Sterol biosynthesis]]
		+	[[Category: Structural genomic]]
		+	[[Category: Structural genomics consortium]]
		+	[[Category: Transmembrane]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 3 17:09:07 2010''