3jz4 - Revision history

OCA at 10:14, 21 February 2024

OCA — Wed, 21 Feb 2024 10:14:10 GMT

←Older revision		Revision as of 10:14, 21 February 2024
Line 1:		Line 1:

	==Crystal structure of E. coli NADP dependent enzyme==		==Crystal structure of E. coli NADP dependent enzyme==
-	<StructureSection load='3jz4' size='340' side='right' caption='[[3jz4]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='3jz4' size='340' side='right'caption='[[3jz4]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3jz4]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3JZ4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3jz4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JZ4 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=NAP:NADP+NICOTINAMIDE~~-~~ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>b2661, gabD, JW2636, NA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~562~~ "~~Bacillus coli~~" ~~Migula 1895])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Succinate-semialdehyde_dehydrogenase_(NAD(P)(~~+~~)) Succinate~~-~~semialdehyde dehydrogenase (NAD(P)(~~+~~))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.16 1.2.1.16]~~ </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jz4 OCA], [https://pdbe.org/3jz4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jz4 RCSB], [https://www.ebi.ac.uk/pdbsum/3jz4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jz4 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3jz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jz4 OCA], [~~http~~://pdbe.org/3jz4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3jz4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3jz4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3jz4 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GABD_ECOLI GABD_ECOLI]] Catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate. It appears to be important for nitrogen metabolism under N limitation conditions.<ref>PMID:20174634</ref> <ref>PMID:7011797</ref>	+	[https://www.uniprot.org/uniprot/GABD_ECOLI GABD_ECOLI] Catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate. It appears to be important for nitrogen metabolism under N limitation conditions.<ref>PMID:20174634</ref> <ref>PMID:7011797</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 21:		Line 20:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jz4 ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jz4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	BACKGROUND: In mammals succinic semialdehyde dehydrogenase (SSADH) plays an essential role in the metabolism of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) to succinic acid (SA). Deficiency of SSADH in humans results in elevated levels of GABA and gamma-Hydroxybutyric acid (GHB), which leads to psychomotor retardation, muscular hypotonia, non-progressive ataxia and seizures. In Escherichia coli, two genetically distinct forms of SSADHs had been described that are essential for preventing accumulation of toxic levels of succinic semialdehyde (SSA) in cells. METHODOLOGY/PRINCIPAL FINDINGS: Here we structurally characterise SSADH encoded by the E coli gabD gene by X-ray crystallographic studies and compare these data with the structure of human SSADH. In the E. coli SSADH structure, electron density for the complete NADP+ cofactor in the binding sites is clearly evident; these data in particular revealing how the nicotinamide ring of the cofactor is positioned in each active site. CONCLUSIONS/SIGNIFICANCE: Our structural data suggest that a deletion of three amino acids in E. coli SSADH permits this enzyme to use NADP+, whereas in contrast the human enzyme utilises NAD+. Furthermore, the structure of E. coli SSADH gives additional insight into human mutations that result in disease.
-
-	The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions.,Langendorf CG, Key TL, Fenalti G, Kan WT, Buckle AM, Caradoc-Davies T, Tuck KL, Law RH, Whisstock JC PLoS One. 2010 Feb 18;5(2):e9280. PMID:20174634<ref>PMID:20174634</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 3jz4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[Aldehyde dehydrogenase\|Aldehyde dehydrogenase]]	+	*[[Aldehyde dehydrogenase 3D structures\|Aldehyde dehydrogenase 3D structures]]
	*[[Succinate-semialdehyde dehydrogenase\|Succinate-semialdehyde dehydrogenase]]		*[[Succinate-semialdehyde dehydrogenase\|Succinate-semialdehyde dehydrogenase]]
	== References ==		== References ==
Line 38:		Line 28:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
-	[[Category: Buckle~~, A M~~]]	+	[[Category: Large Structures]]
-	[[Category: Caradoc-Davies, T]]	+	[[Category: Buckle AM]]
-	[[Category: Fenalti, G]]	+	[[Category: Caradoc-Davies T]]
-	[[Category: Kan~~, W T~~]]	+	[[Category: Fenalti G]]
-	[[Category: Key~~, T L.G~~]]	+	[[Category: Kan WT]]
-	[[Category: Langendorf~~, C G~~]]	+	[[Category: Key TLG]]
-	[[Category: Law~~, R H.P~~]]	+	[[Category: Langendorf CG]]
-	[[Category: Tuck~~, K L~~]]	+	[[Category: Law RHP]]
-	[[Category: Whisstock~~, J C]]~~	+	[[Category: Tuck KL]]
-	~~[[Category: Nadp]]~~	+	[[Category: Whisstock JC]]
-	~~[[Category: Nadp binding]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Tetramer~~]]	+

OCA at 09:22, 26 December 2018

OCA — Wed, 26 Dec 2018 09:22:56 GMT

←Older revision		Revision as of 09:22, 26 December 2018
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/3jz4_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/3jz4_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 17:27, 4 August 2016

OCA — Thu, 04 Aug 2016 17:27:49 GMT

←Older revision		Revision as of 17:27, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of E. coli NADP dependent enzyme==		==Crystal structure of E. coli NADP dependent enzyme==
	<StructureSection load='3jz4' size='340' side='right' caption='[[3jz4]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3jz4' size='340' side='right' caption='[[3jz4]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3jz4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JZ4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3jz4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JZ4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b2661, gabD, JW2636, NA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b2661, gabD, JW2636, NA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Succinate-semialdehyde_dehydrogenase_(NAD(P)(+)) Succinate-semialdehyde dehydrogenase (NAD(P)(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.16 1.2.1.16] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Succinate-semialdehyde_dehydrogenase_(NAD(P)(+)) Succinate-semialdehyde dehydrogenase (NAD(P)(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.16 1.2.1.16] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jz4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jz4 RCSB], [http://www.ebi.ac.uk/pdbsum/3jz4 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jz4 OCA], [http://pdbe.org/3jz4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jz4 RCSB], [http://www.ebi.ac.uk/pdbsum/3jz4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jz4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jz4 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3jz4" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia~~ coli]]	+	[[Category: Bacillus coli migula 1895]]
	[[Category: Buckle, A M]]		[[Category: Buckle, A M]]
	[[Category: Caradoc-Davies, T]]		[[Category: Caradoc-Davies, T]]

OCA at 17:35, 24 December 2014

OCA — Wed, 24 Dec 2014 17:35:02 GMT

←Older revision		Revision as of 17:35, 24 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jz4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jz4 RCSB], [http://www.ebi.ac.uk/pdbsum/3jz4 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jz4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jz4 RCSB], [http://www.ebi.ac.uk/pdbsum/3jz4 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GABD_ECOLI GABD_ECOLI]] Catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate. It appears to be important for nitrogen metabolism under N limitation conditions.<ref>PMID:20174634</ref> <ref>PMID:7011797</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:25, 9 December 2014

OCA — Tue, 09 Dec 2014 09:25:24 GMT

←Older revision		Revision as of 09:25, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3jz4.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of E. coli NADP dependent enzyme==
		+	<StructureSection load='3jz4' size='340' side='right' caption='[[3jz4]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3jz4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JZ4 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b2661, gabD, JW2636, NA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Succinate-semialdehyde_dehydrogenase_(NAD(P)(+)) Succinate-semialdehyde dehydrogenase (NAD(P)(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.16 1.2.1.16] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jz4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jz4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jz4 RCSB], [http://www.ebi.ac.uk/pdbsum/3jz4 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/3jz4_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	BACKGROUND: In mammals succinic semialdehyde dehydrogenase (SSADH) plays an essential role in the metabolism of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) to succinic acid (SA). Deficiency of SSADH in humans results in elevated levels of GABA and gamma-Hydroxybutyric acid (GHB), which leads to psychomotor retardation, muscular hypotonia, non-progressive ataxia and seizures. In Escherichia coli, two genetically distinct forms of SSADHs had been described that are essential for preventing accumulation of toxic levels of succinic semialdehyde (SSA) in cells. METHODOLOGY/PRINCIPAL FINDINGS: Here we structurally characterise SSADH encoded by the E coli gabD gene by X-ray crystallographic studies and compare these data with the structure of human SSADH. In the E. coli SSADH structure, electron density for the complete NADP+ cofactor in the binding sites is clearly evident; these data in particular revealing how the nicotinamide ring of the cofactor is positioned in each active site. CONCLUSIONS/SIGNIFICANCE: Our structural data suggest that a deletion of three amino acids in E. coli SSADH permits this enzyme to use NADP+, whereas in contrast the human enzyme utilises NAD+. Furthermore, the structure of E. coli SSADH gives additional insight into human mutations that result in disease.

-	~~{{STRUCTURE_3jz4\| PDB=3jz4 \| SCENE= }}~~	+	The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions.,Langendorf CG, Key TL, Fenalti G, Kan WT, Buckle AM, Caradoc-Davies T, Tuck KL, Law RH, Whisstock JC PLoS One. 2010 Feb 18;5(2):e9280. PMID:20174634<ref>PMID:20174634</ref>

-	~~===Crystal structure~~ of E. ~~coli NADP dependent enzyme===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20174634}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3jz4]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ4 OCA].~~	+

	==See Also==		==See Also==
	*[[Aldehyde dehydrogenase\|Aldehyde dehydrogenase]]		*[[Aldehyde dehydrogenase\|Aldehyde dehydrogenase]]
-		+	*[[Succinate-semialdehyde dehydrogenase\|Succinate-semialdehyde dehydrogenase]]
-	==~~Reference~~==	+	== References ==
-	<~~ref group="xtra">PMID:020174634<~~/~~ref~~><~~references group="xtra"~~/>	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Buckle, A M.]]	+	[[Category: Buckle, A M]]
-	[[Category: Caradoc-Davies, T.]]	+	[[Category: Caradoc-Davies, T]]
-	[[Category: Fenalti, G.]]	+	[[Category: Fenalti, G]]
-	[[Category: Kan, W T.]]	+	[[Category: Kan, W T]]
-	[[Category: Key, T L.G.]]	+	[[Category: Key, T L.G]]
-	[[Category: Langendorf, C G.]]	+	[[Category: Langendorf, C G]]
-	[[Category: Law, R H.P.]]	+	[[Category: Law, R H.P]]
-	[[Category: Tuck, K L.]]	+	[[Category: Tuck, K L]]
-	[[Category: Whisstock, J C.]]	+	[[Category: Whisstock, J C]]
	[[Category: Nadp]]		[[Category: Nadp]]
	[[Category: Nadp binding]]		[[Category: Nadp binding]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Tetramer]]		[[Category: Tetramer]]

OCA at 07:34, 20 October 2012

OCA — Sat, 20 Oct 2012 07:34:29 GMT

←Older revision		Revision as of 07:34, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3jz4]] is a 4 chain structure ~~of [[Aldehyde dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ4 OCA].	+	[[3jz4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ4 OCA].

	==See Also==		==See Also==

OCA: Protected "3jz4" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 16:45:40 GMT

Protected "3jz4" [edit=sysop:move=sysop]

←Older revision

Revision as of 16:45, 25 July 2012

OCA at 16:45, 25 July 2012

OCA — Wed, 25 Jul 2012 16:45:37 GMT

←Older revision		Revision as of 16:45, 25 July 2012
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-	~~{{Seed}}~~	+	[[Image:3jz4.png\|left\|200px]]
-	[[Image:3jz4.~~jpg~~\|left\|200px]]	+

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3jz4", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3jz4\| PDB=3jz4 \| SCENE= }}		{{STRUCTURE_3jz4\| PDB=3jz4 \| SCENE= }}

	===Crystal structure of E. coli NADP dependent enzyme===		===Crystal structure of E. coli NADP dependent enzyme===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20174634}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20174634 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20174634}}		{{ABSTRACT_PUBMED_20174634}}

	==About this Structure==		==About this Structure==
-	~~3JZ4~~ is a 4 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ4 OCA].	+	[[3jz4]] is a 4 chain structure of [[Aldehyde dehydrogenase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ4 OCA].
		+
		+	==See Also==
		+	*[[Aldehyde dehydrogenase\|Aldehyde dehydrogenase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20174634~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020174634</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Buckle, A M.]]		[[Category: Buckle, A M.]]
Line 38:		Line 29:
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Tetramer]]		[[Category: Tetramer]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 17 09:24:14 2010''

OCA at 07:24, 17 March 2010

OCA — Wed, 17 Mar 2010 07:24:15 GMT

←Older revision		Revision as of 07:24, 17 March 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3jz4.jpg\|left\|200px]]

-	The ~~entry 3jz4~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3jz4", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3jz4\| PDB=3jz4 \| SCENE= }}

-	~~Authors: Langendorf, C.G., Key, T.L.G., Fenalti, G., Kan, W.T., Buckle, A.M., Caradoc-Davies, T., Tuck, K.L., Law, R.H.P., Whisstock, J.C~~.	+	===Crystal structure of E. coli NADP dependent enzyme===

-	Description: Crystal structure of E. coli NADP dependent enzyme

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 30~~ 09:01:~~23 2009~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20174634}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20174634 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20174634}}
		+
		+	==About this Structure==
		+	3JZ4 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ4 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20174634</ref><references group="xtra"/>
		+	[[Category: Escherichia coli]]
		+	[[Category: Buckle, A M.]]
		+	[[Category: Caradoc-Davies, T.]]
		+	[[Category: Fenalti, G.]]
		+	[[Category: Kan, W T.]]
		+	[[Category: Key, T L.G.]]
		+	[[Category: Langendorf, C G.]]
		+	[[Category: Law, R H.P.]]
		+	[[Category: Tuck, K L.]]
		+	[[Category: Whisstock, J C.]]
		+	[[Category: Nadp]]
		+	[[Category: Nadp binding]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Tetramer]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 17 09:24:14 2010''

OCA: New page: '''Unreleased structure''' The entry 3jz4 is ON HOLD Authors: Langendorf, C.G., Key, T.L.G., Fenalti, G., Kan, W.T., Buckle, A.M., Caradoc-Davies, T., Tuck, K.L., Law, R.H.P., Whisstock...

OCA — Wed, 30 Sep 2009 07:01:24 GMT

New page: '''Unreleased structure''' The entry 3jz4 is ON HOLD Authors: Langendorf, C.G., Key, T.L.G., Fenalti, G., Kan, W.T., Buckle, A.M., Caradoc-Davies, T., Tuck, K.L., Law, R.H.P., Whisstock...

New page

'''Unreleased structure'''

The entry 3jz4 is ON HOLD

Authors: Langendorf, C.G., Key, T.L.G., Fenalti, G., Kan, W.T., Buckle, A.M., Caradoc-Davies, T., Tuck, K.L., Law, R.H.P., Whisstock, J.C.

Description: Crystal structure of E. coli NADP dependent enzyme

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 30 09:01:23 2009''