3jz7 - Revision history

OCA at 08:06, 6 September 2023

OCA — Wed, 06 Sep 2023 08:06:26 GMT

←Older revision		Revision as of 08:06, 6 September 2023
Line 1:		Line 1:

	==Crystal structure of the extracellular domains of coxsackie & adenovirus receptor from mouse (mCAR)==		==Crystal structure of the extracellular domains of coxsackie & adenovirus receptor from mouse (mCAR)==
-	<StructureSection load='3jz7' size='340' side='right' caption='[[3jz7]], [[Resolution\|resolution]] 2.19Å' scene=''>	+	<StructureSection load='3jz7' size='340' side='right'caption='[[3jz7]], [[Resolution\|resolution]] 2.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3jz7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3JZ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3jz7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JZ7 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.19Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kac\|1kac]]~~, [[~~1f5w~~\|~~1f5w]], [[1eaj\|1eaj]], [[1jew\|1jew]], [[2wbw\|2wbw]], [[2npl\|2npl~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Car, Cxadr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=10090 LK3 transgenic mice])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jz7 OCA], [https://pdbe.org/3jz7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jz7 RCSB], [https://www.ebi.ac.uk/pdbsum/3jz7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jz7 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3jz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jz7 OCA], [~~http~~://pdbe.org/3jz7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3jz7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3jz7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3jz7 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CXAR_MOUSE CXAR_MOUSE]] Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN (By similarity).<ref>PMID:9036860</ref> <ref>PMID:9420240</ref> <ref>PMID:10814828</ref> In vitro, acts as a receptor for group B coxsackieviruses and subgroup C of adenoviruses (AD2 and AD5).<ref>PMID:9036860</ref> <ref>PMID:9420240</ref> <ref>PMID:10814828</ref>	+	[https://www.uniprot.org/uniprot/CXAR_MOUSE CXAR_MOUSE] Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN (By similarity).<ref>PMID:9036860</ref> <ref>PMID:9420240</ref> <ref>PMID:10814828</ref> In vitro, acts as a receptor for group B coxsackieviruses and subgroup C of adenoviruses (AD2 and AD5).<ref>PMID:9036860</ref> <ref>PMID:9420240</ref> <ref>PMID:10814828</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/3jz7_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/3jz7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Heinemann, U~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Max, K E.A~~]]	+	[[Category: Heinemann U]]
-	[[Category: ~~Adenovirus]]~~	+	[[Category: Max KEA]]
-	~~[[Category: Alternative splicing]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Cell adhesion molecule]]~~	+
-	~~[[Category: Cell junction]]~~	+
-	~~[[Category: Cell membrane]]~~	+
-	~~[[Category: Coxsackievirus]]~~	+
-	~~[[Category: Disulfide bond]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Immunoglobulin domain]]~~	+
-	~~[[Category: Immunoglobuline superfamily]]~~	+
-	~~[[Category: Lipoprotein]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Palmitate]]~~	+
-	~~[[Category: Phosphoprotein]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Secreted]]~~	+
-	~~[[Category: Tight junction]]~~	+
-	~~[[Category: Transmembrane~~]]	+

OCA at 08:22, 1 November 2017

OCA — Wed, 01 Nov 2017 08:22:18 GMT

←Older revision		Revision as of 08:22, 1 November 2017
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	[[Category: Max, K E.A]]		[[Category: Max, K E.A]]
	[[Category: Adenovirus]]		[[Category: Adenovirus]]
		+	[[Category: Alternative splicing]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Cell adhesion molecule]]		[[Category: Cell adhesion molecule]]

OCA at 00:22, 5 August 2016

OCA — Fri, 05 Aug 2016 00:22:42 GMT

←Older revision		Revision as of 00:22, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of the extracellular domains of coxsackie & adenovirus receptor from mouse (mCAR)==		==Crystal structure of the extracellular domains of coxsackie & adenovirus receptor from mouse (mCAR)==
	<StructureSection load='3jz7' size='340' side='right' caption='[[3jz7]], [[Resolution\|resolution]] 2.19Å' scene=''>		<StructureSection load='3jz7' size='340' side='right' caption='[[3jz7]], [[Resolution\|resolution]] 2.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3jz7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JZ7 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3jz7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JZ7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kac\|1kac]], [[1f5w\|1f5w]], [[1eaj\|1eaj]], [[1jew\|1jew]], [[2wbw\|2wbw]], [[2npl\|2npl]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kac\|1kac]], [[1f5w\|1f5w]], [[1eaj\|1eaj]], [[1jew\|1jew]], [[2wbw\|2wbw]], [[2npl\|2npl]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Car, Cxadr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Car, Cxadr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jz7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jz7 RCSB], [http://www.ebi.ac.uk/pdbsum/3jz7 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jz7 OCA], [http://pdbe.org/3jz7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jz7 RCSB], [http://www.ebi.ac.uk/pdbsum/3jz7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jz7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jz7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 29:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3jz7" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Mus musculus~~]]	+	[[Category: Lk3 transgenic mice]]
	[[Category: Heinemann, U]]		[[Category: Heinemann, U]]
	[[Category: Max, K E.A]]		[[Category: Max, K E.A]]

OCA at 14:20, 25 December 2014

OCA — Thu, 25 Dec 2014 14:20:34 GMT

←Older revision		Revision as of 14:20, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jz7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jz7 RCSB], [http://www.ebi.ac.uk/pdbsum/3jz7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jz7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jz7 RCSB], [http://www.ebi.ac.uk/pdbsum/3jz7 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CXAR_MOUSE CXAR_MOUSE]] Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN (By similarity).<ref>PMID:9036860</ref> <ref>PMID:9420240</ref> <ref>PMID:10814828</ref> In vitro, acts as a receptor for group B coxsackieviruses and subgroup C of adenoviruses (AD2 and AD5).<ref>PMID:9036860</ref> <ref>PMID:9420240</ref> <ref>PMID:10814828</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 16:54, 18 December 2014

OCA — Thu, 18 Dec 2014 16:54:19 GMT

←Older revision		Revision as of 16:54, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3jz7\| PDB=3jz7 \| SCENE= }}~~	+	==Crystal structure of the extracellular domains of coxsackie & adenovirus receptor from mouse (mCAR)==
-	===Crystal structure of the extracellular domains of coxsackie & adenovirus receptor from mouse (mCAR)===	+	<StructureSection load='3jz7' size='340' side='right' caption='[[3jz7]], [[Resolution\|resolution]] 2.19Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20181587}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3jz7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JZ7 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1kac\|1kac]], [[1f5w\|1f5w]], [[1eaj\|1eaj]], [[1jew\|1jew]], [[2wbw\|2wbw]], [[2npl\|2npl]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Car, Cxadr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jz7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jz7 RCSB], [http://www.ebi.ac.uk/pdbsum/3jz7 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/3jz7_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The coxsackievirus-adenovirus receptor (CAR) is a member of the Ig superfamily strongly expressed in the developing nervous system. Our histological investigations during development reveal an initial uniform distribution of CAR on all neural cells with a concentration on membranes that face the margins of the nervous system (e.g., the basal laminae and the ventricular side). At more advanced stages, CAR becomes downregulated and restricted to specific regions including areas rich in axonal and dendritic surfaces. To study the function of CAR on neural cells, we used the fiber knob of the adenovirus, extracellular CAR domains, blocking antibodies to CAR, as well as CAR-deficient neural cells. Blocking antibodies were found to inhibit neurite extension in retina organ and retinal explant cultures, whereas the application of the recombinant fiber knob of the adenovirus subtype Ad2 or extracellular CAR domains promoted neurite extension and adhesion to extracellular matrices. We observed a promiscuous interaction of CAR with extracellular matrix glycoproteins, which was deduced from analytical ultracentrifugation experiments, affinity chromatography, and adhesion assays. The membrane proximal Ig domain of CAR, termed D2, was found to bind to a fibronectin fragment, including the heparin-binding domain 2, which promotes neurite extension of wild type, but not of CAR-deficient neural cells. In contrast to heterophilic interactions, homophilic association of CAR involves both Ig domains, as was revealed by ultracentrifugation, chemical cross-linking, and adhesion studies. The results of these functional and binding studies are correlated to a U-shaped homodimer of the complete extracellular domains of CAR detected by x-ray crystallography.

-	~~==Function==~~	+	The coxsackievirus-adenovirus receptor reveals complex homophilic and heterophilic interactions on neural cells.,Patzke C, Max KE, Behlke J, Schreiber J, Schmidt H, Dorner AA, Kroger S, Henning M, Otto A, Heinemann U, Rathjen FG J Neurosci. 2010 Feb 24;30(8):2897-910. PMID:20181587<ref>PMID:20181587</ref>
-	~~[[http://www.uniprot.org/uniprot/CXAR_MOUSE CXAR_MOUSE]] Component of the epithelial apical junction~~ complex ~~that is essential for the tight junction integrity. Proposed to function as a~~ homophilic ~~cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive~~ interactions ~~with AMICA1/JAML located in the plasma membrane of PMN (By similarity)~~.~~<ref>PMID:9036860</ref><ref>PMID:9420240</ref><ref>PMID:10814828</ref> In vitro~~, ~~acts as a receptor for group B coxsackieviruses and subgroup~~ C ~~of adenoviruses~~ (~~AD2 and AD5~~).~~<ref>~~PMID:~~9036860</ref><ref>PMID:9420240</ref>~~<ref>PMID:~~10814828~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3jz7]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ7 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020181587</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
-	[[Category: Heinemann, U.]]	+	[[Category: Heinemann, U]]
-	[[Category: Max, K E.A.]]	+	[[Category: Max, K E.A]]
	[[Category: Adenovirus]]		[[Category: Adenovirus]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]

OCA: Protected "3jz7" [edit=sysop:move=sysop]

OCA — Wed, 27 Mar 2013 09:39:43 GMT

Protected "3jz7" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:39, 27 March 2013

OCA at 09:39, 27 March 2013

OCA — Wed, 27 Mar 2013 09:39:37 GMT

←Older revision		Revision as of 09:39, 27 March 2013
Line 1:		Line 1:
-	{{Seed}}
-	[[Image:3jz7.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3jz7", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3jz7\| PDB=3jz7 \| SCENE= }}		{{STRUCTURE_3jz7\| PDB=3jz7 \| SCENE= }}
-
	===Crystal structure of the extracellular domains of coxsackie & adenovirus receptor from mouse (mCAR)===		===Crystal structure of the extracellular domains of coxsackie & adenovirus receptor from mouse (mCAR)===
		+	{{ABSTRACT_PUBMED_20181587}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/CXAR_MOUSE CXAR_MOUSE]] Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN (By similarity).<ref>PMID:9036860</ref><ref>PMID:9420240</ref><ref>PMID:10814828</ref> In vitro, acts as a receptor for group B coxsackieviruses and subgroup C of adenoviruses (AD2 and AD5).<ref>PMID:9036860</ref><ref>PMID:9420240</ref><ref>PMID:10814828</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20181587}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 20181587~~ is the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20181587}}~~	+

	==About this Structure==		==About this Structure==
-	~~3JZ7~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ7 OCA].	+	[[3jz7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ7 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20181587~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020181587</ref><references group="xtra"/><references/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Heinemann, U.]]		[[Category: Heinemann, U.]]
	[[Category: Max, K E.A.]]		[[Category: Max, K E.A.]]
	[[Category: Adenovirus]]		[[Category: Adenovirus]]
-	[[Category: Alternative splicing]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Cell adhesion molecule]]		[[Category: Cell adhesion molecule]]
Line 46:		Line 32:
	[[Category: Tight junction]]		[[Category: Tight junction]]
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 17 09:30:38 2010''

OCA at 07:30, 17 March 2010

OCA — Wed, 17 Mar 2010 07:30:39 GMT

←Older revision		Revision as of 07:30, 17 March 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3jz7.jpg\|left\|200px]]

-	The ~~entry 3jz7~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3jz7", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3jz7\| PDB=3jz7 \| SCENE= }}

-	~~Authors: Max, K.E.A., Heinemann, U.~~	+	===Crystal structure of the extracellular domains of coxsackie & adenovirus receptor from mouse (mCAR)===

-	Description: Crystal structure of the extracellular domains of coxsackie & adenovirus receptor from mouse (mCAR)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 14 10~~:06:~~52 2009~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20181587}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20181587 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20181587}}
		+
		+	==About this Structure==
		+	3JZ7 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZ7 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20181587</ref><references group="xtra"/>
		+	[[Category: Mus musculus]]
		+	[[Category: Heinemann, U.]]
		+	[[Category: Max, K E.A.]]
		+	[[Category: Adenovirus]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Cell adhesion molecule]]
		+	[[Category: Cell junction]]
		+	[[Category: Cell membrane]]
		+	[[Category: Coxsackievirus]]
		+	[[Category: Disulfide bond]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Immunoglobulin domain]]
		+	[[Category: Immunoglobuline superfamily]]
		+	[[Category: Lipoprotein]]
		+	[[Category: Membrane]]
		+	[[Category: Palmitate]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Receptor]]
		+	[[Category: Secreted]]
		+	[[Category: Tight junction]]
		+	[[Category: Transmembrane]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 17 09:30:38 2010''

OCA at 08:06, 14 October 2009

OCA — Wed, 14 Oct 2009 08:06:52 GMT

←Older revision		Revision as of 08:06, 14 October 2009
Line 3:		Line 3:
	The entry 3jz7 is ON HOLD		The entry 3jz7 is ON HOLD

-	Authors: Max, K. E. A., Heinemann, U.	+	Authors: Max, K.E.A., Heinemann, U.

	Description: Crystal structure of the extracellular domains of coxsackie & adenovirus receptor from mouse (mCAR)		Description: Crystal structure of the extracellular domains of coxsackie & adenovirus receptor from mouse (mCAR)

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 30 09~~:01:25 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 14 10:06:52 2009''

OCA: New page: '''Unreleased structure''' The entry 3jz7 is ON HOLD Authors: Max, K. E. A., Heinemann, U. Description: Crystal structure of the extracellular domains of coxsackie & adenovirus recepto...

OCA — Wed, 30 Sep 2009 07:01:26 GMT

New page: '''Unreleased structure''' The entry 3jz7 is ON HOLD Authors: Max, K. E. A., Heinemann, U. Description: Crystal structure of the extracellular domains of coxsackie & adenovirus recepto...

New page

'''Unreleased structure'''

The entry 3jz7 is ON HOLD

Authors: Max, K. E. A., Heinemann, U.

Description: Crystal structure of the extracellular domains of coxsackie & adenovirus receptor from mouse (mCAR)

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 30 09:01:25 2009''