3jzb - Revision history

OCA at 08:06, 6 September 2023

OCA — Wed, 06 Sep 2023 08:06:30 GMT

←Older revision		Revision as of 08:06, 6 September 2023
Line 1:		Line 1:

	==Crystal Structure of TR-alfa bound to the selective thyromimetic TRIAC==		==Crystal Structure of TR-alfa bound to the selective thyromimetic TRIAC==
-	<StructureSection load='3jzb' size='340' side='right' caption='[[3jzb]], [[Resolution\|resolution]] 2.01Å' scene=''>	+	<StructureSection load='3jzb' size='340' side='right'caption='[[3jzb]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3jzb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3JZB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3jzb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JZB FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=4HY:[4~~-~~(4-HYDROXY-3-IODO-PHENOXY)-3~~,~~5-DIIODO-PHENYL~~]~~-ACETIC+ACID'>4HY</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.007Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~CAS~~:S-(~~DIMETHYLARSENIC~~)~~CYSTEINE~~'>~~CAS~~</scene><~~/td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4HY:[4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC+ACID'>4HY</scene>, <scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
-	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b></td><td class="sblockDat">[[3jzc\|3jzc]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzb OCA], [https://pdbe.org/3jzb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jzb RCSB], [https://www.ebi.ac.uk/pdbsum/3jzb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jzb ProSAT]</span></td></tr>
-	~~<tr id='gene~~'>~~<td class="sblockLbl"><b>[[Gene\|Gene:]]~~</b>~~</td><td class="sblockDat">THRA, hCG_1749555 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3jzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzb OCA], [~~http~~://pdbe.org/3jzb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3jzb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3jzb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3jzb ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/THA_HUMAN THA_HUMAN] Defects in THRA are the cause of congenital hypothyroidism non-goitrous type 6 (CHNG6) [MIM:[https://omim.org/entry/614450 614450]. A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance.<ref>PMID:22168587</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/THA_HUMAN THA_HUMAN] Nuclear hormone receptor. High affinity receptor for triiodothyronine.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Aparicio, R~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Dias, S M.G~~]]	+	[[Category: Aparicio R]]
-	[[Category: ~~Nascimento, A S~~]]	+	[[Category: Dias SMG]]
-	[[Category: ~~Nunes, F M~~]]	+	[[Category: Nascimento AS]]
-	[[Category: ~~Dna-binding]]~~	+	[[Category: Nunes FM]]
-	~~[[Category: Entropy]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Nucleus]]~~	+
-	~~[[Category: Receptor]]~~	+
-	~~[[Category: Thyroid]]~~	+
-	~~[[Category: Tr]]~~	+
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription regulation]]~~	+
-	~~[[Category: Triac]]~~	+
-	~~[[Category: Zinc-finger~~]]	+

OCA at 09:28, 26 December 2018

OCA — Wed, 26 Dec 2018 09:28:50 GMT

←Older revision		Revision as of 09:28, 26 December 2018
Line 1:		Line 1:
		+
	==Crystal Structure of TR-alfa bound to the selective thyromimetic TRIAC==		==Crystal Structure of TR-alfa bound to the selective thyromimetic TRIAC==
	<StructureSection load='3jzb' size='340' side='right' caption='[[3jzb]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='3jzb' size='340' side='right' caption='[[3jzb]], [[Resolution\|resolution]] 2.01Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jzc\|3jzc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jzc\|3jzc]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">THRA, hCG_1749555 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">THRA, hCG_1749555 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzb OCA], [http://pdbe.org/3jzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jzb RCSB], [http://www.ebi.ac.uk/pdbsum/3jzb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzb OCA], [http://pdbe.org/3jzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jzb RCSB], [http://www.ebi.ac.uk/pdbsum/3jzb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jzb ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/3jzb_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/3jzb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3jzb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3jzb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Thyroid hormone receptor\|Thyroid hormone receptor]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 03:02, 7 February 2016

OCA — Sun, 07 Feb 2016 03:02:31 GMT

←Older revision		Revision as of 03:02, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3jzb' size='340' side='right' caption='[[3jzb]], [[Resolution\|resolution]] 2.01Å' scene=''>		<StructureSection load='3jzb' size='340' side='right' caption='[[3jzb]], [[Resolution\|resolution]] 2.01Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3jzb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JZB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3jzb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JZB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HY:[4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC+ACID'>4HY</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HY:[4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC+ACID'>4HY</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jzc\|3jzc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jzc\|3jzc]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">THRA, hCG_1749555 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">THRA, hCG_1749555 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jzb RCSB], [http://www.ebi.ac.uk/pdbsum/3jzb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzb OCA], [http://pdbe.org/3jzb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jzb RCSB], [http://www.ebi.ac.uk/pdbsum/3jzb PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jzb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3jzb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Aparicio, R]]		[[Category: Aparicio, R]]
	[[Category: Dias, S M.G]]		[[Category: Dias, S M.G]]

OCA at 15:22, 18 December 2014

OCA — Thu, 18 Dec 2014 15:22:24 GMT

←Older revision		Revision as of 15:22, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3jzb\| PDB=3jzb \| SCENE= }}~~	+	==Crystal Structure of TR-alfa bound to the selective thyromimetic TRIAC==
-	===Crystal Structure of TR-alfa bound to the selective thyromimetic TRIAC===	+	<StructureSection load='3jzb' size='340' side='right' caption='[[3jzb]], [[Resolution\|resolution]] 2.01Å' scene=''>
-	~~{{ABSTRACT_PUBMED_19926848}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3jzb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JZB FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HY:[4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC+ACID'>4HY</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jzc\|3jzc]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">THRA, hCG_1749555 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jzb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jzb RCSB], [http://www.ebi.ac.uk/pdbsum/3jzb PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/3jzb_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Nuclear receptors are important targets for pharmaceuticals, but similarities between family members cause difficulties in obtaining highly selective compounds. Synthetic ligands that are selective for thyroid hormone (TH) receptor beta (TRbeta) vs. TRalpha reduce cholesterol and fat without effects on heart rate; thus, it is important to understand TRbeta-selective binding. Binding of 3 selective ligands (GC-1, KB141, and GC-24) is characterized at the atomic level; preferential binding depends on a nonconserved residue (Asn-331beta) in the TRbeta ligand-binding cavity (LBC), and GC-24 gains extra selectivity from insertion of a bulky side group into an extension of the LBC that only opens up with this ligand. Here we report that the natural TH 3,5,3'-triodothyroacetic acid (Triac) exhibits a previously unrecognized mechanism of TRbeta selectivity. TR x-ray structures reveal better fit of ligand with the TRalpha LBC. The TRbeta LBC, however, expands relative to TRalpha in the presence of Triac (549 A(3) vs. 461 A(3)), and molecular dynamics simulations reveal that water occupies the extra space. Increased solvation compensates for weaker interactions of ligand with TRbeta and permits greater flexibility of the Triac carboxylate group in TRbeta than in TRalpha. We propose that this effect results in lower entropic restraint and decreases free energy of interactions between Triac and TRbeta, explaining subtype-selective binding. Similar effects could potentially be exploited in nuclear receptor drug design.

-	~~==About this Structure==~~	+	Gaining ligand selectivity in thyroid hormone receptors via entropy.,Martinez L, Nascimento AS, Nunes FM, Phillips K, Aparicio R, Dias SM, Figueira AC, Lin JH, Nguyen P, Apriletti JW, Neves FA, Baxter JD, Webb P, Skaf MS, Polikarpov I Proc Natl Acad Sci U S A. 2009 Nov 19. PMID:19926848<ref>PMID:19926848</ref>
-	~~[[3jzb]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3JZB OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:019926848</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Aparicio, R.]]	+	[[Category: Aparicio, R]]
-	[[Category: Dias, S M.G.]]	+	[[Category: Dias, S M.G]]
-	[[Category: Nascimento, A S.]]	+	[[Category: Nascimento, A S]]
-	[[Category: Nunes, F M.]]	+	[[Category: Nunes, F M]]
	[[Category: Dna-binding]]		[[Category: Dna-binding]]
	[[Category: Entropy]]		[[Category: Entropy]]

OCA: Protected "3jzb" [edit=sysop:move=sysop]

OCA — Sun, 24 Mar 2013 09:59:25 GMT

Protected "3jzb" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:59, 24 March 2013

OCA at 09:59, 24 March 2013

OCA — Sun, 24 Mar 2013 09:59:23 GMT

←Older revision		Revision as of 09:59, 24 March 2013
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-	{{Seed}}
-	[[Image:3jzb.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3jzb", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3jzb\| PDB=3jzb \| SCENE= }}		{{STRUCTURE_3jzb\| PDB=3jzb \| SCENE= }}
-
	===Crystal Structure of TR-alfa bound to the selective thyromimetic TRIAC===		===Crystal Structure of TR-alfa bound to the selective thyromimetic TRIAC===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19926848}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19926848 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19926848}}		{{ABSTRACT_PUBMED_19926848}}

	==About this Structure==		==About this Structure==
-	~~3JZB~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZB OCA].	+	[[3jzb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZB OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19926848~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019926848</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Aparicio, R.]]		[[Category: Aparicio, R.]]
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	[[Category: Triac]]		[[Category: Triac]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 1 09:21:03 2010''

OCA at 05:12, 1 September 2010

OCA — Wed, 01 Sep 2010 05:12:56 GMT

←Older revision		Revision as of 05:12, 1 September 2010
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	{{Seed}}		{{Seed}}
-	[[Image:3jzb.~~jpg~~\|left\|200px]]	+	[[Image:3jzb.png\|left\|200px]]

	<!--		<!--
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	==About this Structure==		==About this Structure==
-	3JZB is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZB OCA].	+	3JZB is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZB OCA].

	==Reference==		==Reference==
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	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Triac]]		[[Category: Triac]]
-	[[Category: Zinc]]
	[[Category: Zinc-finger]]		[[Category: Zinc-finger]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec~~ ~~9 15~~:07:~~57 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 1 09:21:03 2010''

OCA at 13:07, 9 December 2009

OCA — Wed, 09 Dec 2009 13:07:58 GMT

←Older revision		Revision as of 13:07, 9 December 2009
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3jzb.jpg\|left\|200px]]

-	The ~~entry 3jzb~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3jzb", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3jzb\| PDB=3jzb \| SCENE= }}

-	~~Authors: Nascimento, A.S., Dias, S.M.G., Nunes, F.M., Aparicio, R.~~	+	===Crystal Structure of TR-alfa bound to the selective thyromimetic TRIAC===

-	Description: Crystal Structure of TR-alfa bound to the selective thyromimetic TRIAC

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct~~ ~~7 13~~:44:23 2009''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19926848}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19926848 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19926848}}
		+
		+	==About this Structure==
		+	3JZB is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZB OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19926848</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Aparicio, R.]]
		+	[[Category: Dias, S M.G.]]
		+	[[Category: Nascimento, A S.]]
		+	[[Category: Nunes, F M.]]
		+	[[Category: Dna-binding]]
		+	[[Category: Entropy]]
		+	[[Category: Metal-binding]]
		+	[[Category: Nucleus]]
		+	[[Category: Receptor]]
		+	[[Category: Thyroid]]
		+	[[Category: Tr]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription regulation]]
		+	[[Category: Triac]]
		+	[[Category: Zinc]]
		+	[[Category: Zinc-finger]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 9 15:07:57 2009''

OCA at 11:44, 7 October 2009

OCA — Wed, 07 Oct 2009 11:44:23 GMT

←Older revision		Revision as of 11:44, 7 October 2009
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3jzb is ON HOLD	+	The entry 3jzb is ON HOLD until Paper Publication

	Authors: Nascimento, A.S., Dias, S.M.G., Nunes, F.M., Aparicio, R.		Authors: Nascimento, A.S., Dias, S.M.G., Nunes, F.M., Aparicio, R.
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	Description: Crystal Structure of TR-alfa bound to the selective thyromimetic TRIAC		Description: Crystal Structure of TR-alfa bound to the selective thyromimetic TRIAC

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Sep 30 09~~:01:28 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 7 13:44:23 2009''

OCA: New page: '''Unreleased structure''' The entry 3jzb is ON HOLD Authors: Nascimento, A.S., Dias, S.M.G., Nunes, F.M., Aparicio, R. Description: Crystal Structure of TR-alfa bound to the selective...

OCA — Wed, 30 Sep 2009 07:01:28 GMT

New page: '''Unreleased structure''' The entry 3jzb is ON HOLD Authors: Nascimento, A.S., Dias, S.M.G., Nunes, F.M., Aparicio, R. Description: Crystal Structure of TR-alfa bound to the selective...

New page

'''Unreleased structure'''

The entry 3jzb is ON HOLD

Authors: Nascimento, A.S., Dias, S.M.G., Nunes, F.M., Aparicio, R.

Description: Crystal Structure of TR-alfa bound to the selective thyromimetic TRIAC

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 30 09:01:28 2009''