3jzi - Revision history

OCA at 08:06, 6 September 2023

OCA — Wed, 06 Sep 2023 08:06:38 GMT

←Older revision		Revision as of 08:06, 6 September 2023
Line 1:		Line 1:

	==Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series==		==Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series==
-	<StructureSection load='3jzi' size='340' side='right' caption='[[3jzi]], [[Resolution\|resolution]] 2.31Å' scene=''>	+	<StructureSection load='3jzi' size='340' side='right'caption='[[3jzi]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3jzi]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3JZI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3jzi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JZI FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=JZL:7-AMINO-2~~-[~~(2-CHLOROBENZYL)AMINO~~]~~-1-{[(1S,2S)-~~2~~-HYDROXYCYCLOHEPTYL]METHYL}-1H-BENZIMIDAZOLE-5-CARBOXAMIDE'>JZL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.31Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[3jzf\|3jzf]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JZL:7-AMINO-2-[(2-CHLOROBENZYL)AMINO]-1-{[(1S,2S)-2-HYDROXYCYCLOHEPTYL]METHYL}-1H-BENZIMIDAZOLE-5-CARBOXAMIDE'>JZL</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><b>[[~~Gene\|Gene:]~~]~~</b~~></td>~~<td class="sblockDat">accC, fabG, b3256, JW3224 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzi OCA], [https://pdbe.org/3jzi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jzi RCSB], [https://www.ebi.ac.uk/pdbsum/3jzi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jzi ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3jzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzi OCA], [~~http~~://pdbe.org/3jzi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3jzi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3jzi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3jzi ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ACCC_ECOLI ACCC_ECOLI]] This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.	+	[https://www.uniprot.org/uniprot/ACCC_ECOLI ACCC_ECOLI] This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 31:

	==See Also==		==See Also==
-	*[[Acetyl-CoA carboxylase\|Acetyl-CoA carboxylase]]	+	*[[Acetyl-CoA carboxylase 3D structures\|Acetyl-CoA carboxylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ecoli~~]]	+	[[Category: Escherichia coli K-12]]
-	[[Category: Black, T]]	+	[[Category: Large Structures]]
-	[[Category: Cheng, C]]	+	[[Category: Black T]]
-	[[Category: Kawahata, N]]	+	[[Category: Cheng C]]
-	[[Category: Mann, P]]	+	[[Category: Kawahata N]]
-	[[Category: Orth, P]]	+	[[Category: Mann P]]
-	[[Category: Shipps~~, G W~~]]	+	[[Category: Orth P]]
-	[[Category: Soriano, A]]	+	[[Category: Shipps GW]]
-	[[Category: Soucy, K]]	+	[[Category: Soriano A]]
-	[[Category: Sun, B]]	+	[[Category: Soucy K]]
-	[[Category: Xiao, L]]	+	[[Category: Sun B]]
-	[[Category: Yang, Z]]	+	[[Category: Xiao L]]
-	~~[[Category: Accase]]~~	+	[[Category: Yang Z]]
-	~~[[Category: Accc]]~~	+
-	~~[[Category: Acetyl coenzyme-a carboxylase]]~~	+
-	~~[[Category: Atp-binding]]~~	+
-	~~[[Category: Biotin]]~~	+
-	~~[[Category: Biotin carboxylase]]~~	+
-	~~[[Category: Fatty acid biosynthesis]]~~	+
-	~~[[Category: Ligase]]~~	+
-	~~[[Category: Lipid synthesis]]~~	+
-	~~[[Category: Nucleotide-binding~~]]	+

OCA at 09:25, 26 December 2018

OCA — Wed, 26 Dec 2018 09:25:05 GMT

←Older revision		Revision as of 09:25, 26 December 2018
Line 1:		Line 1:
		+
	==Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series==		==Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series==
	<StructureSection load='3jzi' size='340' side='right' caption='[[3jzi]], [[Resolution\|resolution]] 2.31Å' scene=''>		<StructureSection load='3jzi' size='340' side='right' caption='[[3jzi]], [[Resolution\|resolution]] 2.31Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jzf\|3jzf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jzf\|3jzf]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">accC, fabG, b3256, JW3224 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">accC, fabG, b3256, JW3224 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzi OCA], [http://pdbe.org/3jzi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jzi RCSB], [http://www.ebi.ac.uk/pdbsum/3jzi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzi OCA], [http://pdbe.org/3jzi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jzi RCSB], [http://www.ebi.ac.uk/pdbsum/3jzi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jzi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/3jzi_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/3jzi_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 05:02, 7 February 2016

OCA — Sun, 07 Feb 2016 05:02:50 GMT

←Older revision		Revision as of 05:02, 7 February 2016
Line 2:		Line 2:
	<StructureSection load='3jzi' size='340' side='right' caption='[[3jzi]], [[Resolution\|resolution]] 2.31Å' scene=''>		<StructureSection load='3jzi' size='340' side='right' caption='[[3jzi]], [[Resolution\|resolution]] 2.31Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3jzi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia coli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JZI FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3jzi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JZI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JZL:7-AMINO-2-[(2-CHLOROBENZYL)AMINO]-1-{[(1S,2S)-2-HYDROXYCYCLOHEPTYL]METHYL}-1H-BENZIMIDAZOLE-5-CARBOXAMIDE'>JZL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JZL:7-AMINO-2-[(2-CHLOROBENZYL)AMINO]-1-{[(1S,2S)-2-HYDROXYCYCLOHEPTYL]METHYL}-1H-BENZIMIDAZOLE-5-CARBOXAMIDE'>JZL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jzf\|3jzf]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jzf\|3jzf]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">accC, fabG, b3256, JW3224 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=~~562 Escherichia coli~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">accC, fabG, b3256, JW3224 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jzi RCSB], [http://www.ebi.ac.uk/pdbsum/3jzi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzi OCA], [http://pdbe.org/3jzi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jzi RCSB], [http://www.ebi.ac.uk/pdbsum/3jzi PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jzi ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3jzi" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
-	*[[~~Biotin~~ carboxylase\|~~Biotin~~ carboxylase]]	+	*[[Acetyl-CoA carboxylase\|Acetyl-CoA carboxylase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Escherichia coli~~]]	+	[[Category: Ecoli]]
	[[Category: Black, T]]		[[Category: Black, T]]
	[[Category: Cheng, C]]		[[Category: Cheng, C]]

OCA at 08:03, 24 December 2014

OCA — Wed, 24 Dec 2014 08:03:41 GMT

←Older revision		Revision as of 08:03, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3jzi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JZI FirstGlance]. <br>		<table><tr><td colspan='2'>[[3jzi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JZI FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JZL:7-AMINO-2-[(2-CHLOROBENZYL)AMINO]-1-{[(1S,2S)-2-HYDROXYCYCLOHEPTYL]METHYL}-1H-BENZIMIDAZOLE-5-CARBOXAMIDE'>JZL</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JZL:7-AMINO-2-[(2-CHLOROBENZYL)AMINO]-1-{[(1S,2S)-2-HYDROXYCYCLOHEPTYL]METHYL}-1H-BENZIMIDAZOLE-5-CARBOXAMIDE'>JZL</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jzf\|3jzf]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jzf\|3jzf]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">accC, fabG, b3256, JW3224 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">accC, fabG, b3256, JW3224 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jzi RCSB], [http://www.ebi.ac.uk/pdbsum/3jzi PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jzi RCSB], [http://www.ebi.ac.uk/pdbsum/3jzi PDBsum]</span></td></tr>
-	<table>	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ACCC_ECOLI ACCC_ECOLI]] This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
-	[[Category: Black, T.]]	+	[[Category: Black, T]]
-	[[Category: Cheng, C.]]	+	[[Category: Cheng, C]]
-	[[Category: Kawahata, N.]]	+	[[Category: Kawahata, N]]
-	[[Category: Mann, P.]]	+	[[Category: Mann, P]]
-	[[Category: Orth, P.]]	+	[[Category: Orth, P]]
-	[[Category: Shipps, G W.]]	+	[[Category: Shipps, G W]]
-	[[Category: Soriano, A.]]	+	[[Category: Soriano, A]]
-	[[Category: Soucy, K.]]	+	[[Category: Soucy, K]]
-	[[Category: Sun, B.]]	+	[[Category: Sun, B]]
-	[[Category: Xiao, L.]]	+	[[Category: Xiao, L]]
-	[[Category: Yang, Z.]]	+	[[Category: Yang, Z]]
	[[Category: Accase]]		[[Category: Accase]]
	[[Category: Accc]]		[[Category: Accc]]

OCA at 13:16, 29 September 2014

OCA — Mon, 29 Sep 2014 13:16:04 GMT

←Older revision		Revision as of 13:16, 29 September 2014
Line 1:		Line 1:
-	[[~~Image:~~3jzi.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series==
		+	<StructureSection load='3jzi' size='340' side='right' caption='[[3jzi]], [[Resolution\|resolution]] 2.31Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3jzi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JZI FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JZL:7-AMINO-2-[(2-CHLOROBENZYL)AMINO]-1-{[(1S,2S)-2-HYDROXYCYCLOHEPTYL]METHYL}-1H-BENZIMIDAZOLE-5-CARBOXAMIDE'>JZL</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jzf\|3jzf]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">accC, fabG, b3256, JW3224 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jzi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jzi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jzi RCSB], [http://www.ebi.ac.uk/pdbsum/3jzi PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/3jzi_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The biotin carboxylase (AccC) is part of the multi-component bacterial acetyl coenzyme-A carboxylase (ACCase) and is essential for pathogen survival. We describe herein the affinity optimization of an initial hit to give 2-(2-chlorobenzylamino)-1-(cyclohexylmethyl)-1H-benzo[d]imidazole-5-carbox amide (1), which was identified using our proprietary Automated Ligand Identification System (ALIS).(1) The X-ray co-crystal structure of 1 was solved and revealed several key interactions and opportunities for further optimization in the ATP site of AccC. Structure Based Drug Design (SBDD) and parallel synthetic approaches resulted in a novel series of AccC inhibitors, exemplified by (R)-2-(2-chlorobenzylamino)-1-(2,3-dihydro-1H-inden-1-yl)-1H-imidazo[4,5-b ]pyridine-5-carboxamide (40). This compound is a potent and selective inhibitor of bacterial AccC with an IC(50) of 20 nM and a MIC of 0.8 microg/mL against a sensitized strain of Escherichia coli (HS294 E. coli).

-	~~{{STRUCTURE_3jzi\| PDB=3jzi \| SCENE= }}~~	+	Discovery and optimization of antibacterial AccC inhibitors.,Cheng CC, Shipps GW Jr, Yang Z, Sun B, Kawahata N, Soucy KA, Soriano A, Orth P, Xiao L, Mann P, Black T Bioorg Med Chem Lett. 2009 Dec 1;19(23):6507-14. Epub 2009 Oct 28. PMID:19875284<ref>PMID:19875284</ref>

-	~~===Crystal structure~~ of ~~biotin carboxylase from E~~. ~~Coli in complex with benzimidazole series===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_19875284}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3jzi]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org~~/~~wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZI OCA].~~	+

	==See Also==		==See Also==
	*[[Biotin carboxylase\|Biotin carboxylase]]		*[[Biotin carboxylase\|Biotin carboxylase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:019875284<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Black, T.]]		[[Category: Black, T.]]

OCA at 05:39, 20 October 2012

OCA — Sat, 20 Oct 2012 05:39:02 GMT

←Older revision		Revision as of 05:39, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3jzi]] is a 2 chain structure ~~of [[Biotin carboxylase]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZI OCA].	+	[[3jzi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZI OCA].

	==See Also==		==See Also==

OCA: Protected "3jzi" [edit=sysop:move=sysop]

OCA — Wed, 25 Jul 2012 10:43:45 GMT

Protected "3jzi" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:43, 25 July 2012

OCA at 10:43, 25 July 2012

OCA — Wed, 25 Jul 2012 10:43:43 GMT

←Older revision		Revision as of 10:43, 25 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3jzi.png\|left\|200px]]		[[Image:3jzi.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3jzi", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3jzi\| PDB=3jzi \| SCENE= }}		{{STRUCTURE_3jzi\| PDB=3jzi \| SCENE= }}

	===Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series===		===Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_19875284}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 19875284 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_19875284}}		{{ABSTRACT_PUBMED_19875284}}

	==About this Structure==		==About this Structure==
-	~~3JZI~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZI OCA].	+	[[3jzi]] is a 2 chain structure of [[Biotin carboxylase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZI OCA].
		+
		+	==See Also==
		+	*[[Biotin carboxylase\|Biotin carboxylase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~19875284~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:019875284</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Black, T.]]		[[Category: Black, T.]]
Line 46:		Line 37:
	[[Category: Lipid synthesis]]		[[Category: Lipid synthesis]]
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 25 09:45:17 2009''

OCA at 07:45, 25 November 2009

OCA — Wed, 25 Nov 2009 07:45:18 GMT

←Older revision		Revision as of 07:45, 25 November 2009
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3jzi.~~jpg~~\|left\|200px]]	+	[[Image:3jzi.png\|left\|200px]]

	<!--		<!--
Line 12:		Line 12:
	===Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series===		===Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_19875284}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 19875284 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_19875284}}

	==About this Structure==		==About this Structure==
	3JZI is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZI OCA].		3JZI is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZI OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:19875284</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Black, T.]]		[[Category: Black, T.]]
Line 38:		Line 47:
	[[Category: Nucleotide-binding]]		[[Category: Nucleotide-binding]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov ~~4 11~~:02:41 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 25 09:45:17 2009''

OCA at 09:02, 4 November 2009

OCA — Wed, 04 Nov 2009 09:02:42 GMT

←Older revision		Revision as of 09:02, 4 November 2009
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3jzi.jpg\|left\|200px]]

-	The ~~entry 3jzi~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3jzi", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3jzi\| PDB=3jzi \| SCENE= }}

-	~~Authors: Cheng, C., Shipps, G.W., Yang, Z., Sun, B., Kawahata, N., Soucy, K., Soriano, A., Orth, P., Xiao, L., Mann, P., Black, T~~.	+	===Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series===

-	Description: Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct~~ ~~7 13~~:44:25 2009''	+	==About this Structure==
		+	3JZI is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JZI OCA].
		+	[[Category: Escherichia coli]]
		+	[[Category: Black, T.]]
		+	[[Category: Cheng, C.]]
		+	[[Category: Kawahata, N.]]
		+	[[Category: Mann, P.]]
		+	[[Category: Orth, P.]]
		+	[[Category: Shipps, G W.]]
		+	[[Category: Soriano, A.]]
		+	[[Category: Soucy, K.]]
		+	[[Category: Sun, B.]]
		+	[[Category: Xiao, L.]]
		+	[[Category: Yang, Z.]]
		+	[[Category: Accase]]
		+	[[Category: Accc]]
		+	[[Category: Acetyl coenzyme-a carboxylase]]
		+	[[Category: Atp-binding]]
		+	[[Category: Biotin]]
		+	[[Category: Biotin carboxylase]]
		+	[[Category: Fatty acid biosynthesis]]
		+	[[Category: Ligase]]
		+	[[Category: Lipid synthesis]]
		+	[[Category: Nucleotide-binding]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 4 11:02:41 2009''