3k27 - Revision history

OCA at 09:35, 26 December 2018

OCA — Wed, 26 Dec 2018 09:35:55 GMT

←Older revision		Revision as of 09:35, 26 December 2018
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/3k27_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/3k27_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 11:28, 5 August 2016

OCA — Fri, 05 Aug 2016 11:28:02 GMT

←Older revision		Revision as of 11:28, 5 August 2016
Line 1:		Line 1:
		+
	==Complex structure of EED and trimethylated H3K9==		==Complex structure of EED and trimethylated H3K9==
	<StructureSection load='3k27' size='340' side='right' caption='[[3k27]], [[Resolution\|resolution]] 1.76Å' scene=''>		<StructureSection load='3k27' size='340' side='right' caption='[[3k27]], [[Resolution\|resolution]] 1.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3k27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K27 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3k27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K27 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jzn\|3jzn]], [[3k26\|3k26]], [[3jzh\|3jzh]], [[3jzg\|3jzg]], [[3jpx\|3jpx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jzn\|3jzn]], [[3k26\|3k26]], [[3jzh\|3jzh]], [[3jzg\|3jzg]], [[3jpx\|3jpx]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EED ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EED ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k27 RCSB], [http://www.ebi.ac.uk/pdbsum/3k27 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k27 OCA], [http://pdbe.org/3k27 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3k27 RCSB], [http://www.ebi.ac.uk/pdbsum/3k27 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3k27 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k27 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3k27" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bian, C B]]		[[Category: Bian, C B]]

OCA at 18:26, 25 December 2014

OCA — Thu, 25 Dec 2014 18:26:35 GMT

←Older revision		Revision as of 18:26, 25 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k27 RCSB], [http://www.ebi.ac.uk/pdbsum/3k27 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k27 RCSB], [http://www.ebi.ac.uk/pdbsum/3k27 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/EED_HUMAN EED_HUMAN]] Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.<ref>PMID:9584199</ref> <ref>PMID:10581039</ref> <ref>PMID:14532106</ref> <ref>PMID:15385962</ref> <ref>PMID:15231737</ref> <ref>PMID:15225548</ref> <ref>PMID:16357870</ref> <ref>PMID:18285464</ref> <ref>PMID:20974918</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 17:11, 18 December 2014

OCA — Thu, 18 Dec 2014 17:11:18 GMT

←Older revision		Revision as of 17:11, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3k27~~\| ~~PDB~~=3k27 \| ~~SCENE~~= }}	+	==Complex structure of EED and trimethylated H3K9==
-	===~~Complex~~ structure of ~~EED~~ and ~~trimethylated H3K9~~===	+	<StructureSection load='3k27' size='340' side='right' caption='[[3k27]], [[Resolution\|resolution]] 1.76Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20974918}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3k27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K27 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K27 FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=M3L:N-TRIMETHYLLYSINE'>M3L</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3jzn\|3jzn]], [[3k26\|3k26]], [[3jzh\|3jzh]], [[3jzg\|3jzg]], [[3jpx\|3jpx]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EED ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k27 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k27 RCSB], [http://www.ebi.ac.uk/pdbsum/3k27 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/3k27_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The polycomb repressive complex 2 (PRC2) is the major methyltransferase for H3K27 methylation, a modification critical for maintaining repressed gene expression programs throughout development. It has been previously shown that PRC2 maintains histone methylation patterns during DNA replication in part through its ability to bind to H3K27me3. However, the mechanism by which PRC2 recognizes H3K27me3 is unclear. Here we show that the WD40 domain of EED, a PRC2 component, is a methyllysine histone-binding domain. The crystal structures of apo-EED and EED in complex respectively with five different trimethyllysine histone peptides reveal that EED binds these peptides via the top face of its beta-propeller architecture. The ammonium group of the trimethyllysine is accommodated by an aromatic cage formed by three aromatic residues, while its aliphatic chain is flanked by a fourth aromatic residue. Our structural data provide an explanation for the preferential recognition of the Ala-Arg-Lys-Ser motif-containing trimethylated H3K27, H3K9, and H1K26 marks by EED over lower methylation states and other histone methyllysine marks. More importantly, we found that binding of different histone marks by EED differentially regulates the activity and specificity of PRC2. Whereas the H3K27me3 mark stimulates the histone methyltransferase activity of PRC2, the H1K26me3 mark inhibits PRC2 methyltransferase activity on the nucleosome. Moreover, H1K26me3 binding switches the specificity of PRC2 from methylating H3K27 to EED. In addition to determining the molecular basis of EED-methyllysine recognition, our work provides the biochemical characterization of how the activity of a histone methyltransferase is oppositely regulated by two histone marks.

-	~~==Function==~~	+	Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2).,Xu C, Bian C, Yang W, Galka M, Ouyang H, Chen C, Qiu W, Liu H, Jones AE, Mackenzie F, Pan P, Li SS, Wang H, Min J Proc Natl Acad Sci U S A. 2010 Oct 25. PMID:20974918<ref>PMID:20974918</ref>
-	~~[[http://www.uniprot.org/uniprot/EED_HUMAN EED_HUMAN]] Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27'~~ of histone ~~H3, leading to transcriptional repression of~~ the ~~affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase~~ activity ~~on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation~~ of ~~this~~ repressive ~~mark. The~~ PRC2~~/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems~~. ~~Genes repressed by the PRC2/EED-EZH2 complex include HOXC8~~, ~~HOXA9~~, ~~MYT1 and CDKN2A~~.~~<ref>PMID:9584199</ref><ref>PMID:10581039</ref><ref>PMID:14532106</ref><ref>PMID:15385962</ref><ref>PMID:15231737</ref><ref>PMID:15225548</ref><ref>PMID:16357870</ref><ref>~~PMID:~~18285464</ref>~~<ref>PMID:20974918</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3k27]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3K27 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020974918</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Arrowsmith, C H.]]	+	[[Category: Arrowsmith, C H]]
-	[[Category: Bian, C B.]]	+	[[Category: Bian, C B]]
-	[[Category: Bochkarev, A.]]	+	[[Category: Bochkarev, A]]
-	[[Category: Bountra, C.]]	+	[[Category: Bountra, C]]
-	[[Category: Edwards, A M.]]	+	[[Category: Edwards, A M]]
-	[[Category: Min, J.]]	+	[[Category: Min, J]]
-	[[Category: Qiu, W.]]	+	[[Category: Qiu, W]]
-	[[Category: ~~SGC,~~ Structural ~~Genomics Consortium.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Weigelt, J.]]	+	[[Category: Weigelt, J]]
-	[[Category: Xu, C.]]	+	[[Category: Xu, C]]
	[[Category: Alternative initiation]]		[[Category: Alternative initiation]]
	[[Category: Chromatin regulator]]		[[Category: Chromatin regulator]]
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	[[Category: Repressor]]		[[Category: Repressor]]
	[[Category: Sgc]]		[[Category: Sgc]]
-	[[Category: Structural genomic]]
-	[[Category: Structural genomics consortium]]
	[[Category: Transcription]]		[[Category: Transcription]]
	[[Category: Transcription regulation]]		[[Category: Transcription regulation]]
	[[Category: Wd repeat]]		[[Category: Wd repeat]]
	[[Category: Wd40]]		[[Category: Wd40]]

OCA: Protected "3k27" [edit=sysop:move=sysop]

OCA — Wed, 27 Mar 2013 09:29:10 GMT

Protected "3k27" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:29, 27 March 2013

OCA at 09:29, 27 March 2013

OCA — Wed, 27 Mar 2013 09:29:06 GMT

←Older revision		Revision as of 09:29, 27 March 2013
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-	{{Seed}}
-	[[Image:3k27.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3k27", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3k27\| PDB=3k27 \| SCENE= }}		{{STRUCTURE_3k27\| PDB=3k27 \| SCENE= }}
-
	===Complex structure of EED and trimethylated H3K9===		===Complex structure of EED and trimethylated H3K9===
		+	{{ABSTRACT_PUBMED_20974918}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/EED_HUMAN EED_HUMAN]] Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.<ref>PMID:9584199</ref><ref>PMID:10581039</ref><ref>PMID:14532106</ref><ref>PMID:15385962</ref><ref>PMID:15231737</ref><ref>PMID:15225548</ref><ref>PMID:16357870</ref><ref>PMID:18285464</ref><ref>PMID:20974918</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20974918}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov~~), ~~where 20974918 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20974918}}~~	+

	==About this Structure==		==About this Structure==
-	~~3K27~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K27 OCA].	+	[[3k27]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K27 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20974918~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020974918</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
Line 50:		Line 37:
	[[Category: Wd repeat]]		[[Category: Wd repeat]]
	[[Category: Wd40]]		[[Category: Wd40]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 3 11:20:43 2010''

OCA at 08:10, 3 November 2010

OCA — Wed, 03 Nov 2010 08:10:04 GMT

←Older revision		Revision as of 08:10, 3 November 2010
Line 12:		Line 12:
	===Complex structure of EED and trimethylated H3K9===		===Complex structure of EED and trimethylated H3K9===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20974918}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20974918 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20974918}}

	==About this Structure==		==About this Structure==
-	3K27 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K27 OCA].	+	3K27 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K27 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20974918</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Arrowsmith, C H.]]		[[Category: Arrowsmith, C H.]]
Line 27:		Line 36:
	[[Category: Xu, C.]]		[[Category: Xu, C.]]
	[[Category: Alternative initiation]]		[[Category: Alternative initiation]]
-	[[Category: Alternative splicing]]
	[[Category: Chromatin regulator]]		[[Category: Chromatin regulator]]
	[[Category: Gene regulation]]		[[Category: Gene regulation]]
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	[[Category: Wd40]]		[[Category: Wd40]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 23 08~~:54:~~00 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 3 11:20:43 2010''

OCA at 06:54, 23 December 2009

OCA — Wed, 23 Dec 2009 06:54:01 GMT

←Older revision		Revision as of 06:54, 23 December 2009
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	{{Seed}}		{{Seed}}
-	[[Image:3k27.~~jpg~~\|left\|200px]]	+	[[Image:3k27.png\|left\|200px]]

	<!--		<!--
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	[[Category: Wd40]]		[[Category: Wd40]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec ~~16 13~~:55:34 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 23 08:54:00 2009''

OCA at 11:55, 16 December 2009

OCA — Wed, 16 Dec 2009 11:55:36 GMT

←Older revision		Revision as of 11:55, 16 December 2009
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3k27.jpg\|left\|200px]]

-	The ~~entry 3k27~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3k27", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3k27\| PDB=3k27 \| SCENE= }}

-	~~Authors: Bian, C.B., Xu, C., Qiu, W., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J., Structural Genomics Consortium (SGC)~~	+	===Complex structure of EED and trimethylated H3K9===

-	Description: Complex structure of EED and trimethylated H3K9

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov 18 18~~:50:22 2009''	+	==About this Structure==
		+	3K27 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K27 OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Arrowsmith, C H.]]
		+	[[Category: Bian, C B.]]
		+	[[Category: Bochkarev, A.]]
		+	[[Category: Bountra, C.]]
		+	[[Category: Edwards, A M.]]
		+	[[Category: Min, J.]]
		+	[[Category: Qiu, W.]]
		+	[[Category: SGC, Structural Genomics Consortium.]]
		+	[[Category: Weigelt, J.]]
		+	[[Category: Xu, C.]]
		+	[[Category: Alternative initiation]]
		+	[[Category: Alternative splicing]]
		+	[[Category: Chromatin regulator]]
		+	[[Category: Gene regulation]]
		+	[[Category: National project on protein structural and functional analyse]]
		+	[[Category: Nppsfa]]
		+	[[Category: Nucleus]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Repressor]]
		+	[[Category: Sgc]]
		+	[[Category: Structural genomic]]
		+	[[Category: Structural genomics consortium]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription regulation]]
		+	[[Category: Wd repeat]]
		+	[[Category: Wd40]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 16 13:55:34 2009''

OCA at 16:50, 18 November 2009

OCA — Wed, 18 Nov 2009 16:50:23 GMT

←Older revision		Revision as of 16:50, 18 November 2009
Line 5:		Line 5:
	Authors: Bian, C.B., Xu, C., Qiu, W., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J., Structural Genomics Consortium (SGC)		Authors: Bian, C.B., Xu, C., Qiu, W., Bountra, C., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bochkarev, A., Min, J., Structural Genomics Consortium (SGC)

-	Description: ~~complex~~ structure of EED and trimethylated H3K9	+	Description: Complex structure of EED and trimethylated H3K9

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 14 10~~:07:15 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 18 18:50:22 2009''