3k36 - Revision history

OCA at 16:07, 1 November 2023

OCA — Wed, 01 Nov 2023 16:07:22 GMT

←Older revision		Revision as of 16:07, 1 November 2023
Line 3:		Line 3:
	<StructureSection load='3k36' size='340' side='right'caption='[[3k36]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3k36' size='340' side='right'caption='[[3k36]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3k36]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Influenza_b_virus_~~(b/~~perth~~/211/2001) Influenza b virus (b/~~perth~~/211/2001)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K36 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3k36]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_B_virus_(B/Perth/211/2001) Influenza B virus (B/Perth/211/2001)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K36 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL~~</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4~~</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3k37\|3k37]]~~, ~~[[3k38\|3k38]], [[3k39\|3k39]], [[3k3a\|3k3a]]~~<~~/div></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k36 OCA], [https://pdbe.org/3k36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k36 RCSB], [https://www.ebi.ac.uk/pdbsum/3k36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k36 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k36 OCA], [https://pdbe.org/3k36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k36 RCSB], [https://www.ebi.ac.uk/pdbsum/3k36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k36 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q3S340_9INFB Q3S340_9INFB]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Exo-alpha-sialidase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: McKimm-Breschkin~~, J L~~]]	+	[[Category: McKimm-Breschkin JL]]
-	[[Category: Oakley~~, A J]]~~	+	[[Category: Oakley AJ]]
-	~~[[Category: Cell membrane]]~~	+
-	~~[[Category: Glycosidase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Influenza]]~~	+
-	~~[[Category: Membrane]]~~	+
-	~~[[Category: Mutation]]~~	+
-	~~[[Category: Neuraminidase]]~~	+
-	~~[[Category: Resistance]]~~	+
-	~~[[Category: Transmembrane]]~~	+
-	~~[[Category: Virion~~]]	+

OCA at 05:40, 13 July 2022

OCA — Wed, 13 Jul 2022 05:40:04 GMT

←Older revision		Revision as of 05:40, 13 July 2022
Line 3:		Line 3:
	<StructureSection load='3k36' size='340' side='right'caption='[[3k36]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3k36' size='340' side='right'caption='[[3k36]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3k36]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Influenza_b_virus_(b/perth/211/2001) Influenza b virus (b/perth/211/2001)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K36 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3K36 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3k36]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_b_virus_(b/perth/211/2001) Influenza b virus (b/perth/211/2001)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K36 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k37\|3k37]], [[3k38\|3k38]], [[3k39\|3k39]], [[3k3a\|3k3a]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3k37\|3k37]], [[3k38\|3k38]], [[3k39\|3k39]], [[3k3a\|3k3a]]</div></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3k36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k36 OCA], [~~http~~://pdbe.org/3k36 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3k36 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3k36 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3k36 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k36 OCA], [https://pdbe.org/3k36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k36 RCSB], [https://www.ebi.ac.uk/pdbsum/3k36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k36 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:00, 7 October 2020

OCA — Wed, 07 Oct 2020 07:00:02 GMT

←Older revision		Revision as of 07:00, 7 October 2020
Line 1:		Line 1:

	==Crystal Structure of B/Perth Neuraminidase==		==Crystal Structure of B/Perth Neuraminidase==
-	<StructureSection load='3k36' size='340' side='right' caption='[[3k36]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='3k36' size='340' side='right'caption='[[3k36]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3k36]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus_(b/perth/211/2001) Influenza b virus (b/perth/211/2001)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K36 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3K36 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3k36]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus_(b/perth/211/2001) Influenza b virus (b/perth/211/2001)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K36 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3K36 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA-D-MANNOSE~~'>~~MAN~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~SO4~~:~~SULFATE+ION~~'>~~SO4~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k37\|3k37]], [[3k38\|3k38]], [[3k39\|3k39]], [[3k3a\|3k3a]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k37\|3k37]], [[3k38\|3k38]], [[3k39\|3k39]], [[3k3a\|3k3a]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3k36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k36 OCA], [http://pdbe.org/3k36 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3k36 RCSB], [http://www.ebi.ac.uk/pdbsum/3k36 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3k36 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3k36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k36 OCA], [http://pdbe.org/3k36 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3k36 RCSB], [http://www.ebi.ac.uk/pdbsum/3k36 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3k36 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:

	==See Also==		==See Also==
-	*[[Neuraminidase\|Neuraminidase]]	+	*[[Neuraminidase 3D structures\|Neuraminidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 26:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
		+	[[Category: Large Structures]]
	[[Category: McKimm-Breschkin, J L]]		[[Category: McKimm-Breschkin, J L]]
	[[Category: Oakley, A J]]		[[Category: Oakley, A J]]

OCA at 09:48, 26 December 2018

OCA — Wed, 26 Dec 2018 09:48:40 GMT

←Older revision		Revision as of 09:48, 26 December 2018
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3k36]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus_(b/perth/211/2001) Influenza b virus (b/perth/211/2001)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K36 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K36 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3k36]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus_(b/perth/211/2001) Influenza b virus (b/perth/211/2001)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K36 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K36 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=~~SO4~~:~~SULFATE+ION~~'>~~SO4~~</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA~~-D-~~MANNOSE~~'>~~MAN~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL-D-GLUCOSAMINE~~'>~~NAG~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k37\|3k37]], [[3k38\|3k38]], [[3k39\|3k39]], [[3k3a\|3k3a]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k37\|3k37]], [[3k38\|3k38]], [[3k39\|3k39]], [[3k3a\|3k3a]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>

OCA at 20:36, 9 December 2016

OCA — Fri, 09 Dec 2016 20:36:53 GMT

←Older revision		Revision as of 20:36, 9 December 2016
Line 1:		Line 1:
		+
	==Crystal Structure of B/Perth Neuraminidase==		==Crystal Structure of B/Perth Neuraminidase==
	<StructureSection load='3k36' size='340' side='right' caption='[[3k36]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='3k36' size='340' side='right' caption='[[3k36]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3k36]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Influenza_b_virus~~ Influenza b virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K36 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K36 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3k36]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus_(b/perth/211/2001) Influenza b virus (b/perth/211/2001)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K36 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K36 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k37\|3k37]], [[3k38\|3k38]], [[3k39\|3k39]], [[3k3a\|3k3a]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k37\|3k37]], [[3k38\|3k38]], [[3k39\|3k39]], [[3k3a\|3k3a]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k36 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k36 RCSB], [http://www.ebi.ac.uk/pdbsum/3k36 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k36 OCA], [http://pdbe.org/3k36 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3k36 RCSB], [http://www.ebi.ac.uk/pdbsum/3k36 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3k36 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 16:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3k36" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 24:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
-	[[Category: Influenza b virus]]
	[[Category: McKimm-Breschkin, J L]]		[[Category: McKimm-Breschkin, J L]]
	[[Category: Oakley, A J]]		[[Category: Oakley, A J]]

OCA at 10:07, 9 December 2014

OCA — Tue, 09 Dec 2014 10:07:02 GMT

←Older revision		Revision as of 10:07, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3k36.~~png~~\|~~left~~\|~~200px~~]]	+	==Crystal Structure of B/Perth Neuraminidase==
		+	<StructureSection load='3k36' size='340' side='right' caption='[[3k36]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3k36]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus Influenza b virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K36 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K36 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k37\|3k37]], [[3k38\|3k38]], [[3k39\|3k39]], [[3k3a\|3k3a]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Exo-alpha-sialidase Exo-alpha-sialidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.18 3.2.1.18] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k36 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k36 RCSB], [http://www.ebi.ac.uk/pdbsum/3k36 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We have identified a virus, B/Perth/211/2001, with a spontaneous mutation, D197E in the neuraminidase (NA), which confers cross-resistance to all NA inhibitors. We analyzed enzyme properties of the D197 and E197 NAs and compared these to a D197N NA, known to arise after oseltamivir treatment. Zanamivir and peramivir bound slowly to the wild type NA, but binding of oseltamivir was more rapid. The D197E/N mutations resulted in faster binding of all three inhibitors. Analysis of the crystal structures of D197 and E197 NAs with and without inhibitors showed that the D197E mutation compromised the interaction of neighboring R150 with the N-acetyl group, common to the substrate sialic acid and all NA inhibitors. Although rotation of the E275 in the NA active site occurs upon binding peramivir in both the D197 and E197 NAs, this does not occur upon binding oseltamivir in the E197 NA. Lack of the E275 rotation would also account for the loss of slow binding and the partial resistance of influenza B wild type NAs to oseltamivir.

-	~~{{STRUCTURE_3k36\| PDB=3k36 \| SCENE= }}~~	+	Structural and Functional Basis of Resistance to Neuraminidase Inhibitors of Influenza B Viruses.,Oakley AJ, Barrett S, Peat TS, Newman J, Streltsov VA, Waddington L, Saito T, Tashiro M, McKimm-Breschkin JL J Med Chem. 2010 Aug 9. PMID:20695427<ref>PMID:20695427</ref>

-	~~===Crystal Structure of B~~/~~Perth Neuraminidase===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20695427}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3k36]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Influenza_b_virus Influenza b virus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3K36 OCA].~~	+

	==See Also==		==See Also==
	*[[Neuraminidase\|Neuraminidase]]		*[[Neuraminidase\|Neuraminidase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020695427<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
	[[Category: Influenza b virus]]		[[Category: Influenza b virus]]
-	[[Category: McKimm-Breschkin, J L.]]	+	[[Category: McKimm-Breschkin, J L]]
-	[[Category: Oakley, A J.]]	+	[[Category: Oakley, A J]]
	[[Category: Cell membrane]]		[[Category: Cell membrane]]
	[[Category: Glycosidase]]		[[Category: Glycosidase]]

OCA at 11:43, 20 October 2012

OCA — Sat, 20 Oct 2012 11:43:33 GMT

←Older revision		Revision as of 11:43, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3k36]] is a 2 chain structure ~~of [[Neuraminidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus Influenza b virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K36 OCA].	+	[[3k36]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus Influenza b virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K36 OCA].

	==See Also==		==See Also==

OCA: Protected "3k36" [edit=sysop:move=sysop]

OCA — Thu, 26 Jul 2012 06:23:04 GMT

Protected "3k36" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:23, 26 July 2012

OCA at 06:23, 26 July 2012

OCA — Thu, 26 Jul 2012 06:23:03 GMT

←Older revision		Revision as of 06:23, 26 July 2012
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-	{{Seed}}
	[[Image:3k36.png\|left\|200px]]		[[Image:3k36.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3k36", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_3k36\| PDB=3k36 \| SCENE= }}		{{STRUCTURE_3k36\| PDB=3k36 \| SCENE= }}

	===Crystal Structure of B/Perth Neuraminidase===		===Crystal Structure of B/Perth Neuraminidase===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20695427}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20695427 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_20695427}}		{{ABSTRACT_PUBMED_20695427}}

	==About this Structure==		==About this Structure==
-	~~3K36~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Influenza_b_virus Influenza b virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K36 OCA].	+	[[3k36]] is a 2 chain structure of [[Neuraminidase]] with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus Influenza b virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K36 OCA].
		+
		+	==See Also==
		+	*[[Neuraminidase\|Neuraminidase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20695427~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020695427</ref><references group="xtra"/>
	[[Category: Exo-alpha-sialidase]]		[[Category: Exo-alpha-sialidase]]
	[[Category: Influenza b virus]]		[[Category: Influenza b virus]]
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	[[Category: Transmembrane]]		[[Category: Transmembrane]]
	[[Category: Virion]]		[[Category: Virion]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:26:10 2010''

OCA at 07:17, 15 September 2010

OCA — Wed, 15 Sep 2010 07:17:28 GMT

←Older revision		Revision as of 07:17, 15 September 2010
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	{{Seed}}		{{Seed}}
-	[[Image:3k36.~~jpg~~\|left\|200px]]	+	[[Image:3k36.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_3k36\| PDB=3k36 \| SCENE= }}		{{STRUCTURE_3k36\| PDB=3k36 \| SCENE= }}

-	===Crystal Structure of B/Perth ~~Neruaminidase~~===	+	===Crystal Structure of B/Perth Neuraminidase===


Line 39:		Line 39:
	[[Category: Virion]]		[[Category: Virion]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep ~~1 09~~:47:59 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:26:10 2010''