3k71 - Revision history

OCA at 08:10, 6 September 2023

OCA — Wed, 06 Sep 2023 08:10:28 GMT

←Older revision		Revision as of 08:10, 6 September 2023
Line 1:		Line 1:
-	~~{{Large structure}}~~	+
	==Structure of integrin alphaX beta2 ectodomain==		==Structure of integrin alphaX beta2 ectodomain==
-	<StructureSection load='3k71' size='340' side='right' caption='[[3k71]], [[Resolution\|resolution]] 3.95Å' scene=''>	+	<StructureSection load='3k71' size='340' side='right'caption='[[3k71]], [[Resolution\|resolution]] 3.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3k71]] is a 8 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K71 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3K71 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3k71]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K71 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K71 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.95Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k6s\|3k6s]], [[3k72\|3k72]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD11C, ITGAX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CD18, ITGB2, MFI7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k71 OCA], [https://pdbe.org/3k71 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k71 RCSB], [https://www.ebi.ac.uk/pdbsum/3k71 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k71 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3k71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k71 OCA], [~~http~~://pdbe.org/3k71 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3k71 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3k71 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3k71 ProSAT]</span></td></tr>	+
	</table>		</table>
-	{{Large structure}}
-	== Disease ==
-	[[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1) [MIM:[http://omim.org/entry/116920 116920]]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.<ref>PMID:7509236</ref> <ref>PMID:1346613</ref> <ref>PMID:1968911</ref> <ref>PMID:1694220</ref> <ref>PMID:1590804</ref> <ref>PMID:1352501</ref> <ref>PMID:1347532</ref> <ref>PMID:7686755</ref> <ref>PMID:9884339</ref> <ref>PMID:20529581</ref> <ref>PMID:20549317</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ITAX_HUMAN ITAX_HUMAN]] Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. [[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.<ref>PMID:18587400</ref>	+	[https://www.uniprot.org/uniprot/ITAX_HUMAN ITAX_HUMAN] Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 31:

	==See Also==		==See Also==
-	*[[Integrin\|Integrin]]	+	*[[Integrin 3D structures\|Integrin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Chen, X]]	+	[[Category: Large Structures]]
-	[[Category: Mi, L]]	+	[[Category: Chen X]]
-	[[Category: Nishida, N]]	+	[[Category: Mi L]]
-	[[Category: Springer~~, T A~~]]	+	[[Category: Nishida N]]
-	[[Category: Xie, C]]	+	[[Category: Springer TA]]
-	[[Category: Zhu, J]]	+	[[Category: Xie C]]
-	~~[[Category: Cell adhesion]]~~	+	[[Category: Zhu J]]
-	~~[[Category: Cell receptor]]~~	+
-	~~[[Category: Integrin]]~~	+
-	~~[[Category: Pyrrolidone carboxylic acid~~]]	+

OCA at 09:11, 26 December 2018

OCA — Wed, 26 Dec 2018 09:11:03 GMT

←Older revision		Revision as of 09:11, 26 December 2018
Line 1:		Line 1:
		+	{{Large structure}}
	==Structure of integrin alphaX beta2 ectodomain==		==Structure of integrin alphaX beta2 ectodomain==
	<StructureSection load='3k71' size='340' side='right' caption='[[3k71]], [[Resolution\|resolution]] 3.95Å' scene=''>		<StructureSection load='3k71' size='340' side='right' caption='[[3k71]], [[Resolution\|resolution]] 3.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3k71]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K71 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K71 FirstGlance]. <br>		<table><tr><td colspan='2'>[[3k71]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K71 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K71 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:~~MAGNESIUM+ION~~'>MG</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL-D-GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~MAN~~:~~ALPHA~~-D-~~MANNOSE~~'>~~MAN~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k6s\|3k6s]], [[3k72\|3k72]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k6s\|3k6s]], [[3k72\|3k72]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD11C, ITGAX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CD18, ITGB2, MFI7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD11C, ITGAX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CD18, ITGB2, MFI7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k71 OCA], [http://pdbe.org/3k71 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3k71 RCSB], [http://www.ebi.ac.uk/pdbsum/3k71 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k71 OCA], [http://pdbe.org/3k71 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3k71 RCSB], [http://www.ebi.ac.uk/pdbsum/3k71 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3k71 ProSAT]</span></td></tr>
	</table>		</table>
	{{Large structure}}		{{Large structure}}
Line 17:		Line 18:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k7/3k71_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k7/3k71_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:38, 8 February 2016

OCA — Mon, 08 Feb 2016 21:38:12 GMT

←Older revision		Revision as of 21:38, 8 February 2016
Line 2:		Line 2:
	<StructureSection load='3k71' size='340' side='right' caption='[[3k71]], [[Resolution\|resolution]] 3.95Å' scene=''>		<StructureSection load='3k71' size='340' side='right' caption='[[3k71]], [[Resolution\|resolution]] 3.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3k71]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K71 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K71 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3k71]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K71 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K71 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k6s\|3k6s]], [[3k72\|3k72]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k6s\|3k6s]], [[3k72\|3k72]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD11C, ITGAX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~]), CD18, ITGB2, MFI7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD11C, ITGAX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CD18, ITGB2, MFI7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k71 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k71 RCSB], [http://www.ebi.ac.uk/pdbsum/3k71 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k71 OCA], [http://pdbe.org/3k71 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3k71 RCSB], [http://www.ebi.ac.uk/pdbsum/3k71 PDBsum]</span></td></tr>
	</table>		</table>
		+	{{Large structure}}
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1) [MIM:[http://omim.org/entry/116920 116920]]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.<ref>PMID:7509236</ref> <ref>PMID:1346613</ref> <ref>PMID:1968911</ref> <ref>PMID:1694220</ref> <ref>PMID:1590804</ref> <ref>PMID:1352501</ref> <ref>PMID:1347532</ref> <ref>PMID:7686755</ref> <ref>PMID:9884339</ref> <ref>PMID:20529581</ref> <ref>PMID:20549317</ref>		[[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1) [MIM:[http://omim.org/entry/116920 116920]]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.<ref>PMID:7509236</ref> <ref>PMID:1346613</ref> <ref>PMID:1968911</ref> <ref>PMID:1694220</ref> <ref>PMID:1590804</ref> <ref>PMID:1352501</ref> <ref>PMID:1347532</ref> <ref>PMID:7686755</ref> <ref>PMID:9884339</ref> <ref>PMID:20529581</ref> <ref>PMID:20549317</ref>
Line 20:		Line 21:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k71 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 30:		Line 31:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3k71" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 37:		Line 39:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Chen, X]]		[[Category: Chen, X]]
	[[Category: Mi, L]]		[[Category: Mi, L]]

OCA at 17:34, 18 December 2014

OCA — Thu, 18 Dec 2014 17:34:33 GMT

←Older revision		Revision as of 17:34, 18 December 2014
Line 1:		Line 1:
-	~~{{Large~~ structure}}	+	==Structure of integrin alphaX beta2 ectodomain==
-	~~{{STRUCTURE_3k71~~\| ~~PDB~~=3k71 ~~\| SCENE~~= }}	+	<StructureSection load='3k71' size='340' side='right' caption='[[3k71]], [[Resolution\|resolution]] 3.95Å' scene=''>
-	===~~Structure~~ of ~~integrin alphaX beta2 ectodomain~~===	+	== Structural highlights ==
-	~~{{ABSTRACT_PUBMED_20033057}}~~	+	<table><tr><td colspan='2'>[[3k71]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K71 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K71 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3k6s\|3k6s]], [[3k72\|3k72]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CD11C, ITGAX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), CD18, ITGB2, MFI7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k71 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k71 RCSB], [http://www.ebi.ac.uk/pdbsum/3k71 PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1) [MIM:[http://omim.org/entry/116920 116920]]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.<ref>PMID:7509236</ref> <ref>PMID:1346613</ref> <ref>PMID:1968911</ref> <ref>PMID:1694220</ref> <ref>PMID:1590804</ref> <ref>PMID:1352501</ref> <ref>PMID:1347532</ref> <ref>PMID:7686755</ref> <ref>PMID:9884339</ref> <ref>PMID:20529581</ref> <ref>PMID:20549317</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ITAX_HUMAN ITAX_HUMAN]] Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. [[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.<ref>PMID:18587400</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k7/3k71_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	We report the structure of an integrin with an alphaI domain, alpha(X)beta(2), the complement receptor type 4. It was earlier expected that a fixed orientation between the alphaI domain and the beta-propeller domain in which it is inserted would be required for allosteric signal transmission. However, the alphaI domain is highly flexible, enabling two betaI domain conformational states to couple to three alphaI domain states, and greater accessibility for ligand recognition. Although alpha(X)beta(2) is bent similarly to integrins that lack alphaI domains, the terminal domains of the alpha- and beta-legs, calf-2 and beta-tail, are oriented differently than in alphaI-less integrins. Linkers extending to the transmembrane domains are unstructured. Previous mutations in the beta(2)-tail domain support the importance of extension, rather than a deadbolt, in integrin activation. The locations of further activating mutations and antibody epitopes show the critical role of extension, and conversion from the closed to the open headpiece conformation, in integrin activation. Differences among 10 molecules in crystal lattices provide unprecedented information on interdomain flexibility important for modelling integrin extension and activation.

-	~~==Disease==~~	+	Structure of an integrin with an alphaI domain, complement receptor type 4.,Xie C, Zhu J, Chen X, Mi L, Nishida N, Springer TA EMBO J. 2010 Feb 3;29(3):666-79. Epub 2009 Dec 24. PMID:20033057<ref>PMID:20033057</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1~~ (~~LAD1~~) ~~[MIM~~:~~[http://omim~~.~~org/entry/116920 116920]]~~. ~~LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.<ref>~~PMID:7509236</ref><ref>PMID:1346613</ref><ref>PMID:1968911</ref><ref>PMID:1694220</ref><ref>PMID:1590804</ref><ref>PMID:1352501</ref><ref>PMID:1347532</ref><ref>PMID:7686755</ref><ref>PMID:9884339</ref><ref>PMID:20529581</ref><ref>PMID:~~20549317~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/ITAX_HUMAN ITAX_HUMAN]] Integrin alpha-X/beta-2 is~~ a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. [[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the ~~third complement component and for fibrinogen~~. ~~Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain~~. ~~Integrin alpha-M/beta-2 recognizes P1 and P2 peptides~~ of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.<~~ref~~>~~PMID:18587400~~</~~ref~~>	+	</div>
-		+
-	~~==About this Structure==~~	+
-	[[3k71]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K71 OCA].	+

	==See Also==		==See Also==
	*[[Integrin\|Integrin]]		*[[Integrin\|Integrin]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020033057</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Chen, X.]]	+	[[Category: Chen, X]]
-	[[Category: Mi, L.]]	+	[[Category: Mi, L]]
-	[[Category: Nishida, N.]]	+	[[Category: Nishida, N]]
-	[[Category: Springer, T A.]]	+	[[Category: Springer, T A]]
-	[[Category: Xie, C.]]	+	[[Category: Xie, C]]
-	[[Category: Zhu, J.]]	+	[[Category: Zhu, J]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Cell receptor]]		[[Category: Cell receptor]]
	[[Category: Integrin]]		[[Category: Integrin]]
	[[Category: Pyrrolidone carboxylic acid]]		[[Category: Pyrrolidone carboxylic acid]]

OCA at 21:53, 24 March 2013

OCA — Sun, 24 Mar 2013 21:53:13 GMT

←Older revision		Revision as of 21:53, 24 March 2013
Line 3:		Line 3:
	===Structure of integrin alphaX beta2 ectodomain===		===Structure of integrin alphaX beta2 ectodomain===
	{{ABSTRACT_PUBMED_20033057}}		{{ABSTRACT_PUBMED_20033057}}
		+
		+	==Disease==
		+	[[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1) [MIM:[http://omim.org/entry/116920 116920]]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.<ref>PMID:7509236</ref><ref>PMID:1346613</ref><ref>PMID:1968911</ref><ref>PMID:1694220</ref><ref>PMID:1590804</ref><ref>PMID:1352501</ref><ref>PMID:1347532</ref><ref>PMID:7686755</ref><ref>PMID:9884339</ref><ref>PMID:20529581</ref><ref>PMID:20549317</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/ITAX_HUMAN ITAX_HUMAN]] Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. [[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.<ref>PMID:18587400</ref>

	==About this Structure==		==About this Structure==
Line 11:		Line 17:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020033057</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020033057</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, X.]]		[[Category: Chen, X.]]

OCA at 07:59, 11 March 2013

OCA — Mon, 11 Mar 2013 07:59:25 GMT

←Older revision		Revision as of 07:59, 11 March 2013
Line 1:		Line 1:
-	~~[[Image:3k71.png\|left\|200px]]~~	+	{{Large structure}}
-		+
	{{STRUCTURE_3k71\| PDB=3k71 \| SCENE= }}		{{STRUCTURE_3k71\| PDB=3k71 \| SCENE= }}
-
	===Structure of integrin alphaX beta2 ectodomain===		===Structure of integrin alphaX beta2 ectodomain===
-
	{{ABSTRACT_PUBMED_20033057}}		{{ABSTRACT_PUBMED_20033057}}

OCA: Protected "3k71" [edit=sysop:move=sysop]

OCA — Sat, 20 Oct 2012 11:33:35 GMT

Protected "3k71" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:33, 20 October 2012

OCA at 11:33, 20 October 2012

OCA — Sat, 20 Oct 2012 11:33:33 GMT

←Older revision		Revision as of 11:33, 20 October 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3k71.png\|left\|200px]]		[[Image:3k71.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3k71", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3k71\| PDB=3k71 \| SCENE= }}		{{STRUCTURE_3k71\| PDB=3k71 \| SCENE= }}

	===Structure of integrin alphaX beta2 ectodomain===		===Structure of integrin alphaX beta2 ectodomain===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20033057}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20033057 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20033057}}		{{ABSTRACT_PUBMED_20033057}}

	==About this Structure==		==About this Structure==
-	~~3K71~~ is a 8 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K71 OCA].	+	[[3k71]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K71 OCA].
		+
		+	==See Also==
		+	*[[Integrin\|Integrin]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20033057~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020033057</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, X.]]		[[Category: Chen, X.]]
Line 35:		Line 26:
	[[Category: Integrin]]		[[Category: Integrin]]
	[[Category: Pyrrolidone carboxylic acid]]		[[Category: Pyrrolidone carboxylic acid]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 3 13:34:42 2010''

OCA at 11:34, 3 March 2010

OCA — Wed, 03 Mar 2010 11:34:43 GMT

←Older revision		Revision as of 11:34, 3 March 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3k71.~~jpg~~\|left\|200px]]	+	[[Image:3k71.png\|left\|200px]]

	<!--		<!--
Line 12:		Line 12:
	===Structure of integrin alphaX beta2 ectodomain===		===Structure of integrin alphaX beta2 ectodomain===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20033057}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20033057 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20033057}}

	==About this Structure==		==About this Structure==
-	3K71 is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K71 OCA].	+	3K71 is a 8 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K71 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20033057</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Chen, X.]]		[[Category: Chen, X.]]
Line 22:		Line 31:
	[[Category: Xie, C.]]		[[Category: Xie, C.]]
	[[Category: Zhu, J.]]		[[Category: Zhu, J.]]
-	[[Category: Calcium]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Cell receptor]]		[[Category: Cell receptor]]
-	[[Category: Disease mutation]]
-	[[Category: Disulfide bond]]
-	[[Category: Glycoprotein]]
	[[Category: Integrin]]		[[Category: Integrin]]
-	[[Category: Magnesium]]
-	[[Category: Membrane]]
-	[[Category: Phosphoprotein]]
-	[[Category: Polymorphism]]
	[[Category: Pyrrolidone carboxylic acid]]		[[Category: Pyrrolidone carboxylic acid]]
-	[[Category: Receptor]]
-	[[Category: Transmembrane]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jan~~ 13 14:35:57 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 3 13:34:42 2010''

OCA at 12:35, 13 January 2010

OCA — Wed, 13 Jan 2010 12:35:59 GMT

←Older revision		Revision as of 12:35, 13 January 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3k71.jpg\|left\|200px]]

-	The ~~entry 3k71~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3k71", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3k71\| PDB=3k71 \| SCENE= }}

-	~~Authors: Xie, C., Zhu, J., Chen, X., Mi, L., Nishida, N., Springer, T.A.~~	+	===Structure of integrin alphaX beta2 ectodomain===

-	Description: Structure of integrin alphaX beta2 ectodomain

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 28 12~~:57:57 ~~2009~~''	+	==About this Structure==
		+	3K71 is a 8 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K71 OCA].
		+	[[Category: Homo sapiens]]
		+	[[Category: Chen, X.]]
		+	[[Category: Mi, L.]]
		+	[[Category: Nishida, N.]]
		+	[[Category: Springer, T A.]]
		+	[[Category: Xie, C.]]
		+	[[Category: Zhu, J.]]
		+	[[Category: Calcium]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Cell receptor]]
		+	[[Category: Disease mutation]]
		+	[[Category: Disulfide bond]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Integrin]]
		+	[[Category: Magnesium]]
		+	[[Category: Membrane]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Polymorphism]]
		+	[[Category: Pyrrolidone carboxylic acid]]
		+	[[Category: Receptor]]
		+	[[Category: Transmembrane]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 13 14:35:57 2010''