3k9u - Revision history

OCA at 08:12, 6 September 2023

OCA — Wed, 06 Sep 2023 08:12:29 GMT

←Older revision		Revision as of 08:12, 6 September 2023
Line 1:		Line 1:

	==Crystal structure of paia acetyltransferase (ta0374) from thermoplasma acidophilum==		==Crystal structure of paia acetyltransferase (ta0374) from thermoplasma acidophilum==
-	<StructureSection load='3k9u' size='340' side='right' caption='[[3k9u]], [[Resolution\|resolution]] 2.30Å' scene=''>	+	<StructureSection load='3k9u' size='340' side='right'caption='[[3k9u]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3k9u]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"thermoplasma_acidophila"_(sic)_darland_et_al._1970 "thermoplasma acidophila" (sic) darland et al. 1970~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K9U OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3K9U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3k9u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K9U FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f0a\|3f0a]], [[3fix\|3fix]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ta0374 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2303 "Thermoplasma acidophila" (sic) Darland et al. 1970])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k9u OCA], [https://pdbe.org/3k9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k9u RCSB], [https://www.ebi.ac.uk/pdbsum/3k9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k9u ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3k9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k9u OCA], [~~http~~://pdbe.org/3k9u PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3k9u RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3k9u PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3k9u ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PAIA_THEAC PAIA_THEAC] Involved in the protection against polyamine toxicity by regulating their concentration. Could also be involved in the negative control of sporulation as well as production of degradative enzymes such as alpha-amylase, levansucrase and alkaline phosphatase. Catalyzes the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and release both CoA and the acetylated product. It can use a variety of substrates including spermidine, L-tryptophan, L-leucine, L-lysine, dopamine and tyramine.<ref>PMID:21633970</ref> <ref>PMID:23184347</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k9/3k9u_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k9/3k9u_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Anderson, W F]]~~	+	[[Category: Large Structures]]
-	~~[[Category: Filippova, E V]]~~	+
-	~~[[Category: Joachimiak, A]]~~	+
-	~~[[Category: Kiryukhina, O]]~~	+
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Minasov, G]]~~	+
-	~~[[Category: Shuvalova, L]]~~	+
-	~~[[Category: Acetyltransferase]]~~	+
-	~~[[Category: Mcsg]]~~	+
-	~~[[Category: PSI, Protein structure initiative~~]]	+
	[[Category: Thermoplasma acidophilum]]		[[Category: Thermoplasma acidophilum]]
-	[[Category: ~~Transferase~~]]	+	[[Category: Anderson WF]]
		+	[[Category: Filippova EV]]
		+	[[Category: Joachimiak A]]
		+	[[Category: Kiryukhina O]]
		+	[[Category: Minasov G]]
		+	[[Category: Shuvalova L]]

OCA at 13:41, 5 August 2016

OCA — Fri, 05 Aug 2016 13:41:14 GMT

←Older revision		Revision as of 13:41, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal structure of paia acetyltransferase (ta0374) from thermoplasma acidophilum==		==Crystal structure of paia acetyltransferase (ta0374) from thermoplasma acidophilum==
	<StructureSection load='3k9u' size='340' side='right' caption='[[3k9u]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='3k9u' size='340' side='right' caption='[[3k9u]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3k9u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Thermoplasma_acidophilum Thermoplasma acidophilum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K9U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K9U FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3k9u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"thermoplasma_acidophila"_(sic)_darland_et_al._1970 "thermoplasma acidophila" (sic) darland et al. 1970]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K9U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K9U FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f0a\|3f0a]], [[3fix\|3fix]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f0a\|3f0a]], [[3fix\|3fix]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ta0374 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2303 Thermoplasma ~~acidophilum~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ta0374 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2303 "Thermoplasma acidophila" (sic) Darland et al. 1970])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k9u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k9u RCSB], [http://www.ebi.ac.uk/pdbsum/3k9u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k9u OCA], [http://pdbe.org/3k9u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3k9u RCSB], [http://www.ebi.ac.uk/pdbsum/3k9u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3k9u ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 16:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k9u ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 26:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3k9u" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Thermoplasma acidophilum]]
	[[Category: Anderson, W F]]		[[Category: Anderson, W F]]
	[[Category: Filippova, E V]]		[[Category: Filippova, E V]]
Line 41:		Line 42:
	[[Category: Mcsg]]		[[Category: Mcsg]]
	[[Category: PSI, Protein structure initiative]]		[[Category: PSI, Protein structure initiative]]
		+	[[Category: Thermoplasma acidophilum]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 21:46, 3 January 2015

OCA — Sat, 03 Jan 2015 21:46:48 GMT

←Older revision		Revision as of 21:46, 3 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3k9u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K9U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K9U FirstGlance]. <br>		<table><tr><td colspan='2'>[[3k9u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K9U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K9U FirstGlance]. <br>
-	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene><br>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
-	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f0a\|3f0a]], [[3fix\|3fix]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f0a\|3f0a]], [[3fix\|3fix]]</td></tr>
-	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ta0374 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2303 Thermoplasma acidophilum])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ta0374 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2303 Thermoplasma acidophilum])</td></tr>
-	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k9u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k9u RCSB], [http://www.ebi.ac.uk/pdbsum/3k9u PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k9u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k9u RCSB], [http://www.ebi.ac.uk/pdbsum/3k9u PDBsum]</span></td></tr>
-	<table>	+	</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 24:
	Crystal structure of the novel PaiA N-acetyltransferase from Thermoplasma acidophilum involved in the negative control of sporulation and degradative enzyme production.,Filippova EV, Shuvalova L, Minasov G, Kiryukhina O, Zhang Y, Clancy S, Radhakrishnan I, Joachimiak A, Anderson WF Proteins. 2011 Aug;79(8):2566-77. doi: 10.1002/prot.23062. Epub 2011 Jun, 1. PMID:21633970<ref>PMID:21633970</ref>		Crystal structure of the novel PaiA N-acetyltransferase from Thermoplasma acidophilum involved in the negative control of sporulation and degradative enzyme production.,Filippova EV, Shuvalova L, Minasov G, Kiryukhina O, Zhang Y, Clancy S, Radhakrishnan I, Joachimiak A, Anderson WF Proteins. 2011 Aug;79(8):2566-77. doi: 10.1002/prot.23062. Epub 2011 Jun, 1. PMID:21633970<ref>PMID:21633970</ref>

-	From ~~MEDLINEÂ®~~/~~PubMedÂ®~~, a database of the U.S. National Library of Medicine.<br>	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	== References ==		== References ==
Line 31:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Thermoplasma acidophilum]]		[[Category: Thermoplasma acidophilum]]
-	[[Category: Anderson, W F.]]	+	[[Category: Anderson, W F]]
-	[[Category: Filippova, E V.]]	+	[[Category: Filippova, E V]]
-	[[Category: Joachimiak, A.]]	+	[[Category: Joachimiak, A]]
-	[[Category: Kiryukhina, O.]]	+	[[Category: Kiryukhina, O]]
-	[[Category: ~~MCSG, Midwest Center for~~ Structural ~~Genomics.~~]]	+	[[Category: Structural genomic]]
-	[[Category: Minasov, G.]]	+	[[Category: Minasov, G]]
-	[[Category: Shuvalova, L.]]	+	[[Category: Shuvalova, L]]
	[[Category: Acetyltransferase]]		[[Category: Acetyltransferase]]
	[[Category: Mcsg]]		[[Category: Mcsg]]
-	[[Category: ~~Midwest center for structural genomic]]~~	+	[[Category: PSI, Protein structure initiative]]
-	~~[[Category:~~ Protein structure initiative]]	+
-	~~[[Category: Psi-2]]~~	+
-	~~[[Category: Structural genomic]]~~	+
-	~~[[Category: Thermoplasma acidophilum~~]]	+
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 09:40, 21 May 2014

OCA — Wed, 21 May 2014 09:40:00 GMT

←Older revision		Revision as of 09:40, 21 May 2014
Line 1:		Line 1:
-	[[~~Image:~~3k9u.~~png~~\|~~left~~\|200px]]	+	==Crystal structure of paia acetyltransferase (ta0374) from thermoplasma acidophilum==
		+	<StructureSection load='3k9u' size='340' side='right' caption='[[3k9u]], [[Resolution\|resolution]] 2.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3k9u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K9U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K9U FirstGlance]. <br>
		+	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene><br>
		+	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f0a\|3f0a]], [[3fix\|3fix]]</td></tr>
		+	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ta0374 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2303 Thermoplasma acidophilum])</td></tr>
		+	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k9u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k9u RCSB], [http://www.ebi.ac.uk/pdbsum/3k9u PDBsum]</span></td></tr>
		+	<table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k9/3k9u_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	GCN5-related N-acetyltransferases (GNATs) are the most widely distributed acetyltransferase systems among all three domains of life. GNATs appear to be involved in several key processes, including microbial antibiotic resistance, compacting eukaryotic DNA, controlling gene expression, and protein synthesis. Here, we report the crystal structure of a putative GNAT Ta0374 from Thermoplasma acidophilum, a hyperacidophilic bacterium, that has been determined in an apo-form, in complex with its natural ligand (acetyl coenzyme A), and in complex with a product of reaction (coenzyme A) obtained by cocrystallization with spermidine. Sequence and structural analysis reveals that Ta0374 belongs to a novel protein family, PaiA, involved in the negative control of sporulation and degradative enzyme production. The crystal structure of Ta0374 confirms that it binds acetyl coenzyme A in a way similar to other GNATs and is capable of acetylating spermidine. Based on structural and docking analysis, it is expected that Glu53 and Tyr93 are key residues for recognizing spermidine. Additionally, we find that the purification His-Tag in the apo-form structure of Ta0374 prevents binding of acetyl coenzyme A in the crystal, though not in solution, and affects a chain-flip rotation of "motif A" which is the most conserved sequence among canonical acetyltransferases. Proteins 2011; (c) 2011 Wiley-Liss, Inc.

-	~~<!-~~-	+	Crystal structure of the novel PaiA N-acetyltransferase from Thermoplasma acidophilum involved in the negative control of sporulation and degradative enzyme production.,Filippova EV, Shuvalova L, Minasov G, Kiryukhina O, Zhang Y, Clancy S, Radhakrishnan I, Joachimiak A, Anderson WF Proteins. 2011 Aug;79(8):2566-77. doi: 10.1002/prot.23062. Epub 2011 Jun, 1. PMID:21633970<ref>PMID:21633970</ref>
-	~~The line below this paragraph~~, ~~containing "STRUCTURE_3k9u"~~, ~~creates the "Structure Box" on the page~~.	+
-	~~You may change the PDB parameter~~ (~~which sets the PDB file loaded into the applet)~~	+
-	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded~~),	+
-	~~or leave the SCENE parameter empty for the default display~~.	+
-	-->	+
-	~~{{STRUCTURE_3k9u\| PDB=3k9u \| SCENE= }}~~	+

-	~~===Crystal structure~~ of ~~paia acetyltransferase (ta0374) from thermoplasma acidophilum===~~	+	From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-		+	== References ==
-	~~<!--~~	+	<references/>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_21633970}}, adds~~ the ~~Publication Abstract to the page~~	+	__TOC__
-	~~(as it appears on PubMed at http://www~~.~~pubmed~~.~~gov), where 21633970 is the PubMed ID number~~.	+	</StructureSection>
-	-->	+
-	~~{{ABSTRACT_PUBMED_21633970}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3k9u]] is a 2 chain structure with sequence from [http:~~/~~/en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K9U OCA].~~	+
-		+
-	==~~Reference~~==	+
-	<~~ref group="xtra">PMID:021633970<~~/~~ref~~><~~references group="xtra"~~/>	+
	[[Category: Thermoplasma acidophilum]]		[[Category: Thermoplasma acidophilum]]
	[[Category: Anderson, W F.]]		[[Category: Anderson, W F.]]

OCA at 04:43, 27 July 2011

OCA — Wed, 27 Jul 2011 04:43:54 GMT

←Older revision		Revision as of 04:43, 27 July 2011
Line 11:		Line 11:
	===Crystal structure of paia acetyltransferase (ta0374) from thermoplasma acidophilum===		===Crystal structure of paia acetyltransferase (ta0374) from thermoplasma acidophilum===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_21633970}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 21633970 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_21633970}}

	==About this Structure==		==About this Structure==
Line 16:		Line 22:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~021633969~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:021633970</ref><references group="xtra"/>
	[[Category: Thermoplasma acidophilum]]		[[Category: Thermoplasma acidophilum]]
	[[Category: Anderson, W F.]]		[[Category: Anderson, W F.]]

OCA: Protected "3k9u" [edit=sysop:move=sysop]

OCA — Wed, 06 Jul 2011 17:57:40 GMT

Protected "3k9u" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:57, 6 July 2011

OCA at 17:57, 6 July 2011

OCA — Wed, 06 Jul 2011 17:57:38 GMT

←Older revision		Revision as of 17:57, 6 July 2011
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3k9u.png\|left\|200px]]		[[Image:3k9u.png\|left\|200px]]

Line 14:		Line 13:

	==About this Structure==		==About this Structure==
-	~~3K9U~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K9U OCA].	+	[[3k9u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K9U OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:021633969</ref><references group="xtra"/>
	[[Category: Thermoplasma acidophilum]]		[[Category: Thermoplasma acidophilum]]
	[[Category: Anderson, W F.]]		[[Category: Anderson, W F.]]
Line 30:		Line 32:
	[[Category: Structural genomic]]		[[Category: Structural genomic]]
	[[Category: Thermoplasma acidophilum]]		[[Category: Thermoplasma acidophilum]]
-		+	[[Category: Transferase]]
-	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Thu Jan 28 15:17:30 2010''~~	+

OCA at 13:17, 28 January 2010

OCA — Thu, 28 Jan 2010 13:17:31 GMT

←Older revision		Revision as of 13:17, 28 January 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3k9u.~~jpg~~\|left\|200px]]	+	[[Image:3k9u.png\|left\|200px]]

	<!--		<!--
Line 14:		Line 14:

	==About this Structure==		==About this Structure==
-	3K9U is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K9U OCA].	+	3K9U is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K9U OCA].
	[[Category: Thermoplasma acidophilum]]		[[Category: Thermoplasma acidophilum]]
	[[Category: Anderson, W F.]]		[[Category: Anderson, W F.]]
Line 31:		Line 31:
	[[Category: Thermoplasma acidophilum]]		[[Category: Thermoplasma acidophilum]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Wed Nov 18 20~~:20:~~59 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 15:17:30 2010''

OCA at 18:21, 18 November 2009

OCA — Wed, 18 Nov 2009 18:21:00 GMT

←Older revision		Revision as of 18:21, 18 November 2009
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3k9u.jpg\|left\|200px]]

-	The ~~entry 3k9u~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3k9u", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3k9u\| PDB=3k9u \| SCENE= }}

-	~~Authors: Filippova, E.V., Minasov, G., Shuvalova, L., Kiryukhina, O., Joachimiak, A., Anderson, W., Midwest Center for Structural Genomics~~ (~~MCSG~~)	+	===Crystal structure of paia acetyltransferase (ta0374) from thermoplasma acidophilum===

-	Description: CRYSTAL STRUCTURE OF PAIA ACETYLTRANSFERASE (TA0374) FROM THERMOPLASMA ACIDOPHILUM

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 28 12~~:59:08 2009''	+	==About this Structure==
		+	3K9U is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Thermoplasma_acidophilum Thermoplasma acidophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K9U OCA].
		+	[[Category: Thermoplasma acidophilum]]
		+	[[Category: Anderson, W F.]]
		+	[[Category: Filippova, E V.]]
		+	[[Category: Joachimiak, A.]]
		+	[[Category: Kiryukhina, O.]]
		+	[[Category: MCSG, Midwest Center for Structural Genomics.]]
		+	[[Category: Minasov, G.]]
		+	[[Category: Shuvalova, L.]]
		+	[[Category: Acetyltransferase]]
		+	[[Category: Mcsg]]
		+	[[Category: Midwest center for structural genomic]]
		+	[[Category: Protein structure initiative]]
		+	[[Category: Psi-2]]
		+	[[Category: Structural genomic]]
		+	[[Category: Thermoplasma acidophilum]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 18 20:20:59 2009''

OCA: New page: '''Unreleased structure''' The entry 3k9u is ON HOLD Authors: Filippova, E.V., Minasov, G., Shuvalova, L., Kiryukhina, O., Joachimiak, A., Anderson, W., Midwest Center for Structural Ge...

OCA — Wed, 28 Oct 2009 10:59:09 GMT

New page: '''Unreleased structure''' The entry 3k9u is ON HOLD Authors: Filippova, E.V., Minasov, G., Shuvalova, L., Kiryukhina, O., Joachimiak, A., Anderson, W., Midwest Center for Structural Ge...

New page

'''Unreleased structure'''

The entry 3k9u is ON HOLD

Authors: Filippova, E.V., Minasov, G., Shuvalova, L., Kiryukhina, O., Joachimiak, A., Anderson, W., Midwest Center for Structural Genomics (MCSG)

Description: CRYSTAL STRUCTURE OF PAIA ACETYLTRANSFERASE (TA0374) FROM THERMOPLASMA ACIDOPHILUM

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 28 12:59:08 2009''