3kdk - Revision history

OCA at 08:14, 6 September 2023

OCA — Wed, 06 Sep 2023 08:14:05 GMT

←Older revision		Revision as of 08:14, 6 September 2023
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	==Structure of the C-terminal domain of Bacillus subtilis MutL bound to Zn2+==		==Structure of the C-terminal domain of Bacillus subtilis MutL bound to Zn2+==
-	<StructureSection load='3kdk' size='340' side='right' caption='[[3kdk]], [[Resolution\|resolution]] 2.26Å' scene=''>	+	<StructureSection load='3kdk' size='340' side='right'caption='[[3kdk]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kdk]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"vibrio_subtilis"_ehrenberg_1835 "vibrio~~ subtilis~~" ehrenberg 1835~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KDK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3KDK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kdk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KDK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KDK FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.26Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gab\|3gab]]~~, [[~~3kdg~~\|~~3kdg~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>BSU17050, mutL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~1423~~ "~~Vibrio subtilis~~" ~~Ehrenberg 1835])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kdk OCA], [https://pdbe.org/3kdk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kdk RCSB], [https://www.ebi.ac.uk/pdbsum/3kdk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kdk ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3kdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kdk OCA], [~~http~~://pdbe.org/3kdk PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3kdk RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3kdk PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3kdk ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MUTL_BACSU MUTL_BACSU]] This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity). Overexpression of mutSL partially suppresses the high spontaneous mutation frequency of a ytkD/mutM/yfhQ triple disruption which lacks the system required to prevent damage by oxidized guanine (8-oxo-dGTP). This suggests that MutSL also functions to repair mismatches due to oxidative stress in both growing and stationary phase cells.<ref>PMID:19011023</ref>	+	[https://www.uniprot.org/uniprot/MUTL_BACSU MUTL_BACSU] This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity). Overexpression of mutSL partially suppresses the high spontaneous mutation frequency of a ytkD/mutM/yfhQ triple disruption which lacks the system required to prevent damage by oxidized guanine (8-oxo-dGTP). This suggests that MutSL also functions to repair mismatches due to oxidative stress in both growing and stationary phase cells.<ref>PMID:19011023</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</div>		</div>
	<div class="pdbe-citations 3kdk" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3kdk" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[DNA mismatch repair protein 3D structures\|DNA mismatch repair protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Vibrio~~ subtilis ~~ehrenberg 1835~~]]	+	[[Category: Bacillus subtilis]]
-	[[Category: ~~Guarne, A~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Pillon, M C~~]]	+	[[Category: Guarne A]]
-	[[Category: ~~Dna damage]]~~	+	[[Category: Pillon MC]]
-	~~[[Category: Dna repair]]~~	+
-	~~[[Category: Endonuclease]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Mismatch repair]]~~	+
-	~~[[Category: Mutl]]~~	+
-	~~[[Category: Zn-binding protein~~]]	+

OCA at 09:04, 26 December 2018

OCA — Wed, 26 Dec 2018 09:04:55 GMT

←Older revision		Revision as of 09:04, 26 December 2018
Line 3:		Line 3:
	<StructureSection load='3kdk' size='340' side='right' caption='[[3kdk]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='3kdk' size='340' side='right' caption='[[3kdk]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kdk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"~~bacillus_globigii~~"~~_migula_1900~~ "~~bacillus globigii~~" ~~migula 1900~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KDK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KDK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kdk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KDK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KDK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gab\|3gab]], [[3kdg\|3kdg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gab\|3gab]], [[3kdg\|3kdg]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BSU17050, mutL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "~~Bacillus globigii~~" ~~Migula 1900~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BSU17050, mutL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kdk OCA], [http://pdbe.org/3kdk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kdk RCSB], [http://www.ebi.ac.uk/pdbsum/3kdk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kdk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kdk OCA], [http://pdbe.org/3kdk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kdk RCSB], [http://www.ebi.ac.uk/pdbsum/3kdk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kdk ProSAT]</span></td></tr>
	</table>		</table>
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kd/3kdk_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kd/3kdk_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 34:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus globigii migula 1900~~]]	+	[[Category: Vibrio subtilis ehrenberg 1835]]
	[[Category: Guarne, A]]		[[Category: Guarne, A]]
	[[Category: Pillon, M C]]		[[Category: Pillon, M C]]

OCA at 10:47, 5 August 2016

OCA — Fri, 05 Aug 2016 10:47:19 GMT

←Older revision		Revision as of 10:47, 5 August 2016
Line 1:		Line 1:
		+
	==Structure of the C-terminal domain of Bacillus subtilis MutL bound to Zn2+==		==Structure of the C-terminal domain of Bacillus subtilis MutL bound to Zn2+==
	<StructureSection load='3kdk' size='340' side='right' caption='[[3kdk]], [[Resolution\|resolution]] 2.26Å' scene=''>		<StructureSection load='3kdk' size='340' side='right' caption='[[3kdk]], [[Resolution\|resolution]] 2.26Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kdk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bacillus_subtilis Bacillus subtilis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KDK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KDK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kdk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_globigii"_migula_1900 "bacillus globigii" migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KDK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KDK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gab\|3gab]], [[3kdg\|3kdg]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gab\|3gab]], [[3kdg\|3kdg]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BSU17050, mutL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus ~~subtilis~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BSU17050, mutL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Bacillus globigii" Migula 1900])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kdk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kdk RCSB], [http://www.ebi.ac.uk/pdbsum/3kdk PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kdk OCA], [http://pdbe.org/3kdk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kdk RCSB], [http://www.ebi.ac.uk/pdbsum/3kdk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kdk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kdk ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3kdk" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus ~~subtilis~~]]	+	[[Category: Bacillus globigii migula 1900]]
	[[Category: Guarne, A]]		[[Category: Guarne, A]]
	[[Category: Pillon, M C]]		[[Category: Pillon, M C]]

OCA at 18:09, 25 December 2014

OCA — Thu, 25 Dec 2014 18:09:10 GMT

←Older revision		Revision as of 18:09, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kdk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kdk RCSB], [http://www.ebi.ac.uk/pdbsum/3kdk PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kdk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kdk RCSB], [http://www.ebi.ac.uk/pdbsum/3kdk PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MUTL_BACSU MUTL_BACSU]] This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity). Overexpression of mutSL partially suppresses the high spontaneous mutation frequency of a ytkD/mutM/yfhQ triple disruption which lacks the system required to prevent damage by oxidized guanine (8-oxo-dGTP). This suggests that MutSL also functions to repair mismatches due to oxidative stress in both growing and stationary phase cells.<ref>PMID:19011023</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 16:43, 18 December 2014

OCA — Thu, 18 Dec 2014 16:43:26 GMT

←Older revision		Revision as of 16:43, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3kdk\| PDB=3kdk \| SCENE= }}~~	+	==Structure of the C-terminal domain of Bacillus subtilis MutL bound to Zn2+==
-	===Structure of the C-terminal domain of Bacillus subtilis MutL bound to Zn2+===	+	<StructureSection load='3kdk' size='340' side='right' caption='[[3kdk]], [[Resolution\|resolution]] 2.26Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20603082}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3kdk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KDK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KDK FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3gab\|3gab]], [[3kdg\|3kdg]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BSU17050, mutL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kdk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kdk RCSB], [http://www.ebi.ac.uk/pdbsum/3kdk PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kd/3kdk_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	DNA mismatch repair corrects errors that have escaped polymerase proofreading, increasing replication fidelity 100- to 1000-fold in organisms ranging from bacteria to humans. The MutL protein plays a central role in mismatch repair by coordinating multiple protein-protein interactions that signal strand removal upon mismatch recognition by MutS. Here we report the crystal structure of the endonuclease domain of Bacillus subtilis MutL. The structure is organized in dimerization and regulatory subdomains connected by a helical lever spanning the conserved endonuclease motif. Additional conserved motifs cluster around the lever and define a Zn(2+)-binding site that is critical for MutL function in vivo. The structure unveils a powerful inhibitory mechanism to prevent undesired nicking of newly replicated DNA and allows us to propose a model describing how the interaction with MutS and the processivity clamp could license the endonuclease activity of MutL. The structure also provides a molecular framework to propose and test additional roles of MutL in mismatch repair.

-	~~==About this~~ Structure==	+	Structure of the endonuclease domain of MutL: unlicensed to cut.,Pillon MC, Lorenowicz JJ, Uckelmann M, Klocko AD, Mitchell RR, Chung YS, Modrich P, Walker GC, Simmons LA, Friedhoff P, Guarne A Mol Cell. 2010 Jul 9;39(1):145-51. PMID:20603082<ref>PMID:20603082</ref>
-	~~[[3kdk]] is a 2 chain structure with sequence from [http~~:~~//en~~.~~wikipedia~~.~~org/wiki/Bacillus_subtilis Bacillus subtilis]~~. ~~Full crystallographic information is available from [http~~:/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3KDK OCA].~~	+

-	==~~Reference~~==	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~<ref group="xtra">PMID:020603082</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	</div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
-	[[Category: Guarne, A.]]	+	[[Category: Guarne, A]]
-	[[Category: Pillon, M C.]]	+	[[Category: Pillon, M C]]
	[[Category: Dna damage]]		[[Category: Dna damage]]
	[[Category: Dna repair]]		[[Category: Dna repair]]

OCA: Protected "3kdk" [edit=sysop:move=sysop]

OCA — Thu, 04 Apr 2013 02:23:58 GMT

Protected "3kdk" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:23, 4 April 2013

OCA at 02:23, 4 April 2013

OCA — Thu, 04 Apr 2013 02:23:57 GMT

←Older revision		Revision as of 02:23, 4 April 2013
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-	{{Seed}}
-	[[Image:3kdk.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3kdk", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3kdk\| PDB=3kdk \| SCENE= }}		{{STRUCTURE_3kdk\| PDB=3kdk \| SCENE= }}
-
	===Structure of the C-terminal domain of Bacillus subtilis MutL bound to Zn2+===		===Structure of the C-terminal domain of Bacillus subtilis MutL bound to Zn2+===
-
-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20603082}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20603082 is the PubMed ID number.
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	{{ABSTRACT_PUBMED_20603082}}		{{ABSTRACT_PUBMED_20603082}}

	==About this Structure==		==About this Structure==
-	~~3KDK~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KDK OCA].	+	[[3kdk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KDK OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20603082~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020603082</ref><references group="xtra"/><references/>
	[[Category: Bacillus subtilis]]		[[Category: Bacillus subtilis]]
	[[Category: Guarne, A.]]		[[Category: Guarne, A.]]
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	[[Category: Mutl]]		[[Category: Mutl]]
	[[Category: Zn-binding protein]]		[[Category: Zn-binding protein]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 25 08:27:06 2010''

OCA at 04:19, 25 August 2010

OCA — Wed, 25 Aug 2010 04:19:15 GMT

←Older revision		Revision as of 04:19, 25 August 2010
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	{{Seed}}		{{Seed}}
-	[[Image:3kdk.~~jpg~~\|left\|200px]]	+	[[Image:3kdk.png\|left\|200px]]

	<!--		<!--
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	[[Category: Zn-binding protein]]		[[Category: Zn-binding protein]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jul 21 10~~:17:06 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 25 08:27:06 2010''

OCA at 06:10, 21 July 2010

OCA — Wed, 21 Jul 2010 06:10:41 GMT

←Older revision		Revision as of 06:10, 21 July 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3kdk.jpg\|left\|200px]]

-	The ~~entry 3kdk~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3kdk", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3kdk\| PDB=3kdk \| SCENE= }}

-	~~Authors: Guarne, A., Pillon, M.~~C.	+	===Structure of the C-terminal domain of Bacillus subtilis MutL bound to Zn2+===

-	Description: Structure of the C-terminal domain of Bacillus subtilis MutL bound to Zn2+

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov 18 18~~:53:~~39 2009~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20603082}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20603082 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20603082}}
		+
		+	==About this Structure==
		+	3KDK is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KDK OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20603082</ref><references group="xtra"/>
		+	[[Category: Bacillus subtilis]]
		+	[[Category: Guarne, A.]]
		+	[[Category: Pillon, M C.]]
		+	[[Category: Dna damage]]
		+	[[Category: Dna repair]]
		+	[[Category: Endonuclease]]
		+	[[Category: Hydrolase]]
		+	[[Category: Mismatch repair]]
		+	[[Category: Mutl]]
		+	[[Category: Zn-binding protein]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 21 10:17:06 2010''

OCA at 16:53, 18 November 2009

OCA — Wed, 18 Nov 2009 16:53:40 GMT

←Older revision		Revision as of 16:53, 18 November 2009
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	The entry 3kdk is ON HOLD		The entry 3kdk is ON HOLD

-	Authors: ~~Pillon~~, MC, ~~Lorenowicz, JJ, Ucklemann~~, M~~, Klocko, AD, Mitchell, RR, Chung, YS, Walker, GC, Simmons, LA, Friedhoff, P, Guarne, A~~	+	Authors: Guarne, A., Pillon, M.C.

	Description: Structure of the C-terminal domain of Bacillus subtilis MutL bound to Zn2+		Description: Structure of the C-terminal domain of Bacillus subtilis MutL bound to Zn2+

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Oct 28 13~~:01:16 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 18 18:53:39 2009''