3kel - Revision history

OCA at 16:11, 1 November 2023

OCA — Wed, 01 Nov 2023 16:11:43 GMT

←Older revision		Revision as of 16:11, 1 November 2023
Line 1:		Line 1:

	==Crystal Structure of IspH:PP complex==		==Crystal Structure of IspH:PP complex==
-	<StructureSection load='3kel' size='340' side='right' caption='[[3kel]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='3kel' size='340' side='right'caption='[[3kel]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kel]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Ecoli Ecoli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3KEL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kel]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KEL FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f7t\|3f7t]]~~, [[~~3dnf~~\|~~3dnf]], [[3ke8\|3ke8]], [[3ke9\|3ke9]], [[3kef\|3kef]], [[3kem\|3kem~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>b0029, ispH, JW0027, lytB, yaaE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~83333 ECOLI])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kel OCA], [https://pdbe.org/3kel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kel RCSB], [https://www.ebi.ac.uk/pdbsum/3kel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kel ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[http~~:~~//en.wikipedia.org/wiki/4-hydroxy-3-methylbut-~~2-~~enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3kel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kel OCA], [~~http~~://pdbe.org/3kel PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3kel RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3kel PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3kel ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI]] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref>	+	[https://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 31:

	==See Also==		==See Also==
-	*[[4-hydroxy-3-methylbut-2-enyl diphosphate reductase\|4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]	+	*[[4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures\|4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: 4-~~hydroxy-3-methylbut-2-enyl diphosphate reductase~~]]	+	[[Category: Escherichia coli K-12]]
-	[[Category: ~~Ecoli~~]]	+	[[Category: Large Structures]]
-	[[Category: Bacher, A]]	+	[[Category: Bacher A]]
-	[[Category: Eisenreich, W]]	+	[[Category: Eisenreich W]]
-	[[Category: Graewert, T]]	+	[[Category: Graewert T]]
-	[[Category: Groll, M]]	+	[[Category: Groll M]]
-	[[Category: Span, I]]	+	[[Category: Span I]]
-	~~[[Category: Iron]]~~	+
-	~~[[Category: Iron-sulfur]]~~	+
-	~~[[Category: Iron-sulfure protein]]~~	+
-	~~[[Category: Isoprene biosynthesis]]~~	+
-	~~[[Category: Isph]]~~	+
-	~~[[Category: Lytb]]~~	+
-	~~[[Category: Malaria]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Nadp]]~~	+
-	~~[[Category: Non-mevalonic acid pathway]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Tuberculosis~~]]	+

OCA at 08:57, 26 December 2018

OCA — Wed, 26 Dec 2018 08:57:15 GMT

←Older revision		Revision as of 08:57, 26 December 2018
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ke/3kel_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ke/3kel_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:03, 5 August 2016

OCA — Fri, 05 Aug 2016 21:03:26 GMT

←Older revision		Revision as of 21:03, 5 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of IspH:PP complex==		==Crystal Structure of IspH:PP complex==
	<StructureSection load='3kel' size='340' side='right' caption='[[3kel]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3kel' size='340' side='right' caption='[[3kel]], [[Resolution\|resolution]] 1.80Å' scene=''>
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	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b0029, ispH, JW0027, lytB, yaaE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b0029, ispH, JW0027, lytB, yaaE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kel RCSB], [http://www.ebi.ac.uk/pdbsum/3kel PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kel OCA], [http://pdbe.org/3kel PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kel RCSB], [http://www.ebi.ac.uk/pdbsum/3kel PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kel ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kel ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3kel" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 21:53, 25 December 2014

OCA — Thu, 25 Dec 2014 21:53:09 GMT

←Older revision		Revision as of 21:53, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kel RCSB], [http://www.ebi.ac.uk/pdbsum/3kel PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kel RCSB], [http://www.ebi.ac.uk/pdbsum/3kel PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI]] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 16:16, 21 December 2014

OCA — Sun, 21 Dec 2014 16:16:40 GMT

←Older revision		Revision as of 16:16, 21 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3kel~~\| ~~PDB~~=3kel \| ~~SCENE~~= }}	+	==Crystal Structure of IspH:PP complex==
-	===~~Crystal Structure~~ of ~~IspH~~:~~PP complex~~===	+	<StructureSection load='3kel' size='340' side='right' caption='[[3kel]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20080550}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3kel]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KEL FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3f7t\|3f7t]], [[3dnf\|3dnf]], [[3ke8\|3ke8]], [[3ke9\|3ke9]], [[3kef\|3kef]], [[3kem\|3kem]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">b0029, ispH, JW0027, lytB, yaaE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/4-hydroxy-3-methylbut-2-enyl_diphosphate_reductase 4-hydroxy-3-methylbut-2-enyl diphosphate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.17.1.2 1.17.1.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kel RCSB], [http://www.ebi.ac.uk/pdbsum/3kel PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ke/3kel_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) represent the two central intermediates in the biosynthesis of isoprenoids. The recently discovered deoxyxylulose 5-phosphate pathway generates a mixture of IPP and DMAPP in its final step by reductive dehydroxylation of 1-hydroxy-2-methyl-2-butenyl 4-diphosphate. This conversion is catalyzed by IspH protein comprising a central iron-sulfur cluster as electron transfer cofactor in the active site. The five crystal structures of IspH in complex with substrate, converted substrate, products and PP(i) reported in this article provide unique insights into the mechanism of this enzyme. While IspH protein crystallizes with substrate bound to a [4Fe-4S] cluster, crystals of IspH in complex with IPP, DMAPP or inorganic pyrophosphate feature [3Fe-4S] clusters. The IspH:substrate complex reveals a hairpin conformation of the ligand with the C(1) hydroxyl group coordinated to the unique site in a [4Fe-4S] cluster of aconitase type. The resulting alkoxide complex is coupled to a hydrogen-bonding network, which serves as proton reservoir via a Thr167 proton relay. Prolonged x-ray irradiation leads to cleavage of the C(1)-O bond (initiated by reducing photo electrons). The data suggest a reaction mechanism involving a combination of Lewis-acid activation and proton coupled electron transfer. The resulting allyl radical intermediate can acquire a second electron via the iron-sulfur cluster. The reaction may be terminated by the transfer of a proton from the beta-phosphate of the substrate to C(1) (affording DMAPP) or C(3) (affording IPP).

-	~~==Function==~~	+	Probing the reaction mechanism of IspH protein by x-ray structure analysis.,Grawert T, Span I, Eisenreich W, Rohdich F, Eppinger J, Bacher A, Groll M Proc Natl Acad Sci U S A. 2010 Jan 19;107(3):1077-81. Epub 2009 Dec 28. PMID:20080550<ref>PMID:20080550</ref>
-	~~[[http://www~~.~~uniprot~~.~~org/uniprot/ISPH_ECOLI ISPH_ECOLI]] Converts 1-hydroxy-2-methyl-2-~~(E)-~~butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP)~~. ~~Is also involved in penicillin tolerance and control of the stringent response~~. ~~Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>~~PMID:~~19569147</ref>~~ <ref>PMID:20080550</ref> ~~<ref>PMID:22137895</ref>~~	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3kel]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Ecoli Ecoli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3KEL OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:020080550</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[4-hydroxy-3-methylbut-2-enyl diphosphate reductase\|4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]		[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
	[[Category: Ecoli]]		[[Category: Ecoli]]
-	[[Category: Bacher, A.]]	+	[[Category: Bacher, A]]
-	[[Category: Eisenreich, W.]]	+	[[Category: Eisenreich, W]]
-	[[Category: Graewert, T.]]	+	[[Category: Graewert, T]]
-	[[Category: Groll, M.]]	+	[[Category: Groll, M]]
-	[[Category: Span, I.]]	+	[[Category: Span, I]]
	[[Category: Iron]]		[[Category: Iron]]
	[[Category: Iron-sulfur]]		[[Category: Iron-sulfur]]

OCA at 05:58, 4 December 2013

OCA — Wed, 04 Dec 2013 05:58:07 GMT

←Older revision		Revision as of 05:58, 4 December 2013
Line 1:		Line 1:
	{{STRUCTURE_3kel\| PDB=3kel \| SCENE= }}		{{STRUCTURE_3kel\| PDB=3kel \| SCENE= }}
	===Crystal Structure of IspH:PP complex===		===Crystal Structure of IspH:PP complex===
-	{{~~ABSTRACT_PUBMED_020080550~~}}	+	{{ABSTRACT_PUBMED_20080550}}

	==Function==		==Function==
Line 7:		Line 7:

	==About this Structure==		==About this Structure==
-	[[3kel]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia coli~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEL OCA].	+	[[3kel]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEL OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:020080550</ref><references group="xtra"/><references/>		<ref group="xtra">PMID:020080550</ref><references group="xtra"/><references/>
	[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]		[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
-	[[Category: ~~Escherichia coli~~]]	+	[[Category: Ecoli]]
	[[Category: Bacher, A.]]		[[Category: Bacher, A.]]
	[[Category: Eisenreich, W.]]		[[Category: Eisenreich, W.]]

OCA: Protected "3kel" [edit=sysop:move=sysop]

OCA — Thu, 04 Apr 2013 02:09:58 GMT

Protected "3kel" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:09, 4 April 2013

OCA at 02:09, 4 April 2013

OCA — Thu, 04 Apr 2013 02:09:50 GMT

←Older revision		Revision as of 02:09, 4 April 2013
Line 1:		Line 1:
-	{{Seed}}
-	[[Image:3kel.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3kel", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3kel\| PDB=3kel \| SCENE= }}		{{STRUCTURE_3kel\| PDB=3kel \| SCENE= }}
-
	===Crystal Structure of IspH:PP complex===		===Crystal Structure of IspH:PP complex===
		+	{{ABSTRACT_PUBMED_020080550}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI]] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref>

	==About this Structure==		==About this Structure==
-	~~3KEL~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEL OCA].	+	[[3kel]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEL OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:020080550</ref><references group="xtra"/><references/>
	[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]		[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
Line 22:		Line 18:
	[[Category: Groll, M.]]		[[Category: Groll, M.]]
	[[Category: Span, I.]]		[[Category: Span, I.]]
-	[[Category: 3fe-4]]
	[[Category: Iron]]		[[Category: Iron]]
	[[Category: Iron-sulfur]]		[[Category: Iron-sulfur]]
Line 35:		Line 30:
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Tuberculosis]]		[[Category: Tuberculosis]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 13 14:39:12 2010''

OCA at 12:39, 13 January 2010

OCA — Wed, 13 Jan 2010 12:39:13 GMT

←Older revision		Revision as of 12:39, 13 January 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3kel.jpg\|left\|200px]]

-	The ~~entry 3kel~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3kel", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3kel\| PDB=3kel \| SCENE= }}

-	~~Authors~~: ~~Groll, M., Graewert, T., Span, I., Eisenreich, W., Bacher, A.~~	+	===Crystal Structure of IspH:PP complex===

-	Description: Crystal Structure of IspH:PP complex

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov 18 18~~:54:~~14 2009~~''	+	==About this Structure==
		+	3KEL is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEL OCA].
		+	[[Category: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase]]
		+	[[Category: Escherichia coli]]
		+	[[Category: Bacher, A.]]
		+	[[Category: Eisenreich, W.]]
		+	[[Category: Graewert, T.]]
		+	[[Category: Groll, M.]]
		+	[[Category: Span, I.]]
		+	[[Category: 3fe-4]]
		+	[[Category: Iron]]
		+	[[Category: Iron-sulfur]]
		+	[[Category: Iron-sulfure protein]]
		+	[[Category: Isoprene biosynthesis]]
		+	[[Category: Isph]]
		+	[[Category: Lytb]]
		+	[[Category: Malaria]]
		+	[[Category: Metal-binding]]
		+	[[Category: Nadp]]
		+	[[Category: Non-mevalonic acid pathway]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Tuberculosis]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 13 14:39:12 2010''

OCA: New page: '''Unreleased structure''' The entry 3kel is ON HOLD until Paper Publication Authors: Groll, M., Graewert, T., Span, I., Eisenreich, W., Bacher, A. Description: Crystal Structure of Is...

OCA — Wed, 18 Nov 2009 16:54:14 GMT

New page: '''Unreleased structure''' The entry 3kel is ON HOLD until Paper Publication Authors: Groll, M., Graewert, T., Span, I., Eisenreich, W., Bacher, A. Description: Crystal Structure of Is...

New page

'''Unreleased structure'''

The entry 3kel is ON HOLD until Paper Publication

Authors: Groll, M., Graewert, T., Span, I., Eisenreich, W., Bacher, A.

Description: Crystal Structure of IspH:PP complex

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 18 18:54:14 2009''