3kgq - Revision history

OCA at 16:12, 1 November 2023

OCA — Wed, 01 Nov 2023 16:12:42 GMT

←Older revision		Revision as of 16:12, 1 November 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[3kgq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KGQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[3kgq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KGQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACN:ACETONE'>ACN</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Carboxypeptidase_A Carboxypeptidase A], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.1 3.4.17.1] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACN:ACETONE'>ACN</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kgq OCA], [https://pdbe.org/3kgq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kgq RCSB], [https://www.ebi.ac.uk/pdbsum/3kgq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kgq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kgq OCA], [https://pdbe.org/3kgq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kgq RCSB], [https://www.ebi.ac.uk/pdbsum/3kgq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kgq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CBPA1_BOVIN CBPA1_BOVIN]] Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (By similarity).	+	[https://www.uniprot.org/uniprot/CBPA1_BOVIN CBPA1_BOVIN] Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
-	[[Category: Carboxypeptidase A]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Aviles~~, F X~~]]	+	[[Category: Aviles FX]]
-	[[Category: Boix, E]]	+	[[Category: Boix E]]
-	[[Category: Fernandez, D]]	+	[[Category: Fernandez D]]
-	[[Category: Pallares, I]]	+	[[Category: Pallares I]]
-	[[Category: Vendrell, J]]	+	[[Category: Vendrell J]]
-	~~[[Category: Carboxypeptidase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Intestinal protease]]~~	+
-	~~[[Category: Metal-binding]]~~	+
-	~~[[Category: Metalloprotease]]~~	+
-	~~[[Category: Zinc-metallocarboxypeptidase-citrate ternary complex~~]]	+

OCA at 05:40, 13 July 2022

OCA — Wed, 13 Jul 2022 05:40:16 GMT

←Older revision		Revision as of 05:40, 13 July 2022
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	<StructureSection load='3kgq' size='340' side='right'caption='[[3kgq]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3kgq' size='340' side='right'caption='[[3kgq]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kgq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KGQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=3KGQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kgq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KGQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACN:ACETONE'>ACN</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACN:ACETONE'>ACN</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Carboxypeptidase_A Carboxypeptidase A], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.1 3.4.17.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Carboxypeptidase_A Carboxypeptidase A], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.1 3.4.17.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=3kgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kgq OCA], [~~http~~://pdbe.org/3kgq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3kgq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3kgq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3kgq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kgq OCA], [https://pdbe.org/3kgq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kgq RCSB], [https://www.ebi.ac.uk/pdbsum/3kgq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kgq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CBPA1_BOVIN CBPA1_BOVIN]] Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (By similarity).	+	[[https://www.uniprot.org/uniprot/CBPA1_BOVIN CBPA1_BOVIN]] Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:01, 7 October 2020

OCA — Wed, 07 Oct 2020 07:01:43 GMT

←Older revision		Revision as of 07:01, 7 October 2020
Line 1:		Line 1:

	==Carboxypeptidase A liganded to an organic small-molecule: conformational changes==		==Carboxypeptidase A liganded to an organic small-molecule: conformational changes==
-	<StructureSection load='3kgq' size='340' side='right' caption='[[3kgq]], [[Resolution\|resolution]] 1.70Å' scene=''>	+	<StructureSection load='3kgq' size='340' side='right'caption='[[3kgq]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kgq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KGQ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3KGQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kgq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KGQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3KGQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACN:ACETONE'>ACN</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACN:ACETONE'>ACN</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_A Carboxypeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.1 3.4.17.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_A Carboxypeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.1 3.4.17.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3kgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kgq OCA], [http://pdbe.org/3kgq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kgq RCSB], [http://www.ebi.ac.uk/pdbsum/3kgq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kgq ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3kgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kgq OCA], [http://pdbe.org/3kgq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kgq RCSB], [http://www.ebi.ac.uk/pdbsum/3kgq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kgq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Carboxypeptidase\|Carboxypeptidase]]	+	*[[Carboxypeptidase 3D structures\|Carboxypeptidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Carboxypeptidase A]]		[[Category: Carboxypeptidase A]]
		+	[[Category: Large Structures]]
	[[Category: Aviles, F X]]		[[Category: Aviles, F X]]
	[[Category: Boix, E]]		[[Category: Boix, E]]

OCA at 08:59, 4 August 2016

OCA — Thu, 04 Aug 2016 08:59:39 GMT

←Older revision		Revision as of 08:59, 4 August 2016
Line 1:		Line 1:
		+
	==Carboxypeptidase A liganded to an organic small-molecule: conformational changes==		==Carboxypeptidase A liganded to an organic small-molecule: conformational changes==
	<StructureSection load='3kgq' size='340' side='right' caption='[[3kgq]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='3kgq' size='340' side='right' caption='[[3kgq]], [[Resolution\|resolution]] 1.70Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACN:ACETONE'>ACN</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACN:ACETONE'>ACN</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_A Carboxypeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.1 3.4.17.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_A Carboxypeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.1 3.4.17.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kgq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kgq RCSB], [http://www.ebi.ac.uk/pdbsum/3kgq PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kgq OCA], [http://pdbe.org/3kgq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kgq RCSB], [http://www.ebi.ac.uk/pdbsum/3kgq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kgq ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 18:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3kgq" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 07:35, 25 December 2014

OCA — Thu, 25 Dec 2014 07:35:49 GMT

←Older revision		Revision as of 07:35, 25 December 2014
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kgq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kgq RCSB], [http://www.ebi.ac.uk/pdbsum/3kgq PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kgq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kgq RCSB], [http://www.ebi.ac.uk/pdbsum/3kgq PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CBPA1_BOVIN CBPA1_BOVIN]] Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 16:08, 18 December 2014

OCA — Thu, 18 Dec 2014 16:08:32 GMT

←Older revision		Revision as of 16:08, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3kgq\| PDB=3kgq \| SCENE= }}~~	+	==Carboxypeptidase A liganded to an organic small-molecule: conformational changes==
-	===Carboxypeptidase A liganded to an organic small-molecule: conformational changes===	+	<StructureSection load='3kgq' size='340' side='right' caption='[[3kgq]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~{{ABSTRACT_PUBMED_21804935}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3kgq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KGQ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACN:ACETONE'>ACN</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_A Carboxypeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.1 3.4.17.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kgq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kgq RCSB], [http://www.ebi.ac.uk/pdbsum/3kgq PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A high-resolution carboxypeptidase-Zn(2+)-citrate complex was studied by X-ray diffraction and enzyme kinetics for the first time. The citrate molecule acts as a competitive inhibitor of this benchmark zinc-dependent peptidase, chelating the catalytic zinc ion in the active site of the enzyme and inducing a conformational change such that carboxypeptidase adopts the conformation expected to occur by substrate binding. Citrate adopts an extended conformation with half of the molecule facing the zinc ion, while the other half is docked in the S1' hydrophobic specificity pocket of the enzyme, in contrast with the binding mode expected for a substrate like phenylalanine or a peptidomimetic inhibitor like benzylsuccinic acid. Combined structural and enzymatic analysis describes the characteristics of the binding of this ligand that, acting against physiologically relevant zinc-dependent proteases, may serve as a general model in the design of new drug-protecting molecules for the oral delivery of drugs of peptide origin.

-	~~==Function==~~	+	Structural and Functional Analysis of the Complex between Citrate and the Zinc Peptidase Carboxypeptidase A.,Fernandez D, Boix E, Pallares I, Aviles FX, Vendrell J Enzyme Res. 2011;2011:128676. doi: 10.4061/2011/128676. Epub 2011 Jul 25. PMID:21804935<ref>PMID:21804935</ref>
-	~~[[http://www.uniprot.org/uniprot/CBPA1_BOVIN CBPA1_BOVIN]] Carboxypeptidase that catalyzes the release~~ of ~~a C-terminal amino acid~~, ~~but has little or no action with -Asp~~, ~~-Glu~~, ~~-Arg~~, ~~-Lys or -Pro (By similarity)~~.	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3kgq]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3KGQ OCA].~~	+	</div>

-	==~~Reference~~==	+	==See Also==
-	~~<ref group~~=~~"xtra">PMID:021804935</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	*[[Carboxypeptidase\|Carboxypeptidase]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Carboxypeptidase A]]		[[Category: Carboxypeptidase A]]
-	[[Category: Aviles, F X.]]	+	[[Category: Aviles, F X]]
-	[[Category: Boix, E.]]	+	[[Category: Boix, E]]
-	[[Category: Fernandez, D.]]	+	[[Category: Fernandez, D]]
-	[[Category: Pallares, I.]]	+	[[Category: Pallares, I]]
-	[[Category: Vendrell, J.]]	+	[[Category: Vendrell, J]]
	[[Category: Carboxypeptidase]]		[[Category: Carboxypeptidase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 15:45, 19 June 2013

OCA — Wed, 19 Jun 2013 15:45:23 GMT

←Older revision		Revision as of 15:45, 19 June 2013
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-	[[Image:3kgq.png\|left\|200px]]
-
	{{STRUCTURE_3kgq\| PDB=3kgq \| SCENE= }}		{{STRUCTURE_3kgq\| PDB=3kgq \| SCENE= }}
-
	===Carboxypeptidase A liganded to an organic small-molecule: conformational changes===		===Carboxypeptidase A liganded to an organic small-molecule: conformational changes===
		+	{{ABSTRACT_PUBMED_21804935}}

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/CBPA1_BOVIN CBPA1_BOVIN]] Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (By similarity).

	==About this Structure==		==About this Structure==
	[[3kgq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KGQ OCA].		[[3kgq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KGQ OCA].

-	==~~See Also~~==	+	==Reference==
-	*[[Carboxypeptidase\|Carboxypeptidase]]	+	<ref group="xtra">PMID:021804935</ref><references group="xtra"/><references/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Carboxypeptidase A]]		[[Category: Carboxypeptidase A]]

OCA at 14:15, 20 October 2012

OCA — Sat, 20 Oct 2012 14:15:25 GMT

←Older revision		Revision as of 14:15, 20 October 2012
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	==About this Structure==		==About this Structure==
-	[[3kgq]] is a 1 chain structure ~~of [[Carboxypeptidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KGQ OCA].	+	[[3kgq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KGQ OCA].

	==See Also==		==See Also==

OCA at 14:33, 26 July 2012

OCA — Thu, 26 Jul 2012 14:33:20 GMT

←Older revision		Revision as of 14:33, 26 July 2012
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	[[Image:3kgq.png\|left\|200px]]		[[Image:3kgq.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3kgq", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
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	{{STRUCTURE_3kgq\| PDB=3kgq \| SCENE= }}		{{STRUCTURE_3kgq\| PDB=3kgq \| SCENE= }}

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	==About this Structure==		==About this Structure==
-	[[3kgq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KGQ OCA].	+	[[3kgq]] is a 1 chain structure of [[Carboxypeptidase]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KGQ OCA].
		+
		+	==See Also==
		+	*[[Carboxypeptidase\|Carboxypeptidase]]
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Carboxypeptidase A]]		[[Category: Carboxypeptidase A]]

OCA: Protected "3kgq" [edit=sysop:move=sysop]

OCA — Wed, 03 Aug 2011 08:04:45 GMT

Protected "3kgq" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:04, 3 August 2011