3ki2 - Revision history

OCA at 08:16, 6 September 2023

OCA — Wed, 06 Sep 2023 08:16:24 GMT

←Older revision		Revision as of 08:16, 6 September 2023
Line 3:		Line 3:
	<StructureSection load='3ki2' size='340' side='right'caption='[[3ki2]], [[Resolution\|resolution]] 1.28Å' scene=''>		<StructureSection load='3ki2' size='340' side='right'caption='[[3ki2]], [[Resolution\|resolution]] 1.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ki2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KI2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ki2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KI2 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=G9G:2~~-~~(4-METHYLPIPERAZIN-1-YL)BENZO[C][1~~,~~5]NAPHTHYRIDIN-6(5H)-ONE'>G9G</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.28Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>~~[[~~Related_structure~~\|~~Related:~~]]~~</b></td><td class="sblockDat"><div style='overflow: auto~~; ~~max-height: 3em;'>[[3ess\|3ess]], [[2q6m\|2q6m]], [[2q5t\|2q5t]], [[3ki0\|3ki0]], [[3ki1\|3ki1]], [[3ki3\|3ki3]], [[3ki4\|3ki4]], [[3ki5\|3ki5]], [[3ki6\|3ki6]], [[3ki7\|3ki7]]</div>~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G9G:2-(4-METHYLPIPERAZIN-1-YL)BENZO[C][1,5]NAPHTHYRIDIN-6(5H)-ONE'>G9G</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>chxa, toxA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~666~~ "~~Bacillo virgola del Koch~~" ~~Trevisan 1884])</td~~><~~/tr>~~	+
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/NAD~~(+)--~~diphthamide_ADP~~-~~ribosyltransferase NAD(+~~)~~--diphthamide ADP-ribosyltransferase~~], ~~with EC number [https://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=2.4.2.36 2.4.2.36]~~ </~~span~~></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ki2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ki2 OCA], [https://pdbe.org/3ki2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ki2 RCSB], [https://www.ebi.ac.uk/pdbsum/3ki2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ki2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ki2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ki2 OCA], [https://pdbe.org/3ki2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ki2 RCSB], [https://www.ebi.ac.uk/pdbsum/3ki2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ki2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/CHXA_VIBCL CHXA_VIBCL]] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref>	+	[https://www.uniprot.org/uniprot/CHXA_VIBCL CHXA_VIBCL] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref>

	==See Also==		==See Also==
Line 19:		Line 17:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillo virgola del koch trevisan 1884]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Edwards, P R~~]]	+	[[Category: Vibrio cholerae]]
-	[[Category: ~~Jorgensen, R~~]]	+	[[Category: Edwards PR]]
-	[[Category: ~~Merrill, A~~ R]]	+	[[Category: Jorgensen R]]
-	[[Category: ~~Adp-ribosyl transferase]]~~	+	[[Category: Merrill AR]]
-	~~[[Category: Alpha-beta complex]]~~	+
-	~~[[Category: Diphthamide]]~~	+
-	~~[[Category: Toxin]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 13:35, 4 May 2022

OCA — Wed, 04 May 2022 13:35:11 GMT

←Older revision		Revision as of 13:35, 4 May 2022
Line 1:		Line 1:

	==Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-G==		==Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-G==
-	<StructureSection load='3ki2' size='340' side='right' caption='[[3ki2]], [[Resolution\|resolution]] 1.28Å' scene=''>	+	<StructureSection load='3ki2' size='340' side='right'caption='[[3ki2]], [[Resolution\|resolution]] 1.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ki2]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KI2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3KI2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ki2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KI2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G9G:2-(4-METHYLPIPERAZIN-1-YL)BENZO[C][1,5]NAPHTHYRIDIN-6(5H)-ONE'>G9G</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=G9G:2-(4-METHYLPIPERAZIN-1-YL)BENZO[C][1,5]NAPHTHYRIDIN-6(5H)-ONE'>G9G</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ess\|3ess]], [[2q6m\|2q6m]], [[2q5t\|2q5t]], [[3ki0\|3ki0]], [[3ki1\|3ki1]], [[3ki3\|3ki3]], [[3ki4\|3ki4]], [[3ki5\|3ki5]], [[3ki6\|3ki6]], [[3ki7\|3ki7]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ess\|3ess]], [[2q6m\|2q6m]], [[2q5t\|2q5t]], [[3ki0\|3ki0]], [[3ki1\|3ki1]], [[3ki3\|3ki3]], [[3ki4\|3ki4]], [[3ki5\|3ki5]], [[3ki6\|3ki6]], [[3ki7\|3ki7]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">chxa, toxA ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=666 "Bacillo virgola del Koch" Trevisan 1884])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">chxa, toxA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=666 "Bacillo virgola del Koch" Trevisan 1884])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/NAD(+)--diphthamide_ADP-ribosyltransferase NAD(+)--diphthamide ADP-ribosyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.36 2.4.2.36] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/NAD(+)--diphthamide_ADP-ribosyltransferase NAD(+)--diphthamide ADP-ribosyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.36 2.4.2.36] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3ki2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ki2 OCA], [~~http~~://pdbe.org/3ki2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3ki2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3ki2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3ki2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ki2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ki2 OCA], [https://pdbe.org/3ki2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ki2 RCSB], [https://www.ebi.ac.uk/pdbsum/3ki2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ki2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/CHXA_VIBCL CHXA_VIBCL]] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref>	+	[[https://www.uniprot.org/uniprot/CHXA_VIBCL CHXA_VIBCL]] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref>

	==See Also==		==See Also==
-	*[[Exotoxin\|Exotoxin]]	+	*[[Exotoxin 3D structures\|Exotoxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 20:		Line 20:
	</StructureSection>		</StructureSection>
	[[Category: Bacillo virgola del koch trevisan 1884]]		[[Category: Bacillo virgola del koch trevisan 1884]]
		+	[[Category: Large Structures]]
	[[Category: Edwards, P R]]		[[Category: Edwards, P R]]
	[[Category: Jorgensen, R]]		[[Category: Jorgensen, R]]

OCA at 21:19, 4 August 2016

OCA — Thu, 04 Aug 2016 21:19:15 GMT

←Older revision		Revision as of 21:19, 4 August 2016
Line 1:		Line 1:
		+
	==Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-G==		==Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-G==
	<StructureSection load='3ki2' size='340' side='right' caption='[[3ki2]], [[Resolution\|resolution]] 1.28Å' scene=''>		<StructureSection load='3ki2' size='340' side='right' caption='[[3ki2]], [[Resolution\|resolution]] 1.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3ki2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Vibrio_cholerae Vibrio cholerae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KI2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KI2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3ki2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KI2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KI2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G9G:2-(4-METHYLPIPERAZIN-1-YL)BENZO[C][1,5]NAPHTHYRIDIN-6(5H)-ONE'>G9G</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G9G:2-(4-METHYLPIPERAZIN-1-YL)BENZO[C][1,5]NAPHTHYRIDIN-6(5H)-ONE'>G9G</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ess\|3ess]], [[2q6m\|2q6m]], [[2q5t\|2q5t]], [[3ki0\|3ki0]], [[3ki1\|3ki1]], [[3ki3\|3ki3]], [[3ki4\|3ki4]], [[3ki5\|3ki5]], [[3ki6\|3ki6]], [[3ki7\|3ki7]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ess\|3ess]], [[2q6m\|2q6m]], [[2q5t\|2q5t]], [[3ki0\|3ki0]], [[3ki1\|3ki1]], [[3ki3\|3ki3]], [[3ki4\|3ki4]], [[3ki5\|3ki5]], [[3ki6\|3ki6]], [[3ki7\|3ki7]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">chxa, toxA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=666 ~~Vibrio cholerae~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">chxa, toxA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=666 "Bacillo virgola del Koch" Trevisan 1884])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)--diphthamide_ADP-ribosyltransferase NAD(+)--diphthamide ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.36 2.4.2.36] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)--diphthamide_ADP-ribosyltransferase NAD(+)--diphthamide ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.36 2.4.2.36] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ki2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ki2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ki2 RCSB], [http://www.ebi.ac.uk/pdbsum/3ki2 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ki2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ki2 OCA], [http://pdbe.org/3ki2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ki2 RCSB], [http://www.ebi.ac.uk/pdbsum/3ki2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ki2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~Q5EK40_VIBCH Q5EK40_VIBCH~~]] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref>	+	[[http://www.uniprot.org/uniprot/CHXA_VIBCL CHXA_VIBCL]] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref>

	==See Also==		==See Also==
Line 18:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Vibrio cholerae~~]]	+	[[Category: Bacillo virgola del koch trevisan 1884]]
	[[Category: Edwards, P R]]		[[Category: Edwards, P R]]
	[[Category: Jorgensen, R]]		[[Category: Jorgensen, R]]

OCA at 13:14, 25 December 2014

OCA — Thu, 25 Dec 2014 13:14:13 GMT

←Older revision		Revision as of 13:14, 25 December 2014
Line 9:		Line 9:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ki2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ki2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ki2 RCSB], [http://www.ebi.ac.uk/pdbsum/3ki2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ki2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ki2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ki2 RCSB], [http://www.ebi.ac.uk/pdbsum/3ki2 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q5EK40_VIBCH Q5EK40_VIBCH]] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref>

	==See Also==		==See Also==
	*[[Exotoxin\|Exotoxin]]		*[[Exotoxin\|Exotoxin]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 14:49, 18 December 2014

OCA — Thu, 18 Dec 2014 14:49:35 GMT

←Older revision		Revision as of 14:49, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3ki2\| PDB=3ki2 \| SCENE= }}~~	+	==Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-G==
-	===Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-G===	+	<StructureSection load='3ki2' size='340' side='right' caption='[[3ki2]], [[Resolution\|resolution]] 1.28Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3ki2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KI2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KI2 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G9G:2-(4-METHYLPIPERAZIN-1-YL)BENZO[C][1,5]NAPHTHYRIDIN-6(5H)-ONE'>G9G</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ess\|3ess]], [[2q6m\|2q6m]], [[2q5t\|2q5t]], [[3ki0\|3ki0]], [[3ki1\|3ki1]], [[3ki3\|3ki3]], [[3ki4\|3ki4]], [[3ki5\|3ki5]], [[3ki6\|3ki6]], [[3ki7\|3ki7]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">chxa, toxA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=666 Vibrio cholerae])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)--diphthamide_ADP-ribosyltransferase NAD(+)--diphthamide ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.36 2.4.2.36] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ki2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ki2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ki2 RCSB], [http://www.ebi.ac.uk/pdbsum/3ki2 PDBsum]</span></td></tr>
		+	</table>

-	==~~Function~~==	+	==See Also==
-	[[~~http://www.uniprot.org/uniprot/Q5EK40_VIBCH Q5EK40_VIBCH~~]] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref>	+	*[[Exotoxin\|Exotoxin]]
-		+	__TOC__
-	~~==About this Structure==~~	+	</StructureSection>
-	[[3ki2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KI2 OCA].	+
-		+
-	~~==Reference==~~	+
-	~~<references group="xtra"/>~~<~~references~~/>	+
	[[Category: Vibrio cholerae]]		[[Category: Vibrio cholerae]]
-	[[Category: Edwards, P R.]]	+	[[Category: Edwards, P R]]
-	[[Category: Jorgensen, R.]]	+	[[Category: Jorgensen, R]]
-	[[Category: Merrill, A R.]]	+	[[Category: Merrill, A R]]
	[[Category: Adp-ribosyl transferase]]		[[Category: Adp-ribosyl transferase]]
	[[Category: Alpha-beta complex]]		[[Category: Alpha-beta complex]]

OCA: Protected "3ki2" [edit=sysop:move=sysop]

OCA — Thu, 04 Apr 2013 02:13:39 GMT

Protected "3ki2" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:13, 4 April 2013

OCA at 02:13, 4 April 2013

OCA — Thu, 04 Apr 2013 02:13:37 GMT

←Older revision		Revision as of 02:13, 4 April 2013
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-	{{Seed}}
-	[[Image:3ki2.jpg\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3ki2", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3ki2\| PDB=3ki2 \| SCENE= }}		{{STRUCTURE_3ki2\| PDB=3ki2 \| SCENE= }}
-
	===Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-G===		===Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-G===

		+	==Function==
		+	[[http://www.uniprot.org/uniprot/Q5EK40_VIBCH Q5EK40_VIBCH]] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref>

	==About this Structure==		==About this Structure==
-	~~3KI2~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KI2 OCA].	+	[[3ki2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KI2 OCA].
		+
		+	==Reference==
		+	<references group="xtra"/><references/>
	[[Category: Vibrio cholerae]]		[[Category: Vibrio cholerae]]
	[[Category: Edwards, P R.]]		[[Category: Edwards, P R.]]
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	[[Category: Toxin]]		[[Category: Toxin]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 27 12:08:37 2010''

OCA at 08:58, 27 October 2010

OCA — Wed, 27 Oct 2010 08:58:15 GMT

←Older revision		Revision as of 08:58, 27 October 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3ki2.jpg\|left\|200px]]

-	The ~~entry 3ki2~~ is ~~ON HOLD~~ ~~until Oct 25 2011~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3ki2", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3ki2\| PDB=3ki2 \| SCENE= }}

-	~~Authors: Jorgensen, R., Edwards, P.R., Merrill, A.R.~~	+	===Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-G===

-	Description: Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-G

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct ~~13 10~~:26:47 2010''	+	==About this Structure==
		+	3KI2 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KI2 OCA].
		+	[[Category: Vibrio cholerae]]
		+	[[Category: Edwards, P R.]]
		+	[[Category: Jorgensen, R.]]
		+	[[Category: Merrill, A R.]]
		+	[[Category: Adp-ribosyl transferase]]
		+	[[Category: Alpha-beta complex]]
		+	[[Category: Diphthamide]]
		+	[[Category: Toxin]]
		+	[[Category: Transferase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 27 12:08:37 2010''

OCA at 07:16, 13 October 2010

OCA — Wed, 13 Oct 2010 07:16:59 GMT

←Older revision		Revision as of 07:16, 13 October 2010
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3ki2 is ON HOLD until ~~Paper Publication~~	+	The entry 3ki2 is ON HOLD until Oct 25 2011

	Authors: Jorgensen, R., Edwards, P.R., Merrill, A.R.		Authors: Jorgensen, R., Edwards, P.R., Merrill, A.R.
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	Description: Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-G		Description: Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-G

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov 25 09~~:12:~~51 2009~~''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 13 10:26:47 2010''

OCA at 07:12, 25 November 2009

OCA — Wed, 25 Nov 2009 07:12:51 GMT

←Older revision		Revision as of 07:12, 25 November 2009
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 3ki2 is ON HOLD	+	The entry 3ki2 is ON HOLD until Paper Publication

	Authors: Jorgensen, R., Edwards, P.R., Merrill, A.R.		Authors: Jorgensen, R., Edwards, P.R., Merrill, A.R.
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	Description: Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-G		Description: Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-G

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov ~~18 18~~:56:26 2009''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 25 09:12:51 2009''