3kjn - Revision history

OCA at 09:48, 26 December 2018

OCA — Wed, 26 Dec 2018 09:48:15 GMT

←Older revision		Revision as of 09:48, 26 December 2018
Line 18:		Line 18:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kj/3kjn_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kj/3kjn_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:50, 5 August 2016

OCA — Fri, 05 Aug 2016 07:50:46 GMT

←Older revision		Revision as of 07:50, 5 August 2016
Line 1:		Line 1:
		+
	==Caspase 8 bound to a covalent inhibitor==		==Caspase 8 bound to a covalent inhibitor==
	<StructureSection load='3kjn' size='340' side='right' caption='[[3kjn]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='3kjn' size='340' side='right' caption='[[3kjn]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kjn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KJN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kjn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KJN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B93:(3S)-3-({[(5S)-2-{2-[(1H-BENZIMIDAZOL-5-YLCARBONYL)AMINO]ETHYL}-7-(CYCLOHEXYLMETHYL)-1,3-DIOXO-2,3,5,8-TETRAHYDRO-1H-[1,2,4]TRIAZOLO[1,2-A]PYRIDAZIN-5-YL]CARBONYL}AMINO)-4-OXOPENTANOIC+ACID'>B93</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B93:(3S)-3-({[(5S)-2-{2-[(1H-BENZIMIDAZOL-5-YLCARBONYL)AMINO]ETHYL}-7-(CYCLOHEXYLMETHYL)-1,3-DIOXO-2,3,5,8-TETRAHYDRO-1H-[1,2,4]TRIAZOLO[1,2-A]PYRIDAZIN-5-YL]CARBONYL}AMINO)-4-OXOPENTANOIC+ACID'>B93</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kjf\|3kjf]], [[3kjq\|3kjq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kjf\|3kjf]], [[3kjq\|3kjq]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP8, MCH5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP8, MCH5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-8 Caspase-8], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.61 3.4.22.61] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-8 Caspase-8], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.61 3.4.22.61] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kjn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kjn RCSB], [http://www.ebi.ac.uk/pdbsum/3kjn PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kjn OCA], [http://pdbe.org/3kjn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kjn RCSB], [http://www.ebi.ac.uk/pdbsum/3kjn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kjn ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 22:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kjn ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 31:		Line 32:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3kjn" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 39:		Line 41:
	</StructureSection>		</StructureSection>
	[[Category: Caspase-8]]		[[Category: Caspase-8]]
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Blinn, J]]		[[Category: Blinn, J]]
	[[Category: Finzel, B C]]		[[Category: Finzel, B C]]

OCA at 18:02, 18 December 2014

OCA — Thu, 18 Dec 2014 18:02:17 GMT

←Older revision		Revision as of 18:02, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3kjn~~\| ~~PDB~~=3kjn \| ~~SCENE~~= }}	+	==Caspase 8 bound to a covalent inhibitor==
-	===Caspase 8 ~~bound to~~ a ~~covalent inhibitor~~===	+	<StructureSection load='3kjn' size='340' side='right' caption='[[3kjn]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20580860}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3kjn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KJN FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B93:(3S)-3-({[(5S)-2-{2-[(1H-BENZIMIDAZOL-5-YLCARBONYL)AMINO]ETHYL}-7-(CYCLOHEXYLMETHYL)-1,3-DIOXO-2,3,5,8-TETRAHYDRO-1H-[1,2,4]TRIAZOLO[1,2-A]PYRIDAZIN-5-YL]CARBONYL}AMINO)-4-OXOPENTANOIC+ACID'>B93</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kjf\|3kjf]], [[3kjq\|3kjq]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CASP8, MCH5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-8 Caspase-8], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.61 3.4.22.61] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kjn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kjn RCSB], [http://www.ebi.ac.uk/pdbsum/3kjn PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/CASP8_HUMAN CASP8_HUMAN]] Defects in CASP8 are the cause of caspase-8 deficiency (CASP8D) [MIM:[http://omim.org/entry/607271 607271]]. CASP8D is a disorder resembling autoimmune lymphoproliferative syndrome (ALPS). It is characterized by lymphadenopathy, splenomegaly, and defective CD95-induced apoptosis of peripheral blood lymphocytes (PBLs). It leads to defects in activation of T-lymphocytes, B-lymphocytes, and natural killer cells leading to immunodeficiency characterized by recurrent sinopulmonary and herpes simplex virus infections and poor responses to immunization.<ref>PMID:12353035</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CASP8_HUMAN CASP8_HUMAN]] Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-\|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.<ref>PMID:12010809</ref> <ref>PMID:9006941</ref>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kj/3kjn_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Because of their central role in programmed cell death, the caspases are attractive targets for developing new therapeutics against cancer and autoimmunity, myocardial infarction and ischemic damage, and neurodegenerative diseases. We chose to target caspase-3, an executioner caspase, and caspase-8, an initiator caspase, based on the vast amount of information linking their functions to diseases. Through a structure-based drug design approach, a number of novel beta-strand peptidomimetic compounds were synthesized. Kinetic studies of caspase-3 and caspase-8 inhibition were carried out with these urazole ring-containing irreversible peptidomimetics and a known irreversible caspase inhibitor, Z-VAD-fmk. Using a stopped-flow fluorescence assay, we were able to determine individual kinetic parameters of caspase-3 and caspase-8 inhibition by these inhibitors. Z-VAD-fmk and the peptidomimetic inhibitors inhibit caspase-3 and caspase-8 via a three-step kinetic mechanism. Inhibition of both caspase-3 and caspase-8 by Z-VAD-fmk and of caspase-3 by the peptidomimetic inhibitors proceeds via two rapid equilibrium steps followed by a relatively fast inactivation step. However, caspase-8 inhibition by the peptidomimetics goes through a rapid equilibrium step, a slow-binding reversible step, and an extremely slow inactivation step. The crystal structures of inhibitor complexes of caspases-3 and -8 validate the design of the inhibitors by illustrating in detail how they mimic peptide substrates. One of the caspase-8 structures also shows binding at a secondary, allosteric site, providing a possible route to the development of noncovalent small molecule modulators of caspase activity.

-	~~==Disease==~~	+	Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors.,Wang Z, Watt W, Brooks NA, Harris MS, Urban J, Boatman D, McMillan M, Kahn M, Heinrikson RL, Finzel BC, Wittwer AJ, Blinn J, Kamtekar S, Tomasselli AG Biochim Biophys Acta. 2010 Sep;1804(9):1817-1831. Epub 2010 May 24. PMID:20580860<ref>PMID:20580860</ref>
-	~~[[http://www.uniprot.org/uniprot/CASP8_HUMAN CASP8_HUMAN]] Defects in CASP8 are the cause~~ of caspase-8 ~~deficiency (CASP8D) [MIM:[http://omim.org/entry/607271 607271]]. CASP8D is~~ a ~~disorder resembling autoimmune lymphoproliferative syndrome (ALPS)~~. ~~It is characterized by lymphadenopathy~~, ~~splenomegaly~~, ~~and defective CD95-induced apoptosis of peripheral blood lymphocytes~~ (~~PBLs~~)~~. It leads to defects in activation of T~~-~~lymphocytes, B-lymphocytes, and natural killer cells leading to immunodeficiency characterized by recurrent sinopulmonary and herpes simplex virus infections and poor responses to immunization~~.<ref>PMID:~~12353035~~</ref>	+

-	~~==Function==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[http:~~/~~/www.uniprot.org/uniprot/CASP8_HUMAN CASP8_HUMAN]] Most upstream protease~~ of the ~~activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death~~. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. ~~Proteolytic fragments~~ of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-\|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.<~~ref~~>~~PMID:12010809~~</~~ref~~>~~<ref>PMID:9006941</ref>~~	+	</div>
-		+
-	~~==About this Structure==~~	+
-	[[3kjn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KJN OCA].	+

	==See Also==		==See Also==
	*[[Caspase\|Caspase]]		*[[Caspase\|Caspase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020580860</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Caspase-8]]		[[Category: Caspase-8]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
-	[[Category: Blinn, J.]]	+	[[Category: Blinn, J]]
-	[[Category: Finzel, B C.]]	+	[[Category: Finzel, B C]]
-	[[Category: Harris, M S.]]	+	[[Category: Harris, M S]]
-	[[Category: Kamtekar, S.]]	+	[[Category: Kamtekar, S]]
-	[[Category: Tomasselli, A G.]]	+	[[Category: Tomasselli, A G]]
-	[[Category: Wang, Z.]]	+	[[Category: Wang, Z]]
-	[[Category: Watt, W.]]	+	[[Category: Watt, W]]
	[[Category: Caspase 8]]		[[Category: Caspase 8]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]

OCA at 18:02, 24 March 2013

OCA — Sun, 24 Mar 2013 18:02:25 GMT

←Older revision		Revision as of 18:02, 24 March 2013
Line 1:		Line 1:
-	[[Image:3kjn.png\|left\|200px]]
-
	{{STRUCTURE_3kjn\| PDB=3kjn \| SCENE= }}		{{STRUCTURE_3kjn\| PDB=3kjn \| SCENE= }}
-
	===Caspase 8 bound to a covalent inhibitor===		===Caspase 8 bound to a covalent inhibitor===
		+	{{ABSTRACT_PUBMED_20580860}}

-	~~{{ABSTRACT_PUBMED_20580860}}~~	+	==Disease==
		+	[[http://www.uniprot.org/uniprot/CASP8_HUMAN CASP8_HUMAN]] Defects in CASP8 are the cause of caspase-8 deficiency (CASP8D) [MIM:[http://omim.org/entry/607271 607271]]. CASP8D is a disorder resembling autoimmune lymphoproliferative syndrome (ALPS). It is characterized by lymphadenopathy, splenomegaly, and defective CD95-induced apoptosis of peripheral blood lymphocytes (PBLs). It leads to defects in activation of T-lymphocytes, B-lymphocytes, and natural killer cells leading to immunodeficiency characterized by recurrent sinopulmonary and herpes simplex virus infections and poor responses to immunization.<ref>PMID:12353035</ref>
		+
		+	==Function==
		+	[[http://www.uniprot.org/uniprot/CASP8_HUMAN CASP8_HUMAN]] Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-\|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.<ref>PMID:12010809</ref><ref>PMID:9006941</ref>

	==About this Structure==		==About this Structure==
Line 14:		Line 16:

	==Reference==		==Reference==
-	<ref group="xtra">PMID:020580860</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020580860</ref><references group="xtra"/><references/>
	[[Category: Caspase-8]]		[[Category: Caspase-8]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 19:13, 20 October 2012

OCA — Sat, 20 Oct 2012 19:13:18 GMT

←Older revision		Revision as of 19:13, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3kjn]] is a 2 chain structure ~~of [[Caspase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KJN OCA].	+	[[3kjn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KJN OCA].

	==See Also==		==See Also==

OCA: Protected "3kjn" [edit=sysop:move=sysop]

OCA — Fri, 27 Jul 2012 06:39:58 GMT

Protected "3kjn" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:39, 27 July 2012

OCA at 06:39, 27 July 2012

OCA — Fri, 27 Jul 2012 06:39:57 GMT

←Older revision		Revision as of 06:39, 27 July 2012
Line 1:		Line 1:
-	{{Seed}}
	[[Image:3kjn.png\|left\|200px]]		[[Image:3kjn.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3kjn", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3kjn\| PDB=3kjn \| SCENE= }}		{{STRUCTURE_3kjn\| PDB=3kjn \| SCENE= }}

	===Caspase 8 bound to a covalent inhibitor===		===Caspase 8 bound to a covalent inhibitor===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20580860}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20580860 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20580860}}		{{ABSTRACT_PUBMED_20580860}}

	==About this Structure==		==About this Structure==
-	~~3KJN~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KJN OCA].	+	[[3kjn]] is a 2 chain structure of [[Caspase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KJN OCA].
		+
		+	==See Also==
		+	*[[Caspase\|Caspase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20580860~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020580860</ref><references group="xtra"/>
	[[Category: Caspase-8]]		[[Category: Caspase-8]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
Line 40:		Line 31:
	[[Category: Urazole]]		[[Category: Urazole]]
	[[Category: Zymogen]]		[[Category: Zymogen]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:13:04 2010''

OCA at 07:05, 18 August 2010

OCA — Wed, 18 Aug 2010 07:05:31 GMT

←Older revision		Revision as of 07:05, 18 August 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3kjn.~~jpg~~\|left\|200px]]	+	[[Image:3kjn.png\|left\|200px]]

	<!--		<!--
Line 33:		Line 33:
	[[Category: Wang, Z.]]		[[Category: Wang, Z.]]
	[[Category: Watt, W.]]		[[Category: Watt, W.]]
-	~~[[Category: Apoptosis]]~~	+	[[Category: Caspase 8]]
-	[[Category: Caspase ~~caspase~~ 8 ~~apoptosis kinetics peptidomimetic inhibitor urazole]]~~	+	[[Category: Hydrolase-hydrolase inhibitor complex]]
-	~~[[Category: Disease mutation~~]]	+	[[Category: Kinetic]]
-	[[Category: Hydrolase]]	+	[[Category: Peptidomimetic inhibitor]]
-	[[Category: ~~Phosphoprotein~~]]	+
-	[[Category: ~~Protease~~]]	+
	[[Category: Thiol protease]]		[[Category: Thiol protease]]
		+	[[Category: Urazole]]
	[[Category: Zymogen]]		[[Category: Zymogen]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 11 23:55:39 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:13:04 2010''

OCA at 19:48, 11 August 2010

OCA — Wed, 11 Aug 2010 19:48:22 GMT

←Older revision		Revision as of 19:48, 11 August 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3kjn.jpg\|left\|200px]]

-	The ~~entry 3kjn~~ is ~~ON HOLD~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3kjn", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3kjn\| PDB=3kjn \| SCENE= }}

-	~~Authors: Kamtekar, S., Watt, W., Finzel, B.C., Harris, M.S., Blinn, J., Wang, Z., Tomasselli, A.G.~~	+	===Caspase 8 bound to a covalent inhibitor===

-	Description: Caspase 8 bound to a covalent inhibitor

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Nov 18 18~~:57:~~25 2009~~''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20580860}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20580860 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20580860}}
		+
		+	==About this Structure==
		+	3KJN is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KJN OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20580860</ref><references group="xtra"/>
		+	[[Category: Caspase-8]]
		+	[[Category: Homo sapiens]]
		+	[[Category: Blinn, J.]]
		+	[[Category: Finzel, B C.]]
		+	[[Category: Harris, M S.]]
		+	[[Category: Kamtekar, S.]]
		+	[[Category: Tomasselli, A G.]]
		+	[[Category: Wang, Z.]]
		+	[[Category: Watt, W.]]
		+	[[Category: Apoptosis]]
		+	[[Category: Caspase caspase 8 apoptosis kinetics peptidomimetic inhibitor urazole]]
		+	[[Category: Disease mutation]]
		+	[[Category: Hydrolase]]
		+	[[Category: Phosphoprotein]]
		+	[[Category: Protease]]
		+	[[Category: Thiol protease]]
		+	[[Category: Zymogen]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 11 23:55:39 2010''

OCA: New page: '''Unreleased structure''' The entry 3kjn is ON HOLD Authors: Kamtekar, S., Watt, W., Finzel, B.C., Harris, M.S., Blinn, J., Wang, Z., Tomasselli, A.G. Description: Caspase 8 bound to ...

OCA — Wed, 18 Nov 2009 16:57:26 GMT

New page: '''Unreleased structure''' The entry 3kjn is ON HOLD Authors: Kamtekar, S., Watt, W., Finzel, B.C., Harris, M.S., Blinn, J., Wang, Z., Tomasselli, A.G. Description: Caspase 8 bound to ...

New page

'''Unreleased structure'''

The entry 3kjn is ON HOLD

Authors: Kamtekar, S., Watt, W., Finzel, B.C., Harris, M.S., Blinn, J., Wang, Z., Tomasselli, A.G.

Description: Caspase 8 bound to a covalent inhibitor

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 18 18:57:25 2009''