3kk9 - Revision history

OCA at 12:26, 13 October 2021

OCA — Wed, 13 Oct 2021 12:26:15 GMT

←Older revision		Revision as of 12:26, 13 October 2021
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	==CaMKII Substrate Complex B==		==CaMKII Substrate Complex B==
-	<StructureSection load='3kk9' size='340' side='right' caption='[[3kk9]], [[Resolution\|resolution]] 3.21Å' scene=''>	+	<StructureSection load='3kk9' size='340' side='right'caption='[[3kk9]], [[Resolution\|resolution]] 3.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kk9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KK9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3KK9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kk9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KK9 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kk8\|3kk8]], [[3kl8\|3kl8]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3kk8\|3kk8]], [[3kl8\|3kl8]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">unc-43, K11E8.1, K11E8.1d ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">unc-43, K11E8.1, K11E8.1d ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3kk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kk9 OCA], [~~http~~://pdbe.org/3kk9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3kk9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3kk9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3kk9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kk9 OCA], [https://pdbe.org/3kk9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kk9 RCSB], [https://www.ebi.ac.uk/pdbsum/3kk9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kk9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/KCC2D_CAEEL KCC2D_CAEEL]] Acts in the signaling of a variety of pathways and processes. Phosphorylates 'Ser-319' of daf-16 in response to stress signals, such as heat, starvation and oxidation, which plays a role in prolonging lifespan. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Has roles in locomotion, oocyte maturation, brood size, egg laying, defecation, meiotic maturation and neuronal cell fate specification. Required for the regulation of synaptic density and neuromuscular junction morphology. Regulates the synaptic trafficking of glr-1. Bidirectional modulator of neurotransmitter release with negative modulatory effects mainly mediated via slo-1 activation. Involved in activation of ADF neurons and increased tph-1 transcription following exposure to pathogenic bacteria which leads to learned olfactory aversion to the bacteria. Implicated in the muscle regulation of spicule protraction. In conjunction with egl-2 has a role in the suppression of mating behavior under food deprivation to encourage foraging. Involved in restricting str-2 expression to only one of the two AWC neurons. May suppress the functional response to an internal pacemaker, perhaps by modulating the activity of the IP3 receptor.<ref>PMID:10571181</ref> <ref>PMID:12221132</ref> <ref>PMID:15166144</ref> <ref>PMID:16079277</ref> <ref>PMID:16267094</ref> <ref>PMID:17898212</ref> <ref>PMID:17941711</ref> <ref>PMID:17942636</ref> <ref>PMID:21145946</ref> <ref>PMID:21771813</ref> <ref>PMID:22629462</ref> <ref>PMID:23325232</ref> <ref>PMID:23663262</ref> <ref>PMID:23805378</ref>	+	[[https://www.uniprot.org/uniprot/KCC2D_CAEEL KCC2D_CAEEL]] Acts in the signaling of a variety of pathways and processes. Phosphorylates 'Ser-319' of daf-16 in response to stress signals, such as heat, starvation and oxidation, which plays a role in prolonging lifespan. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Has roles in locomotion, oocyte maturation, brood size, egg laying, defecation, meiotic maturation and neuronal cell fate specification. Required for the regulation of synaptic density and neuromuscular junction morphology. Regulates the synaptic trafficking of glr-1. Bidirectional modulator of neurotransmitter release with negative modulatory effects mainly mediated via slo-1 activation. Involved in activation of ADF neurons and increased tph-1 transcription following exposure to pathogenic bacteria which leads to learned olfactory aversion to the bacteria. Implicated in the muscle regulation of spicule protraction. In conjunction with egl-2 has a role in the suppression of mating behavior under food deprivation to encourage foraging. Involved in restricting str-2 expression to only one of the two AWC neurons. May suppress the functional response to an internal pacemaker, perhaps by modulating the activity of the IP3 receptor.<ref>PMID:10571181</ref> <ref>PMID:12221132</ref> <ref>PMID:15166144</ref> <ref>PMID:16079277</ref> <ref>PMID:16267094</ref> <ref>PMID:17898212</ref> <ref>PMID:17941711</ref> <ref>PMID:17942636</ref> <ref>PMID:21145946</ref> <ref>PMID:21771813</ref> <ref>PMID:22629462</ref> <ref>PMID:23325232</ref> <ref>PMID:23663262</ref> <ref>PMID:23805378</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
-	*[[Calcium/~~Calmodulin-~~dependent protein kinase\|Calcium/~~Calmodulin-~~dependent protein kinase]]	+	*[[Calcium/calmodulin dependent protein kinase 3D structures\|Calcium/calmodulin dependent protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Caeel]]		[[Category: Caeel]]
		+	[[Category: Large Structures]]
	[[Category: Barclay, L A]]		[[Category: Barclay, L A]]
	[[Category: Chao, L H]]		[[Category: Chao, L H]]

OCA at 09:17, 26 December 2018

OCA — Wed, 26 Dec 2018 09:17:00 GMT

←Older revision		Revision as of 09:17, 26 December 2018
Line 1:		Line 1:
		+
	==CaMKII Substrate Complex B==		==CaMKII Substrate Complex B==
	<StructureSection load='3kk9' size='340' side='right' caption='[[3kk9]], [[Resolution\|resolution]] 3.21Å' scene=''>		<StructureSection load='3kk9' size='340' side='right' caption='[[3kk9]], [[Resolution\|resolution]] 3.21Å' scene=''>
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kk8\|3kk8]], [[3kl8\|3kl8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kk8\|3kk8]], [[3kl8\|3kl8]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">unc-43, K11E8.1, K11E8.1d ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">unc-43, K11E8.1, K11E8.1d ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kk9 OCA], [http://pdbe.org/3kk9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kk9 RCSB], [http://www.ebi.ac.uk/pdbsum/3kk9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kk9 OCA], [http://pdbe.org/3kk9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kk9 RCSB], [http://www.ebi.ac.uk/pdbsum/3kk9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kk9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kk/3kk9_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kk/3kk9_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 3kk9" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3kk9" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Calcium/Calmodulin-dependent protein kinase\|Calcium/Calmodulin-dependent protein kinase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 01:06, 9 February 2016

OCA — Tue, 09 Feb 2016 01:06:38 GMT

←Older revision		Revision as of 01:06, 9 February 2016
Line 2:		Line 2:
	<StructureSection load='3kk9' size='340' side='right' caption='[[3kk9]], [[Resolution\|resolution]] 3.21Å' scene=''>		<StructureSection load='3kk9' size='340' side='right' caption='[[3kk9]], [[Resolution\|resolution]] 3.21Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kk9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Caenorhabditis_elegans Caenorhabditis elegans~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KK9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kk9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caeel Caeel]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KK9 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kk8\|3kk8]], [[3kl8\|3kl8]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kk8\|3kk8]], [[3kl8\|3kl8]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">unc-43, K11E8.1, K11E8.1d ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 ~~Caenorhabditis elegans~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">unc-43, K11E8.1, K11E8.1d ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 CAEEL])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kk9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kk9 RCSB], [http://www.ebi.ac.uk/pdbsum/3kk9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kk9 OCA], [http://pdbe.org/3kk9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kk9 RCSB], [http://www.ebi.ac.uk/pdbsum/3kk9 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/~~Q9U6Q0_CAEEL Q9U6Q0_CAEEL~~]] ~~Role~~ in ~~locomotion~~ and ~~neuronal cell fate specification~~. ~~Required for the regulation~~ of ~~synaptic density~~, ~~egg laying~~, ~~defecation~~, ~~and meiotic maturation~~. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Regulates the synaptic trafficking of glr-1. Bidirectional modulator of neurotransmitter release with negative modulatory effects mainly mediated via slo-1 activation. May suppress the functional response to an internal pacemaker, perhaps by modulating the activity of the IP3 receptor.<ref>PMID:15166144</ref> <ref>PMID:16079277</ref> <ref>PMID:17898212</ref> <ref>PMID:17942636</ref>	+	[[http://www.uniprot.org/uniprot/KCC2D_CAEEL KCC2D_CAEEL]] Acts in the signaling of a variety of pathways and processes. Phosphorylates 'Ser-319' of daf-16 in response to stress signals, such as heat, starvation and oxidation, which plays a role in prolonging lifespan. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Has roles in locomotion, oocyte maturation, brood size, egg laying, defecation, meiotic maturation and neuronal cell fate specification. Required for the regulation of synaptic density and neuromuscular junction morphology. Regulates the synaptic trafficking of glr-1. Bidirectional modulator of neurotransmitter release with negative modulatory effects mainly mediated via slo-1 activation. Involved in activation of ADF neurons and increased tph-1 transcription following exposure to pathogenic bacteria which leads to learned olfactory aversion to the bacteria. Implicated in the muscle regulation of spicule protraction. In conjunction with egl-2 has a role in the suppression of mating behavior under food deprivation to encourage foraging. Involved in restricting str-2 expression to only one of the two AWC neurons. May suppress the functional response to an internal pacemaker, perhaps by modulating the activity of the IP3 receptor.<ref>PMID:10571181</ref> <ref>PMID:12221132</ref> <ref>PMID:15166144</ref> <ref>PMID:16079277</ref> <ref>PMID:16267094</ref> <ref>PMID:17898212</ref> <ref>PMID:17941711</ref> <ref>PMID:17942636</ref> <ref>PMID:21145946</ref> <ref>PMID:21771813</ref> <ref>PMID:22629462</ref> <ref>PMID:23325232</ref> <ref>PMID:23663262</ref> <ref>PMID:23805378</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kk9 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3kk9" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Caenorhabditis elegans~~]]	+	[[Category: Caeel]]
	[[Category: Barclay, L A]]		[[Category: Barclay, L A]]
	[[Category: Chao, L H]]		[[Category: Chao, L H]]

OCA at 03:23, 25 December 2014

OCA — Thu, 25 Dec 2014 03:23:14 GMT

←Older revision		Revision as of 03:23, 25 December 2014
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kk9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kk9 RCSB], [http://www.ebi.ac.uk/pdbsum/3kk9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kk9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kk9 RCSB], [http://www.ebi.ac.uk/pdbsum/3kk9 PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q9U6Q0_CAEEL Q9U6Q0_CAEEL]] Role in locomotion and neuronal cell fate specification. Required for the regulation of synaptic density, egg laying, defecation, and meiotic maturation. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Regulates the synaptic trafficking of glr-1. Bidirectional modulator of neurotransmitter release with negative modulatory effects mainly mediated via slo-1 activation. May suppress the functional response to an internal pacemaker, perhaps by modulating the activity of the IP3 receptor.<ref>PMID:15166144</ref> <ref>PMID:16079277</ref> <ref>PMID:17898212</ref> <ref>PMID:17942636</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 16:06, 18 December 2014

OCA — Thu, 18 Dec 2014 16:06:34 GMT

←Older revision		Revision as of 16:06, 18 December 2014
Line 1:		Line 1:
-	~~{{STRUCTURE_3kk9~~\| ~~PDB~~=3kk9 \| ~~SCENE~~= }}	+	==CaMKII Substrate Complex B==
-	===~~CaMKII Substrate Complex B~~===	+	<StructureSection load='3kk9' size='340' side='right' caption='[[3kk9]], [[Resolution\|resolution]] 3.21Å' scene=''>
-	~~{{ABSTRACT_PUBMED_20139983}}~~	+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3kk9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KK9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KK9 FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kk8\|3kk8]], [[3kl8\|3kl8]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">unc-43, K11E8.1, K11E8.1d ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kk9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kk9 RCSB], [http://www.ebi.ac.uk/pdbsum/3kk9 PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kk/3kk9_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The dodecameric holoenzyme of calcium-calmodulin-dependent protein kinase II (CaMKII) responds to high-frequency Ca(2+) pulses to become Ca(2+) independent. A simple coincidence-detector model for Ca(2+)-frequency dependency assumes noncooperative activation of kinase domains. We show that activation of CaMKII by Ca(2+)-calmodulin is cooperative, with a Hill coefficient of approximately 3.0, implying sequential kinase-domain activation beyond dimeric units. We present data for a model in which cooperative activation includes the intersubunit 'capture' of regulatory segments. Such a capture interaction is seen in a crystal structure that shows extensive contacts between the regulatory segment of one kinase and the catalytic domain of another. These interactions are mimicked by a natural inhibitor of CaMKII. Our results show that a simple coincidence-detection model cannot be operative and point to the importance of kinetic dissection of the frequency-response mechanism in future experiments.

-	~~==Function==~~	+	Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation.,Chao LH, Pellicena P, Deindl S, Barclay LA, Schulman H, Kuriyan J Nat Struct Mol Biol. 2010 Mar;17(3):264-72. Epub 2010 Feb 7. PMID:20139983<ref>PMID:20139983</ref>
-	~~[[http://www~~.~~uniprot.org/uniprot/Q9U6Q0_CAEEL Q9U6Q0_CAEEL]] Role in locomotion and neuronal cell fate specification. Required for the regulation of synaptic density~~, ~~egg laying~~, ~~defecation~~, ~~and meiotic maturation~~. ~~Required for viability under chronic osmotic stress in which it acts downstream of osr~~-1. ~~Regulates the synaptic trafficking of glr-1~~. Bidirectional modulator of neurotransmitter release with negative modulatory effects mainly mediated via slo-1 activation. May suppress the functional response to an internal pacemaker, perhaps by modulating the activity of the IP3 receptor.<ref>PMID:~~15166144</ref> <ref>PMID:16079277</ref> <ref>PMID:17898212</ref>~~ <ref>PMID:~~17942636~~</ref>	+

-	~~==About this Structure==~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[3kk9]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3KK9 OCA].~~	+	</div>
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	~~<ref group="xtra">PMID:020139983</ref>~~<references ~~group="xtra"~~/><~~references~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Caenorhabditis elegans]]		[[Category: Caenorhabditis elegans]]
-	[[Category: Barclay, L A.]]	+	[[Category: Barclay, L A]]
-	[[Category: Chao, L H.]]	+	[[Category: Chao, L H]]
-	[[Category: Deindl, S.]]	+	[[Category: Deindl, S]]
-	[[Category: Kuriyan, J.]]	+	[[Category: Kuriyan, J]]
-	[[Category: Pellicena, P.]]	+	[[Category: Pellicena, P]]
-	[[Category: Schulman, H.]]	+	[[Category: Schulman, H]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Camkii]]		[[Category: Camkii]]

OCA: Protected "3kk9" [edit=sysop:move=sysop]

OCA — Thu, 04 Apr 2013 02:43:49 GMT

Protected "3kk9" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:43, 4 April 2013

OCA at 02:43, 4 April 2013

OCA — Thu, 04 Apr 2013 02:43:36 GMT

←Older revision		Revision as of 02:43, 4 April 2013
Line 1:		Line 1:
-	{{Seed}}
-	[[Image:3kk9.png\|left\|200px]]
-
-	<!--
-	The line below this paragraph, containing "STRUCTURE_3kk9", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3kk9\| PDB=3kk9 \| SCENE= }}		{{STRUCTURE_3kk9\| PDB=3kk9 \| SCENE= }}
-
	===CaMKII Substrate Complex B===		===CaMKII Substrate Complex B===
		+	{{ABSTRACT_PUBMED_20139983}}

-		+	==Function==
-	~~<!--~~	+	[[http://www.uniprot.org/uniprot/Q9U6Q0_CAEEL Q9U6Q0_CAEEL]] Role in locomotion and neuronal cell fate specification. Required for the regulation of synaptic density, egg laying, defecation, and meiotic maturation. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Regulates the synaptic trafficking of glr-1. Bidirectional modulator of neurotransmitter release with negative modulatory effects mainly mediated via slo-1 activation. May suppress the functional response to an internal pacemaker, perhaps by modulating the activity of the IP3 receptor.<ref>PMID:15166144</ref> <ref>PMID:16079277</ref> <ref>PMID:17898212</ref> <ref>PMID:17942636</ref>
-	~~The line below this paragraph, {{ABSTRACT_PUBMED_20139983}}, adds the Publication Abstract to the page~~	+
-	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 20139983 is~~ the ~~PubMed ID number~~.	+
-	-->	+
-	~~{{ABSTRACT_PUBMED_20139983}}~~	+

	==About this Structure==		==About this Structure==
-	~~3KK9~~ is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KK9 OCA].	+	[[3kk9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KK9 OCA].

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20139983~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020139983</ref><references group="xtra"/><references/>
	[[Category: Caenorhabditis elegans]]		[[Category: Caenorhabditis elegans]]
	[[Category: Barclay, L A.]]		[[Category: Barclay, L A.]]
Line 37:		Line 24:
	[[Category: Serine/threonine-protein kinase]]		[[Category: Serine/threonine-protein kinase]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 26 08:40:10 2010''

OCA at 04:35, 26 May 2010

OCA — Wed, 26 May 2010 04:35:59 GMT

←Older revision		Revision as of 04:35, 26 May 2010
Line 29:		Line 29:
	[[Category: Deindl, S.]]		[[Category: Deindl, S.]]
	[[Category: Kuriyan, J.]]		[[Category: Kuriyan, J.]]
-	[[Category: ~~Pelliecna~~, P.]]	+	[[Category: Pellicena, P.]]
	[[Category: Schulman, H.]]		[[Category: Schulman, H.]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
Line 38:		Line 38:
	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Mar 24~~ 08:26:21 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 26 08:40:10 2010''

OCA at 06:26, 24 March 2010

OCA — Wed, 24 Mar 2010 06:26:22 GMT

←Older revision		Revision as of 06:26, 24 March 2010
Line 1:		Line 1:
	{{Seed}}		{{Seed}}
-	[[Image:3kk9.~~jpg~~\|left\|200px]]	+	[[Image:3kk9.png\|left\|200px]]

	<!--		<!--
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	===CaMKII Substrate Complex B===		===CaMKII Substrate Complex B===

		+
		+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20139983}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20139983 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20139983}}

	==About this Structure==		==About this Structure==
	3KK9 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KK9 OCA].		3KK9 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KK9 OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20139983</ref><references group="xtra"/>
	[[Category: Caenorhabditis elegans]]		[[Category: Caenorhabditis elegans]]
	[[Category: Barclay, L A.]]		[[Category: Barclay, L A.]]
Line 29:		Line 38:
	[[Category: Transferase]]		[[Category: Transferase]]

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Feb 10 17~~:58:09 2010''	+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 24 08:26:21 2010''

OCA at 15:58, 10 February 2010

OCA — Wed, 10 Feb 2010 15:58:10 GMT

←Older revision		Revision as of 15:58, 10 February 2010
Line 1:		Line 1:
-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3kk9.jpg\|left\|200px]]

-	The ~~entry 3kk9~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3kk9", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3kk9\| PDB=3kk9 \| SCENE= }}

-	~~Authors: Kuriyan, J., Chao, L.H., Pelliecna, P., Deindl, S., Barclay, L.A., Schulman, H.~~	+	===CaMKII Substrate Complex B===

-	Description: Protein Kianse complex B

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Dec 16 12~~:34:~~32 2009~~''	+	==About this Structure==
		+	3KK9 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KK9 OCA].
		+	[[Category: Caenorhabditis elegans]]
		+	[[Category: Barclay, L A.]]
		+	[[Category: Chao, L H.]]
		+	[[Category: Deindl, S.]]
		+	[[Category: Kuriyan, J.]]
		+	[[Category: Pelliecna, P.]]
		+	[[Category: Schulman, H.]]
		+	[[Category: Atp-binding]]
		+	[[Category: Camkii]]
		+	[[Category: Kinase]]
		+	[[Category: Nucleotide-binding]]
		+	[[Category: Serine/threonine-protein kinase]]
		+	[[Category: Transferase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 10 17:58:09 2010''