3kqo - Revision history

OCA at 08:21, 6 September 2023

OCA — Wed, 06 Sep 2023 08:21:34 GMT

←Older revision		Revision as of 08:21, 6 September 2023
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	==Crystal Structure of hPNMT in Complex AdoHcy and 6-Chloropurine==		==Crystal Structure of hPNMT in Complex AdoHcy and 6-Chloropurine==
-	<StructureSection load='3kqo' size='340' side='right' caption='[[3kqo]], [[Resolution\|resolution]] 2.40Å' scene=''>	+	<StructureSection load='3kqo' size='340' side='right'caption='[[3kqo]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kqo]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KQO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3KQO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kqo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KQO FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=ES4:6-CHLORO-9H-PURINE'>ES4</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kpj\|3kpj]]~~, [[~~3kpu~~\|3kpu]], [[3kpv\|3kpv]], [[3kpw\|3kpw]], [[3kpy\|3kpy]], [[3kqm\|3kqm]], [[3kqp\|3kqp]], [[3kqq\|3kqq]], [[3kqs\|3kqs]], [[3kqt\|3kqt]], [[3kqv\|3kqv]], [[3kqw\|3kqw]], [[3kqy\|3kqy]], [[3kr0\|3kr0]], [[3kr1\|3kr1]], [[3kr2\|3kr2]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ES4:6-CHLORO-9H-PURINE'>ES4</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>PNMT, PENT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~9606 HUMAN])</td~~><~~/tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kqo OCA], [https://pdbe.org/3kqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kqo RCSB], [https://www.ebi.ac.uk/pdbsum/3kqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kqo ProSAT]</span></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[http~~:~~//en.wikipedia.org/wiki/Phenylethanolamine_N~~-~~methyltransferase Phenylethanolamine N~~-~~methyltransferase], with EC number [http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28]~~ </~~span~~></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=3kqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kqo OCA], [~~http~~://pdbe.org/3kqo PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=3kqo RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/3kqo PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=3kqo ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PNMT_HUMAN PNMT_HUMAN]] Converts noradrenaline to adrenaline.	+	[https://www.uniprot.org/uniprot/PNMT_HUMAN PNMT_HUMAN] Converts noradrenaline to adrenaline.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
-	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kq/3kqo_consurf.spt"</scriptWhenChecked>	+	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kq/3kqo_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 31:		Line 29:
	</div>		</div>
	<div class="pdbe-citations 3kqo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3kqo" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phenylethanolamine N-methyltransferase\|Phenylethanolamine N-methyltransferase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Phenylethanolamine N-methyltransferase~~]]	+	[[Category: Large Structures]]
-	[[Category: Drinkwater, N]]	+	[[Category: Drinkwater N]]
-	[[Category: Martin~~, J L]]~~	+	[[Category: Martin JL]]
-	~~[[Category: Catecholamine biosynthesis]]~~	+
-	~~[[Category: Fragment screening]]~~	+
-	~~[[Category: Methyltransferase]]~~	+
-	~~[[Category: S-adenosyl-l-methionine]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 08:39, 1 November 2017

OCA — Wed, 01 Nov 2017 08:39:15 GMT

←Older revision		Revision as of 08:39, 1 November 2017
Line 31:		Line 31:
	</div>		</div>
	<div class="pdbe-citations 3kqo" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 3kqo" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Phenylethanolamine N-methyltransferase\|Phenylethanolamine N-methyltransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 21:27, 4 August 2016

OCA — Thu, 04 Aug 2016 21:27:11 GMT

←Older revision		Revision as of 21:27, 4 August 2016
Line 1:		Line 1:
		+
	==Crystal Structure of hPNMT in Complex AdoHcy and 6-Chloropurine==		==Crystal Structure of hPNMT in Complex AdoHcy and 6-Chloropurine==
	<StructureSection load='3kqo' size='340' side='right' caption='[[3kqo]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='3kqo' size='340' side='right' caption='[[3kqo]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[3kqo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KQO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KQO FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[3kqo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KQO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KQO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ES4:6-CHLORO-9H-PURINE'>ES4</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ES4:6-CHLORO-9H-PURINE'>ES4</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kpj\|3kpj]], [[3kpu\|3kpu]], [[3kpv\|3kpv]], [[3kpw\|3kpw]], [[3kpy\|3kpy]], [[3kqm\|3kqm]], [[3kqp\|3kqp]], [[3kqq\|3kqq]], [[3kqs\|3kqs]], [[3kqt\|3kqt]], [[3kqv\|3kqv]], [[3kqw\|3kqw]], [[3kqy\|3kqy]], [[3kr0\|3kr0]], [[3kr1\|3kr1]], [[3kr2\|3kr2]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kpj\|3kpj]], [[3kpu\|3kpu]], [[3kpv\|3kpv]], [[3kpw\|3kpw]], [[3kpy\|3kpy]], [[3kqm\|3kqm]], [[3kqp\|3kqp]], [[3kqq\|3kqq]], [[3kqs\|3kqs]], [[3kqt\|3kqt]], [[3kqv\|3kqv]], [[3kqw\|3kqw]], [[3kqy\|3kqy]], [[3kr0\|3kr0]], [[3kr1\|3kr1]], [[3kr2\|3kr2]]</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PNMT, PENT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PNMT, PENT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylethanolamine_N-methyltransferase Phenylethanolamine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylethanolamine_N-methyltransferase Phenylethanolamine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kqo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kqo RCSB], [http://www.ebi.ac.uk/pdbsum/3kqo PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kqo OCA], [http://pdbe.org/3kqo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kqo RCSB], [http://www.ebi.ac.uk/pdbsum/3kqo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kqo ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
-	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].	+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kqo ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
		+	<div class="pdbe-citations 3kqo" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 36:		Line 38:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Homo sapiens~~]]	+	[[Category: Human]]
	[[Category: Phenylethanolamine N-methyltransferase]]		[[Category: Phenylethanolamine N-methyltransferase]]
	[[Category: Drinkwater, N]]		[[Category: Drinkwater, N]]

OCA at 19:49, 24 December 2014

OCA — Wed, 24 Dec 2014 19:49:42 GMT

←Older revision		Revision as of 19:49, 24 December 2014
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kqo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kqo RCSB], [http://www.ebi.ac.uk/pdbsum/3kqo PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kqo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kqo RCSB], [http://www.ebi.ac.uk/pdbsum/3kqo PDBsum]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PNMT_HUMAN PNMT_HUMAN]] Converts noradrenaline to adrenaline.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:50, 9 December 2014

OCA — Tue, 09 Dec 2014 08:50:35 GMT

←Older revision		Revision as of 08:50, 9 December 2014
Line 1:		Line 1:
-	[[~~Image:~~3kqo.~~png~~\|~~left~~\|200px]]	+	==Crystal Structure of hPNMT in Complex AdoHcy and 6-Chloropurine==
		+	<StructureSection load='3kqo' size='340' side='right' caption='[[3kqo]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[3kqo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KQO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KQO FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ES4:6-CHLORO-9H-PURINE'>ES4</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3kpj\|3kpj]], [[3kpu\|3kpu]], [[3kpv\|3kpv]], [[3kpw\|3kpw]], [[3kpy\|3kpy]], [[3kqm\|3kqm]], [[3kqp\|3kqp]], [[3kqq\|3kqq]], [[3kqs\|3kqs]], [[3kqt\|3kqt]], [[3kqv\|3kqv]], [[3kqw\|3kqw]], [[3kqy\|3kqy]], [[3kr0\|3kr0]], [[3kr1\|3kr1]], [[3kr2\|3kr2]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PNMT, PENT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylethanolamine_N-methyltransferase Phenylethanolamine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.28 2.1.1.28] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kqo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kqo RCSB], [http://www.ebi.ac.uk/pdbsum/3kqo PDBsum]</span></td></tr>
		+	</table>
		+	== Evolutionary Conservation ==
		+	[[Image:Consurf_key_small.gif\|200px\|right]]
		+	Check<jmol>
		+	<jmolCheckbox>
		+	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kq/3kqo_consurf.spt"</scriptWhenChecked>
		+	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
		+	<text>to colour the structure by Evolutionary Conservation</text>
		+	</jmolCheckbox>
		+	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
		+	<div style="clear:both"></div>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	CNS (central nervous system) adrenaline (epinephrine) is implicated in a wide range of physiological and pathological conditions. PNMT (phenylethanolamine N-methyltransferase) catalyses the final step in the biosynthesis of adrenaline, the conversion of noradrenaline (norepinephrine) to adrenaline by methylation. To help elucidate the role of CNS adrenaline, and to develop potential drug leads, potent, selective and CNS-active inhibitors are required. The fragment screening approach has advantages over other lead discovery methods including high hit rates, more efficient hits and the ability to sample chemical diversity more easily. In the present study we applied fragment-based screening approaches to the enzyme PNMT. We used crystallography as the primary screen and identified 12 hits from a small commercial library of 384 drug-like fragments. The hits include nine chemicals with two fused rings and three single-ring chemical systems. Eight of the hits come from three chemical classes: benzimidazoles (a known class of PNMT inhibitor), purines and quinolines. Nine of the hits have measurable binding affinities (~5-700 muM) as determined by isothermal titration calorimetry and all nine have ligand efficiencies of 0.39 kcal/mol per heavy atom or better (1 kcal approximately 4.184 kJ). We synthesized five elaborated benzimidazole compounds and characterized their binding to PNMT, showing for the first time how this class of inhibitors interact with the noradrenaline-binding site. Finally, we performed a pilot study with PNMT for fragment-based screening by MS showing that this approach could be used as a fast and efficient first-pass screening method prior to characterization of binding mode and affinity of hits.

-	~~{{STRUCTURE_3kqo\| PDB=3kqo \| SCENE= }}~~	+	Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors.,Drinkwater N, Vu H, Lovell KM, Criscione KR, Collins BM, Prisinzano TE, Poulsen SA, McLeish MJ, Grunewald GL, Martin JL Biochem J. 2010 Oct 1;431(1):51-61. PMID:20642456<ref>PMID:20642456</ref>

-	~~===Crystal Structure~~ of ~~hPNMT in Complex AdoHcy and 6-Chloropurine===~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~{{ABSTRACT_PUBMED_20642456}}~~	+
-		+
-	~~==About this Structure==~~	+
-	~~[[3kqo]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=3KQO OCA].~~	+

	==See Also==		==See Also==
	*[[Phenylethanolamine N-methyltransferase\|Phenylethanolamine N-methyltransferase]]		*[[Phenylethanolamine N-methyltransferase\|Phenylethanolamine N-methyltransferase]]
-		+	== References ==
-	==~~Reference~~==	+	<references/>
-	<~~ref group="xtra">PMID:020642456<~~/~~ref~~><~~references group="xtra"~~/>	+	__TOC__
		+	</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phenylethanolamine N-methyltransferase]]		[[Category: Phenylethanolamine N-methyltransferase]]
-	[[Category: Drinkwater, N.]]	+	[[Category: Drinkwater, N]]
-	[[Category: Martin, J L.]]	+	[[Category: Martin, J L]]
	[[Category: Catecholamine biosynthesis]]		[[Category: Catecholamine biosynthesis]]
	[[Category: Fragment screening]]		[[Category: Fragment screening]]

OCA at 08:33, 20 October 2012

OCA — Sat, 20 Oct 2012 08:33:38 GMT

←Older revision		Revision as of 08:33, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
-	[[3kqo]] is a 2 chain structure ~~of [[Phenylethanolamine N-methyltransferase]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KQO OCA].	+	[[3kqo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KQO OCA].

	==See Also==		==See Also==

OCA at 19:55, 25 July 2012

OCA — Wed, 25 Jul 2012 19:55:22 GMT

←Older revision		Revision as of 19:55, 25 July 2012
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	[[Image:3kqo.png\|left\|200px]]		[[Image:3kqo.png\|left\|200px]]

-	<!--
-	The line below this paragraph, containing "STRUCTURE_3kqo", creates the "Structure Box" on the page.
-	You may change the PDB parameter (which sets the PDB file loaded into the applet)
-	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-	or leave the SCENE parameter empty for the default display.
-	-->
	{{STRUCTURE_3kqo\| PDB=3kqo \| SCENE= }}		{{STRUCTURE_3kqo\| PDB=3kqo \| SCENE= }}

	===Crystal Structure of hPNMT in Complex AdoHcy and 6-Chloropurine===		===Crystal Structure of hPNMT in Complex AdoHcy and 6-Chloropurine===

-
-	<!--
-	The line below this paragraph, {{ABSTRACT_PUBMED_20642456}}, adds the Publication Abstract to the page
-	(as it appears on PubMed at http://www.pubmed.gov), where 20642456 is the PubMed ID number.
-	-->
	{{ABSTRACT_PUBMED_20642456}}		{{ABSTRACT_PUBMED_20642456}}

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	==See Also==		==See Also==
-	*[[Phenylethanolamine N-methyltransferase]]	+	*[[Phenylethanolamine N-methyltransferase\|Phenylethanolamine N-methyltransferase]]

	==Reference==		==Reference==
-	<ref group="xtra">PMID:~~20642456~~</ref><references group="xtra"/>	+	<ref group="xtra">PMID:020642456</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Phenylethanolamine N-methyltransferase]]		[[Category: Phenylethanolamine N-methyltransferase]]

OCA: Protected "3kqo" [edit=sysop:move=sysop]

OCA — Sun, 26 Dec 2010 23:47:18 GMT

Protected "3kqo" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:47, 26 December 2010

OCA at 23:47, 26 December 2010

OCA — Sun, 26 Dec 2010 23:47:17 GMT

←Older revision		Revision as of 23:47, 26 December 2010
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-	~~{{Seed}}~~	+	[[Image:3kqo.png\|left\|200px]]
-	[[Image:3kqo.~~jpg~~\|left\|200px]]	+

	<!--		<!--
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	==About this Structure==		==About this Structure==
-	~~3KQO~~ is a 2 ~~chains~~ structure with ~~sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KQO OCA].	+	[[3kqo]] is a 2 chain structure of [[Phenylethanolamine N-methyltransferase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KQO OCA].
		+
		+	==See Also==
		+	*[[Phenylethanolamine N-methyltransferase]]

	==Reference==		==Reference==
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	[[Category: S-adenosyl-l-methionine]]		[[Category: S-adenosyl-l-methionine]]
	[[Category: Transferase]]		[[Category: Transferase]]
-
-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 29 08:13:53 2010''

OCA at 05:04, 29 September 2010

OCA — Wed, 29 Sep 2010 05:04:39 GMT

←Older revision		Revision as of 05:04, 29 September 2010
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-	~~'''Unreleased structure'''~~	+	{{Seed}}
		+	[[Image:3kqo.jpg\|left\|200px]]

-	The ~~entry 3kqo~~ is ~~ON HOLD~~ ~~until Paper Publication~~	+	<!--
		+	The line below this paragraph, containing "STRUCTURE_3kqo", creates the "Structure Box" on the page.
		+	You may change the PDB parameter (which sets the PDB file loaded into the applet)
		+	or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
		+	or leave the SCENE parameter empty for the default display.
		+	-->
		+	{{STRUCTURE_3kqo\| PDB=3kqo \| SCENE= }}

-	~~Authors: Drinkwater, N., Martin, J.L.~~	+	===Crystal Structure of hPNMT in Complex AdoHcy and 6-Chloropurine===

-	Description: Crystal Structure of hPNMT in Complex AdoHcy and 6-Chloropurine

-	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed ~~Jun 16~~ 08:27:40 2010''	+	<!--
		+	The line below this paragraph, {{ABSTRACT_PUBMED_20642456}}, adds the Publication Abstract to the page
		+	(as it appears on PubMed at http://www.pubmed.gov), where 20642456 is the PubMed ID number.
		+	-->
		+	{{ABSTRACT_PUBMED_20642456}}
		+
		+	==About this Structure==
		+	3KQO is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KQO OCA].
		+
		+	==Reference==
		+	<ref group="xtra">PMID:20642456</ref><references group="xtra"/>
		+	[[Category: Homo sapiens]]
		+	[[Category: Phenylethanolamine N-methyltransferase]]
		+	[[Category: Drinkwater, N.]]
		+	[[Category: Martin, J L.]]
		+	[[Category: Catecholamine biosynthesis]]
		+	[[Category: Fragment screening]]
		+	[[Category: Methyltransferase]]
		+	[[Category: S-adenosyl-l-methionine]]
		+	[[Category: Transferase]]
		+
		+	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 29 08:13:53 2010''